IMP
Process View
heparan sulfate proteoglycan metabolic process
The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.
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Click on a gene's description to view its network relationships with genes known to be involved in "heparan sulfate proteoglycan metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Pten | phosphatase and tensin homolog | 0.637 | ||
| Psen1 | presenilin 1 | 0.532 | ||
| Foxc1 | forkhead box C1 | 0.407 | ||
| Apc | adenomatosis polyposis coli | 0.399 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.384 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.326 | ||
| Twsg1 | twisted gastrulation homolog 1 (Drosophila) | 0.310 | ||
| Trp53 | transformation related protein 53 | 0.226 | ||
| Sulf2 | sulfatase 2 | 0.214 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.200 | ||
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.171 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.171 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.134 | ||
| Rb1 | retinoblastoma 1 | 0.125 | ||
| Gsk3b | glycogen synthase kinase 3 beta | 0.097 | ||
| Sulf1 | sulfatase 1 | 0.088 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.083 | ||
| Acvr1 | activin A receptor, type 1 | 0.079 | ||
| Ctnna1 | catenin (cadherin associated protein), alpha 1 | 0.069 | ||
| Pax6 | paired box gene 6 | 0.067 | ||
| Kif3a | kinesin family member 3A | 0.060 | ||
| Rdh10 | retinol dehydrogenase 10 (all-trans) | 0.058 | ||
| Htt | huntingtin | 0.054 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.053 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.051 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.050 | ||
| Rarb | retinoic acid receptor, beta | 0.049 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.048 | Human | |
| Ccnd1 | cyclin D1 | 0.047 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.046 | ||
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.046 | ||
| Chuk | conserved helix-loop-helix ubiquitous kinase | 0.046 | ||
| F12 | coagulation factor XII (Hageman factor) | 0.044 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.042 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.041 | ||
| Egfr | epidermal growth factor receptor | 0.041 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.037 | ||
| Kit | kit oncogene | 0.036 | ||
| Ndst1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.034 | Mouse Fly | |
| Numb | numb gene homolog (Drosophila) | 0.034 | ||
| Ptch1 | patched homolog 1 | 0.033 | ||
| Ctnnbip1 | catenin beta interacting protein 1 | 0.033 | ||
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.032 | ||
| Ctnnd1 | catenin (cadherin associated protein), delta 1 | 0.025 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.024 | ||
| Mad2l2 | MAD2 mitotic arrest deficient-like 2 (yeast) | 0.023 | ||
| Galnt2 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 | 0.023 | ||
| Tax1bp3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.021 | ||
| Akt1 | thymoma viral proto-oncogene 1 | 0.021 | ||
| Plxnd1 | plexin D1 | 0.021 | ||
| Maged1 | melanoma antigen, family D, 1 | 0.021 | ||
| Sox11 | SRY-box containing gene 11 | 0.020 | ||
| Braf | Braf transforming gene | 0.020 | ||
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.020 | ||
| Smo | smoothened homolog (Drosophila) | 0.019 | ||
| Cited2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.019 | ||
| Sh3rf1 | SH3 domain containing ring finger 1 | 0.018 | ||
| Rnpepl1 | arginyl aminopeptidase (aminopeptidase B)-like 1 | 0.018 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.018 | ||
| Ski | ski sarcoma viral oncogene homolog (avian) | 0.017 | ||
| Fzd7 | frizzled homolog 7 (Drosophila) | 0.017 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.017 | ||
| Nf2 | neurofibromatosis 2 | 0.017 | ||
| Scara3 | scavenger receptor class A, member 3 | 0.017 | ||
| Npc1 | Niemann Pick type C1 | 0.016 | ||
| Sgpl1 | sphingosine phosphate lyase 1 | 0.016 | ||
| Nr2f6 | nuclear receptor subfamily 2, group F, member 6 | 0.016 | ||
| Ext1 | exostoses (multiple) 1 | 0.016 | ||
| Gja1 | gap junction protein, alpha 1 | 0.015 | ||
| Serpinc1 | serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 | 0.015 | ||
| Kif7 | kinesin family member 7 | 0.015 | ||
| Kitl | kit ligand | 0.015 | ||
| Jup | junction plakoglobin | 0.014 | ||
| Gtf3c1 | general transcription factor III C 1 | 0.014 | ||
| Gna11 | guanine nucleotide binding protein, alpha 11 | 0.014 | ||
| Bmp1 | bone morphogenetic protein 1 | 0.014 | ||
| Apba1 | amyloid beta (A4) precursor protein binding, family A, member 1 | 0.014 | ||
| Smad2 | MAD homolog 2 (Drosophila) | 0.014 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.014 | ||
| Psen2 | presenilin 2 | 0.013 | ||
| Hipk2 | homeodomain interacting protein kinase 2 | 0.013 | ||
| Gna12 | guanine nucleotide binding protein, alpha 12 | 0.013 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.013 | ||
| Wls | wntless homolog (Drosophila) | 0.013 | ||
| Extl3 | exostoses (multiple)-like 3 | 0.013 | Zebrafish Mouse Worm Fly | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.013 | ||
| Abl1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.012 | ||
| Rac1 | RAS-related C3 botulinum substrate 1 | 0.012 | ||
| Flrt2 | fibronectin leucine rich transmembrane protein 2 | 0.012 | ||
| Efnb2 | ephrin B2 | 0.012 | ||
| Gm13011 | predicted gene 13011 | 0.012 | ||
| Apaf1 | apoptotic peptidase activating factor 1 | 0.012 | ||
| Itgav | integrin alpha V | 0.012 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.012 | ||
| Fastk | Fas-activated serine/threonine kinase | 0.012 | ||
| Hic1 | hypermethylated in cancer 1 | 0.011 | ||
| Sox4 | SRY-box containing gene 4 | 0.011 | ||
| Mllt1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 | 0.011 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.011 | ||
| Prkar1a | protein kinase, cAMP dependent regulatory, type I, alpha | 0.011 | ||
| Plod3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 0.011 | ||
| Bcl9l | B-cell CLL/lymphoma 9-like | 0.010 | ||
| Pak1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.010 | ||
| Cdk14 | cyclin-dependent kinase 14 | 0.010 | ||
| Ets2 | E26 avian leukemia oncogene 2, 3' domain | 0.010 | ||
| Boll | bol, boule-like (Drosophila) | 0.010 | ||
| Plec | plectin | 0.010 | ||
| Pkdcc | protein kinase domain containing, cytoplasmic | 0.010 | ||
| Pcdhb2 | protocadherin beta 2 | 0.010 | ||
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.010 |