IMP

Process View

Mus musculus

2 genes annotated in mouse

optic vesicle morphogenesis

The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "optic vesicle morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "optic vesicle morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Eya1	eyes absent 1 homolog (Drosophila)	0.997
Tcfap2a	transcription factor AP-2, alpha	0.997
Shh	sonic hedgehog	0.994
Pax3	paired box gene 3	0.984
Msx1	homeobox, msh-like 1	0.965
Tbx1	T-box 1	0.959
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.958	Mouse
Fgf8	fibroblast growth factor 8	0.935
Prrx1	paired related homeobox 1	0.892
Pitx2	paired-like homeodomain transcription factor 2	0.887
Hand1	heart and neural crest derivatives expressed transcript 1	0.885
Dlx5	distal-less homeobox 5	0.875
Otx2	orthodenticle homolog 2 (Drosophila)	0.873
Fgfr2	fibroblast growth factor receptor 2	0.860
Hand2	heart and neural crest derivatives expressed transcript 2	0.816
Bmp7	bone morphogenetic protein 7	0.815
Msx2	homeobox, msh-like 2	0.815
Gli3	GLI-Kruppel family member GLI3	0.813
Foxc1	forkhead box C1	0.809
Smo	smoothened homolog (Drosophila)	0.633
Pax6	paired box gene 6	0.605
Bmp4	bone morphogenetic protein 4	0.605
Sox9	SRY-box containing gene 9	0.553
Isl1	ISL1 transcription factor, LIM/homeodomain	0.543
Foxc2	forkhead box C2	0.494
Hoxa2	homeobox A2	0.435
Gsc	goosecoid homeobox	0.409
Prrx2	paired related homeobox 2	0.398
Alx4	aristaless-like homeobox 4	0.380
Pax9	paired box gene 9	0.376
Hoxa1	homeobox A1	0.373
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.372	Mouse
Foxg1	forkhead box G1	0.358
Sox2	SRY-box containing gene 2	0.318
Fgf3	fibroblast growth factor 3	0.304
Hoxa3	homeobox A3	0.271
Tcfap2c	transcription factor AP-2, gamma	0.270	Mouse
Gbx2	gastrulation brain homeobox 2	0.246
Fgf10	fibroblast growth factor 10	0.205
Rarg	retinoic acid receptor, gamma	0.201
Tbx15	T-box 15	0.199
Tead3	TEA domain family member 3	0.184
Alx3	aristaless-like homeobox 3	0.174
Hoxd3	homeobox D3	0.171
Alx1	ALX homeobox 1	0.143
Col2a1	collagen, type II, alpha 1	0.137
Pax2	paired box gene 2	0.134
Ednra	endothelin receptor type A	0.123
Tgfb2	transforming growth factor, beta 2	0.120
Pax7	paired box gene 7	0.114
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.111
Hoxd13	homeobox D13	0.110
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.099
Dlx1	distal-less homeobox 1	0.099
Gli2	GLI-Kruppel family member GLI2	0.092
Chrd	chordin	0.084
Nog	noggin	0.082
Emx2	empty spiracles homolog 2 (Drosophila)	0.081
Krt15	keratin 15	0.080
Hmx1	H6 homeobox 1	0.078
Pitx1	paired-like homeodomain transcription factor 1	0.069
Rarb	retinoic acid receptor, beta	0.068
Pbx1	pre B-cell leukemia transcription factor 1	0.067
Wnt3a	wingless-related MMTV integration site 3A	0.066
Sall4	sal-like 4 (Drosophila)	0.062
Rhpn1	rhophilin, Rho GTPase binding protein 1	0.061
Dlx6	distal-less homeobox 6	0.060
Hoxb3	homeobox B3	0.060
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.059
Lhx3	LIM homeobox protein 3	0.054
Lmx1b	LIM homeobox transcription factor 1 beta	0.054
Runx2	runt related transcription factor 2	0.052
Dlx2	distal-less homeobox 2	0.050
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.049
Neurog1	neurogenin 1	0.047
Tyr	tyrosinase	0.046
Foxi3	forkhead box I3	0.044
Sall3	sal-like 3 (Drosophila)	0.044
Hoxb13	homeobox B13	0.044
Hes5	hairy and enhancer of split 5 (Drosophila)	0.042
Krt14	keratin 14	0.042
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.041
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.041
Hmx3	H6 homeobox 3	0.040
Hoxd9	homeobox D9	0.040
Chd7	chromodomain helicase DNA binding protein 7	0.039
Wnt1	wingless-related MMTV integration site 1	0.039
Uncx	UNC homeobox	0.038
Ntf3	neurotrophin 3	0.037
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.035
Rax	retina and anterior neural fold homeobox	0.034
Lhx5	LIM homeobox protein 5	0.033
Pou3f4	POU domain, class 3, transcription factor 4	0.033
Tulp1	tubby like protein 1	0.032
En1	engrailed 1	0.032
Pax8	paired box gene 8	0.031
Fgfr1	fibroblast growth factor receptor 1	0.031
Myf5	myogenic factor 5	0.031
Hoxd11	homeobox D11	0.031
Otx1	orthodenticle homolog 1 (Drosophila)	0.031
Hoxa13	homeobox A13	0.030
Hoxb1	homeobox B1	0.030
Sox3	SRY-box containing gene 3	0.029
Fgf15	fibroblast growth factor 15	0.029
Barx2	BarH-like homeobox 2	0.028
Tlx2	T-cell leukemia, homeobox 2	0.028
Ctf1	cardiotrophin 1	0.028
Hes1	hairy and enhancer of split 1 (Drosophila)	0.028
Emid2	EMI domain containing 2	0.027
Dlx3	distal-less homeobox 3	0.027
Foxd2	forkhead box D2	0.027
Trp63	transformation related protein 63	0.027
Tbx3	T-box 3	0.027
Sox11	SRY-box containing gene 11	0.027
Pou5f1	POU domain, class 5, transcription factor 1	0.027
Efna4	ephrin A4	0.026
Sim2	single-minded homolog 2 (Drosophila)	0.026
Plac1	placental specific protein 1	0.026
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.026
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.026
Cdh3	cadherin 3	0.026
Hmx2	H6 homeobox 2	0.026
Col9a2	collagen, type IX, alpha 2	0.025
Lrp2	low density lipoprotein receptor-related protein 2	0.025
Hoxd4	homeobox D4	0.025
Bmp2	bone morphogenetic protein 2	0.025
Pax1	paired box gene 1	0.025
Jag1	jagged 1	0.025
Mesp1	mesoderm posterior 1	0.025
Hoxb4	homeobox B4	0.024
Gjb5	gap junction protein, beta 5	0.024
Hoxa4	homeobox A4	0.024
Foxd1	forkhead box D1	0.024
Efna2	ephrin A2	0.024
Krt5	keratin 5	0.023
Hoxc5	homeobox C5	0.023
Neurog2	neurogenin 2	0.023
Lhx1	LIM homeobox protein 1	0.023
Col9a1	collagen, type IX, alpha 1	0.023
Cldn4	claudin 4	0.022
En2	engrailed 2	0.022
Atoh7	atonal homolog 7 (Drosophila)	0.020
Tlx3	T-cell leukemia, homeobox 3	0.020
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.020
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.020
Hoxc8	homeobox C8	0.020
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.020
Emx1	empty spiracles homolog 1 (Drosophila)	0.020
Gja3	gap junction protein, alpha 3	0.019
Pkp1	plakophilin 1	0.019
Fgf17	fibroblast growth factor 17	0.018
Neurod1	neurogenic differentiation 1	0.018
Hoxb9	homeobox B9	0.018
Esrrb	estrogen related receptor, beta	0.017
Myog	myogenin	0.017
Drd4	dopamine receptor D4	0.017
Matn3	matrilin 3	0.017
Zic3	zinc finger protein of the cerebellum 3	0.017
Slc22a6	solute carrier family 22 (organic anion transporter), member 6	0.017
Hoxa9	homeobox A9	0.017
Bnc1	basonuclin 1	0.017
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.017
Cldn8	claudin 8	0.017
Wnt6	wingless-related MMTV integration site 6	0.016
Foxe3	forkhead box E3	0.016
Neurod4	neurogenic differentiation 4	0.016
Vangl2	vang-like 2 (van gogh, Drosophila)	0.016
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.016
Hoxa10	homeobox A10	0.016
Nhlh1	nescient helix loop helix 1	0.015
Fgfr3	fibroblast growth factor receptor 3	0.015
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.015
Zic2	zinc finger protein of the cerebellum 2	0.015
Sim1	single-minded homolog 1 (Drosophila)	0.015
Lmx1a	LIM homeobox transcription factor 1 alpha	0.015
Twist2	twist homolog 2 (Drosophila)	0.015
Ece1	endothelin converting enzyme 1	0.015
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.015
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.015
Foxh1	forkhead box H1	0.015
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.015
Hrc	histidine rich calcium binding protein	0.015
T	brachyury	0.014
Gpr50	G-protein-coupled receptor 50	0.014
Tbx2	T-box 2	0.014
Barx1	BarH-like homeobox 1	0.014
Krtdap	keratinocyte differentiation associated protein	0.014
Hoxc4	homeobox C4	0.014
Gata3	GATA binding protein 3	0.014
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.014	Mouse
Hoxd1	homeobox D1	0.014
Mab21l2	mab-21-like 2 (C. elegans)	0.014
Kcnn1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	0.014
Col17a1	collagen, type XVII, alpha 1	0.013
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.013
Gjb4	gap junction protein, beta 4	0.013
Lgals7	lectin, galactose binding, soluble 7	0.013
Krt17	keratin 17	0.013
Crygd	crystallin, gamma D	0.013
Pou3f3	POU domain, class 3, transcription factor 3	0.013
Myf6	myogenic factor 6	0.013
Cldn6	claudin 6	0.013
Hoxb6	homeobox B6	0.013
Gli1	GLI-Kruppel family member GLI1	0.013
Dmrt1	doublesex and mab-3 related transcription factor 1	0.012
Tcf15	transcription factor 15	0.012
Mdfi	MyoD family inhibitor	0.012
Phlda2	pleckstrin homology-like domain, family A, member 2	0.012
Evx1	even skipped homeotic gene 1 homolog	0.012
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.012
Efs	embryonal Fyn-associated substrate	0.012
Clcnka	chloride channel Ka	0.012
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.012
Nkx6-1	NK6 homeobox 1	0.012
Nodal	nodal	0.012
Zfp185	zinc finger protein 185	0.012
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.012
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.012
Irx3	Iroquois related homeobox 3 (Drosophila)	0.012
Zeb1	zinc finger E-box binding homeobox 1	0.011
Vegfa	vascular endothelial growth factor A	0.011
Nrk	Nik related kinase	0.011
Foxi1	forkhead box I1	0.011
Tecta	tectorin alpha	0.011
Hoxb7	homeobox B7	0.011
Lef1	lymphoid enhancer binding factor 1	0.011
Vax1	ventral anterior homeobox containing gene 1	0.011
Hoxd10	homeobox D10	0.011
Psapl1	prosaposin-like 1	0.011
Col22a1	collagen, type XXII, alpha 1	0.011
Hoxc6	homeobox C6	0.011
Hmga2	high mobility group AT-hook 2	0.011
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
Irs3	insulin receptor substrate 3	0.011
Nrtn	neurturin	0.010
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.010	Mouse
Vsx2	visual system homeobox 2	0.010
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.010
Zic1	zinc finger protein of the cerebellum 1	0.010
Dlk1	delta-like 1 homolog (Drosophila)	0.010
Adra2b	adrenergic receptor, alpha 2b	0.010
Tal2	T-cell acute lymphocytic leukemia 2	0.010
Hoxd12	homeobox D12	0.010
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.010
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.010
Pou4f2	POU domain, class 4, transcription factor 2	0.010