The network for 'positive regulation of transmembrane transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of transmembrane transport

Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.

Homo sapiens
Name Description Probability Func Analog Organism
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.998
GSTM1 glutathione S-transferase mu 1 0.998
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.975
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.957
S100B S100 calcium binding protein B 0.922
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.893
KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1 0.832
GSTM2 glutathione S-transferase mu 2 (muscle) 0.798
KCNE1 potassium voltage-gated channel, Isk-related family, member 1 0.774
CCR5 chemokine (C-C motif) receptor 5 0.732
GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 0.630
TBX5 T-box 5 0.594
KIAA1683 KIAA1683 0.526
CCL4 chemokine (C-C motif) ligand 4 0.500
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.401
NRP1 neuropilin 1 0.320
CCL2 chemokine (C-C motif) ligand 2 0.315
PDZK1 PDZ domain containing 1 0.291
CRHR1 corticotropin releasing hormone receptor 1 0.291
S100A4 S100 calcium binding protein A4 0.281
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.278
GSTM4 glutathione S-transferase mu 4 0.276
ADORA2A adenosine A2a receptor 0.264
CXCL9 chemokine (C-X-C motif) ligand 9 0.252
KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5 0.211
PLAU plasminogen activator, urokinase 0.189
CANX calnexin 0.189
CCL5 chemokine (C-C motif) ligand 5 0.189
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.185
KLHL3 kelch-like 3 (Drosophila) 0.184
MPDZ multiple PDZ domain protein 0.163
GOPC golgi-associated PDZ and coiled-coil motif containing 0.161
CALCOCO2 calcium binding and coiled-coil domain 2 0.147
PDLIM1 PDZ and LIM domain 1 0.146
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.139
TBC1D10A TBC1 domain family, member 10A 0.139
SSTR2 somatostatin receptor 2 0.125
TGIF1 TGFB-induced factor homeobox 1 0.124
DPP4 dipeptidyl-peptidase 4 0.123
CCL13 chemokine (C-C motif) ligand 13 0.123
VAC14 Vac14 homolog (S. cerevisiae) 0.120
DTNA dystrobrevin, alpha 0.116
S100A6 S100 calcium binding protein A6 0.094
CXCL10 chemokine (C-X-C motif) ligand 10 0.093
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.092
SOD1 superoxide dismutase 1, soluble 0.090
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.087
SSTR3 somatostatin receptor 3 0.086
CA12 carbonic anhydrase XII 0.082
ADAM11 ADAM metallopeptidase domain 11 0.079
CCL8 chemokine (C-C motif) ligand 8 0.078
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.078
WNK1 WNK lysine deficient protein kinase 1 0.075
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.074
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.070
CCL3 chemokine (C-C motif) ligand 3 0.067
ORAI1 ORAI calcium release-activated calcium modulator 1 0.066
PTEN phosphatase and tensin homolog 0.065
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.064
CCL22 chemokine (C-C motif) ligand 22 0.064
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.063
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.063
EMP3 epithelial membrane protein 3 0.063
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.063
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.062
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.062
CXCL11 chemokine (C-X-C motif) ligand 11 0.061
MYOZ1 myozenin 1 0.059
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.059
MICA MHC class I polypeptide-related sequence A 0.059
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.059
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.058
SLC9A3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.058
TSC22D4 TSC22 domain family, member 4 0.055
KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.053
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.051
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.051
EZR ezrin 0.051
SDC2 syndecan 2 0.051
OXSR1 oxidative-stress responsive 1 0.050
CLCN3 chloride channel 3 0.050
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.049
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.049
CCKBR cholecystokinin B receptor 0.049
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.046
TMSB10 thymosin beta 10 0.046
IDE insulin-degrading enzyme 0.046
IL6 interleukin 6 (interferon, beta 2) 0.043
CCL19 chemokine (C-C motif) ligand 19 0.042
SYNM synemin, intermediate filament protein 0.042
KIF1A kinesin family member 1A 0.042
SLC9A1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.042
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.041
TRIM29 tripartite motif containing 29 0.040
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.040
HRH3 histamine receptor H3 0.039
CXCL13 chemokine (C-X-C motif) ligand 13 0.039
IFNG interferon, gamma 0.039
MMP23B matrix metallopeptidase 23B 0.039
PRKCG protein kinase C, gamma 0.039
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.609
Vegfa vascular endothelial growth factor A 0.465
Lin7c lin-7 homolog C (C. elegans) 0.280
Kdr kinase insert domain protein receptor 0.263
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.248
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.227
Ikbkg inhibitor of kappaB kinase gamma 0.209
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.189
Ednrb endothelin receptor type B 0.186
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.170
Casq2 calsequestrin 2 0.162
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.153
Slc4a4 solute carrier family 4 (anion exchanger), member 4 0.145
Mybpc3 myosin binding protein C, cardiac 0.129
Ttn titin 0.111
Flt1 FMS-like tyrosine kinase 1 0.110
Emx1 empty spiracles homolog 1 (Drosophila) 0.108
Pthlh parathyroid hormone-like peptide 0.107
Tecta tectorin alpha 0.099
Pygm muscle glycogen phosphorylase 0.097
Hand1 heart and neural crest derivatives expressed transcript 1 0.096
Pten phosphatase and tensin homolog 0.087
Kcnk3 potassium channel, subfamily K, member 3 0.084
Plcg1 phospholipase C, gamma 1 0.084
Sox9 SRY-box containing gene 9 0.080
Fgfr3 fibroblast growth factor receptor 3 0.078
Tcf21 transcription factor 21 0.075
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.072
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.069
Eya1 eyes absent 1 homolog (Drosophila) 0.065
Runx2 runt related transcription factor 2 0.064
Cckbr cholecystokinin B receptor 0.064
Myo6 myosin VI 0.063
Dlg4 discs, large homolog 4 (Drosophila) 0.062
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.062
Fgfr2 fibroblast growth factor receptor 2 0.061
Ptprb protein tyrosine phosphatase, receptor type, B 0.059
Zeb1 zinc finger E-box binding homeobox 1 0.057
Dag1 dystroglycan 1 0.056
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.054
Wwox WW domain-containing oxidoreductase 0.053
Kitl kit ligand 0.053
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.053
Ctnnb1 catenin (cadherin associated protein), beta 1 0.052
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.050
Gli2 GLI-Kruppel family member GLI2 0.050
Stim1 stromal interaction molecule 1 0.049
Sufu suppressor of fused homolog (Drosophila) 0.048
Hif3a hypoxia inducible factor 3, alpha subunit 0.048
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.048
Stim2 stromal interaction molecule 2 0.046
Hand2 heart and neural crest derivatives expressed transcript 2 0.046
Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 0.046
Fgf8 fibroblast growth factor 8 0.045
Apc adenomatosis polyposis coli 0.045
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.045
Drd2 dopamine receptor D2 0.045
Traf3ip2 TRAF3 interacting protein 2 0.044
Srpk3 serine/arginine-rich protein specific kinase 3 0.044
Itpr1 inositol 1,4,5-trisphosphate receptor 1 0.043
Ptch1 patched homolog 1 0.042
Atoh7 atonal homolog 7 (Drosophila) 0.042
Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 0.042
Foxc2 forkhead box C2 0.041
Bmp7 bone morphogenetic protein 7 0.041
Espn espin 0.041
Scn1a sodium channel, voltage-gated, type I, alpha 0.041
Inha inhibin alpha 0.041
Adrb3 adrenergic receptor, beta 3 0.040
St14 suppression of tumorigenicity 14 (colon carcinoma) 0.040
Cyld cylindromatosis (turban tumor syndrome) 0.039
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.039
Fgf22 fibroblast growth factor 22 0.038
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.038
Car7 carbonic anhydrase 7 0.038
Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 0.038
Frmd5 FERM domain containing 5 0.038
Pax2 paired box gene 2 0.038
Fgf23 fibroblast growth factor 23 0.037
Dtna dystrobrevin alpha 0.037
Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 0.037
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.037
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.036
Hoxd3 homeobox D3 0.036
Plp1 proteolipid protein (myelin) 1 0.035
Sstr4 somatostatin receptor 4 0.035
Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 0.035
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.034
Grm1 glutamate receptor, metabotropic 1 0.034
Tcf15 transcription factor 15 0.034
Flt4 FMS-like tyrosine kinase 4 0.034
Pou3f4 POU domain, class 3, transcription factor 4 0.034
Des desmin 0.034
Epor erythropoietin receptor 0.033
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.033
Chuk conserved helix-loop-helix ubiquitous kinase 0.032
Meox2 mesenchyme homeobox 2 0.032
Acvrl1 activin A receptor, type II-like 1 0.032
Ift88 intraflagellar transport 88 homolog (Chlamydomonas) 0.032
Fktn fukutin 0.032
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Rattus norvegicus
Name Description Probability Func Analog Organism
Anxa2 annexin A2 0.387
S100a6 S100 calcium binding protein A6 0.304
S100a9 S100 calcium binding protein A9 0.255
S100a10 S100 calcium binding protein A10 0.207
S100a8 S100 calcium binding protein A8 0.196
Anxa1 annexin A1 0.160
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.157
Fgf14 fibroblast growth factor 14 0.127
Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.090
Dcc deleted in colorectal carcinoma 0.090
Plp2 proteolipid protein 2 (colonic epithelium-enriched) 0.085
Phkg1 phosphorylase kinase, gamma 1 0.074
Ctrc chymotrypsin C (caldecrin) 0.065
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.063
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.058
S100a4 S100 calcium-binding protein A4 0.051
Sox17 SRY (sex determining region Y)-box 17 0.050
Kcna6 potassium voltage gated channel, shaker related subfamily, member 6 0.047
Lgals3 lectin, galactoside-binding, soluble, 3 0.047
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.046
Fgfr2 fibroblast growth factor receptor 2 0.045
Pdyn prodynorphin 0.044
Rims1 regulating synaptic membrane exocytosis 1 0.043
Timp1 TIMP metallopeptidase inhibitor 1 0.042
Inha inhibin alpha 0.041
Rph3a rabphilin 3A 0.041
Slc6a17 solute carrier family 6 (neurotransmitter transporter), member 17 0.041
Mdh1 malate dehydrogenase 1, NAD (soluble) 0.039
Tspo translocator protein 0.039
Nfasc neurofascin 0.035
Klk1b3 kallikrein 1-related peptidase b3 0.035
Csrnp2 cysteine-serine-rich nuclear protein 2 0.035
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.032
Pdzk1ip1 PDZK1 interacting protein 1 0.031
Crhr1 corticotropin releasing hormone receptor 1 0.030
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.030
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.029
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.029
Nptxr neuronal pentraxin receptor 0.028
Arpc1b actin related protein 2/3 complex, subunit 1B 0.028
Anxa5 annexin A5 0.028
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.028
S100a11 S100 calcium binding protein A11 (calizzarin) 0.027
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.026
Pax6 paired box 6 0.025
Kif12 kinesin family member 12 0.025
Sftpd surfactant protein D 0.025
Kalrn kalirin, RhoGEF kinase 0.025
Fabp5 fatty acid binding protein 5, epidermal 0.025
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.024
Cd79b Cd79b molecule, immunoglobulin-associated beta 0.024
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.023
Pnliprp2 pancreatic lipase-related protein 2 0.023
Spata9 spermatogenesis associated 9 0.022
Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.022
Nos3 nitric oxide synthase 3, endothelial cell 0.022
LOC100363469 ribosomal protein S24-like 0.021
Prr13 proline rich 13 0.021
Nrxn2 neurexin 2 0.021
Crip cysteine-rich intestinal protein 0.021
Mc5r melanocortin 5 receptor 0.021
St18 suppression of tumorigenicity 18 0.021
Casq2 calsequestrin 2 (cardiac muscle) 0.021
Cav3 caveolin 3 0.021
Adra1a adrenergic, alpha-1A-, receptor 0.020
Edn2 endothelin 2 0.020
Grk4 G protein-coupled receptor kinase 4 0.020
Gucy2e guanylate cyclase 2E 0.020
Prl8a2 prolactin family 8, subfamily a, member 2 0.020
Nxph3 neurexophilin 3 0.020
Cstb cystatin B (stefin B) 0.019
Mep1a meprin 1 alpha 0.019
Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.019
Fgf10 fibroblast growth factor 10 0.019
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.019
Acr acrosin 0.019
Cd9 CD9 molecule 0.019
Sstr1 somatostatin receptor 1 0.018
RGD1564327 similar to integrin alpha 8 0.018
Spt1 salivary protein 1 0.018
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.018
Gnb3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.018
Gja1 gap junction protein, alpha 1 0.018
Cel carboxyl ester lipase 0.018
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.018
Kcnt1 potassium channel, subfamily T, member 1 0.018
Tff2 trefoil factor 2 0.018
Ndufa4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 0.017
Myh6 myosin, heavy chain 6, cardiac muscle, alpha 0.017
Lim2 lens intrinsic membrane protein 2 0.017
Kcnk13 potassium channel, subfamily K, member 13 0.017
Adm adrenomedullin 0.017
Fibcd1 fibrinogen C domain containing 1 0.017
LOC286980 putative pheromone receptor (Go-VN13B) 0.016
Chrnb4 cholinergic receptor, nicotinic, beta 4 0.016
Lrrc4b leucine rich repeat containing 4B 0.016
Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.016
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.016
Sct secretin 0.016
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism