The network for 'regulation of calcium mediated signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of calcium mediated signaling

Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.

Homo sapiens
Name Description Probability Func Analog Organism
LCK lymphocyte-specific protein tyrosine kinase 0.999
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.920
LAT linker for activation of T cells 0.739
CCR5 chemokine (C-C motif) receptor 5 0.726
VAV1 vav 1 guanine nucleotide exchange factor 0.719
CD247 CD247 molecule 0.596
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.588
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.510
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.385
CD3D CD3d molecule, delta (CD3-TCR complex) 0.271
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.257
CCL4 chemokine (C-C motif) ligand 4 0.254
CD28 CD28 molecule 0.232
FYN FYN oncogene related to SRC, FGR, YES 0.191
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.182
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.170
DPP4 dipeptidyl-peptidase 4 0.150
CCL8 chemokine (C-C motif) ligand 8 0.147
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.121
FYB FYN binding protein 0.118
CTNND1 catenin (cadherin-associated protein), delta 1 0.114
PSEN2 presenilin 2 (Alzheimer disease 4) 0.109
PLCG1 phospholipase C, gamma 1 0.106
CCL13 chemokine (C-C motif) ligand 13 0.103
SYK spleen tyrosine kinase 0.101
PTPRC protein tyrosine phosphatase, receptor type, C 0.100
ITK IL2-inducible T-cell kinase 0.095
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.090
CCL2 chemokine (C-C motif) ligand 2 0.088
CXCL9 chemokine (C-X-C motif) ligand 9 0.085
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.083
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.079
AXIN1 axin 1 0.078
CCR7 chemokine (C-C motif) receptor 7 0.074
DSG2 desmoglein 2 0.074
CCR1 chemokine (C-C motif) receptor 1 0.073
CD163 CD163 molecule 0.069
SH3BP2 SH3-domain binding protein 2 0.064
IGF2R insulin-like growth factor 2 receptor 0.061
ITGB1BP3 integrin beta 1 binding protein 3 0.060
CCL19 chemokine (C-C motif) ligand 19 0.058
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.055
PTPRJ protein tyrosine phosphatase, receptor type, J 0.053
PLK3 polo-like kinase 3 0.052
MATK megakaryocyte-associated tyrosine kinase 0.045
SLAMF8 SLAM family member 8 0.044
IDE insulin-degrading enzyme 0.041
CCL3 chemokine (C-C motif) ligand 3 0.039
JUP junction plakoglobin 0.038
C1QA complement component 1, q subcomponent, A chain 0.038
IL7R interleukin 7 receptor 0.037
CD2 CD2 molecule 0.035
CCL22 chemokine (C-C motif) ligand 22 0.034
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.031
FHL1 four and a half LIM domains 1 0.030
IL10 interleukin 10 0.030
IL6 interleukin 6 (interferon, beta 2) 0.029
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.029
IL2RB interleukin 2 receptor, beta 0.029
SASH3 SAM and SH3 domain containing 3 0.029
IL1B interleukin 1, beta 0.029
CCL7 chemokine (C-C motif) ligand 7 0.028
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.028
CXCL3 chemokine (C-X-C motif) ligand 3 0.027
AQP9 aquaporin 9 0.027
SH2D1A SH2 domain containing 1A 0.026
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.026
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.025
CXCL10 chemokine (C-X-C motif) ligand 10 0.025
DSP desmoplakin 0.024
PSEN1 presenilin 1 0.024
CSF1R colony stimulating factor 1 receptor 0.023
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.023
CXCL13 chemokine (C-X-C motif) ligand 13 0.023
CCL5 chemokine (C-C motif) ligand 5 0.023
FPR3 formyl peptide receptor 3 0.022
IL1RN interleukin 1 receptor antagonist 0.022
HCK hemopoietic cell kinase 0.021
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.021
IL8 interleukin 8 0.021
TREM1 triggering receptor expressed on myeloid cells 1 0.021
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.021
CXCL5 chemokine (C-X-C motif) ligand 5 0.020
RGS1 regulator of G-protein signaling 1 0.019
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.019
C3AR1 complement component 3a receptor 1 0.018
CYBB cytochrome b-245, beta polypeptide 0.018
CST7 cystatin F (leukocystatin) 0.018
HMG20A high mobility group 20A 0.018
DARC Duffy blood group, chemokine receptor 0.017
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.017
IL2RG interleukin 2 receptor, gamma 0.017
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.017
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.017
CCR4 chemokine (C-C motif) receptor 4 0.017
PLEK pleckstrin 0.017
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.017
ADORA3 adenosine A3 receptor 0.016
IFNG interferon, gamma 0.016
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
p2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.142
cdh4 cadherin 4, retinal 0.125
neurod neurogenic differentiation 0.089
inha inhibin, alpha 0.063
phox2b paired-like homeobox 2b 0.058
rspo1 R-spondin homolog (Xenopus laevis) 0.055
crx cone-rod homeobox 0.050
paqr8 progestin and adipoQ receptor family member VIII 0.045
scg3 secretogranin III 0.027
tbr1b T-box, brain, 1b 0.026
fshb follicle stimulating hormone, beta polypeptide 0.026
phox2a paired-like homeobox 2a 0.024
tsc22d3 TSC22 domain family, member 3 0.024
gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.024
trpm2 transient receptor potential cation channel, subfamily M, member 2 0.024
igf2b insulin-like growth factor 2b 0.023
nadl1.1 neural adhesion molecule L1.1 0.021
eomesb eomesodermin homolog b 0.020
zgc:172101 zgc:172101 0.019
zgc:112161 zgc:112161 0.019
hoxb4a homeo box B4a 0.018
usp9 ubiquitin specific peptidase 9 0.018
ahcyl2 S-adenosylhomocysteine hydrolase-like 2 0.018
prnprs1 prion protein, related sequence 1 0.018
lhb luteinizing hormone, beta polypeptide 0.018
gb:bm036580 gb:bm036580 0.017
dlx6a distal-less homeobox gene 6a 0.017
prox1 prospero-related homeobox gene 1 0.017
paqr7b progestin and adipoQ receptor family member VII, b 0.016
sdf4 stromal cell derived factor 4 0.016
neurod6a neurogenic differentiation 6a 0.016
bhlhe41 basic helix-loop-helix family, member e41 0.016
eng2b engrailed 2b 0.015
p2rx3b purinergic receptor P2X, ligand-gated ion channel, 3b 0.015
fes feline sarcoma oncogene 0.015
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.015
zgc:110306 zgc:110306 0.014
k23 k23 gene 0.014
inhbab inhibin, beta Ab 0.014
scn8aa sodium channel, voltage-gated, type VIII, alpha a 0.014
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.014
entpd3 ectonucleoside triphosphate diphosphohydrolase 3 0.014
tgfbr1a transforming growth factor, beta receptor I a 0.014
prkd1 protein kinase D1 0.013
prkcz protein kinase C, zeta 0.013
sb:cb540 sb:cb540 0.013
zgc:86635 zgc:86635 0.013
LOC559976 similar to glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.012
dab2 disabled homolog 2 (Drosophila) 0.012
fabp10b fatty acid binding protein 10b, liver basic 0.012
LOC557722 similar to transient receptor potential cation channel, subfamily M, member 5 0.012
atp6v0cb ATPase, H+ transporting, lysosomal, V0 subunit c, b 0.011
sept6 septin 6 0.011
stmn2a stathmin-like 2a 0.011
flrt1b fibronectin leucine rich transmembrane 1b 0.011
pou3f3b POU class 3 homeobox 3b 0.011
atp1a3a ATPase, Na+/K+ transporting, alpha 3a polypeptide 0.011
elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.011
ptprc protein tyrosine phosphatase, receptor type, C 0.011
dpysl4 dihydropyrimidinase-like 4 0.011
cplx2l complexin 2, like 0.011
suclg2 succinate-CoA ligase, GDP-forming, beta subunit 0.011
hlxb9la homeo box HB9 like a 0.011
cbfb core-binding factor, beta subunit 0.011
prkcd protein kinase C, delta 0.011
mcf2l MCF.2 cell line derived transforming sequence-like and mcf.2 cell line derived transforming sequence-like 0.011
pax6a paired box gene 6a 0.011
islr2 immunoglobulin superfamily containing leucine-rich repeat 2 0.011
zgc:171629 zgc:171629 0.010
pcdh18b protocadherin 18b 0.010
kiss1 KiSS-1 metastasis-suppressor 0.010
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.010
tpsn tapasin 0.010
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.010
mllt11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.010
si:dkey-177p2.3 si:dkey-177p2.3 0.010
prox1b prospero-related homeobox gene 1b 0.010
ca5 carbonic anhydrase V 0.010
stmn2b stathmin-like 2b 0.010
pcdh1g3 protocadherin 1 gamma 3 0.010
ndfip1 Nedd4 family interacting protein 1 0.010
calca calcitonin/calcitonin-related polypeptide, alpha 0.010
sb:eu652 sb:eu652 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.873
Neurod1 neurogenic differentiation 1 0.810
Cd8a CD8 antigen, alpha chain 0.796
Ptprc protein tyrosine phosphatase, receptor type, C 0.763
Cd7 CD7 antigen 0.705
Pax6 paired box gene 6 0.642
Cd4 CD4 antigen 0.634
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.534
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.439
Timp1 tissue inhibitor of metalloproteinase 1 0.396
Neurod4 neurogenic differentiation 4 0.381
Mecom MDS1 and EVI1 complex locus 0.330
Neurog2 neurogenin 2 0.329
Inpp5d inositol polyphosphate-5-phosphatase D 0.326
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.325
Cd3e CD3 antigen, epsilon polypeptide 0.321
Rag1 recombination activating gene 1 0.292
Cd247 CD247 antigen 0.247
Cd8b1 CD8 antigen, beta chain 1 0.243
Fasl Fas ligand (TNF superfamily, member 6) 0.229
Gnrh1 gonadotropin releasing hormone 1 0.228
Neurog3 neurogenin 3 0.227
Grb2 growth factor receptor bound protein 2 0.223
Batf basic leucine zipper transcription factor, ATF-like 0.222
Cd22 CD22 antigen 0.221
Lck lymphocyte protein tyrosine kinase 0.202
Bcar1 breast cancer anti-estrogen resistance 1 0.181
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.167
Cxcr3 chemokine (C-X-C motif) receptor 3 0.160
Cd6 CD6 antigen 0.152
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.146
Il2rb interleukin 2 receptor, beta chain 0.138
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.134
AF251705 cDNA sequence AF251705 0.129
Itk IL2-inducible T-cell kinase 0.122
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.122
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.118
Isl1 ISL1 transcription factor, LIM/homeodomain 0.117
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.115
Gpr132 G protein-coupled receptor 132 0.114
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.113
Cd28 CD28 antigen 0.110
Hcst hematopoietic cell signal transducer 0.110
Pdx1 pancreatic and duodenal homeobox 1 0.108
Cd19 CD19 antigen 0.102
Cd160 CD160 antigen 0.094
Sept1 septin 1 0.092
Ptf1a pancreas specific transcription factor, 1a 0.088
Tgfbr2 transforming growth factor, beta receptor II 0.087
C3ar1 complement component 3a receptor 1 0.087
Zap70 zeta-chain (TCR) associated protein kinase 0.085
L1cam L1 cell adhesion molecule 0.083
Foxa2 forkhead box A2 0.081
Il4 interleukin 4 0.081
Gzma granzyme A 0.080
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.079
Kiss1 KiSS-1 metastasis-suppressor 0.076
Nfam1 Nfat activating molecule with ITAM motif 1 0.074
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.068
Ptk2 PTK2 protein tyrosine kinase 2 0.066
Hic1 hypermethylated in cancer 1 0.065
Mb myoglobin 0.064
Tyrobp TYRO protein tyrosine kinase binding protein 0.063
Notch4 Notch gene homolog 4 (Drosophila) 0.063
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.062
Insm1 insulinoma-associated 1 0.058
Il27ra interleukin 27 receptor, alpha 0.058
Mefv Mediterranean fever 0.057
Cd96 CD96 antigen 0.057
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.057
Gata1 GATA binding protein 1 0.056
Il10ra interleukin 10 receptor, alpha 0.054
Ccr9 chemokine (C-C motif) receptor 9 0.053
Lair1 leukocyte-associated Ig-like receptor 1 0.052
Ncr1 natural cytotoxicity triggering receptor 1 0.051
Aplp2 amyloid beta (A4) precursor-like protein 2 0.050
Rgs14 regulator of G-protein signaling 14 0.050
Dok1 docking protein 1 0.050
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.049
Gp9 glycoprotein 9 (platelet) 0.048
Igk immunoglobulin kappa chain complex 0.047
Pou4f2 POU domain, class 4, transcription factor 2 0.047
Snai1 snail homolog 1 (Drosophila) 0.046
Nkg7 natural killer cell group 7 sequence 0.046
Rhoh ras homolog gene family, member H 0.046
Itgal integrin alpha L 0.046
Col4a3 collagen, type IV, alpha 3 0.045
Clec4d C-type lectin domain family 4, member d 0.044
Cd3g CD3 antigen, gamma polypeptide 0.044
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.044
Tbxas1 thromboxane A synthase 1, platelet 0.043
App amyloid beta (A4) precursor protein 0.043
Sla2 Src-like-adaptor 2 0.042
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.042
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.042
Fyn Fyn proto-oncogene 0.042
Ctsw cathepsin W 0.041
Lhx3 LIM homeobox protein 3 0.041
Csf1r colony stimulating factor 1 receptor 0.041
Cst7 cystatin F (leukocystatin) 0.040
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Rattus norvegicus
Name Description Probability Func Analog Organism
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.027
Pacs1 phosphofurin acidic cluster sorting protein 1 0.018
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.015
Itgb7 integrin, beta 7 0.015
Il2rg interleukin 2 receptor, gamma 0.015
Syn1 synapsin I 0.015
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) 0.014
Emcn endomucin 0.012
Utrn utrophin 0.011
Ccl4 chemokine (C-C motif) ligand 4 0.010
Ank2 ankyrin 2, neuronal 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
UBI4 Ubi4p 0.011