The network for 'negative regulation of cellular macromolecule biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular macromolecule biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process.

Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.999
CTCF CG8591 gene product from transcript CG8591-RA 0.999
Snr1 Snf5-related 1 0.999
Iswi Imitation SWI 0.999
Sir2 CG5216 gene product from transcript CG5216-RA 0.998
CtBP C-terminal Binding Protein 0.997
N Notch 0.997
shn schnurri 0.996
Pc Polycomb 0.995
ato atonal 0.992
nmo nemo 0.991
en engrailed 0.986
JIL-1 CG6297 gene product from transcript CG6297-RA 0.985
gpp grappa 0.984
lwr lesswright 0.981
gsb gooseberry 0.977
esc extra sexcombs 0.972
gro groucho 0.968
smt3 CG4494 gene product from transcript CG4494-RA 0.967
InR Insulin-like receptor 0.966
tll tailless 0.965
pan pangolin 0.964
Scm Sex comb on midleg 0.961
Pp1-87B Protein phosphatase 1 at 87B 0.961
D1 D1 chromosomal protein 0.954
kn knot 0.953
slmb supernumerary limbs 0.952
Acf1 ATP-dependent chromatin assembly factor large subunit 0.950
lola longitudinals lacking 0.948
ash1 absent, small, or homeotic discs 1 0.947
hep hemipterous 0.947
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.946
ci cubitus interruptus 0.943
tkv thickveins 0.942
Spt5 CG7626 gene product from transcript CG7626-RA 0.941
dco discs overgrown 0.939
Ubx Ultrabithorax 0.939
Trl Trithorax-like 0.938
Pcl Polycomblike 0.935
osa CG7467 gene product from transcript CG7467-RD 0.935
ara araucan 0.932
HLHm7 E(spl) region transcript m7 0.932
how held out wings 0.931
cnc cap-n-collar 0.930
Nf-YC Nuclear factor Y-box C 0.926
pb proboscipedia 0.926
bowl brother of odd with entrails limited 0.923
polybromo CG11375 gene product from transcript CG11375-RA 0.921
ed echinoid 0.920
tin tinman 0.918
Smr Smrter 0.918
sax saxophone 0.913
salm spalt major 0.908
Rpd3 CG7471 gene product from transcript CG7471-RA 0.907
foxo forkhead box, sub-group O 0.907
pr-set7 CG3307 gene product from transcript CG3307-RC 0.906
prd paired 0.904
Moe Moesin 0.902
Fmr1 CG6203 gene product from transcript CG6203-RC 0.901
E(spl) Enhancer of split 0.899
eya eyes absent 0.897
hth homothorax 0.895
mam mastermind 0.895
nub nubbin 0.894
Hel25E Helicase at 25E 0.890
yki yorkie 0.887
mor moira 0.886
E(var)3-9 Enhancer of variegation 3-9 0.883
lid little imaginal discs 0.879
kay kayak 0.878
tup tailup 0.875
stwl stonewall 0.874
His2Av Histone H2A variant 0.870
kis kismet 0.860
fru fruitless 0.857
mirr mirror 0.857
Su(var)3-7 Suppressor of variegation 3-7 0.851
E2f2 E2F transcription factor 2 0.845
vas vasa 0.840
barr barren 0.837
fu fused 0.833
Pcaf CG4107 gene product from transcript CG4107-RA 0.832
Optix CG18455 gene product from transcript CG18455-RA 0.832
Jarid2 CG3654 gene product from transcript CG3654-RD 0.831
CycB Cyclin B 0.831
e(y)3 enhancer of yellow 3 0.831
EcR Ecdysone receptor 0.827
sti sticky 0.823
crm cramped 0.823
eyg eyegone 0.818
klu klumpfuss 0.816
dpp decapentaplegic 0.816
rin rasputin 0.814
psq pipsqueak 0.812
brat brain tumor 0.808
rpr reaper 0.805
ss spineless 0.802
h hairy 0.797
Su(z)2 Suppressor of zeste 2 0.787
CSN8 COP9 complex homolog subunit 8 0.784
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.963
elt-6 Protein ELT-6 0.945
pha-4 Protein PHA-4 0.887
hlh-2 Protein HLH-2 0.781
egl-13 Protein EGL-13 0.559
nhr-2 Protein NHR-2 0.557
inx-3 Protein INX-3 0.448
his-1 Protein HIS-1 0.439
nhr-67 Protein NHR-67 0.408
his-64 Protein HIS-64 0.375
wrm-1 Protein WRM-1 0.361
egl-27 Protein EGL-27 0.346
mab-5 Protein MAB-5 0.283
his-16 Protein HIS-16 0.276
his-31 Protein HIS-31 0.262
his-5 Protein HIS-5 0.255
let-502 Protein LET-502 0.254
egl-46 Protein EGL-46 0.252
mcm-7 Protein MCM-7 0.250
eor-1 Protein EOR-1 0.224
daf-14 Protein DAF-14 0.221
unc-62 Protein UNC-62 0.211
F55F8.9 Protein F55F8.9 0.203
lin-53 Protein LIN-53 0.197
hda-1 Protein HDA-1 0.191
tbx-8 Protein TBX-8 0.188
CELE_F54D5.5 Protein F54D5.5 0.187
nhr-46 Protein NHR-46 0.186
fkh-2 Protein FKH-2 0.181
eftu-2 Protein EFTU-2 0.177
daf-12 Protein DAF-12 0.174
F39B2.1 Protein F39B2.1 0.173
ceh-27 Protein CEH-27 0.172
hlh-1 Protein HLH-1 0.172
attf-2 Protein ATTF-2 0.170
his-3 Protein HIS-3 0.168
T28F4.1 Protein T28F4.1 0.163
mes-4 Protein MES-4 0.160
CELE_C24H12.5 Protein C24H12.5 0.153
unc-73 Protein UNC-73 0.148
his-62 Protein HIS-62 0.147
his-51 Protein HIS-51 0.146
spr-5 Protein SPR-5 0.146
his-68 Protein HIS-68 0.145
his-61 Protein HIS-61 0.145
pry-1 Protein PRY-1 0.145
lin-40 Protein LIN-40 0.143
his-50 Protein HIS-50 0.142
hlh-30 Protein HLH-30 0.140
his-38 Protein HIS-38 0.137
rad-26 Protein RAD-26 0.133
nhr-25 Protein NHR-25 0.133
lin-66 Protein LIN-66 0.131
mix-1 Protein MIX-1 0.128
cnd-1 Protein CND-1 0.124
hbl-1 Protein HBL-1 0.120
hil-2 Protein HIL-2 0.119
npp-3 Protein NPP-3 0.118
C27F2.8 Protein C27F2.8 0.118
klp-16 Protein KLP-16 0.117
his-29 Protein HIS-29 0.117
his-42 Protein HIS-42 0.117
his-4 Protein HIS-4 0.114
hum-6 Protein HUM-6 0.111
hcp-3 Protein HCP-3 0.110
cnt-2 Protein CNT-2 0.110
his-46 Protein HIS-46 0.109
his-47 Protein HIS-47 0.108
T09B4.5 Protein T09B4.5 0.108
csn-4 Protein CSN-4 0.107
lin-35 Protein LIN-35 0.105
nhr-34 Protein NHR-34 0.105
qua-1 Protein QUA-1 0.104
snr-2 Protein SNR-2 0.104
kle-2 Protein KLE-2 0.103
daf-4 Protein DAF-4 0.103
mig-38 Protein MIG-38 0.101
egl-44 Protein EGL-44 0.100
F26B1.2 Protein F26B1.2 0.097
zip-7 Protein ZIP-7 0.093
daf-1 Protein DAF-1 0.093
lmn-1 Protein LMN-1 0.092
eef-1A.1 Protein EEF-1A.1 0.091
ulp-2 Protein ULP-2 0.089
Y54E5A.7 Protein Y54E5A.7 0.088
acs-4 Protein ACS-4 0.088
eya-1 Protein EYA-1 0.087
sma-6 Protein SMA-6 0.087
atn-1 Protein ATN-1 0.086
Y45G5AM.9 Protein Y45G5AM.9 0.086
his-24 Protein HIS-24 0.086
B0464.2 Protein B0464.2 0.086
lsy-22 Protein LSY-22 0.084
his-52 Protein HIS-52 0.083
tam-1 Protein TAM-1 0.083
hmg-4 Protein HMG-4 0.083
ima-2 Protein IMA-2 0.082
mex-5 Protein MEX-5 0.082
tag-260 Protein TAG-260 0.082
Y82E9BR.13 Protein Y82E9BR.13 0.081
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Danio rerio
Name Description Probability Func Analog Organism
notch1a notch homolog 1a 0.911
gata6 GATA-binding protein 6 0.739
gli1 GLI-Kruppel family member 1 0.737
dlx2a distal-less homeobox gene 2a 0.684
chd chordin 0.670
foxa3 forkhead box A3 0.651
robo3 roundabout homolog 3 0.651
wnt5b wingless-type MMTV integration site family, member 5b 0.632
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.570
bmp2b bone morphogenetic protein 2b 0.529
fgf3 fibroblast growth factor 3 0.510
prox1 prospero-related homeobox gene 1 0.492
tfap2a transcription factor AP-2 alpha 0.474
vsx2 visual system homeobox 2 0.437
snai1b snail homolog 1b (Drosophila) 0.408
hp1bp3 heterochromatin protein 1, binding protein 3 0.402
dlc deltaC 0.389
lhx1a LIM homeobox 1a 0.387
mbnl2 muscleblind-like 2 (Drosophila) 0.377
her11 hairy-related 11 0.373
tp53 tumor protein p53 0.369
eng2a engrailed 2a 0.369
pou3f3a POU class 3 homeobox 3a 0.356
mab21l2 mab-21-like 2 0.347
gro1 groucho 1 0.337
spry4 sprouty (Drosophila) homolog 4 0.310
nkx2.5 NK2 transcription factor related 5 0.309
boc brother of CDO 0.279
sox19a SRY-box containing gene 19a 0.277
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.273
sox9b SRY-box containing gene 9b 0.271
hnf1ba HNF1 homeobox Ba 0.271
egr1 early growth response 1 0.266
emx1 empty spiracles homeobox 1 0.266
pax2a paired box gene 2a 0.262
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.262
her1 hairy-related 1 0.261
her6 hairy-related 6 0.245
nkx1.2la NK1 transcription factor related 2-like,a 0.245
sall1a sal-like 1a (Drosophila) 0.241
kctd15a potassium channel tetramerisation domain containing 15a 0.238
per2 period homolog 2 (Drosophila) 0.235
ndr2 nodal-related 2 0.234
dct dopachrome tautomerase 0.234
nova2 neuro-oncological ventral antigen 2 0.228
etv2 ets variant gene 2 0.224
fsta follistatin a 0.223
hmgb1a high-mobility group box 1a 0.218
hoxb1b homeo box B1b 0.217
kdrl kinase insert domain receptor like 0.216
ripply1 ripply1 0.215
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.212
foxi1 forkhead box I1 0.211
hmx1 H6 homeo box 1 0.209
otx1b orthodenticle homolog 1b 0.202
prdm14 PR domain containing 14 0.198
otx2 orthodenticle homolog 2 0.194
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.194
igf1rb insulin-like growth factor 1b receptor 0.193
vcana versican a 0.188
gbx2 gastrulation brain homeo box 2 0.184
grem2 gremlin 2, cysteine knot superfamily 0.177
smc3 structural maintenance of chromosomes 3 0.170
sesn1 sestrin 1 0.166
mespa mesoderm posterior a 0.163
junb jun B proto-oncogene 0.159
twist3 twist3 0.159
cdh5 cadherin 5 0.157
fgf19 fibroblast growth factor 19 0.156
wnt1 wingless-type MMTV integration site family, member 1 0.154
nkx2.3 NK2 transcription factor related 3 0.154
jag2 jagged 2 0.153
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.152
foxa2 forkhead box A2 0.152
tfeb transcription factor EB 0.152
tll1 tolloid-like 1 0.152
prdm5 PR domain containing 5 0.151
axin2 axin 2 (conductin, axil) 0.148
lhx1b LIM homeobox 1b 0.147
bmp4 bone morphogenetic protein 4 0.147
plekhg4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.146
fezf2 FEZ family zinc finger 2 0.144
cmyb transcription factor cmyb 0.144
neo1 neogenin 1 0.141
sox1a SRY-box containing gene 1a 0.141
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.137
tpm4 tropomyosin 4 0.136
runx1 runt-related transcription factor 1 0.133
pea3 ETS-domain transcription factor pea3 0.132
sox9a SRY-box containing gene 9a 0.131
fgfr1a fibroblast growth factor receptor 1a 0.131
fzd7a frizzled homolog 7a 0.129
ncor1 nuclear receptor co-repressor 1 0.128
alcamb activated leukocyte cell adhesion molecule b 0.127
vent ventral expressed homeobox 0.126
vax1 ventral anterior homeobox 1 0.125
cry1a cryptochrome 1a 0.124
tcf12 transcription factor 12 0.123
pou3f2 POU class 3 homeobox 2 0.123
smyhc1 slow myosin heavy chain 1 0.121
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.911
Jun Jun oncogene 0.904
Fos FBJ osteosarcoma oncogene 0.809
Dusp1 dual specificity phosphatase 1 0.795
Btg2 BTG family, member 2 0.694
Smad7 SMAD family member 7 0.614
Tgfbr2 transforming growth factor, beta receptor II 0.593
Egr1 early growth response 1 0.579
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.575
Nfib nuclear factor I/B 0.574
Trim28 tripartite motif-containing 28 0.572
Nono non-POU domain containing, octamer-binding 0.572
Ier2 immediate early response 2 0.540
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.478
Nfia nuclear factor I/A 0.429
Fgfr1 Fibroblast growth factor receptor 1 0.419
Klf2 Kruppel-like factor 2 (lung) 0.410
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.395
Socs3 suppressor of cytokine signaling 3 0.389
Pcna proliferating cell nuclear antigen 0.376
Id1 inhibitor of DNA binding 1 0.361
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.353
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.351
Kdm6b lysine (K)-specific demethylase 6B 0.339
Foxi2 forkhead box I2 0.328
Tcfe2a transcription factor E2a 0.321
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.320
Shox2 short stature homeobox 2 0.292
Siah1a seven in absentia 1A 0.287
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.283
Neurog1 neurogenin 1 0.274
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.271
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.269
MGC112830 similar to transcription factor 0.267
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.260
Stat5b signal transducer and activator of transcription 5B 0.260
Foxe3 forkhead box E3 0.258
Pde4b phosphodiesterase 4B, cAMP specific 0.244
Myh9 myosin, heavy chain 9, non-muscle 0.244
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.240
Arnt aryl hydrocarbon receptor nuclear translocator 0.239
Iapp islet amyloid polypeptide 0.237
Hoxb7 homeo box B7 0.237
Myc myelocytomatosis oncogene 0.233
Eif1ay eukaryotic translation initiation factor 1A, Y-linked 0.232
Cga glycoprotein hormones, alpha polypeptide 0.231
Brd3 bromodomain containing 3 0.230
Hoxd3 homeo box D3 0.227
S100a8 S100 calcium binding protein A8 0.226
Casp2 caspase 2 0.226
Hes1 hairy and enhancer of split 1 (Drosophila) 0.226
Lzts2 leucine zipper, putative tumor suppressor 2 0.225
Cand1 cullin-associated and neddylation-dissociated 1 0.225
Eif4h eukaryotic translation initiation factor 4H 0.223
Hnrpd heterogeneous nuclear ribonucleoprotein D 0.213
Hoxc4 homeo box C4 0.211
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.208
Msmb microseminoprotein, beta 0.208
Dcc deleted in colorectal carcinoma 0.206
Pou3f2 POU class 3 homeobox 2 0.203
Hdac2 histone deacetylase 2 0.203
Kcnt1 potassium channel, subfamily T, member 1 0.200
Jak1 Janus kinase 1 0.195
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.193
Arf6 ADP-ribosylation factor 6 0.192
Gse1 genetic suppressor element 1 0.190
Sf1 splicing factor 1 0.189
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.186
Plagl1 pleiomorphic adenoma gene-like 1 0.185
Csrnp1 cysteine-serine-rich nuclear protein 1 0.185
Klf6 Kruppel-like factor 6 0.185
Barhl1 BarH-like homeobox 1 0.183
St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.182
Hmgb1 high mobility group box 1 0.182
Baiap2 BAI1-associated protein 2 0.182
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.177
Dbp D site of albumin promoter (albumin D-box) binding protein 0.177
Eef2 eukaryotic translation elongation factor 2 0.176
Ptma prothymosin alpha 0.175
Slc12a1 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 0.171
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.170
Dctn4 dynactin 4 0.169
Zfp36l2 zinc finger protein 36, C3H type-like 2 0.168
Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 0.167
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.167
Usf2 upstream transcription factor 2, c-fos interacting 0.167
Irs3 insulin receptor substrate 3 0.167
Atp6v1g3 ATPase, H+ transporting, lysosomal V1 subunit G3 0.166
Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.166
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.165
Znf76 zinc finger protein 76 (expressed in testis) 0.162
Klf9 Kruppel-like factor 9 0.161
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.161
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.159
Ubtf upstream binding transcription factor, RNA polymerase I 0.157
Rnps1 ribonucleic acid binding protein S1 0.157
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.156
Dcaf15 DDB1 and CUL4 associated factor 15 0.156
Cd40lg CD40 ligand 0.156
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.155
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPD3 Rpd3p 0.999
GLC7 Glc7p 0.997
HHF1 Hhf1p 0.993
HHT1 Hht1p 0.993
SIR2 Sir2p 0.993
SPT16 Spt16p 0.991
SIN3 Sin3p 0.989
RAP1 Rap1p 0.983
RPN4 Rpn4p 0.972
RLF2 Rlf2p 0.956
YTA7 Yta7p 0.950
CYC8 Cyc8p 0.948
PHO23 Pho23p 0.943
CTI6 Cti6p 0.937
RCO1 Rco1p 0.935
ORC5 Orc5p 0.930
SIR4 Sir4p 0.926
ORC2 Orc2p 0.924
RXT2 Rxt2p 0.923
GLN3 Gln3p 0.920
SIN4 Sin4p 0.919
HDA1 Hda1p 0.917
GAL11 Gal11p 0.900
ISW2 Isw2p 0.897
CTF18 Ctf18p 0.895
HTA2 Hta2p 0.887
RIF1 Rif1p 0.883
ASF1 Asf1p 0.882
HOG1 Hog1p 0.878
CKA2 Cka2p 0.862
YAK1 Yak1p 0.862
SAS2 Sas2p 0.850
SIR3 Sir3p 0.840
HTB1 Htb1p 0.838
SWI4 Swi4p 0.832
RSC2 Rsc2p 0.808
HTZ1 Htz1p 0.807
AFT1 Aft1p 0.807
SNT1 Snt1p 0.800
BRE2 Bre2p 0.794
BRE1 Bre1p 0.791
SSN3 Ssn3p 0.768
SSD1 Ssd1p 0.763
SET1 Set1p 0.746
UME1 Ume1p 0.738
SDS3 Sds3p 0.732
SET2 Set2p 0.721
ADR1 Adr1p 0.716
MED2 Med2p 0.710
HTA1 Hta1p 0.698
SNF1 Snf1p 0.698
DED1 Ded1p 0.695
BDF1 Bdf1p 0.684
EAF3 Eaf3p 0.679
NMD2 Nmd2p 0.674
HTB2 Htb2p 0.672
PGD1 Pgd1p 0.667
RGR1 Rgr1p 0.666
HAT1 Hat1p 0.657
CSE2 Cse2p 0.654
HMO1 Hmo1p 0.652
SUM1 Sum1p 0.632
SCH9 Sch9p 0.628
DHH1 Dhh1p 0.628
LGE1 Lge1p 0.618
IFH1 Ifh1p 0.611
SAS4 Sas4p 0.610
ROX3 Rox3p 0.610
PAP2 Pap2p 0.584
SPT21 Spt21p 0.584
HHF2 Hhf2p 0.575
ORC1 Orc1p 0.572
NRG1 Nrg1p 0.571
HDA3 Hda3p 0.570
IZH4 Izh4p 0.567
SPP1 Spp1p 0.559
UBP8 Ubp8p 0.555
DCP2 Dcp2p 0.553
SRM1 Srm1p 0.548
PHO4 Pho4p 0.546
PHO85 Pho85p 0.537
NUT1 Nut1p 0.532
PRT1 Prt1p 0.531
VPS36 Vps36p 0.531
HST1 Hst1p 0.531
YRA1 Yra1p 0.528
HCM1 Hcm1p 0.527
HHO1 Hho1p 0.525
RLM1 Rlm1p 0.521
FUS3 Fus3p 0.520
FKH2 Fkh2p 0.518
CDC6 Cdc6p 0.517
RSC4 Rsc4p 0.511
SPT10 Spt10p 0.509
REG1 Reg1p 0.508
MSN2 Msn2p 0.505
SET3 Set3p 0.500
NTO1 Nto1p 0.495
SAS5 Sas5p 0.492
HAA1 Haa1p 0.491