IMP

Process View

Homo sapiens

12 genes annotated in human

phospholipid catabolic process

The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "phospholipid catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "phospholipid catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	1.000
PRKCZ	protein kinase C, zeta	1.000	Human
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.995
APOE	apolipoprotein E	0.989
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.987
NUMB	numb homolog (Drosophila)	0.987
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.987
ZNF71	zinc finger protein 71	0.934
APOA1	apolipoprotein A-I	0.932
ALB	albumin	0.920
NOXA1	NADPH oxidase activator 1	0.915
CCDC115	coiled-coil domain containing 115	0.855
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.704	Human
F11R	F11 receptor	0.542
VHL	von Hippel-Lindau tumor suppressor	0.538
CRP	C-reactive protein, pentraxin-related	0.523
MAPT	microtubule-associated protein tau	0.455
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.307
NCF1	neutrophil cytosolic factor 1	0.277
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.272
APOB	apolipoprotein B (including Ag(x) antigen)	0.247
PICK1	protein interacting with PRKCA 1	0.228
PDPK1	3-phosphoinositide dependent protein kinase-1	0.213
HP	haptoglobin	0.205
SH3RF1	SH3 domain containing ring finger 1	0.201
CDCP1	CUB domain containing protein 1	0.180
CYBA	cytochrome b-245, alpha polypeptide	0.173
NMT2	N-myristoyltransferase 2	0.145
DCTN1	dynactin 1	0.142
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.135
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.128
LRP1	low density lipoprotein receptor-related protein 1	0.120
SETDB1	SET domain, bifurcated 1	0.109
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.097
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.093
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.085
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.082
APOA2	apolipoprotein A-II	0.081
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.077
APOC2	apolipoprotein C-II	0.071
BRF2	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	0.070
NCF2	neutrophil cytosolic factor 2	0.070
TTR	transthyretin	0.066
PCSK9	proprotein convertase subtilisin/kexin type 9	0.064
CFL1	cofilin 1 (non-muscle)	0.064
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.064
PEBP4	phosphatidylethanolamine-binding protein 4	0.063
CARD11	caspase recruitment domain family, member 11	0.063
SQLE	squalene epoxidase	0.056
APOC1	apolipoprotein C-I	0.055
PKN3	protein kinase N3	0.054
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.053
PRKCA	protein kinase C, alpha	0.050
TSC22D1	TSC22 domain family, member 1	0.049
LRRK2	leucine-rich repeat kinase 2	0.048
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.047
AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.046	Human
A2M	alpha-2-macroglobulin	0.045
PRKCI	protein kinase C, iota	0.044	Human
GPX4	glutathione peroxidase 4 (phospholipid hydroperoxidase)	0.042
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.040
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.039
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.039
BAD	BCL2-associated agonist of cell death	0.039
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.038
PDIA3	protein disulfide isomerase family A, member 3	0.037
BCL3	B-cell CLL/lymphoma 3	0.037
FOXO3	forkhead box O3	0.036
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.035
KAT2B	K(lysine) acetyltransferase 2B	0.034
DENND5A	DENN/MADD domain containing 5A	0.033
ITGB5	integrin, beta 5	0.032
FGA	fibrinogen alpha chain	0.032
APOC3	apolipoprotein C-III	0.031
FYN	FYN oncogene related to SRC, FGR, YES	0.031
APOA4	apolipoprotein A-IV	0.031
INSIG1	insulin induced gene 1	0.029
ASXL1	additional sex combs like 1 (Drosophila)	0.028
CCL14	chemokine (C-C motif) ligand 14	0.028
RICTOR	RPTOR independent companion of MTOR, complex 2	0.026
RHEB	Ras homolog enriched in brain	0.025
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.025
PRKCB	protein kinase C, beta	0.025
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.024
STK4	serine/threonine kinase 4	0.023
WWC1	WW and C2 domain containing 1	0.022
MAP2K5	mitogen-activated protein kinase kinase 5	0.022
FAM129A	family with sequence similarity 129, member A	0.022
ASGR2	asialoglycoprotein receptor 2	0.020
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.020
MINK1	misshapen-like kinase 1	0.019
FOXO1	forkhead box O1	0.019
SREBF2	sterol regulatory element binding transcription factor 2	0.019
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.018
POFUT1	protein O-fucosyltransferase 1	0.018
RPTOR	regulatory associated protein of MTOR, complex 1	0.018
CCHCR1	coiled-coil alpha-helical rod protein 1	0.018
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.017
TRIM9	tripartite motif containing 9	0.017
LCAT	lecithin-cholesterol acyltransferase	0.017
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.017
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.016
SESN2	sestrin 2	0.016
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.016	Rat
BCAR1	breast cancer anti-estrogen resistance 1	0.016
ADAP1	ArfGAP with dual PH domains 1	0.016
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.016
FGB	fibrinogen beta chain	0.015
ARHGAP32	Rho GTPase activating protein 32	0.015
PGF	placental growth factor	0.014
SQSTM1	sequestosome 1	0.013
THEM4	thioesterase superfamily member 4	0.013
RUNX1	runt-related transcription factor 1	0.013
PAWR	PRKC, apoptosis, WT1, regulator	0.013
SORBS2	sorbin and SH3 domain containing 2	0.013
LIMK1	LIM domain kinase 1	0.012
RARA	retinoic acid receptor, alpha	0.012
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.012
HSF1	heat shock transcription factor 1	0.012
PRDX1	peroxiredoxin 1	0.012
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.012
SREBF1	sterol regulatory element binding transcription factor 1	0.011
SPRR2A	small proline-rich protein 2A	0.010
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.010
BAG3	BCL2-associated athanogene 3	0.010
AKT1S1	AKT1 substrate 1 (proline-rich)	0.010