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Rattus norvegicus

16 genes annotated in rat

leukocyte activation involved in immune response

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
Hck	hemopoietic cell kinase	0.626	Rat
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.589
Ptprc	protein tyrosine phosphatase, receptor type, C	0.547	Mouse
Ptafr	platelet-activating factor receptor	0.340
Il2rb	interleukin 2 receptor, beta	0.335
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.324	Rat
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.262	Rat
Cd4	Cd4 molecule	0.258
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.237
Cybb	cytochrome b-245, beta polypeptide	0.237
Cd247	Cd247 molecule	0.216
Ms4a11	membrane-spanning 4-domains, subfamily A, member 11	0.210	Rat
Vav1	vav 1 guanine nucleotide exchange factor	0.191
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.169
Calm1	calmodulin 1	0.146
Ctse	cathepsin E	0.140
Mmp12	matrix metallopeptidase 12	0.139
Il1b	interleukin 1 beta	0.122
Il2rg	interleukin 2 receptor, gamma	0.114
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.107
Slc25a5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.102
Cd38	CD38 molecule	0.097
Tgfbr3	transforming growth factor, beta receptor III	0.094
Ppp2ca	protein phosphatase 2, catalytic subunit, alpha isoform	0.089
Morf4l2	mortality factor 4 like 2	0.085
Clec4a3	C-type lectin domain family 4, member a3	0.082
Pgam1	phosphoglycerate mutase 1 (brain)	0.079
RGD1304644	similar to RIKEN cDNA 2310046K01	0.078
Inpp5d	inositol polyphosphate-5-phosphatase D	0.076
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.076
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.075
Casp1	caspase 1	0.074
Mef2d	myocyte enhancer factor 2D	0.073
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.071	Rat
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.069	Mouse Rat
Neurl3	neuralized homolog 3 (Drosophila)	0.068
Igsf6	immunoglobulin superfamily, member 6	0.067
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.067
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.066
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.062
Tgfbr2	transforming growth factor, beta receptor II	0.061
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.061	Rat
Cd53	Cd53 molecule	0.060
Ccr5	chemokine (C-C motif) receptor 5	0.060
Tbxas1	thromboxane A synthase 1, platelet	0.059
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.059
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.058
Sirpa	signal-regulatory protein alpha	0.058
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.057
Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.056
C5ar1	complement component 5a receptor 1	0.055
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.054	Rat
Icam1	intercellular adhesion molecule 1	0.053
Il9r	interleukin 9 receptor	0.052
Lta	lymphotoxin alpha (TNF superfamily, member 1)	0.051
Wdr1	WD repeat domain 1	0.048
Padi3	peptidyl arginine deiminase, type III	0.047
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.047
Ciita	class II, major histocompatibility complex, transactivator	0.047
Tlr4	toll-like receptor 4	0.047	Mouse
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.047
Ywhaq	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.045	Rat
Cd8b	CD8b molecule	0.044
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.044
Cd3g	CD3 molecule, gamma	0.043
Klhl6	kelch-like 6 (Drosophila)	0.043
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.043
Olr1496	olfactory receptor 1496	0.039
Gzmk	granzyme K	0.039
Cxcr3	chemokine (C-X-C motif) receptor 3	0.038
Psd4	pleckstrin and Sec7 domain containing 4	0.038
Prlhr	prolactin releasing hormone receptor	0.037
Cd68	Cd68 molecule	0.037
Ripk3	receptor-interacting serine-threonine kinase 3	0.037
Hpgds	hematopoietic prostaglandin D synthase	0.035
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.034
Srxn1	sulfiredoxin 1 homolog (S. cerevisiae)	0.034
Slc15a3	solute carrier family 15, member 3	0.034
Ccl3	chemokine (C-C motif) ligand 3	0.033	Human
Hspa8	heat shock protein 8	0.033
Olr1469	olfactory receptor Olr1469	0.033
Folr2	folate receptor 2 (fetal)	0.033
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.032
Csf1	colony stimulating factor 1 (macrophage)	0.032
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.032
Cpa3	carboxypeptidase A3, mast cell	0.031
Hdac7	histone deacetylase 7	0.031
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.031
Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7	0.031
Nrarp	Notch-regulated ankyrin repeat protein	0.031
Arl11	ADP-ribosylation factor-like 11	0.031
Ncan	neurocan	0.030
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.030
Sell	selectin L	0.029
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.029	Mouse
Icos	inducible T-cell co-stimulator	0.029
Laptm5	lysosomal protein transmembrane 5	0.029
Stat3	signal transducer and activator of transcription 3	0.028
Cd86	CD86 molecule	0.028
Tlr7	toll-like receptor 7	0.027
Cltc	clathrin, heavy chain (Hc)	0.027
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.027
Klrb1a	killer cell lectin-like receptor subfamily B, member 1A	0.026
Aplnr	apelin receptor	0.026
Hrh2	histamine receptor H 2	0.026
Zwint	ZW10 interactor	0.026
Fcnb	ficolin B	0.026
Mpeg1	macrophage expressed 1	0.026
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.026	Rat
Dock8	dedicator of cytokinesis 8	0.025
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.025
Calm2	calmodulin 2	0.024
RGD1306474	similar to RIKEN cDNA 9530003J23	0.024
Prkcd	protein kinase C, delta	0.024
Cmklr1	chemokine-like receptor 1	0.024
Acrv1	acrosomal vesicle protein 1	0.024
Arrdc1	arrestin domain containing 1	0.024
Rhob	ras homolog gene family, member B	0.024
Pld2	phospholipase D2	0.024
Dnase1l3	deoxyribonuclease 1-like 3	0.024
Fgf7	fibroblast growth factor 7	0.023
Rab6a	RAB6A, member RAS oncogene family	0.023
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.023
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.023
Cyp2s1	cytochrome P450, family 2, subfamily s, polypeptide 1	0.023
Sbno2	strawberry notch homolog 2 (Drosophila)	0.022	Human Mouse
Itgb7	integrin, beta 7	0.022
Lcp2	lymphocyte cytosolic protein 2	0.022
Plcb2	phospholipase C, beta 2	0.022
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.022
Lilrb3l	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like	0.021
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.021
Bak1	BCL2-antagonist/killer 1	0.021
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.021
Ppp2cb	protein phosphatase 2, catalytic subunit, beta isoform	0.021
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.021
Il18r1	interleukin 18 receptor 1	0.021
Rab10	RAB10, member RAS oncogene family	0.021
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.021
Lep	leptin	0.020
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.020
Fgd4	FYVE, RhoGEF and PH domain containing 4	0.020
Adcy10	adenylate cyclase 10 (soluble)	0.020
Cd37	CD37 molecule	0.020
Il17ra	interleukin 17 receptor A	0.020
Arhgap25	Rho GTPase activating protein 25	0.020
Havcr1	hepatitis A virus cellular receptor 1	0.020
Arhgap4	Rho GTPase activating protein 4	0.020
Sla	src-like adaptor	0.020
Mcpt2	mast cell protease 2	0.020
Ncr1	natural cytotoxicity triggering receptor 1	0.019
Ap2m1	adaptor-related protein complex 2, mu 1 subunit	0.019
Faslg	Fas ligand (TNF superfamily, member 6)	0.019
Nptn	neuroplastin	0.018
Meis3	Meis homeobox 3	0.018
Anxa3	annexin A3	0.018	Human
Igh-6	immunoglobulin heavy chain 6	0.018
Bdkrb2	bradykinin receptor B2	0.018
RT1-A3	RT1 class I, locus A3	0.018
Prkch	protein kinase C, eta	0.018
Adrb2	adrenergic, beta-2-, receptor, surface	0.018
Grm6	glutamate receptor, metabotropic 6	0.018
Fgb	fibrinogen beta chain	0.017
Tcf4	transcription factor 4	0.017
Hmha1	histocompatibility (minor) HA-1	0.017
Hspa12b	heat shock protein 12B	0.017
Il1a	interleukin 1 alpha	0.017
Bcl3	B-cell CLL/lymphoma 3	0.017
Stat6	signal transducer and activator of transcription 6	0.017	Mouse
Nlrp6	NLR family, pyrin domain containing 6	0.017
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.017
Cd6	Cd6 molecule	0.017
Pitpna	phosphatidylinositol transfer protein, alpha	0.016
Phox2a	paired-like homeobox 2a	0.016
Lst1	leukocyte specific transcript 1	0.016
Cd3d	CD3 molecule, delta	0.016
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.016
Sfrp4	secreted frizzled-related protein 4	0.016
LOC100363783	rCG53773-like	0.016
Socs3	suppressor of cytokine signaling 3	0.016
Hbegf	heparin-binding EGF-like growth factor	0.016
Casp8	caspase 8	0.015
Slc22a25	solute carrier family 22, member 25	0.015
Grin2c	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.015
Map2k1	mitogen activated protein kinase kinase 1	0.015
Fcgr1a	Fc fragment of IgG, high affinity Ia, receptor (CD64)	0.015
Eif2c2	eukaryotic translation initiation factor 2C, 2	0.015
Gfra2	GDNF family receptor alpha 2	0.015
Ncf4	neutrophil cytosolic factor 4	0.015
Sdc3	syndecan 3	0.015
Prf1	perforin 1 (pore forming protein)	0.015
Fnbp1	formin binding protein 1	0.015
Cd8a	CD8a molecule	0.015
Tpm3	tropomyosin 3, gamma	0.015
Fut2	fucosyltransferase 2 (secretor status included)	0.015
Txnrd1	thioredoxin reductase 1	0.015
Lypd3	Ly6/Plaur domain containing 3	0.015
Cxcl13	chemokine (C-X-C motif) ligand 13	0.015
Litaf	lipopolysaccharide-induced TNF factor	0.015
Fkbp1a	FK506 binding protein 1a	0.015
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.015
Zyx	zyxin	0.015
Epor	erythropoietin receptor	0.015
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.015
Hsbp1	heat shock factor binding protein 1	0.014
P2ry2	purinergic receptor P2Y, G-protein coupled, 2	0.014
Myo9a	myosin IXA	0.014
Cd40	CD40 molecule, TNF receptor superfamily member 5	0.014
Prkcb	protein kinase C, beta	0.014
Il7r	interleukin 7 receptor	0.014
Irf5	interferon regulatory factor 5	0.014
Mutyh	mutY homolog (E. coli)	0.014
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.014
Lyl1	lymphoblastic leukemia derived sequence 1	0.013
Fam46a	family with sequence similarity 46, member A	0.013
Dusp2	dual specificity phosphatase 2	0.013
Bcl2	B-cell CLL/lymphoma 2	0.013
Scn11a	sodium channel, voltage-gated, type XI, alpha	0.013
Lims1	LIM and senescent cell antigen-like domains 1	0.013
Cand1	cullin-associated and neddylation-dissociated 1	0.013
LOC100364854	similar to RIKEN cDNA A430107P09 gene-like	0.013
Nfix	nuclear factor I/X (CCAAT-binding transcription factor)	0.013
Foxo1	forkhead box O1	0.013
Nrg2	neuregulin 2	0.013
Fcgr3a	Fc fragment of IgG, low affinity IIIa, receptor	0.013
Gak	cyclin G associated kinase	0.013
Slc9a4	solute carrier family 9 (sodium/hydrogen exchanger), member 4	0.013
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.013
Gls	glutaminase	0.013
Dcc	deleted in colorectal carcinoma	0.013
Myh9	myosin, heavy chain 9, non-muscle	0.013
Eif4h	eukaryotic translation initiation factor 4H	0.013
Rhoh	ras homolog gene family, member H	0.013
Tubb2a	tubulin, beta 2a	0.013
Tmem101	transmembrane protein 101	0.013
Fcgr2a	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.012
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.012
Mcpt3	mast cell peptidase 3	0.012
LOC56764	dnaj-like protein	0.012
Tal1	T-cell acute lymphocytic leukemia 1	0.012
Ets1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.012
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.012
Ap3m1	adaptor-related protein complex 3, mu 1 subunit	0.012
Il1r1	interleukin 1 receptor, type I	0.012
Adam2	ADAM metallopeptidase domain 2	0.012
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.012
C3	complement component 3	0.012
Dchs1	dachsous 1 (Drosophila)	0.012
Cd2	Cd2 molecule	0.012
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	0.012
RGD1559588	similar to cell surface receptor FDFACT	0.012
Gjb4	gap junction protein, beta 4	0.012
Arrb2	arrestin, beta 2	0.012
Cfp	complement factor properdin	0.011
Cxcr4	chemokine (C-X-C motif) receptor 4	0.011
S1pr2	sphingosine-1-phosphate receptor 2	0.011
Il13ra2	interleukin 13 receptor, alpha 2	0.011
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.011
Mov10	Moloney leukemia virus 10	0.011
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.011
Hspa13	heat shock protein 13	0.011
Apol3	apolipoprotein L, 3	0.011
Syk	spleen tyrosine kinase	0.011
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.011
Pla2g2c	phospholipase A2, group IIC	0.011
Adora1	adenosine A1 receptor	0.011
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.011
Aqp8	aquaporin 8	0.011
N5	DNA binding protein N5	0.011
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.011
Ccl22	chemokine (C-C motif) ligand 22	0.011
Hdac1l	histone deacetylase 1-like	0.011
Nckap1	NCK-associated protein 1	0.011
Dok3	docking protein 3	0.011
Ntn1	netrin 1	0.011
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.011
Itgb2	integrin, beta 2	0.011
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.011
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.011
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.011
Aspg	asparaginase homolog (S. cerevisiae)	0.010
Nras	neuroblastoma ras oncogene	0.010
Zfp382	zinc finger protein 382	0.010
Oprk1	opioid receptor, kappa 1	0.010
Bcl2a1d	B-cell leukemia/lymphoma 2 related protein A1d	0.010
Smad1	SMAD family member 1	0.010
Crhr2	corticotropin releasing hormone receptor 2	0.010	Rat
LOC687856	similar to Myeloid cell surface antigen CD33 precursor (Siglec-3)	0.010