IMP

Process View

Homo sapiens

15 genes annotated in human

negative regulation of neuron projection development

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of neuron projection development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of neuron projection development" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC2	histone deacetylase 2	1.000	Mouse Fly
HDAC1	histone deacetylase 1	0.999	Fly
FGF1	fibroblast growth factor 1 (acidic)	0.786
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.585
TTR	transthyretin	0.405
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.255
FYN	FYN oncogene related to SRC, FGR, YES	0.255
PSEN2	presenilin 2 (Alzheimer disease 4)	0.219
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.192
RBBP4	retinoblastoma binding protein 4	0.178
FGFR1	fibroblast growth factor receptor 1	0.176	Fly
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.148
TEX11	testis expressed 11	0.130
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.125
GRB7	growth factor receptor-bound protein 7	0.113
TNK2	tyrosine kinase, non-receptor, 2	0.112
VEGFA	vascular endothelial growth factor A	0.107
BCAR1	breast cancer anti-estrogen resistance 1	0.105
RBBP7	retinoblastoma binding protein 7	0.100
CPE	carboxypeptidase E	0.087
A2M	alpha-2-macroglobulin	0.084
RAB5A	RAB5A, member RAS oncogene family	0.081
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.072
CHDH	choline dehydrogenase	0.072
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.071
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.071
MTA1	metastasis associated 1	0.067
FGFR2	fibroblast growth factor receptor 2	0.066	Fly
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.058
COL4A3BP	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	0.053
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.052
NGFR	nerve growth factor receptor	0.051	Rat
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.051
LRP6	low density lipoprotein receptor-related protein 6	0.051
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.046
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.043
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.042
STMN2	stathmin-like 2	0.041
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.041
C17orf28	chromosome 17 open reading frame 28	0.038
WASL	Wiskott-Aldrich syndrome-like	0.037
ATN1	atrophin 1	0.037
GOLGA2	golgin A2	0.035
FAM160A2	family with sequence similarity 160, member A2	0.035
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.035
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.035
FZD1	frizzled homolog 1 (Drosophila)	0.033
NCOA1	nuclear receptor coactivator 1	0.032
NEGR1	neuronal growth regulator 1	0.032
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.031
HLA-DMB	major histocompatibility complex, class II, DM beta	0.030
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.030
MAP1S	microtubule-associated protein 1S	0.028
ALK	anaplastic lymphoma receptor tyrosine kinase	0.028
TAF1D	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	0.027
JAG2	jagged 2	0.027
TMSB4X	thymosin beta 4, X-linked	0.026
CCDC85A	coiled-coil domain containing 85A	0.026
DCC	deleted in colorectal carcinoma	0.025
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.024
GABARAP	GABA(A) receptor-associated protein	0.024
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.024
EPOR	erythropoietin receptor	0.024
NCSTN	nicastrin	0.024
CXCR4	chemokine (C-X-C motif) receptor 4	0.023
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.023
ALB	albumin	0.023
RXRA	retinoid X receptor, alpha	0.022
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.021
MYO6	myosin VI	0.021
MBD2	methyl-CpG binding domain protein 2	0.021
TGFB3	transforming growth factor, beta 3	0.021
FGFR3	fibroblast growth factor receptor 3	0.021	Fly
CTGF	connective tissue growth factor	0.021
FGF2	fibroblast growth factor 2 (basic)	0.021
RTN4	reticulon 4	0.020
COL5A1	collagen, type V, alpha 1	0.020
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.020
SPOP	speckle-type POZ protein	0.019
FGF10	fibroblast growth factor 10	0.019
CHD4	chromodomain helicase DNA binding protein 4	0.019
BBS10	Bardet-Biedl syndrome 10	0.019
RCOR1	REST corepressor 1	0.019
APP	amyloid beta (A4) precursor protein	0.019
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.019
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.019
LCMT1	leucine carboxyl methyltransferase 1	0.019
SETDB1	SET domain, bifurcated 1	0.019
LCAT	lecithin-cholesterol acyltransferase	0.019
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.018
NELL2	NEL-like 2 (chicken)	0.018
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.018
PKP4	plakophilin 4	0.017
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.016
GANAB	glucosidase, alpha; neutral AB	0.016
SAP30	Sin3A-associated protein, 30kDa	0.016
RAP1A	RAP1A, member of RAS oncogene family	0.016
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.016
PDLIM4	PDZ and LIM domain 4	0.016
TSC22D4	TSC22 domain family, member 4	0.015
HMG20B	high mobility group 20B	0.015
JAK3	Janus kinase 3	0.015
CDK6	cyclin-dependent kinase 6	0.015
MTA3	metastasis associated 1 family, member 3	0.015
CLIP1	CAP-GLY domain containing linker protein 1	0.015
SESN2	sestrin 2	0.015
FLNB	filamin B, beta	0.015
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.015
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.014
RB1CC1	RB1-inducible coiled-coil 1	0.014
FAM118B	family with sequence similarity 118, member B	0.014
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.014
CXCL14	chemokine (C-X-C motif) ligand 14	0.014
MAPK11	mitogen-activated protein kinase 11	0.014
HP	haptoglobin	0.014
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.013
RUNDC3A	RUN domain containing 3A	0.013
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.013
KCNRG	potassium channel regulator	0.013
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.013	Human
PRKD2	protein kinase D2	0.013
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.013
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.013
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.013
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.013
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.012
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.012
HSF2	heat shock transcription factor 2	0.012
NONO	non-POU domain containing, octamer-binding	0.012
THY1	Thy-1 cell surface antigen	0.012	Rat
BGN	biglycan	0.012
PXN	paxillin	0.012
ANAPC7	anaphase promoting complex subunit 7	0.012
MAPT	microtubule-associated protein tau	0.012
PTN	pleiotrophin	0.012
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.012
CDYL	chromodomain protein, Y-like	0.011
RBP4	retinol binding protein 4, plasma	0.011
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.011
IMMT	inner membrane protein, mitochondrial	0.011
IL12RB2	interleukin 12 receptor, beta 2	0.011
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.011
SLIT2	slit homolog 2 (Drosophila)	0.011
SOCS1	suppressor of cytokine signaling 1	0.011
HDAC3	histone deacetylase 3	0.011
EFS	embryonal Fyn-associated substrate	0.011
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.011
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.010
FIBP	fibroblast growth factor (acidic) intracellular binding protein	0.010
KIAA0408	KIAA0408	0.010
PSEN1	presenilin 1	0.010	Mouse
BMI1	BMI1 polycomb ring finger oncogene	0.010
FBLN1	fibulin 1	0.010
FRS2	fibroblast growth factor receptor substrate 2	0.010