IMP

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Mus musculus

16 genes annotated in mouse

positive regulation of histone methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of histone methylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of histone methylation" (in gray)

Name	Description	Probability	Func Analog Organism
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.997
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.987
Dnmt3a	DNA methyltransferase 3A	0.640
Brca1	breast cancer 1	0.633
Jarid2	jumonji, AT rich interactive domain 2	0.605
Trim28	tripartite motif-containing 28	0.569
Clk1	CDC-like kinase 1	0.534
Trim24	tripartite motif-containing 24	0.431
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.367
Mtf2	metal response element binding transcription factor 2	0.347
Rb1	retinoblastoma 1	0.344
Eed	embryonic ectoderm development	0.299
Brd4	bromodomain containing 4	0.251
Kdm5a	lysine (K)-specific demethylase 5A	0.229
Kdm2b	lysine (K)-specific demethylase 2B	0.226
Ncoa6	nuclear receptor coactivator 6	0.220
Stk38	serine/threonine kinase 38	0.208
Trp53	transformation related protein 53	0.205
Setx	senataxin	0.172
Atm	ataxia telangiectasia mutated homolog (human)	0.171
E2f1	E2F transcription factor 1	0.148
Brca2	breast cancer 2	0.139
Ezh1	enhancer of zeste homolog 1 (Drosophila)	0.138
Rbbp4	retinoblastoma binding protein 4	0.136
Hells	helicase, lymphoid specific	0.134
Msh2	mutS homolog 2 (E. coli)	0.106
Crebbp	CREB binding protein	0.097
Parp1	poly (ADP-ribose) polymerase family, member 1	0.077
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.077
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.067
Gata1	GATA binding protein 1	0.067
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.063	Fly
Tnrc6b	trinucleotide repeat containing 6b	0.063
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.061	Fly
Hira	histone cell cycle regulation defective homolog A (S. cerevisiae)	0.059
Hexim1	hexamethylene bis-acetamide inducible 1	0.058
Mll2	myeloid/lymphoid or mixed-lineage leukemia 2	0.057
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.054
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.050
Myf5	myogenic factor 5	0.047
Ccnt2	cyclin T2	0.046
Rbl2	retinoblastoma-like 2	0.046
Sfrs18	serine/arginine-rich splicing factor 18	0.044
Ilf3	interleukin enhancer binding factor 3	0.043
Brd8	bromodomain containing 8	0.043
Hist1h1e	histone cluster 1, H1e	0.041
Smc3	structural maintenace of chromosomes 3	0.041
Prpf8	pre-mRNA processing factor 8	0.037
Dnmt1	DNA methyltransferase (cytosine-5) 1	0.034	Human
Chaf1a	chromatin assembly factor 1, subunit A (p150)	0.034
Kdm1a	lysine (K)-specific demethylase 1A	0.033
Foxo3	forkhead box O3	0.031
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.030
D4Wsu53e	DNA segment, Chr 4, Wayne State University 53, expressed	0.029
Ep300	E1A binding protein p300	0.029
Zfp292	zinc finger protein 292	0.028
Rcor2	REST corepressor 2	0.028
Ewsr1	Ewing sarcoma breakpoint region 1	0.027
Ncaph	non-SMC condensin I complex, subunit H	0.027
Ttc14	tetratricopeptide repeat domain 14	0.026
Ncapd3	non-SMC condensin II complex, subunit D3	0.025
Aebp2	AE binding protein 2	0.025
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.025
Nucks1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.025
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.024
Zc3h18	zinc finger CCCH-type containing 18	0.024
Bap1	Brca1 associated protein 1	0.024
Dnmt3l	DNA (cytosine-5-)-methyltransferase 3-like	0.023
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.022
Hist1h3g	histone cluster 1, H3g	0.022
Nup155	nucleoporin 155	0.022
Ddx17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.021
Leo1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.021
Suv39h1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.021
Bclaf1	BCL2-associated transcription factor 1	0.020
Papolg	poly(A) polymerase gamma	0.020
Zfp445	zinc finger protein 445	0.020
Pum1	pumilio 1 (Drosophila)	0.019
Nbn	nibrin	0.019
Zfp236	zinc finger protein 236	0.019
Msx1	homeobox, msh-like 1	0.019
Tbx1	T-box 1	0.019
Luc7l3	LUC7-like 3 (S. cerevisiae)	0.019
Pou2f1	POU domain, class 2, transcription factor 1	0.018
Taf4a	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.018
Ylpm1	YLP motif containing 1	0.018
Pax3	paired box gene 3	0.017	Mouse
Zfp592	zinc finger protein 592	0.017
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.017
Crebzf	CREB/ATF bZIP transcription factor	0.017
Rxra	retinoid X receptor alpha	0.017
Nr2c2	nuclear receptor subfamily 2, group C, member 2	0.017
Dtl	denticleless homolog (Drosophila)	0.017
Hcfc1	host cell factor C1	0.017
Lrwd1	leucine-rich repeats and WD repeat domain containing 1	0.016
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.016
Pom121	nuclear pore membrane protein 121	0.016
Sp4	trans-acting transcription factor 4	0.016
Zbtb45	zinc finger and BTB domain containing 45	0.016
Med23	mediator complex subunit 23	0.016
Cct4	chaperonin containing Tcp1, subunit 4 (delta)	0.015
Trp53bp1	transformation related protein 53 binding protein 1	0.015
Wwox	WW domain-containing oxidoreductase	0.015
Usp37	ubiquitin specific peptidase 37	0.015
Atad5	ATPase family, AAA domain containing 5	0.015
Hdac1	histone deacetylase 1	0.015
Irs2	insulin receptor substrate 2	0.015
Prpf38b	PRP38 pre-mRNA processing factor 38 (yeast) domain containing B	0.014
Terf1	telomeric repeat binding factor 1	0.014
2810403A07Rik	RIKEN cDNA 2810403A07 gene	0.014
Rqcd1	rcd1 (required for cell differentiation) homolog 1 (S. pombe)	0.014
Stmn1	stathmin 1	0.014
Srsf4	serine/arginine-rich splicing factor 4	0.014
Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1	0.014
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.014
Casp3	caspase 3	0.014
Otx2	orthodenticle homolog 2 (Drosophila)	0.014
Aip	aryl-hydrocarbon receptor-interacting protein	0.014
Asxl2	additional sex combs like 2 (Drosophila)	0.014
Chek2	CHK2 checkpoint homolog (S. pombe)	0.014
Ppm1g	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	0.013
Usp48	ubiquitin specific peptidase 48	0.013
Mdm4	transformed mouse 3T3 cell double minute 4	0.013
Upf3b	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.013
Morc3	microrchidia 3	0.013
Donson	downstream neighbor of SON	0.013
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.013
Fam76b	family with sequence similarity 76, member B	0.013
Ubp1	upstream binding protein 1	0.013
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.013
Ip6k1	inositol hexaphosphate kinase 1	0.013
Pold3	polymerase (DNA-directed), delta 3, accessory subunit	0.013
Thoc2	THO complex 2	0.013
Tia1	cytotoxic granule-associated RNA binding protein 1	0.013
Mybl2	myeloblastosis oncogene-like 2	0.013
Smpd4	sphingomyelin phosphodiesterase 4	0.013
Bod1l	biorientation of chromosomes in cell division 1-like	0.012
Srrm1	serine/arginine repetitive matrix 1	0.012
Trp73	transformation related protein 73	0.012
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.012
Cand1	cullin associated and neddylation disassociated 1	0.012
Dmd	dystrophin, muscular dystrophy	0.012
Slc2a8	solute carrier family 2, (facilitated glucose transporter), member 8	0.012
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.012
Atg2a	ATG2 autophagy related 2 homolog A (S. cerevisiae)	0.012
Thrap3	thyroid hormone receptor associated protein 3	0.012
Arl6ip6	ADP-ribosylation factor-like 6 interacting protein 6	0.012
Paf1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.012
Tubgcp3	tubulin, gamma complex associated protein 3	0.012
Odf2	outer dense fiber of sperm tails 2	0.012
Zfp187	zinc finger protein 187	0.012
Clk4	CDC like kinase 4	0.012
Tpx2	TPX2, microtubule-associated protein homolog (Xenopus laevis)	0.011
Rhag	Rhesus blood group-associated A glycoprotein	0.011
Hnrnpul1	heterogeneous nuclear ribonucleoprotein U-like 1	0.011
Hmgb1	high mobility group box 1	0.011
Ncor1	nuclear receptor co-repressor 1	0.011
Patz1	POZ (BTB) and AT hook containing zinc finger 1	0.011
Cul9	cullin 9	0.011
Pcmtd2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.011
Pask	PAS domain containing serine/threonine kinase	0.011
Fam134a	family with sequence similarity 134, member A	0.010
Lig1	ligase I, DNA, ATP-dependent	0.010
Smc1a	structural maintenance of chromosomes 1A	0.010
Herc1	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1	0.010
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.010
Ctcf	CCCTC-binding factor	0.010
Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.010
Lef1	lymphoid enhancer binding factor 1	0.010
Ccnl2	cyclin L2	0.010
Ckap5	cytoskeleton associated protein 5	0.010