IMP

Process View

Mus musculus

5 genes annotated in mouse

amacrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "amacrine cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "amacrine cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Pax6	paired box gene 6	0.999
Otx2	orthodenticle homolog 2 (Drosophila)	0.998
Isl1	ISL1 transcription factor, LIM/homeodomain	0.977
Ptf1a	pancreas specific transcription factor, 1a	0.972
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.969
Tcfap2a	transcription factor AP-2, alpha	0.829
Msx1	homeobox, msh-like 1	0.796
Neurod1	neurogenic differentiation 1	0.755
Pitx2	paired-like homeodomain transcription factor 2	0.727
Pax3	paired box gene 3	0.633
Nhlh1	nescient helix loop helix 1	0.529	Mouse
Msx2	homeobox, msh-like 2	0.448
Fgf8	fibroblast growth factor 8	0.430
Onecut1	one cut domain, family member 1	0.424
Pou4f2	POU domain, class 4, transcription factor 2	0.410
En1	engrailed 1	0.405
Emx1	empty spiracles homolog 1 (Drosophila)	0.403
Foxc2	forkhead box C2	0.379
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.357
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.345
Gli3	GLI-Kruppel family member GLI3	0.314
Lhx3	LIM homeobox protein 3	0.306
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.288
Pdx1	pancreatic and duodenal homeobox 1	0.279
Foxc1	forkhead box C1	0.272
Neurog3	neurogenin 3	0.263	Mouse
Hoxa1	homeobox A1	0.260
Gli2	GLI-Kruppel family member GLI2	0.245
Gsc	goosecoid homeobox	0.230
Sox2	SRY-box containing gene 2	0.219
Kiss1	KiSS-1 metastasis-suppressor	0.215
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.200
Sox11	SRY-box containing gene 11	0.189
Foxg1	forkhead box G1	0.184
Insm1	insulinoma-associated 1	0.142
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.129
Mecom	MDS1 and EVI1 complex locus	0.129
Lhx5	LIM homeobox protein 5	0.128
Hoxd13	homeobox D13	0.126
Lmx1b	LIM homeobox transcription factor 1 beta	0.120
Tlx3	T-cell leukemia, homeobox 3	0.112
Eya1	eyes absent 1 homolog (Drosophila)	0.111
Dlx5	distal-less homeobox 5	0.110
Gpr50	G-protein-coupled receptor 50	0.107
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.106
Gata4	GATA binding protein 4	0.105
Prrx2	paired related homeobox 2	0.103
Gbx2	gastrulation brain homeobox 2	0.098
Snai1	snail homolog 1 (Drosophila)	0.094
Prrx1	paired related homeobox 1	0.094
Foxd2	forkhead box D2	0.094
Atoh7	atonal homolog 7 (Drosophila)	0.093	Mouse
Gata1	GATA binding protein 1	0.093
Pitx1	paired-like homeodomain transcription factor 1	0.087
Alx3	aristaless-like homeobox 3	0.087
Bmp4	bone morphogenetic protein 4	0.084
Neurog1	neurogenin 1	0.082	Mouse
Pax9	paired box gene 9	0.078
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.077
Sox9	SRY-box containing gene 9	0.077
Lhx9	LIM homeobox protein 9	0.075
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.073
Nkx3-2	NK3 homeobox 2	0.072
Dlx2	distal-less homeobox 2	0.070
Hoxa11	homeobox A11	0.066
Sim2	single-minded homolog 2 (Drosophila)	0.066
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.065
Neurod4	neurogenic differentiation 4	0.063
Vsx2	visual system homeobox 2	0.063
Zic1	zinc finger protein of the cerebellum 1	0.059
Pax2	paired box gene 2	0.059
Col2a1	collagen, type II, alpha 1	0.054
Hmx1	H6 homeobox 1	0.053
Tbx15	T-box 15	0.053
Hoxb1	homeobox B1	0.053
Hoxd3	homeobox D3	0.050
Tgfb2	transforming growth factor, beta 2	0.047
Prph2	peripherin 2	0.046
Srrm4	serine/arginine repetitive matrix 4	0.046
Lmx1a	LIM homeobox transcription factor 1 alpha	0.045
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.045
T	brachyury	0.044
Pitx3	paired-like homeodomain transcription factor 3	0.044
Hoxd11	homeobox D11	0.044
Smo	smoothened homolog (Drosophila)	0.042
Dcc	deleted in colorectal carcinoma	0.042
Col22a1	collagen, type XXII, alpha 1	0.041
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.040
Zeb1	zinc finger E-box binding homeobox 1	0.039
Gdf11	growth differentiation factor 11	0.039
Hoxa13	homeobox A13	0.039
Pou4f3	POU domain, class 4, transcription factor 3	0.039
Fgf15	fibroblast growth factor 15	0.038
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.038
Alx4	aristaless-like homeobox 4	0.038
Tbx1	T-box 1	0.037
Hoxc5	homeobox C5	0.037
Runx2	runt related transcription factor 2	0.036
Myog	myogenin	0.036
Prox1	prospero-related homeobox 1	0.035
Tnnt3	troponin T3, skeletal, fast	0.035
Foxd3	forkhead box D3	0.035
Ntf3	neurotrophin 3	0.033
Mab21l2	mab-21-like 2 (C. elegans)	0.032
Edar	ectodysplasin-A receptor	0.032
Fgf17	fibroblast growth factor 17	0.030
Prph	peripherin	0.030
Phox2b	paired-like homeobox 2b	0.030
Evx1	even skipped homeotic gene 1 homolog	0.030
Fgfr2	fibroblast growth factor receptor 2	0.029
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.027
Foxb1	forkhead box B1	0.027
Dsg4	desmoglein 4	0.027
Meox2	mesenchyme homeobox 2	0.027
Hoxa10	homeobox A10	0.026
Ldb3	LIM domain binding 3	0.026
Foxa2	forkhead box A2	0.026
Foxe3	forkhead box E3	0.026
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.025
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.025
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.024
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.024
Tcfap2c	transcription factor AP-2, gamma	0.023
Arx	aristaless related homeobox	0.023
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.023
Nog	noggin	0.022
Igfbpl1	insulin-like growth factor binding protein-like 1	0.022
Myf5	myogenic factor 5	0.021
Uncx	UNC homeobox	0.021
Bmp7	bone morphogenetic protein 7	0.021
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.021
Lmo2	LIM domain only 2	0.020
Ebf2	early B-cell factor 2	0.020
Hes1	hairy and enhancer of split 1 (Drosophila)	0.020
Hes5	hairy and enhancer of split 5 (Drosophila)	0.019
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.019
Sp8	trans-acting transcription factor 8	0.019
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.018
Neurog2	neurogenin 2	0.018	Mouse
Wnt6	wingless-related MMTV integration site 6	0.018
Pou3f2	POU domain, class 3, transcription factor 2	0.018
Zic2	zinc finger protein of the cerebellum 2	0.017
Evx2	even skipped homeotic gene 2 homolog	0.017
Gsx2	GS homeobox 2	0.017
Fgf6	fibroblast growth factor 6	0.016
Rax	retina and anterior neural fold homeobox	0.016
Dlx6	distal-less homeobox 6	0.016
Otx1	orthodenticle homolog 1 (Drosophila)	0.016
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.016
Sox1	SRY-box containing gene 1	0.016
Cdx2	caudal type homeobox 2	0.016
Hoxd12	homeobox D12	0.016
Ush1g	Usher syndrome 1G homolog (human)	0.016
Hoxb9	homeobox B9	0.015
Tbx5	T-box 5	0.015
Efna2	ephrin A2	0.015
Hoxc6	homeobox C6	0.015
Dab1	disabled homolog 1 (Drosophila)	0.015
Tbr1	T-box brain gene 1	0.015
Hesx1	homeobox gene expressed in ES cells	0.015
Ebf3	early B-cell factor 3	0.015
Dscam	Down syndrome cell adhesion molecule	0.014
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.014
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.014
Eya4	eyes absent 4 homolog (Drosophila)	0.014
Mip	major intrinsic protein of eye lens fiber	0.014
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.014
Nhlh2	nescient helix loop helix 2	0.014	Mouse
Dmrt3	doublesex and mab-3 related transcription factor 3	0.013
Foxd4	forkhead box D4	0.013
Nkx6-1	NK6 homeobox 1	0.013
Des	desmin	0.013
Trim10	tripartite motif-containing 10	0.013
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.013
Barx1	BarH-like homeobox 1	0.012
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.012
Magel2	melanoma antigen, family L, 2	0.012
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.012
Dlx1	distal-less homeobox 1	0.012
Mybpc3	myosin binding protein C, cardiac	0.012
Olfr70	olfactory receptor 70	0.012
Krt14	keratin 14	0.012
Obsl1	obscurin-like 1	0.011
Rhd	Rh blood group, D antigen	0.011
Zic3	zinc finger protein of the cerebellum 3	0.011
Crb1	crumbs homolog 1 (Drosophila)	0.011
Gcm1	glial cells missing homolog 1 (Drosophila)	0.011
Col13a1	collagen, type XIII, alpha 1	0.011
Gja3	gap junction protein, alpha 3	0.011
Irx4	Iroquois related homeobox 4 (Drosophila)	0.011
Atoh1	atonal homolog 1 (Drosophila)	0.011	Mouse
Crx	cone-rod homeobox containing gene	0.011
Matn1	matrilin 1, cartilage matrix protein	0.011
Lhx1	LIM homeobox protein 1	0.011
Reln	reelin	0.011
Tbx20	T-box 20	0.011
Pax7	paired box gene 7	0.011
Fgf9	fibroblast growth factor 9	0.011
Col9a1	collagen, type IX, alpha 1	0.011
Ins2	insulin II	0.010
Shox2	short stature homeobox 2	0.010
Hes2	hairy and enhancer of split 2 (Drosophila)	0.010
Lhx4	LIM homeobox protein 4	0.010
2310002J15Rik	RIKEN cDNA 2310002J15 gene	0.010
Bdnf	brain derived neurotrophic factor	0.010
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.010