The network for 'demethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

demethylation

The process of removing one or more methyl groups from a molecule.

Homo sapiens
Name Description Probability Func Analog Organism
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.925
BCOR BCL6 corepressor 0.865
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.616
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.485
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.324
DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked 0.306
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.298
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.297
GADD45A growth arrest and DNA-damage-inducible, alpha 0.224
BRD4 bromodomain containing 4 0.214
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.211
ZFX zinc finger protein, X-linked 0.205
SSRP1 structure specific recognition protein 1 0.199
USP9Y ubiquitin specific peptidase 9, Y-linked 0.195
HDAC3 histone deacetylase 3 0.186
MAGEA2 melanoma antigen family A, 2 0.180
CCNL1 cyclin L1 0.174
NCOR1 nuclear receptor corepressor 1 0.169
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.157
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.154
RPS4Y1 ribosomal protein S4, Y-linked 1 0.151
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.148
HIST1H3B histone cluster 1, H3b 0.140
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.139
CHD4 chromodomain helicase DNA binding protein 4 0.138
RLF rearranged L-myc fusion 0.135
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.134
ZNF217 zinc finger protein 217 0.132
UBXN7 UBX domain protein 7 0.122
CYorf15A chromosome Y open reading frame 15A 0.121
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.112
PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 0.111
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 0.103
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.101
HDAC1 histone deacetylase 1 0.098
PHB2 prohibitin 2 0.093
C8A complement component 8, alpha polypeptide 0.089
ZNF512B zinc finger protein 512B 0.087
ZCCHC17 zinc finger, CCHC domain containing 17 0.087
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.087
YBX1 Y box binding protein 1 0.085
ZNF292 zinc finger protein 292 0.083
PGRMC1 progesterone receptor membrane component 1 0.074
F9 coagulation factor IX 0.073
MKRN1 makorin ring finger protein 1 0.068
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.066
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.064
NONO non-POU domain containing, octamer-binding 0.063
A1CF APOBEC1 complementation factor 0.062
KDM5D lysine (K)-specific demethylase 5D 0.061
RIOK3 RIO kinase 3 (yeast) 0.059
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.058
BCL6 B-cell CLL/lymphoma 6 0.057
MASP2 mannan-binding lectin serine peptidase 2 0.056
FBXO33 F-box protein 33 0.051
MTA1 metastasis associated 1 0.051
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 0.051
MED13L mediator complex subunit 13-like 0.051
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.049
PRMT6 protein arginine methyltransferase 6 0.049
HBP1 HMG-box transcription factor 1 0.048
ADH6 alcohol dehydrogenase 6 (class V) 0.047
RXRA retinoid X receptor, alpha 0.046
HIST1H4F histone cluster 1, H4f 0.042
UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked 0.042
ELL elongation factor RNA polymerase II 0.041
CHD8 chromodomain helicase DNA binding protein 8 0.041
HELZ helicase with zinc finger 0.041
BRD2 bromodomain containing 2 0.041
USP9X ubiquitin specific peptidase 9, X-linked 0.040
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 0.040
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.040
NCOA3 nuclear receptor coactivator 3 0.038
ZFY zinc finger protein, Y-linked 0.037
KLHL24 kelch-like 24 (Drosophila) 0.036
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0.035
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.034
OXA1L oxidase (cytochrome c) assembly 1-like 0.033
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.033
AHCY adenosylhomocysteinase 0.032
SNAI1 snail homolog 1 (Drosophila) 0.032
POLH polymerase (DNA directed), eta 0.032
CCNG2 cyclin G2 0.031
PPP4C protein phosphatase 4, catalytic subunit 0.030
WDR48 WD repeat domain 48 0.030
MEPCE methylphosphate capping enzyme 0.029
RCOR3 REST corepressor 3 0.029
EIF3D eukaryotic translation initiation factor 3, subunit D 0.029
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 0.028
ALDOB aldolase B, fructose-bisphosphate 0.028
TP53BP1 tumor protein p53 binding protein 1 0.028
PELI1 pellino homolog 1 (Drosophila) 0.028
SKIL SKI-like oncogene 0.028
LAMC3 laminin, gamma 3 0.027
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.027
SMAD7 SMAD family member 7 0.027
C6 complement component 6 0.027
JARID2 jumonji, AT rich interactive domain 2 0.027
ZCCHC6 zinc finger, CCHC domain containing 6 0.026
H3F3C H3 histone, family 3C 0.026
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cyp1a cytochrome P450, family 1, subfamily A 0.037
wu:fi04c06 wu:fi04c06 0.015
tm4sf4 transmembrane 4 L six family member 4 0.012
npepps aminopeptidase puromycin sensitive 0.012
dopey1 dopey family member 1 0.012
dedd1 death effector domain-containing 1 0.012
hnf4g hepatocyte nuclear factor 4, gamma 0.011
myef2 myelin expression factor 2 0.011
fabp10a fatty acid binding protein 10a, liver basic 0.010
abca3 ATP-binding cassette, sub-family A (ABC1), member 3 0.010
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.010
ankrd12 ankyrin repeat domain 12 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Aos1 CG12276 gene product from transcript CG12276-RA 0.027
CG11985 CG11985 gene product from transcript CG11985-RA 0.020
Ssb-c31a Single stranded-binding protein c31A 0.014
Rab11 Rab-protein 11 0.014
TfIIA-S Transcription-factor-IIA-S 0.011
geminin CG3183 gene product from transcript CG3183-RA 0.011
Ras85D Ras oncogene at 85D 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Rnf2 ring finger protein 2 0.958
Idi1 isopentenyl-diphosphate delta isomerase 0.626
Zfp292 zinc finger protein 292 0.550
Kdm1a lysine (K)-specific demethylase 1A 0.507
Sin3a transcriptional regulator, SIN3A (yeast) 0.433
Kdm2b lysine (K)-specific demethylase 2B 0.340
Csnk2a1 casein kinase 2, alpha 1 polypeptide 0.276
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.250
Ctbp1 C-terminal binding protein 1 0.245
Sqle squalene epoxidase 0.200
Trim28 tripartite motif-containing 28 0.196
Clk1 CDC-like kinase 1 0.161
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 0.154
Bcor BCL6 interacting corepressor 0.144
Ddx3y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked 0.139
Gm5806 predicted gene 5806 0.132
Men1 multiple endocrine neoplasia 1 0.120
Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 0.098
Sc4mol sterol-C4-methyl oxidase-like 0.096
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.091
Otc ornithine transcarbamylase 0.090
Cbx8 chromobox homolog 8 (Drosophila Pc class) 0.087
Cbx3 chromobox homolog 3 (Drosophila HP1 gamma) 0.078
Nup62 nucleoporin 62 0.069
Clk4 CDC like kinase 4 0.065
Arid4b AT rich interactive domain 4B (RBP1-like) 0.062
Rnps1 ribonucleic acid binding protein S1 0.061
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.052
Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked 0.049
Mbtd1 mbt domain containing 1 0.048
Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 0.044
Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 0.043
Nanog Nanog homeobox 0.040
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.040
Zfp654 zinc finger protein 654 0.038
Cdk2ap1 CDK2 (cyclin-dependent kinase 2)-associated protein 1 0.038
Trim24 tripartite motif-containing 24 0.037
Hdac1 histone deacetylase 1 0.034
A930001N09Rik RIKEN cDNA A930001N09 gene 0.031
Srm spermidine synthase 0.029
Cyp3a16 cytochrome P450, family 3, subfamily a, polypeptide 16 0.028
Lin28a lin-28 homolog A (C. elegans) 0.028
Ces2a carboxylesterase 2A 0.027
Snrpa small nuclear ribonucleoprotein polypeptide A 0.026
Ints3 integrator complex subunit 3 0.026
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.026
Ints5 integrator complex subunit 5 0.026
Uty ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome 0.025
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.025
Jarid2 jumonji, AT rich interactive domain 2 0.025
Morf4l1 mortality factor 4 like 1 0.025
Zmym2 zinc finger, MYM-type 2 0.025
Kdm4c lysine (K)-specific demethylase 4C 0.024
Sult1d1 sulfotransferase family 1D, member 1 0.024
Impdh2 inosine 5'-phosphate dehydrogenase 2 0.024
Pcgf2 polycomb group ring finger 2 0.024
Sult1b1 sulfotransferase family 1B, member 1 0.023
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.023
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.023
Tdg thymine DNA glycosylase 0.023
Ubap2 ubiquitin-associated protein 2 0.023
Klhl24 kelch-like 24 (Drosophila) 0.023
Xrn1 5'-3' exoribonuclease 1 0.022
F9 coagulation factor IX 0.022
Cyp3a41b cytochrome P450, family 3, subfamily a, polypeptide 41B 0.022
Eif4a2 eukaryotic translation initiation factor 4A2 0.022
Srsf4 serine/arginine-rich splicing factor 4 0.021
Arid1a AT rich interactive domain 1A (SWI-like) 0.021
March7 membrane-associated ring finger (C3HC4) 7 0.021
Csnk2a2 casein kinase 2, alpha prime polypeptide 0.021
Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) 0.021
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.020
Avl9 AVL9 homolog (S. cerevisiase) 0.019
Ino80e INO80 complex subunit E 0.019
Lss lanosterol synthase 0.019
Mga MAX gene associated 0.019
Zfc3h1 zinc finger, C3H1-type containing 0.019
Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 0.019
Phc1 polyhomeotic-like 1 (Drosophila) 0.019
Ccnt2 cyclin T2 0.019
Cps1 carbamoyl-phosphate synthetase 1 0.018
Tex10 testis expressed gene 10 0.018
Fbl fibrillarin 0.018
Ces1g carboxylesterase 1G 0.018
Pom121 nuclear pore membrane protein 121 0.018
Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 0.018
Ldlr low density lipoprotein receptor 0.018
U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 0.018
Rlf rearranged L-myc fusion sequence 0.018
Upf2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.018
Prdm1 PR domain containing 1, with ZNF domain 0.018
Stard4 StAR-related lipid transfer (START) domain containing 4 0.018
Kti12 KTI12 homolog, chromatin associated (S. cerevisiae) 0.018
Fiz1 Flt3 interacting zinc finger protein 1 0.018
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.018
Rbm14 RNA binding motif protein 14 0.017
Fbxo38 F-box protein 38 0.017
Bap1 Brca1 associated protein 1 0.017
Mogs mannosyl-oligosaccharide glucosidase 0.017
Cul9 cullin 9 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
Sc4mol sterol-C4-methyl oxidase-like 0.212
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.181
Sqle squalene epoxidase 0.152
Idi1 isopentenyl-diphosphate delta isomerase 1 0.146
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.092
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.061
Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.060
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.045
Acat3 acetyl-Coenzyme A acetyltransferase 3 0.042
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.038
Insig1 insulin induced gene 1 0.035
Fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 0.031
Dhcr7 7-dehydrocholesterol reductase 0.030
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.022
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.017
A1i3 alpha-1-inhibitor III 0.017
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.016
Otc ornithine carbamoyltransferase 0.016
Sc5dl sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like 0.016
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.015
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.014
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.013
LOC293989 cytochrome P450-like 0.013
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.013
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.012
Arid4a AT rich interactive domain 4A (Rbp1 like) 0.012
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.011
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.011
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.011
Olr1701 olfactory receptor 1701 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism