IMP

Process View

Homo sapiens

28 genes annotated in human

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sterol metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "sterol metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
DHCR7	7-dehydrocholesterol reductase	0.998
SC4MOL	sterol-C4-methyl oxidase-like	0.990	Yeast
FGFR2	fibroblast growth factor receptor 2	0.990
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.967
INSIG1	insulin induced gene 1	0.941	Mouse
SREBF2	sterol regulatory element binding transcription factor 2	0.918
SQLE	squalene epoxidase	0.911	Yeast
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.910	Mouse
FDPS	farnesyl diphosphate synthase	0.862
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.829	Yeast
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.820	Human
IDI1	isopentenyl-diphosphate delta isomerase 1	0.790
C14orf1	chromosome 14 open reading frame 1	0.714	Yeast
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.663	Human
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.655
CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1	0.644	Yeast Rat
DHCR24	24-dehydrocholesterol reductase	0.548
NSDHL	NAD(P) dependent steroid dehydrogenase-like	0.524	Yeast
APOA1	apolipoprotein A-I	0.396
LDLR	low density lipoprotein receptor	0.387	Mouse
ACAT2	acetyl-CoA acetyltransferase 2	0.345
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.327
APOE	apolipoprotein E	0.297
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.268	Yeast
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.262	Human
LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.234
MVD	mevalonate (diphospho) decarboxylase	0.221
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.203
HP	haptoglobin	0.189
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.179
FGB	fibrinogen beta chain	0.152
MED15	mediator complex subunit 15	0.151
A2M	alpha-2-macroglobulin	0.143
EBP	emopamil binding protein (sterol isomerase)	0.135	Mouse
IL4R	interleukin 4 receptor	0.108
ZFYVE9	zinc finger, FYVE domain containing 9	0.095
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.088	Yeast
SMAD4	SMAD family member 4	0.079
ACAA2	acetyl-CoA acyltransferase 2	0.076
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.075	Yeast
SC5DL	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like	0.074
APOC1	apolipoprotein C-I	0.073
CHMP1A	chromatin modifying protein 1A	0.072
HSPB1	heat shock 27kDa protein 1	0.071
FRS2	fibroblast growth factor receptor substrate 2	0.068
APOA2	apolipoprotein A-II	0.067
SMAD3	SMAD family member 3	0.059
FADS1	fatty acid desaturase 1	0.059
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.054
FGFR1	fibroblast growth factor receptor 1	0.049
STARD4	StAR-related lipid transfer (START) domain containing 4	0.048
ACAA1	acetyl-CoA acyltransferase 1	0.047
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.046
JUN	jun proto-oncogene	0.046
FGA	fibrinogen alpha chain	0.044
FASN	fatty acid synthase	0.041
LCAT	lecithin-cholesterol acyltransferase	0.039
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.038
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.036
MVK	mevalonate kinase	0.036
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.035
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.035	Human
CXXC5	CXXC finger protein 5	0.035
PSEN1	presenilin 1	0.032
LRP1	low density lipoprotein receptor-related protein 1	0.032	Mouse
HNF4A	hepatocyte nuclear factor 4, alpha	0.032
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.031
PDZK1	PDZ domain containing 1	0.030
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.030
APOC3	apolipoprotein C-III	0.030
FBXL15	F-box and leucine-rich repeat protein 15	0.028
TALDO1	transaldolase 1	0.028
SMAD2	SMAD family member 2	0.027
TKT	transketolase	0.026
PGRMC1	progesterone receptor membrane component 1	0.026
DEDD	death effector domain containing	0.026
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.025	Yeast
FADS2	fatty acid desaturase 2	0.024
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.024
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.023	Yeast
TM7SF2	transmembrane 7 superfamily member 2	0.023
EPS15	epidermal growth factor receptor pathway substrate 15	0.022
ALB	albumin	0.022
TTR	transthyretin	0.021
CAPRIN2	caprin family member 2	0.020
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.020
SMAD1	SMAD family member 1	0.020
WNK1	WNK lysine deficient protein kinase 1	0.020
PRDX1	peroxiredoxin 1	0.020
MBL2	mannose-binding lectin (protein C) 2, soluble	0.020
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.020
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.020
SCP2	sterol carrier protein 2	0.020
COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.019
PGD	phosphogluconate dehydrogenase	0.019
ANKRD13A	ankyrin repeat domain 13A	0.019
FGF2	fibroblast growth factor 2 (basic)	0.019	Human
HSPB8	heat shock 22kDa protein 8	0.018
MASP2	mannan-binding lectin serine peptidase 2	0.018
APOC2	apolipoprotein C-II	0.018
DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)	0.017
PEX19	peroxisomal biogenesis factor 19	0.017
CREBBP	CREB binding protein	0.017
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.016
KLF5	Kruppel-like factor 5 (intestinal)	0.016
EFR3A	EFR3 homolog A (S. cerevisiae)	0.016
DYNLL1	dynein, light chain, LC8-type 1	0.016
STX12	syntaxin 12	0.016
SKIL	SKI-like oncogene	0.016
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.016
ADAM15	ADAM metallopeptidase domain 15	0.016
ILVBL	ilvB (bacterial acetolactate synthase)-like	0.015
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.015
PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.015
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.015
OSBPL9	oxysterol binding protein-like 9	0.015	Yeast
TMEM30B	transmembrane protein 30B	0.015
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.014
FGL1	fibrinogen-like 1	0.014	Mouse
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.014
ACACA	acetyl-CoA carboxylase alpha	0.014
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.014
ECH1	enoyl CoA hydratase 1, peroxisomal	0.013
ACSS2	acyl-CoA synthetase short-chain family member 2	0.013
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.013
EPAS1	endothelial PAS domain protein 1	0.013
SH3KBP1	SH3-domain kinase binding protein 1	0.013
PRMT2	protein arginine methyltransferase 2	0.013
AADAC	arylacetamide deacetylase (esterase)	0.012
NDUFC1	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa	0.012
ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	0.012
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.012
ALDOC	aldolase C, fructose-bisphosphate	0.012
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.012
PRDX6	peroxiredoxin 6	0.012
ABHD3	abhydrolase domain containing 3	0.012
WDR13	WD repeat domain 13	0.012
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.011
ANTXR2	anthrax toxin receptor 2	0.011
POR	P450 (cytochrome) oxidoreductase	0.011	Rat
PCSK9	proprotein convertase subtilisin/kexin type 9	0.011
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.011
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.011
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.011
MPDU1	mannose-P-dolichol utilization defect 1	0.011
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.011
NOSTRIN	nitric oxide synthase trafficker	0.010
AR	androgen receptor	0.010
PARK7	Parkinson disease (autosomal recessive, early onset) 7	0.010
TBC1D10A	TBC1 domain family, member 10A	0.010
NDFIP2	Nedd4 family interacting protein 2	0.010
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.010
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.010
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.010
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.010
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.010
NEK7	NIMA (never in mitosis gene a)-related kinase 7	0.010
SMAD7	SMAD family member 7	0.010
ADARB1	adenosine deaminase, RNA-specific, B1	0.010
FBXW12	F-box and WD repeat domain containing 12	0.010