IMP

Process View

Mus musculus

4 genes annotated in mouse

cellular response to fluid shear stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to fluid shear stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to fluid shear stress" (in gray)

Name	Description	Probability	Func Analog Organism
Mef2d	myocyte enhancer factor 2D	1.000	Mouse
Pkd1	polycystic kidney disease 1 homolog	0.998	Mouse
Hdac5	histone deacetylase 5	0.992
Hdac4	histone deacetylase 4	0.989	Mouse
Mef2c	myocyte enhancer factor 2C	0.940
Ncor2	nuclear receptor co-repressor 2	0.934
Fbn1	fibrillin 1	0.816
Hdac7	histone deacetylase 7	0.402	Mouse
Bicc1	bicaudal C homolog 1 (Drosophila)	0.392
Apoe	apolipoprotein E	0.333
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.292
Runx2	runt related transcription factor 2	0.218
Cys1	cystin 1	0.193
Plat	plasminogen activator, tissue	0.154
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.135
Bcl2	B-cell leukemia/lymphoma 2	0.135
Il6st	interleukin 6 signal transducer	0.116
Dusp1	dual specificity phosphatase 1	0.112
Invs	inversin	0.100
Klf2	Kruppel-like factor 2 (lung)	0.097	Human
Mmp9	matrix metallopeptidase 9	0.092
Timp3	tissue inhibitor of metalloproteinase 3	0.083
Col1a1	collagen, type I, alpha 1	0.079
Fos	FBJ osteosarcoma oncogene	0.078
Twist2	twist homolog 2 (Drosophila)	0.076
Ski	ski sarcoma viral oncogene homolog (avian)	0.070
Cic	capicua homolog (Drosophila)	0.069
Snrk	SNF related kinase	0.059
Megf8	multiple EGF-like-domains 8	0.058
Mks1	Meckel syndrome, type 1	0.057
Lphn1	latrophilin 1	0.055
Ptgs2	prostaglandin-endoperoxide synthase 2	0.051
Phf1	PHD finger protein 1	0.044
Timp2	tissue inhibitor of metalloproteinase 2	0.040
Ifngr1	interferon gamma receptor 1	0.040
Mef2a	myocyte enhancer factor 2A	0.040	Mouse
Per1	period homolog 1 (Drosophila)	0.039
Ldlr	low density lipoprotein receptor	0.037
Notch2	Notch gene homolog 2 (Drosophila)	0.037
Qk	quaking	0.036
Klf4	Kruppel-like factor 4 (gut)	0.035	Human
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.035
Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.035
Sox17	SRY-box containing gene 17	0.034
Zbtb20	zinc finger and BTB domain containing 20	0.033
Foxo1	forkhead box O1	0.033
Kctd12	potassium channel tetramerisation domain containing 12	0.030
Pecam1	platelet/endothelial cell adhesion molecule 1	0.030
Trim3	tripartite motif-containing 3	0.029
Lemd2	LEM domain containing 2	0.029
Fgfr3	fibroblast growth factor receptor 3	0.029
Col5a1	collagen, type V, alpha 1	0.028
Thra	thyroid hormone receptor alpha	0.028
Rere	arginine glutamic acid dipeptide (RE) repeats	0.027
Sh2b3	SH2B adaptor protein 3	0.027
Adcy6	adenylate cyclase 6	0.026
Fmnl3	formin-like 3	0.026
Btg2	B-cell translocation gene 2, anti-proliferative	0.026
Ltbp3	latent transforming growth factor beta binding protein 3	0.026
Pkhd1	polycystic kidney and hepatic disease 1	0.026
Ypel3	yippee-like 3 (Drosophila)	0.025
Vcan	versican	0.025
Wdr26	WD repeat domain 26	0.025
Spnb2	spectrin beta 2	0.024
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.024
Lox	lysyl oxidase	0.023
Marveld1	MARVEL (membrane-associating) domain containing 1	0.023
Gucy1a3	guanylate cyclase 1, soluble, alpha 3	0.023
Npr2	natriuretic peptide receptor 2	0.022
Ncoa3	nuclear receptor coactivator 3	0.021
Smad7	MAD homolog 7 (Drosophila)	0.021
Tenc1	tensin like C1 domain-containing phosphatase	0.021
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.021
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.020
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.020
Mprip	myosin phosphatase Rho interacting protein	0.020
Pkd2	polycystic kidney disease 2	0.020
Sun2	Sad1 and UNC84 domain containing 2	0.020
Mib2	mindbomb homolog 2 (Drosophila)	0.019
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.019
Pias3	protein inhibitor of activated STAT 3	0.019
Ift140	intraflagellar transport 140 homolog (Chlamydomonas)	0.019
Osbpl5	oxysterol binding protein-like 5	0.019
Col6a1	collagen, type VI, alpha 1	0.019
Slc25a2	solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2	0.019
Atp13a2	ATPase type 13A2	0.018
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.018
Thbd	thrombomodulin	0.018
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.018
Vamp2	vesicle-associated membrane protein 2	0.018
Slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.018
Mfng	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.018
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.017
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.017
Egr1	early growth response 1	0.017
Ptrf	polymerase I and transcript release factor	0.017
Abi3bp	ABI gene family, member 3 (NESH) binding protein	0.017
Mtap7d1	microtubule-associated protein 7 domain containing 1	0.017
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.017
Rgl2	ral guanine nucleotide dissociation stimulator-like 2	0.016
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.016
Mmp2	matrix metallopeptidase 2	0.016	Rat
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.016
Cav1	caveolin 1, caveolae protein	0.016
Hdac9	histone deacetylase 9	0.015	Mouse
Abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.015
Frmd6	FERM domain containing 6	0.015
Gm11397	predicted gene 11397	0.015
Akap3	A kinase (PRKA) anchor protein 3	0.015
Ccdc39	coiled-coil domain containing 39	0.015
Ctdsp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	0.015
Npc1	Niemann Pick type C1	0.015
Foxj2	forkhead box J2	0.015
Rin2	Ras and Rab interactor 2	0.015
Meox2	mesenchyme homeobox 2	0.015
Csf1	colony stimulating factor 1 (macrophage)	0.014
Hlx	H2.0-like homeobox	0.014
Prkd2	protein kinase D2	0.014
Nfix	nuclear factor I/X	0.014
S1pr1	sphingosine-1-phosphate receptor 1	0.014
Zmynd11	zinc finger, MYND domain containing 11	0.014
Phldb1	pleckstrin homology-like domain, family B, member 1	0.014
Klrc3	killer cell lectin-like receptor subfamily C, member 3	0.014
Sh3pxd2b	SH3 and PX domains 2B	0.014
Tsc22d4	TSC22 domain family, member 4	0.014
Sgk1	serum/glucocorticoid regulated kinase 1	0.014
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.014
9030425E11Rik	RIKEN cDNA 9030425E11 gene	0.014
Zbtb4	zinc finger and BTB domain containing 4	0.014
Icam2	intercellular adhesion molecule 2	0.013
Ltbp4	latent transforming growth factor beta binding protein 4	0.013
Evi5	ecotropic viral integration site 5	0.013
Angptl2	angiopoietin-like 2	0.013
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.013
Leng8	leukocyte receptor cluster (LRC) member 8	0.013
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.013
Mxra8	matrix-remodelling associated 8	0.013
Rab12	RAB12, member RAS oncogene family	0.013
Mmp11	matrix metallopeptidase 11	0.013
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.013
Sipa1	signal-induced proliferation associated gene 1	0.012
Col1a2	collagen, type I, alpha 2	0.012
Fzd1	frizzled homolog 1 (Drosophila)	0.012
Slc44a2	solute carrier family 44, member 2	0.012
Kank3	KN motif and ankyrin repeat domains 3	0.012
Rasgrp2	RAS, guanyl releasing protein 2	0.012
Reck	reversion-inducing-cysteine-rich protein with kazal motifs	0.012
Sec14l1	SEC14-like 1 (S. cerevisiae)	0.012
Pbxip1	pre-B-cell leukemia transcription factor interacting protein 1	0.012
Vhl	von Hippel-Lindau tumor suppressor	0.012
Sipa1l2	signal-induced proliferation-associated 1 like 2	0.012
Jun	Jun oncogene	0.012
Svil	supervillin	0.012
Myocd	myocardin	0.012
Adamts10	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10	0.011
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.011
Tgfbr2	transforming growth factor, beta receptor II	0.011
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.011
Fam193b	family with sequence similarity 193, member B	0.011
Emilin1	elastin microfibril interfacer 1	0.011
Tlr4	toll-like receptor 4	0.011
Defb8	defensin beta 8	0.011
Ttc28	tetratricopeptide repeat domain 28	0.011
Rhob	ras homolog gene family, member B	0.011
Notch3	Notch gene homolog 3 (Drosophila)	0.011
Dtx3	deltex 3 homolog (Drosophila)	0.011
Zeb2	zinc finger E-box binding homeobox 2	0.011
Foxp1	forkhead box P1	0.011
Cul7	cullin 7	0.011
2700081O15Rik	RIKEN cDNA 2700081O15 gene	0.010
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.010
Tgfb2	transforming growth factor, beta 2	0.010
Grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.010
Tef	thyrotroph embryonic factor	0.010
Ubl3	ubiquitin-like 3	0.010
Thbs3	thrombospondin 3	0.010
Lrp1	low density lipoprotein receptor-related protein 1	0.010