IMP

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Danio rerio

1 genes annotated in zebrafish

intra s dna damage checkpoint

A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "intra s dna damage checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "intra s dna damage checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
rasl11b	RAS-like, family 11, member B	0.324
trmt2a	trm2 tRNA methyltransferase 2 homolog A (S. cerevisiae)	0.284
zgc:73273	zgc:73273	0.202
ddb2	damage-specific DNA binding protein 2	0.185
chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.178
id3	inhibitor of DNA binding 3	0.153	Zebrafish
vldlr	very low density lipoprotein receptor	0.151
nup43	nucleoporin 43	0.145
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.131
rnaseh2b	ribonuclease H2, subunit B	0.119
lfng	lunatic fringe homolog	0.111
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.109
mab21l1	mab-21-like 1	0.102
gins2	GINS complex subunit 2	0.096
rpa3	replication protein A3	0.094
gmnn	geminin, DNA replication inhibitor	0.070
thoc3	THO complex 3	0.069
fanci	Fanconi anemia, complementation group I	0.066
mtx1b	metaxin 1b	0.065
tyms	thymidylate synthase	0.062
id1	inhibitor of DNA binding 1	0.061	Zebrafish
her9	hairy-related 9	0.059
prim1	primase polypeptide 1	0.058
mdkb	midkine-related growth factor b	0.057
pdcd8	programmed cell death 8 (apoptosis-inducing factor)	0.051
sb:eu1555	sb:eu1555	0.050
inka1a	induced in neural crest by AP2, 1a	0.048
hat1	histone acetyltransferase 1	0.047
zgc:92648	zgc:92648	0.046
brip1	BRCA1 interacting protein C-terminal helicase 1	0.046
setdb1a	SET domain, bifurcated 1a	0.044
gstm	glutathione S-transferase M	0.043
dhfr	dihydrofolate reductase	0.043
umps	uridine monophosphate synthetase	0.042
sox11a	SRY-box containing gene 11a	0.042
zgc:154110	zgc:154110	0.041
coro1b	coronin, actin binding protein, 1B	0.041
palb2	partner and localizer of BRCA2	0.041
arl4ab	ADP-ribosylation factor-like 4ab	0.040
mbd3b	methyl-CpG binding domain protein 3b	0.040
cdk2	cyclin-dependent kinase 2	0.039
gemin5	gem (nuclear organelle) associated protein 5	0.039
adka	adenosine kinase a	0.038
zgc:56197	zgc:56197	0.038
nap1l1	nucleosome assembly protein 1, like 1	0.036
fen1	flap structure-specific endonuclease 1	0.035
zgc:66326	zgc:66326	0.035
gins1	GINS complex subunit 1 (Psf1 homolog)	0.035
wdr76	WD repeat domain 76	0.035
crabp2b	cellular retinoic acid binding protein 2, b	0.033
lap3	leucine aminopeptidase 3	0.032
thumpd3	THUMP domain containing 3	0.032
cited3	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 3	0.032
orc1	origin recognition complex, subunit 1	0.031
pcna	proliferating cell nuclear antigen	0.031
zgc:73142	zgc:73142	0.030
triap1	TP53 regulated inhibitor of apoptosis 1	0.029
zgc:114104	zgc:114104	0.029
rps2	ribosomal protein S2	0.028
si:dkey-8l13.1	si:dkey-8l13.1	0.028
ccdc58	coiled-coil domain containing 58	0.028
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.027
si:dkey-42i9.4	si:dkey-42i9.4	0.027
cox4i2	cytochrome c oxidase subunit IV isoform 2	0.026
xbp1	X-box binding protein 1	0.025
fabp7a	fatty acid binding protein 7, brain, a	0.025
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.025
csrp1a	cysteine and glycine-rich protein 1a	0.025
nasp	nuclear autoantigenic sperm protein (histone-binding)	0.025
lmo4a	LIM domain only 4a	0.025
adnp2b	ADNP homeobox 2b	0.024
dync2i1	dynein, cytoplasmic 2, intermediate chain 1	0.024
hells	helicase, lymphoid-specific	0.024
lrig1	leucine-rich repeats and immunoglobulin-like domains 1	0.023
si:ch211-204c21.1	si:ch211-204c21.1	0.023
sb:cb288	sb:cb288	0.023
wdhd1	WD repeat and HMG-box DNA binding protein 1	0.023
frzb	frizzled-related protein	0.023
eaf1	ELL associated factor 1	0.023
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.022
stmn1b	stathmin 1b	0.022
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.022
als2b	amyotrophic lateral sclerosis 2b (juvenile)	0.022
fscn1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	0.021
fstl1b	follistatin-like 1b	0.021
nutf2l	nuclear transport factor 2, like	0.021
pole2	polymerase (DNA directed), epsilon 2	0.021
cacnb3a	calcium channel, voltage-dependent, beta 3a	0.020
zgc:77165	zgc:77165	0.020
orc5	origin recognition complex, subunit 5	0.020
msh6	mutS homolog 6 (E. coli)	0.020
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.020
setd6	SET domain containing 6	0.019
ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.019
fam84a	family with sequence similarity 84, member A	0.019
map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.019
impdh2	IMP (inosine monophosphate) dehydrogenase 2	0.019
myca	myelocytomatosis oncogene a	0.019
mpped2	metallophosphoesterase domain containing 2	0.019
ppdpfb	pancreatic progenitor cell differentiation and proliferation factor b	0.019
ptmaa	prothymosin, alpha a	0.019
si:dkey-27i16.2	si:dkey-27i16.2	0.018
zgc:91870	zgc:91870	0.018
iba57	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)	0.018
aggf1	angiogenic factor with G patch and FHA domains 1	0.018
timm50	translocase of inner mitochondrial membrane 50 homolog (yeast)	0.018
zgc:174506	zgc:174506	0.018
exosc8	exosome component 8	0.017
sox3	SRY-box containing gene 3	0.017
btg2	B-cell translocation gene 2	0.017
pola2	polymerase (DNA directed), alpha 2	0.017
zgc:110586	zgc:110586	0.017
LOC563801	poly(A) RNA polymerase, mitochondrial-like	0.017
orc6	origin recognition complex, subunit 6	0.017
si:ch211-233e16.1	si:ch211-233e16.1	0.017
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.017
btg3	B-cell translocation gene 3	0.016
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.016
zgc:56259	zgc:56259	0.016
gtdc1	glycosyltransferase-like domain containing 1	0.016
crip2	cysteine-rich protein 2	0.016
fzd7b	frizzled homolog 7b	0.015
zwilch	Zwilch, kinetochore associated, homolog (Drosophila)	0.015
pold2	polymerase (DNA directed), delta 2, regulatory subunit	0.015
otpb	orthopedia homolog b	0.015
zgc:110425	zgc:110425	0.015
mpv17	MpV17 transgene, murine homolog, glomerulosclerosis	0.015
zc4h2	zinc finger, C4H2 domain containing	0.015
zgc:110113	zgc:110113	0.015
h1fx	H1 histone family, member X	0.015
zgc:154061	zgc:154061	0.015
zgc:85644	zgc:85644	0.015
nsun4	NOL1/NOP2/Sun domain family, member 4	0.015
ccnd1	cyclin D1	0.015
cdt1	chromatin licensing and DNA replication factor 1	0.015
rfc2	replication factor C (activator 1) 2	0.015
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.014
zgc:112056	zgc:112056	0.014
zgc:110434	zgc:110434	0.014
wdr12	WD repeat domain 12	0.014
zgc:172136	zgc:172136	0.014
nsmce4a	non-SMC element 4 homolog A (S. cerevisiae)	0.014
rnf41	ring finger protein 41	0.014
zgc:110608	zgc:110608	0.014
usp1	ubiquitin specific protease 1	0.014
zgc:153910	zgc:153910	0.014
zgc:174888	zgc:174888	0.014
ndufs7	NADH dehydrogenase (ubiquinone) Fe-S protein 7, (NADH-coenzyme Q reductase)	0.014
sox4a	SRY-box containing gene 4a	0.013
rad51c	rad51 homolog C (S. cerevisiae)	0.013
mrrf	mitochondrial ribosome recycling factor	0.013
zgc:56628	zgc:56628	0.013
hist2h2l	histone 2, H2, like	0.013
snai2	snail homolog 2 (Drosophila)	0.013
rab12	RAB12, member RAS oncogene family	0.013
anapc5	anaphase promoting complex subunit 5	0.013
zfhx3	zinc finger homeobox 3	0.013
skp2	S-phase kinase-associated protein 2 (p45)	0.013
hsf2	heat shock factor 2	0.013
lypla1	lysophospholipase I	0.012
sesn1	sestrin 1	0.012
metrnl	meteorin, glial cell differentiation regulator-like	0.012
hmgb1b	high-mobility group box 1b	0.012
khdrbs1b	KH domain containing, RNA binding, signal transduction associated 1b	0.012
lmo7b	LIM domain only 7b	0.012
atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	0.012
tceb2	transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B)	0.012
mmp2	matrix metalloproteinase 2	0.012
naa15b	N(alpha)-acetyltransferase 15, NatA auxiliary subunit b	0.012
aldh18a1	aldehyde dehydrogenase 18 family, member A1	0.012
kmo	kynurenine 3-monooxygenase	0.012
slc25a26	solute carrier family 25, member 26	0.012
chaf1a	chromatin assembly factor 1, subunit A (p150)	0.012
pdcd4a	programmed cell death 4a	0.012
pmpca	peptidase (mitochondrial processing) alpha	0.012
pnp4a	purine nucleoside phosphorylase 4a	0.012
fkbp3	FK506 binding protein 3	0.011
acad11	acyl-Coenzyme A dehydrogenase family, member 11	0.011
c21orf59l	c21orf59 homolog (H. sapiens), like	0.011
zgc:162269	zgc:162269	0.011
ebf3	early B-cell factor 3	0.011
zgc:86870	zgc:86870	0.011
arl4cb	ADP-ribosylation factor-like 4Cb	0.011
fmo5	flavin containing monooxygenase 5	0.011
dera	2-deoxyribose-5-phosphate aldolase homolog (C. elegans)	0.011
ifi30	interferon gamma inducible protein 30	0.011
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.011
zgc:64040	zgc:64040	0.011
cdkn3	cyclin-dependent kinase inhibitor 3	0.011
atp6v1ba	ATPase, H+ transporting, lysosomal, V1 subunit B, member a	0.011
id:ibd5051	id:ibd5051	0.011
tube1	tubulin, epsilon 1	0.011
pprc1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	0.011
timm13	translocase of inner mitochondrial membrane 13 homolog (yeast)	0.011
gstcd	glutathione S-transferase, C-terminal domain containing	0.011
cry5	cryptochrome 5	0.011
zgc:63523	zgc:63523	0.011
trap1	TNF receptor-associated protein 1	0.011
tcf4	transcription factor 4	0.011
sestd1	SEC14 and spectrin domains 1	0.011
p2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.010
ccne	cyclin E	0.010
setd4	SET domain containing 4	0.010
lrrn1	leucine rich repeat neuronal 1	0.010
tp53inp1	tumor protein p53 inducible nuclear protein 1	0.010
flrt3	fibronectin leucine rich transmembrane 3	0.010
chid1	chitinase domain containing 1	0.010
rfc4	replication factor C (activator 1) 4	0.010
pdcd11	programmed cell death 11	0.010
cd9a	CD9 antigen (p24) a	0.010