IMP

Process View

Mus musculus

8 genes annotated in mouse

negative regulation of cell fate commitment

Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

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In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.840
Fgfr2	fibroblast growth factor receptor 2	0.657
Foxc1	forkhead box C1	0.593
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.536
Vangl2	vang-like 2 (van gogh, Drosophila)	0.411
Hand1	heart and neural crest derivatives expressed transcript 1	0.409
Otx2	orthodenticle homolog 2 (Drosophila)	0.409
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.397	Fly
Pax3	paired box gene 3	0.381
Fgf8	fibroblast growth factor 8	0.348	Zebrafish
Tcfap2a	transcription factor AP-2, alpha	0.284
Foxc2	forkhead box C2	0.232
Bmp4	bone morphogenetic protein 4	0.229	Zebrafish
Gli3	GLI-Kruppel family member GLI3	0.223
Rarg	retinoic acid receptor, gamma	0.217
Sox9	SRY-box containing gene 9	0.174	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.147
Hand2	heart and neural crest derivatives expressed transcript 2	0.143
Pou5f1	POU domain, class 5, transcription factor 1	0.124
Prrx1	paired related homeobox 1	0.122
Meox2	mesenchyme homeobox 2	0.113
Fgfr1	fibroblast growth factor receptor 1	0.103	Zebrafish
Vangl1	vang-like 1 (van gogh, Drosophila)	0.103
Smo	smoothened homolog (Drosophila)	0.098
Eya1	eyes absent 1 homolog (Drosophila)	0.094	Fly
Ednra	endothelin receptor type A	0.086
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.073
Rara	retinoic acid receptor, alpha	0.072
Msx1	homeobox, msh-like 1	0.063
Dlx5	distal-less homeobox 5	0.061
Foxg1	forkhead box G1	0.061
Alx4	aristaless-like homeobox 4	0.060
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.056	Fly
Sall4	sal-like 4 (Drosophila)	0.054
Bmp7	bone morphogenetic protein 7	0.052	Zebrafish
Sfrp2	secreted frizzled-related protein 2	0.050
Tbx1	T-box 1	0.047
Pax2	paired box gene 2	0.047
Hes1	hairy and enhancer of split 1 (Drosophila)	0.045
Pax6	paired box gene 6	0.044
Prrx2	paired related homeobox 2	0.043
Gbx2	gastrulation brain homeobox 2	0.043
Sall3	sal-like 3 (Drosophila)	0.042
Wnt3a	wingless-related MMTV integration site 3A	0.040	Human
Acvr1	activin A receptor, type 1	0.040
Nkx2-1	NK2 homeobox 1	0.040
Sox4	SRY-box containing gene 4	0.037	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.036
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.033
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.028
Eda	ectodysplasin-A	0.027
Emx1	empty spiracles homolog 1 (Drosophila)	0.026
Smad6	MAD homolog 6 (Drosophila)	0.026
Lrp6	low density lipoprotein receptor-related protein 6	0.026
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.025	Human
Fgfr3	fibroblast growth factor receptor 3	0.025
Gata4	GATA binding protein 4	0.025
Gsc	goosecoid homeobox	0.025
Sox2	SRY-box containing gene 2	0.024	Mouse
Gli2	GLI-Kruppel family member GLI2	0.022
En1	engrailed 1	0.022
Pitx1	paired-like homeodomain transcription factor 1	0.021
Chrd	chordin	0.021
Chd7	chromodomain helicase DNA binding protein 7	0.020
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.020
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.020
Pitx2	paired-like homeodomain transcription factor 2	0.020
Ret	ret proto-oncogene	0.019
Sfrp1	secreted frizzled-related protein 1	0.018	Mouse
Dll1	delta-like 1 (Drosophila)	0.018
Sharpin	SHANK-associated RH domain interacting protein	0.018
Efnb2	ephrin B2	0.018
Nkx3-2	NK3 homeobox 2	0.016
Whrn	whirlin	0.016
Rxra	retinoid X receptor alpha	0.016
Smad3	MAD homolog 3 (Drosophila)	0.015
Foxf1a	forkhead box F1a	0.015
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.015
Pax8	paired box gene 8	0.015
Sox3	SRY-box containing gene 3	0.015	Mouse
Smad7	MAD homolog 7 (Drosophila)	0.014
Alx3	aristaless-like homeobox 3	0.013
Nodal	nodal	0.013
Hoxa5	homeobox A5	0.013
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.013
Tcf15	transcription factor 15	0.013
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.013
T	brachyury	0.012
She	src homology 2 domain-containing transforming protein E	0.012
Lrp2	low density lipoprotein receptor-related protein 2	0.012
Axin1	axin 1	0.012
Nf1	neurofibromatosis 1	0.012
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.012
Alx1	ALX homeobox 1	0.012
Sox10	SRY-box containing gene 10	0.011	Mouse
Sox13	SRY-box containing gene 13	0.011
Cldn7	claudin 7	0.011
Hoxa3	homeobox A3	0.011
Nog	noggin	0.011	Zebrafish
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.011
Cldn5	claudin 5	0.011
Sox11	SRY-box containing gene 11	0.011	Mouse
Samd4b	sterile alpha motif domain containing 4B	0.011
Axin2	axin2	0.010
Lmx1b	LIM homeobox transcription factor 1 beta	0.010
Fgf3	fibroblast growth factor 3	0.010