The network for 'gene silencing by mirna' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

gene silencing by mirna

Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.

Homo sapiens
Name Description Probability Func Analog Organism
DICER1 dicer 1, ribonuclease type III 1.000
EIF2C2 eukaryotic translation initiation factor 2C, 2 1.000
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.000
TNRC6A trinucleotide repeat containing 6A 1.000
EIF2C1 eukaryotic translation initiation factor 2C, 1 1.000
TNRC6B trinucleotide repeat containing 6B 0.994
EIF2C3 eukaryotic translation initiation factor 2C, 3 0.978
EIF2C4 eukaryotic translation initiation factor 2C, 4 0.920
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.891
IPO8 importin 8 0.774
TNRC6C trinucleotide repeat containing 6C 0.646
DGCR8 DiGeorge syndrome critical region gene 8 0.620
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.595
PABPC1 poly(A) binding protein, cytoplasmic 1 0.414
PAX3 paired box 3 0.367
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.357
LIN28B lin-28 homolog B (C. elegans) 0.353
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.343
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.343
SF1 splicing factor 1 0.304
STAT1 signal transducer and activator of transcription 1, 91kDa 0.299
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) 0.247
KLF6 Kruppel-like factor 6 0.242
HIPK3 homeodomain interacting protein kinase 3 0.202
FOXD3 forkhead box D3 0.199
DROSHA drosha, ribonuclease type III 0.187
C17orf85 chromosome 17 open reading frame 85 0.177
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.169
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.163
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.157
ACTN1 actinin, alpha 1 0.146
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.126
TRIM71 tripartite motif containing 71 0.123
IER2 immediate early response 2 0.110
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.109
POGZ pogo transposable element with ZNF domain 0.107
PAN3 PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 0.099
PARP9 poly (ADP-ribose) polymerase family, member 9 0.091
TRRAP transformation/transcription domain-associated protein 0.084
HCFC1 host cell factor C1 (VP16-accessory protein) 0.080
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.077
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.076
FUS fused in sarcoma 0.075
YY1 YY1 transcription factor 0.075
C20orf20 chromosome 20 open reading frame 20 0.074
SP1 Sp1 transcription factor 0.074
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.073
PARP12 poly (ADP-ribose) polymerase family, member 12 0.073
TRIM25 tripartite motif containing 25 0.072
HTT huntingtin 0.069
RUVBL1 RuvB-like 1 (E. coli) 0.068
DTX3L deltex 3-like (Drosophila) 0.062
FTSJD2 FtsJ methyltransferase domain containing 2 0.061
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.059
CYLD cylindromatosis (turban tumor syndrome) 0.058
DMAP1 DNA methyltransferase 1 associated protein 1 0.056
JUND jun D proto-oncogene 0.055
DAZL deleted in azoospermia-like 0.055
FOS FBJ murine osteosarcoma viral oncogene homolog 0.053
TARDBP TAR DNA binding protein 0.051
MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse) 0.051
VASP vasodilator-stimulated phosphoprotein 0.050
EGR1 early growth response 1 0.049
JUNB jun B proto-oncogene 0.048
ESR1 estrogen receptor 1 0.048
SOX2 SRY (sex determining region Y)-box 2 0.048
PARN poly(A)-specific ribonuclease (deadenylation nuclease) 0.046
HOXA9 homeobox A9 0.045
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.044
SOX10 SRY (sex determining region Y)-box 10 0.039
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.036
LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.034
SAMD9 sterile alpha motif domain containing 9 0.034
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.033
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.033
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 0.031
IFI44 interferon-induced protein 44 0.031
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.031
FLNB filamin B, beta 0.030
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 0.029
PARP14 poly (ADP-ribose) polymerase family, member 14 0.029
SCRIB scribbled homolog (Drosophila) 0.028
STAT2 signal transducer and activator of transcription 2, 113kDa 0.028
SNAI1 snail homolog 1 (Drosophila) 0.027
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.027
INO80 INO80 homolog (S. cerevisiae) 0.026
MOCS3 molybdenum cofactor synthesis 3 0.025
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.025
ISG15 ISG15 ubiquitin-like modifier 0.025
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.024
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.024
EPSTI1 epithelial stromal interaction 1 (breast) 0.024
SAMD9L sterile alpha motif domain containing 9-like 0.023
SAFB2 scaffold attachment factor B2 0.022
NCOA3 nuclear receptor coactivator 3 0.022
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.021
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.021
DUSP1 dual specificity phosphatase 1 0.021
MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.021
SRRM2 serine/arginine repetitive matrix 2 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
rsp-8 Protein RSP-8 0.012
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Danio rerio
Name Description Probability Func Analog Organism
aplnra apelin receptor a 0.304
LOC570775 protein argonaute-1-like 0.204
wu:fk48d07 wu:fk48d07 0.085
hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.055
dzip1 DAZ interacting protein 1 0.048
bon bonnie and clyde 0.036
ptges prostaglandin E synthase 0.036
ints6 integrator complex subunit 6 0.035
eif2c4 eukaryotic translation initiation factor 2C, 4 0.035
sh3bp5 SH3-domain binding protein 5 (BTK-associated) 0.033
hnrnpu heterogeneous nuclear ribonucleoprotein U 0.033
zgc:193933 zgc:193933 0.032
acvr1b activin A receptor, type IB 0.031
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.026
satb2 SATB homeobox 2 0.025
ubr5 ubiquitin protein ligase E3 component n-recognin 5 0.025
srsf2 serine/arginine-rich splicing factor 2 0.025
ewsr1b Ewing sarcoma breakpoint region 1b 0.024
cdk7 cyclin-dependent kinase 7 0.023
hnrnpm heterogeneous nuclear ribonucleoprotein M 0.022
hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 0.020
slit1b slit homolog 1b (Drosophila) 0.019
raver1 ribonucleoprotein, PTB-binding 1 0.019
opa1 optic atrophy 1 (human) 0.018
ewsr1a Ewing sarcoma breakpoint region 1a 0.018
her15.2 hairy and enhancer of split-related 15.2 0.018
lppr3b lipid phosphate phosphatase-related protein type 3b 0.017
ssr4 signal sequence receptor, delta 0.017
egfl7 EGF-like-domain, multiple 7 0.016
nadl1.1 neural adhesion molecule L1.1 0.016
mapk3 mitogen-activated protein kinase 3 0.016
extl3 exostoses (multiple)-like 3 0.016
si:ch211-114c12.2 si:ch211-114c12.2 0.015
ctr9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.015
fkbp10 FK506 binding protein 10 0.015
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.015
seta SET translocation (myeloid leukemia-associated) A 0.015
rbmx RNA binding motif protein, X-linked 0.015
ppp1cbl protein phosphatase 1, catalytic subunit, beta isoform, like 0.014
srsf11 serine/arginine-rich splicing factor 11 0.014
LOC555504 novel protocadherin protein 0.014
rpn2 ribophorin II 0.014
rest RE1-silencing transcription factor 0.013
cdk8 cyclin-dependent kinase 8 0.013
pou5f1 POU domain, class 5, transcription factor 1 0.013
wu:fa97a01 wu:fa97a01 0.013
LOC555163 myelin protein zero-like protein 1-like 0.013
mtmr8 myotubularin related protein 8 0.013
mapk1 mitogen-activated protein kinase 1 0.012
hnrnpl2 heterogeneous nuclear ribonucleoprotein L2 0.012
ints2 integrator complex subunit 2 0.012
ef1a elongation factor 1-alpha 0.012
figf c-fos induced growth factor 0.012
zgc:153290 zgc:153290 0.012
xrn2 5'-3' exoribonuclease 2 0.011
si:ch211-59d15.5 si:ch211-59d15.5 0.011
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.011
rbm22 RNA binding motif protein 22 0.011
celf1 cugbp, Elav-like family member 1 0.011
ccnh cyclin H 0.011
acvr1l activin A receptor, type I like 0.011
gro1 groucho 1 0.011
k23 k23 gene 0.011
prkd1 protein kinase D1 0.011
ppib peptidylprolyl isomerase B (cyclophilin B) 0.011
smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.011
sfrs3b splicing factor, arginine/serine-rich 3b 0.010
LOC100535786 transcription elongation regulator 1-like 0.010
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.010
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.010
bad BCL2-antagonist of cell death 0.010
ubr3 ubiquitin protein ligase E3 component n-recognin 3 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
pasha partner of drosha 0.621
lid little imaginal discs 0.575
Vps16A Vacuolar protein sorting 16A 0.492
Ge-1 CG6181 gene product from transcript CG6181-RA 0.457
AGO1 Argonaute-1 0.440
sxc super sex combs 0.399
drosha CG8730 gene product from transcript CG8730-RA 0.368
Nipped-A CG33554 gene product from transcript CG33554-RE 0.311
CG9772 CG9772 gene product from transcript CG9772-RB 0.269
tho2 CG31671 gene product from transcript CG31671-RA 0.250
sw short wing 0.226
Rm62 CG10279 gene product from transcript CG10279-RD 0.202
lig lingerer 0.176
Dlic Dynein light intermediate chain 0.156
Tao-1 CG14217 gene product from transcript CG14217-RF 0.149
loqs loquacious 0.147
Aos1 CG12276 gene product from transcript CG12276-RA 0.147
Usp7 ubiquitin-specific protease 7 0.125
fl(2)d female lethal d 0.119
Dcr-1 Dicer-1 0.115
Patr-1 Protein associated with topo II related - 1 0.109
drd drop dead 0.100
egg eggless 0.088
Nipped-B CG17704 gene product from transcript CG17704-RI 0.087
CG8443 CG8443 gene product from transcript CG8443-RA 0.082
brm brahma 0.080
Hel25E Helicase at 25E 0.079
Smox Smad on X 0.071
MAN1 CG3167 gene product from transcript CG3167-RA 0.069
Sep2 Septin-2 0.067
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.065
Ube3a Ubiquitin protein ligase E3A 0.063
vfl vielfaltig 0.061
Snr1 Snf5-related 1 0.060
CG34415 CG34415 gene product from transcript CG34415-RC 0.060
gw gawky 0.059
Parg Poly(ADP-ribose) glycohydrolase 0.055
Cbp80 cap binding protein 80 0.053
Fs Follistatin 0.051
Aac11 CG6582 gene product from transcript CG6582-RA 0.048
king-tubby king tubby 0.047
e(y)3 enhancer of yellow 3 0.047
CTCF CG8591 gene product from transcript CG8591-RA 0.045
rin rasputin 0.045
l(1)G0289 lethal (1) G0289 0.045
CtBP C-terminal Binding Protein 0.043
moi modigliani 0.043
Atx2 Ataxin-2 0.042
px plexus 0.042
wnd wallenda 0.041
RYBP Ring and YY1 Binding Protein 0.039
trc tricornered 0.038
Rat1 CG10354 gene product from transcript CG10354-RA 0.038
Hrb98DE Heterogeneous nuclear ribonucleoprotein at 98DE 0.037
koi klaroid 0.037
Ars2 CG7843 gene product from transcript CG7843-RA 0.036
krz kurtz 0.033
dlp dally-like 0.033
Hr4 CG16902 gene product from transcript CG16902-RC 0.032
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.031
mub mushroom-body expressed 0.030
Lk6 CG17342 gene product from transcript CG17342-RA 0.030
CG4747 CG4747 gene product from transcript CG4747-RB 0.030
zpg zero population growth 0.029
Ptp61F Protein tyrosine phosphatase 61F 0.029
kirre kin of irre 0.028
east enhanced adult sensory threshold 0.028
U2A CG1406 gene product from transcript CG1406-RA 0.027
Vps26 Vacuolar protein sorting 26 0.027
Trn Transportin 0.027
lark CG8597 gene product from transcript CG8597-RD 0.027
CG34350 CG34350 gene product from transcript CG34350-RA 0.026
CG3773 CG3773 gene product from transcript CG3773-RA 0.025
Tango6 Transport and Golgi organization 6 0.025
ash1 absent, small, or homeotic discs 1 0.025
fax failed axon connections 0.025
spas spastin 0.025
atms antimeros 0.024
nocte no circadian temperature entrainment 0.024
path pathetic 0.023
CG10107 CG10107 gene product from transcript CG10107-RA 0.023
da daughterless 0.023
TER94 CG2331 gene product from transcript CG2331-RA 0.022
CG15440 CG15440 gene product from transcript CG15440-RA 0.022
CG42260 CG42260 gene product from transcript CG42260-RB 0.022
alc alicorn 0.021
CG9821 CG9821 gene product from transcript CG9821-RB 0.021
Pcaf CG4107 gene product from transcript CG4107-RA 0.021
CG10289 CG10289 gene product from transcript CG10289-RA 0.020
Eip75B Ecdysone-induced protein 75B 0.020
Coprox Coproporphyrinogen oxidase 0.020
Lam Lamin 0.019
Mlp84B Muscle LIM protein at 84B 0.019
Ulp1 CG12359 gene product from transcript CG12359-RA 0.019
Hr51 Hormone receptor 51 0.019
lap like-AP180 0.019
tll tailless 0.018
CG2875 CG2875 gene product from transcript CG2875-RB 0.018
Sry-beta Serendipity beta 0.018
Nf-YA Nuclear factor Y-box A 0.018
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Mus musculus
Name Description Probability Func Analog Organism
Eif2c2 eukaryotic translation initiation factor 2C, 2 1.000
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.998
Brd4 bromodomain containing 4 0.986
Trrap transformation/transcription domain-associated protein 0.983
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.979
Tnrc6c trinucleotide repeat containing 6C 0.976
Tnrc6b trinucleotide repeat containing 6b 0.968
Bptf bromodomain PHD finger transcription factor 0.963
Eif2c1 eukaryotic translation initiation factor 2C, 1 0.961
Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.957
Mll3 myeloid/lymphoid or mixed-lineage leukemia 3 0.946
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.944
Nanog Nanog homeobox 0.935
Akap9 A kinase (PRKA) anchor protein (yotiao) 9 0.899
Trim32 tripartite motif-containing 32 0.827
Junb Jun-B oncogene 0.787
Tcfcp2l1 transcription factor CP2-like 1 0.776
Safb scaffold attachment factor B 0.686
Trim25 tripartite motif-containing 25 0.671
Smad4 MAD homolog 4 (Drosophila) 0.648
Fos FBJ osteosarcoma oncogene 0.620
Chd4 chromodomain helicase DNA binding protein 4 0.612
Hsf2 heat shock factor 2 0.610
Phf21a PHD finger protein 21A 0.577
Lin28b lin-28 homolog B (C. elegans) 0.536
Btg2 B-cell translocation gene 2, anti-proliferative 0.472
Dusp1 dual specificity phosphatase 1 0.414
Ash1l ash1 (absent, small, or homeotic)-like (Drosophila) 0.382
Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.375
Uba2 ubiquitin-like modifier activating enzyme 2 0.373
Dmap1 DNA methyltransferase 1-associated protein 1 0.360
Ehmt1 euchromatic histone methyltransferase 1 0.360
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.347
Lin28a lin-28 homolog A (C. elegans) 0.347
Arid1a AT rich interactive domain 1A (SWI-like) 0.339
Sh3gl2 SH3-domain GRB2-like 2 0.334
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.316
Bach1 BTB and CNC homology 1 0.311
Dhx30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.310
Cul7 cullin 7 0.299
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.288
Mcl1 myeloid cell leukemia sequence 1 0.281
Nisch nischarin 0.276
Trim71 tripartite motif-containing 71 0.263
Stat2 signal transducer and activator of transcription 2 0.256
Tnrc6a trinucleotide repeat containing 6a 0.234
Btg1 B-cell translocation gene 1, anti-proliferative 0.209
Trim21 tripartite motif-containing 21 0.209
Dag1 dystroglycan 1 0.209
Atr ataxia telangiectasia and Rad3 related 0.201
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.181
Safb2 scaffold attachment factor B2 0.178
Zbtb20 zinc finger and BTB domain containing 20 0.177
Drosha drosha, ribonuclease type III 0.175
BC006779 cDNA sequence BC006779 0.167
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.163
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.162
Pabpc1 poly(A) binding protein, cytoplasmic 1 0.160
Pcbp2 poly(rC) binding protein 2 0.157
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.151
Pum1 pumilio 1 (Drosophila) 0.149
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.149
Wdr77 WD repeat domain 77 0.147
Ptma prothymosin alpha 0.146
Unc93b1 unc-93 homolog B1 (C. elegans) 0.145
Rc3h1 RING CCCH (C3H) domains 1 0.144
Wnk1 WNK lysine deficient protein kinase 1 0.141
Gatad2b GATA zinc finger domain containing 2B 0.137
Tgfbr2 transforming growth factor, beta receptor II 0.136
Rtp4 receptor transporter protein 4 0.130
Csrnp1 cysteine-serine-rich nuclear protein 1 0.130
Fam193b family with sequence similarity 193, member B 0.129
Egr1 early growth response 1 0.128
Mx2 myxovirus (influenza virus) resistance 2 0.123
Npc1 Niemann Pick type C1 0.120
Srsf9 serine/arginine-rich splicing factor 9 0.120
Ier2 immediate early response 2 0.119
Rxra retinoid X receptor alpha 0.118
Htt huntingtin 0.115
Plxna1 plexin A1 0.112
Samd9l sterile alpha motif domain containing 9-like 0.112
Gon4l gon-4-like (C.elegans) 0.111
Mbtd1 mbt domain containing 1 0.108
Mov10 Moloney leukemia virus 10 0.108
Mcm3ap minichromosome maintenance deficient 3 (S. cerevisiae) associated protein 0.106
Nf1 neurofibromatosis 1 0.104
Gigyf1 GRB10 interacting GYF protein 1 0.101
Jun Jun oncogene 0.098
Dync1i1 dynein cytoplasmic 1 intermediate chain 1 0.098
Cpsf1 cleavage and polyadenylation specific factor 1 0.096
Ubn2 ubinuclein 2 0.096
Irf9 interferon regulatory factor 9 0.094
Myc myelocytomatosis oncogene 0.094
Plekha5 pleckstrin homology domain containing, family A member 5 0.089
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.088
Crebbp CREB binding protein 0.085
Parp12 poly (ADP-ribose) polymerase family, member 12 0.085
Stat3 signal transducer and activator of transcription 3 0.080
Nfyc nuclear transcription factor-Y gamma 0.080
Zfp462 zinc finger protein 462 0.080
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gng10 guanine nucleotide binding protein (G protein), gamma 10 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism