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Homo sapiens

14 genes annotated in human

transforming growth factor beta production

The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "transforming growth factor beta production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "transforming growth factor beta production" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD3	SMAD family member 3	0.999
SMAD1	SMAD family member 1	0.992	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.967
SMAD5	SMAD family member 5	0.960	Human
SMAD2	SMAD family member 2	0.955	Human
SMAD7	SMAD family member 7	0.954	Human
CCR5	chemokine (C-C motif) receptor 5	0.949
CCL4	chemokine (C-C motif) ligand 4	0.934	Human
LTBP2	latent transforming growth factor beta binding protein 2	0.807	Human
SMAD4	SMAD family member 4	0.754
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.751
ATN1	atrophin 1	0.620
FBLN5	fibulin 5	0.591	Human
ENG	endoglin	0.503
DPP4	dipeptidyl-peptidase 4	0.502
CXCL9	chemokine (C-X-C motif) ligand 9	0.492
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.425
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.349
DSG2	desmoglein 2	0.339
ARNT	aryl hydrocarbon receptor nuclear translocator	0.282
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.267	Human
CCL2	chemokine (C-C motif) ligand 2	0.254	Human
ELN	elastin	0.242
LOXL1	lysyl oxidase-like 1	0.233
RUNX1	runt-related transcription factor 1	0.204
CCL19	chemokine (C-C motif) ligand 19	0.198	Human
CD164	CD164 molecule, sialomucin	0.183
FSTL1	follistatin-like 1	0.180
JUP	junction plakoglobin	0.179
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.175
CCL5	chemokine (C-C motif) ligand 5	0.174	Human
IDE	insulin-degrading enzyme	0.171
CPD	carboxypeptidase D	0.163
CCL3	chemokine (C-C motif) ligand 3	0.148	Human
SKIL	SKI-like oncogene	0.148
DARC	Duffy blood group, chemokine receptor	0.118
CXCL11	chemokine (C-X-C motif) ligand 11	0.115
CCL8	chemokine (C-C motif) ligand 8	0.111	Human
TM9SF2	transmembrane 9 superfamily member 2	0.109
AR	androgen receptor	0.108
CCR7	chemokine (C-C motif) receptor 7	0.105
CCL22	chemokine (C-C motif) ligand 22	0.096	Human
EGLN1	egl nine homolog 1 (C. elegans)	0.089
CXCL10	chemokine (C-X-C motif) ligand 10	0.087
CXXC5	CXXC finger protein 5	0.086
LOX	lysyl oxidase	0.084
CCL13	chemokine (C-C motif) ligand 13	0.079	Human
VCAM1	vascular cell adhesion molecule 1	0.079
LENG8	leukocyte receptor cluster (LRC) member 8	0.074
VHL	von Hippel-Lindau tumor suppressor	0.068
COL6A2	collagen, type VI, alpha 2	0.067
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.066
FBLN1	fibulin 1	0.065	Human
BGN	biglycan	0.063
CTNND1	catenin (cadherin-associated protein), delta 1	0.063
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.062
LAMB2	laminin, beta 2 (laminin S)	0.058
IL6	interleukin 6 (interferon, beta 2)	0.057
CXCL13	chemokine (C-X-C motif) ligand 13	0.055
SMAD6	SMAD family member 6	0.054	Human
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.053
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.051
DMPK	dystrophia myotonica-protein kinase	0.050
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.050
FBN1	fibrillin 1	0.047
NNMT	nicotinamide N-methyltransferase	0.047
TCF4	transcription factor 4	0.046
GFI1B	growth factor independent 1B transcription repressor	0.046
TGFBR1	transforming growth factor, beta receptor 1	0.046
EGLN3	egl nine homolog 3 (C. elegans)	0.045
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.043
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.043
TRIP6	thyroid hormone receptor interactor 6	0.042
SELE	selectin E	0.041
DSP	desmoplakin	0.037
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.034
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.034
IL8	interleukin 8	0.034
IFNG	interferon, gamma	0.032
PLSCR4	phospholipid scramblase 4	0.032
GATA2	GATA binding protein 2	0.032	Human
CXCL12	chemokine (C-X-C motif) ligand 12	0.032
SH3KBP1	SH3-domain kinase binding protein 1	0.031
SP1	Sp1 transcription factor	0.031
RGS1	regulator of G-protein signaling 1	0.030
IL1B	interleukin 1, beta	0.029
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.028
FBLN2	fibulin 2	0.028	Human
HDAC9	histone deacetylase 9	0.028
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.027
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.027
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.027
ITM2B	integral membrane protein 2B	0.027
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.027
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.027
CCL7	chemokine (C-C motif) ligand 7	0.026	Human
IL10	interleukin 10	0.026
ZFPM1	zinc finger protein, multitype 1	0.026
RHOXF2	Rhox homeobox family, member 2	0.026
ECM1	extracellular matrix protein 1	0.025
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.025
TGFB3	transforming growth factor, beta 3	0.025
PCOLCE	procollagen C-endopeptidase enhancer	0.024
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.024
NOV	nephroblastoma overexpressed gene	0.023
PSEN1	presenilin 1	0.023
TNF	tumor necrosis factor	0.023
ZMYM2	zinc finger, MYM-type 2	0.023
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.022
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.022
GLIS2	GLIS family zinc finger 2	0.022
CD83	CD83 molecule	0.022
LAMB1	laminin, beta 1	0.022
MFAP4	microfibrillar-associated protein 4	0.022
CTGF	connective tissue growth factor	0.022
GAS6	growth arrest-specific 6	0.021
CXCL2	chemokine (C-X-C motif) ligand 2	0.021
CD2	CD2 molecule	0.021
CCL21	chemokine (C-C motif) ligand 21	0.021
AQP1	aquaporin 1 (Colton blood group)	0.021
MKL2	MKL/myocardin-like 2	0.021
FGFR1	fibroblast growth factor receptor 1	0.020
SOX7	SRY (sex determining region Y)-box 7	0.020
FOXO3	forkhead box O3	0.019
COL5A1	collagen, type V, alpha 1	0.019
IGFBP7	insulin-like growth factor binding protein 7	0.019
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.019
IL18RAP	interleukin 18 receptor accessory protein	0.019
IL2RB	interleukin 2 receptor, beta	0.018
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.018
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.017
IGFBP5	insulin-like growth factor binding protein 5	0.017
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.016
NOTCH3	notch 3	0.016
MRC2	mannose receptor, C type 2	0.016
LRRC32	leucine rich repeat containing 32	0.016
ADAMTSL4	ADAMTS-like 4	0.016
HDAC7	histone deacetylase 7	0.015
TFPI2	tissue factor pathway inhibitor 2	0.015
CH25H	cholesterol 25-hydroxylase	0.015
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.015
EMILIN1	elastin microfibril interfacer 1	0.015
ABI1	abl-interactor 1	0.015
CCR4	chemokine (C-C motif) receptor 4	0.015
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.015
LTBP1	latent transforming growth factor beta binding protein 1	0.015	Human
DAZAP2	DAZ associated protein 2	0.015
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.015
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.015
IL7R	interleukin 7 receptor	0.015
UBXN4	UBX domain protein 4	0.015
FAM107A	family with sequence similarity 107, member A	0.014
FBXL15	F-box and leucine-rich repeat protein 15	0.014
UBD	ubiquitin D	0.014
KIAA0913	KIAA0913	0.014
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.014
JAG2	jagged 2	0.014
TRIM29	tripartite motif containing 29	0.014
PKP2	plakophilin 2	0.014
COL8A1	collagen, type VIII, alpha 1	0.014
IDO1	indoleamine 2,3-dioxygenase 1	0.014
CCL17	chemokine (C-C motif) ligand 17	0.014	Human
EBI3	Epstein-Barr virus induced 3	0.014
RNF13	ring finger protein 13	0.014
MAPK14	mitogen-activated protein kinase 14	0.013
RGL1	ral guanine nucleotide dissociation stimulator-like 1	0.013
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.013	Human
BMP2	bone morphogenetic protein 2	0.013
BMP4	bone morphogenetic protein 4	0.013
CXCL5	chemokine (C-X-C motif) ligand 5	0.013
SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.013
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.013
SFRP1	secreted frizzled-related protein 1	0.013
EFCAB4B	EF-hand calcium binding domain 4B	0.013
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.013	Human
DPT	dermatopontin	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.012
PGRMC1	progesterone receptor membrane component 1	0.012
EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	0.012	Human
MYH11	myosin, heavy chain 11, smooth muscle	0.012
TMEM123	transmembrane protein 123	0.012
SS18	synovial sarcoma translocation, chromosome 18	0.012
INHBA	inhibin, beta A	0.012
KRTAP4-12	keratin associated protein 4-12	0.012
PARVA	parvin, alpha	0.012
FMOD	fibromodulin	0.012
AEBP1	AE binding protein 1	0.012
SULF1	sulfatase 1	0.012
MEGF11	multiple EGF-like-domains 11	0.011
GJA4	gap junction protein, alpha 4, 37kDa	0.011
CHRD	chordin	0.011
LAMP3	lysosomal-associated membrane protein 3	0.011
DCHS1	dachsous 1 (Drosophila)	0.011
FPR3	formyl peptide receptor 3	0.011
MFAP2	microfibrillar-associated protein 2	0.011
NBL1	neuroblastoma, suppression of tumorigenicity 1	0.011
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.011
IGFBP6	insulin-like growth factor binding protein 6	0.011
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.011
IL2RG	interleukin 2 receptor, gamma	0.011
COL6A1	collagen, type VI, alpha 1	0.011
SYNPO	synaptopodin	0.011
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.011
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.010
TNC	tenascin C	0.010
MOXD1	monooxygenase, DBH-like 1	0.010
ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	0.010
DSG3	desmoglein 3	0.010
C2	complement component 2	0.010
EVC2	Ellis van Creveld syndrome 2	0.010
WNT2	wingless-type MMTV integration site family member 2	0.010