IMP

Process View

Mus musculus

1 genes annotated in mouse

macula densa development

GO:0072024

The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "macula densa development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "macula densa development" (in gray)

Name	Description	Probability	Func Analog Organism
Sall4	sal-like 4 (Drosophila)	0.974
Sox2	SRY-box containing gene 2	0.968
Pax2	paired box gene 2	0.943
Otx2	orthodenticle homolog 2 (Drosophila)	0.903
Nanog	Nanog homeobox	0.810
Pax6	paired box gene 6	0.696
Sall3	sal-like 3 (Drosophila)	0.579
Hmx3	H6 homeobox 3	0.577
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.463
Chd7	chromodomain helicase DNA binding protein 7	0.451
Atoh7	atonal homolog 7 (Drosophila)	0.427
Tbx10	T-box 10	0.306
Foxg1	forkhead box G1	0.302
Emx1	empty spiracles homolog 1 (Drosophila)	0.275
Gbx2	gastrulation brain homeobox 2	0.274
Sall1	sal-like 1 (Drosophila)	0.206
Insm1	insulinoma-associated 1	0.203
Hes5	hairy and enhancer of split 5 (Drosophila)	0.198
Lmx1a	LIM homeobox transcription factor 1 alpha	0.181
Isl1	ISL1 transcription factor, LIM/homeodomain	0.177
Pax3	paired box gene 3	0.174
Vax1	ventral anterior homeobox containing gene 1	0.169
Zic2	zinc finger protein of the cerebellum 2	0.167
Pou4f3	POU domain, class 4, transcription factor 3	0.158	Mouse
Otx1	orthodenticle homolog 1 (Drosophila)	0.149
Atoh1	atonal homolog 1 (Drosophila)	0.132
Eya1	eyes absent 1 homolog (Drosophila)	0.130
Dlx1	distal-less homeobox 1	0.128
Fgf8	fibroblast growth factor 8	0.127
Hmx1	H6 homeobox 1	0.126
Tcfcp2l1	transcription factor CP2-like 1	0.121
Fgf3	fibroblast growth factor 3	0.115
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.110
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.108
Emx2	empty spiracles homolog 2 (Drosophila)	0.107
S1pr2	sphingosine-1-phosphate receptor 2	0.105
Bdnf	brain derived neurotrophic factor	0.105
Gdf11	growth differentiation factor 11	0.099
Sox3	SRY-box containing gene 3	0.099
Fgf15	fibroblast growth factor 15	0.094
Tlx3	T-cell leukemia, homeobox 3	0.089
Lhx3	LIM homeobox protein 3	0.087
Cdx1	caudal type homeobox 1	0.085
Lhx1	LIM homeobox protein 1	0.084
Sox1	SRY-box containing gene 1	0.082
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.080
Esrrb	estrogen related receptor, beta	0.079
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.072
Srrm4	serine/arginine repetitive matrix 4	0.067
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.065
Uncx	UNC homeobox	0.065
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.064
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.062
Tcfap2c	transcription factor AP-2, gamma	0.062
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.062
Hoxd13	homeobox D13	0.061
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.059
Pou3f3	POU domain, class 3, transcription factor 3	0.058
Rac2	RAS-related C3 botulinum substrate 2	0.056
Phox2a	paired-like homeobox 2a	0.053
Grxcr1	glutaredoxin, cysteine rich 1	0.052
Foxd2	forkhead box D2	0.051
Lhx5	LIM homeobox protein 5	0.050
Vangl2	vang-like 2 (van gogh, Drosophila)	0.050
Gli3	GLI-Kruppel family member GLI3	0.048
Hoxa1	homeobox A1	0.047
Gdnf	glial cell line derived neurotrophic factor	0.046
Lmx1b	LIM homeobox transcription factor 1 beta	0.045
Neurog1	neurogenin 1	0.045
Dlx5	distal-less homeobox 5	0.044
Sox11	SRY-box containing gene 11	0.043
Wnt7a	wingless-related MMTV integration site 7A	0.042
Ybx2	Y box protein 2	0.042
Slc26a4	solute carrier family 26, member 4	0.041
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.041
Pou3f2	POU domain, class 3, transcription factor 2	0.039	Mouse
Wnt7b	wingless-related MMTV integration site 7B	0.039
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.038
BC024139	cDNA sequence BC024139	0.037
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.036
Sox8	SRY-box containing gene 8	0.036
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.036
Pou3f1	POU domain, class 3, transcription factor 1	0.034	Mouse
Espn	espin	0.034
Socs1	suppressor of cytokine signaling 1	0.033
Wnt6	wingless-related MMTV integration site 6	0.033
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.033
Fgf4	fibroblast growth factor 4	0.032
Foxb1	forkhead box B1	0.031
Neurod1	neurogenic differentiation 1	0.031
Nog	noggin	0.031
Dll3	delta-like 3 (Drosophila)	0.031
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.031
Hoxb1	homeobox B1	0.031
Msi1	Musashi homolog 1(Drosophila)	0.030
Shh	sonic hedgehog	0.030
Robo3	roundabout homolog 3 (Drosophila)	0.030
Foxi1	forkhead box I1	0.030
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.029
Npas1	neuronal PAS domain protein 1	0.029
Apoa1	apolipoprotein A-I	0.028
Hoxd11	homeobox D11	0.028
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.028
Wnt1	wingless-related MMTV integration site 1	0.027
En1	engrailed 1	0.027
Onecut1	one cut domain, family member 1	0.027
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.027
Zfp42	zinc finger protein 42	0.027
Rax	retina and anterior neural fold homeobox	0.026
Hoxb13	homeobox B13	0.026
Etv2	ets variant gene 2	0.026
Cux2	cut-like homeobox 2	0.026
Amh	anti-Mullerian hormone	0.026
Il10ra	interleukin 10 receptor, alpha	0.026
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.025
Gata3	GATA binding protein 3	0.025
Zfp771	zinc finger protein 771	0.025
Neurog2	neurogenin 2	0.024
Stag3	stromal antigen 3	0.023
Lef1	lymphoid enhancer binding factor 1	0.023
Gjb5	gap junction protein, beta 5	0.023
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.023
Fgf17	fibroblast growth factor 17	0.023
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.022
H2-Oa	histocompatibility 2, O region alpha locus	0.022
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.022
Mdfi	MyoD family inhibitor	0.022
Ush1g	Usher syndrome 1G homolog (human)	0.022
Oprd1	opioid receptor, delta 1	0.022
Jag1	jagged 1	0.021
Efna2	ephrin A2	0.021
Nppc	natriuretic peptide type C	0.021
Neurog3	neurogenin 3	0.021
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.020
Cabp7	calcium binding protein 7	0.020
Nrtn	neurturin	0.020
Prph2	peripherin 2	0.020
Foxl2	forkhead box L2	0.020
Hes3	hairy and enhancer of split 3 (Drosophila)	0.019
T	brachyury	0.019
Sult4a1	sulfotransferase family 4A, member 1	0.019
Lhx4	LIM homeobox protein 4	0.019
Gsx1	GS homeobox 1	0.019
Gpr50	G-protein-coupled receptor 50	0.019
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.019
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.019
H1foo	H1 histone family, member O, oocyte-specific	0.019
Cd8b1	CD8 antigen, beta chain 1	0.018
Dmgdh	dimethylglycine dehydrogenase precursor	0.018
Mmp24	matrix metallopeptidase 24	0.018
Vsx2	visual system homeobox 2	0.018
Pax8	paired box gene 8	0.018
Igfbpl1	insulin-like growth factor binding protein-like 1	0.018
Syt6	synaptotagmin VI	0.018
Alx4	aristaless-like homeobox 4	0.018
Hoxa4	homeobox A4	0.018
2610109H07Rik	RIKEN cDNA 2610109H07 gene	0.018
Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	0.018
Olig2	oligodendrocyte transcription factor 2	0.018
Tcfap2a	transcription factor AP-2, alpha	0.017
Sim1	single-minded homolog 1 (Drosophila)	0.017
Fam59b	family with sequence similarity 59, member B	0.017
Cxcr5	chemokine (C-X-C motif) receptor 5	0.017
Sept1	septin 1	0.017
Il11	interleukin 11	0.017
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.017
Rag2	recombination activating gene 2	0.017
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.017
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.017
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.017
Shd	src homology 2 domain-containing transforming protein D	0.016
Rcor2	REST corepressor 2	0.016
Gpr3	G-protein coupled receptor 3	0.016
Fgf5	fibroblast growth factor 5	0.016
Scrt2	scratch homolog 2, zinc finger protein (Drosophila)	0.015
Utf1	undifferentiated embryonic cell transcription factor 1	0.015
Theg	testicular haploid expressed gene	0.015
Sit1	suppression inducing transmembrane adaptor 1	0.015
Tnp2	transition protein 2	0.015
Prop1	paired like homeodomain factor 1	0.015
Pnoc	prepronociceptin	0.015
Wnt8a	wingless-related MMTV integration site 8A	0.015
Foxn1	forkhead box N1	0.015
Artn	artemin	0.015
Fmnl1	formin-like 1	0.015
Dlx4	distal-less homeobox 4	0.014
Efna4	ephrin A4	0.014
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.014
Foxe3	forkhead box E3	0.014
Lama1	laminin, alpha 1	0.014
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.014
Dpf1	D4, zinc and double PHD fingers family 1	0.014
Grid1	glutamate receptor, ionotropic, delta 1	0.014
Onecut3	one cut domain, family member 3	0.014
AI118078	expressed sequence AI118078	0.014
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.014
Fgf21	fibroblast growth factor 21	0.014
Ptprt	protein tyrosine phosphatase, receptor type, T	0.014
Kcnt1	potassium channel, subfamily T, member 1	0.013
Cdx2	caudal type homeobox 2	0.013
Sox21	SRY-box containing gene 21	0.013
Btbd17	BTB (POZ) domain containing 17	0.013
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.013
Cd27	CD27 antigen	0.013
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.013
Fezf2	Fez family zinc finger 2	0.013
Col9a2	collagen, type IX, alpha 2	0.013
Mta1	metastasis associated 1	0.013
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.013
Asprv1	aspartic peptidase, retroviral-like 1	0.012
Foxk1	forkhead box K1	0.012
Pou5f1	POU domain, class 5, transcription factor 1	0.012	Mouse
Pou4f1	POU domain, class 4, transcription factor 1	0.012	Mouse
Tssk2	testis-specific serine kinase 2	0.012
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.012
Lhx2	LIM homeobox protein 2	0.012
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.012
C1ql1	complement component 1, q subcomponent-like 1	0.012
Pkp3	plakophilin 3	0.012
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.012
Dcc	deleted in colorectal carcinoma	0.012
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.012
Gdap1l1	ganglioside-induced differentiation-associated protein 1-like 1	0.012
Rlbp1	retinaldehyde binding protein 1	0.012
Adra2b	adrenergic receptor, alpha 2b	0.012
Wnt3	wingless-related MMTV integration site 3	0.012
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.012
Gatad2b	GATA zinc finger domain containing 2B	0.012
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.012
Fzd10	frizzled homolog 10 (Drosophila)	0.012
Foxh1	forkhead box H1	0.012
Mycs	myc-like oncogene, s-myc protein	0.012
Insrr	insulin receptor-related receptor	0.012
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.012
Sh2d2a	SH2 domain protein 2A	0.012
Hoxa7	homeobox A7	0.012
Epha8	Eph receptor A8	0.012
Onecut2	one cut domain, family member 2	0.012
Rasgrp1	RAS guanyl releasing protein 1	0.012
Ppy	pancreatic polypeptide	0.012
En2	engrailed 2	0.012
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.012
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.012
Tmem198	transmembrane protein 198	0.012
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.011
Nefm	neurofilament, medium polypeptide	0.011
Col2a1	collagen, type II, alpha 1	0.011
Tgif2	TGFB-induced factor homeobox 2	0.011
Ctrl	chymotrypsin-like	0.011
Hoxd3	homeobox D3	0.011
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.011
Chrm4	cholinergic receptor, muscarinic 4	0.011
Msx3	homeobox, msh-like 3	0.011
Dmrt3	doublesex and mab-3 related transcription factor 3	0.011
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.011
Batf	basic leucine zipper transcription factor, ATF-like	0.011
Dmrt1	doublesex and mab-3 related transcription factor 1	0.011
Hoxd12	homeobox D12	0.011
Thsd7b	thrombospondin, type I, domain containing 7B	0.011
Crabp1	cellular retinoic acid binding protein I	0.011
Foxn4	forkhead box N4	0.011
Rpl24	ribosomal protein L24	0.011
Hmx2	H6 homeobox 2	0.011
Zic4	zinc finger protein of the cerebellum 4	0.011
Adam11	a disintegrin and metallopeptidase domain 11	0.011
Wnt8b	wingless related MMTV integration site 8b	0.011
Hoxa13	homeobox A13	0.011
Crybb2	crystallin, beta B2	0.011
Kndc1	kinase non-catalytic C-lobe domain (KIND) containing 1	0.011
Cnpy1	canopy 1 homolog (zebrafish)	0.011
Cyp2w1	cytochrome P450, family 2, subfamily w, polypeptide 1	0.011
Tmem132e	transmembrane protein 132E	0.011
Aym1	activator of yeast meiotic promoters 1	0.011
Dnmt3l	DNA (cytosine-5-)-methyltransferase 3-like	0.010
Rfx4	regulatory factor X, 4 (influences HLA class II expression)	0.010
Hmgb4	high-mobility group box 4	0.010
Wnt2b	wingless related MMTV integration site 2b	0.010
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.010
Zbtb12	zinc finger and BTB domain containing 12	0.010
Irx1	Iroquois related homeobox 1 (Drosophila)	0.010
Matn3	matrilin 3	0.010
Shisa9	shisa homolog 9 (Xenopus laevis)	0.010
Tead3	TEA domain family member 3	0.010
Gsc	goosecoid homeobox	0.010
Lgals7	lectin, galactose binding, soluble 7	0.010
Nup62-il4i1	Nup62-Il4i1 protein	0.010
BC057022	cDNA sequence BC057022	0.010
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.010