The network for 'defecation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

defecation

The expulsion of feces from the rectum.

Mus musculus
Name Description Probability Func Analog Organism
Lef1 lymphoid enhancer binding factor 1 0.984
Klc1 kinesin light chain 1 0.920
Tcf7 transcription factor 7, T-cell specific 0.806
Gli3 GLI-Kruppel family member GLI3 0.756
Otx2 orthodenticle homolog 2 (Drosophila) 0.741
Mapk8 mitogen-activated protein kinase 8 0.739
Htt huntingtin 0.690
Rims2 regulating synaptic membrane exocytosis 2 0.672
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.610
Rims1 regulating synaptic membrane exocytosis 1 0.574
Fbxl20 F-box and leucine-rich repeat protein 20 0.555
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.531
Itpr3 inositol 1,4,5-triphosphate receptor 3 0.478
Ctnnb1 catenin (cadherin associated protein), beta 1 0.467
Stx1a syntaxin 1A (brain) 0.446
Fgfr1 fibroblast growth factor receptor 1 0.432
En1 engrailed 1 0.416
Otx1 orthodenticle homolog 1 (Drosophila) 0.391
Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 0.383
Itpr2 inositol 1,4,5-triphosphate receptor 2 0.358
Syp synaptophysin 0.344
Psen1 presenilin 1 0.325
Pax2 paired box gene 2 0.288
Gli2 GLI-Kruppel family member GLI2 0.262
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.260
Ctnna2 catenin (cadherin associated protein), alpha 2 0.255
Snap25 synaptosomal-associated protein 25 0.247
Usp9x ubiquitin specific peptidase 9, X chromosome 0.239
Stoml2 stomatin (Epb7.2)-like 2 0.232
Ythdf3 YTH domain family 3 0.228
Mrpl12 mitochondrial ribosomal protein L12 0.227
Gsk3b glycogen synthase kinase 3 beta 0.213
Axin2 axin2 0.213
Ehd3 EH-domain containing 3 0.210
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.201
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.201
Slc4a4 solute carrier family 4 (anion exchanger), member 4 0.198
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.179
Shh sonic hedgehog 0.175
Dus1l dihydrouridine synthase 1-like (S. cerevisiae) 0.174
Krtap5-1 keratin associated protein 5-1 0.165
Hsp90b1 heat shock protein 90, beta (Grp94), member 1 0.163
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.160
En2 engrailed 2 0.160
Clstn1 calsyntenin 1 0.159
Plcg1 phospholipase C, gamma 1 0.159
Gpr27 G protein-coupled receptor 27 0.153
Lrpprc leucine-rich PPR-motif containing 0.151
Fjx1 four jointed box 1 (Drosophila) 0.151
Msx1 homeobox, msh-like 1 0.150
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.149
Rnf208 ring finger protein 208 0.144
Arf6 ADP-ribosylation factor 6 0.142
Fam19a5 family with sequence similarity 19, member A5 0.140
Dab1 disabled homolog 1 (Drosophila) 0.140
Auts2 autism susceptibility candidate 2 0.138
Emx1 empty spiracles homolog 1 (Drosophila) 0.134
Ina internexin neuronal intermediate filament protein, alpha 0.134
Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 0.131
Notch3 Notch gene homolog 3 (Drosophila) 0.130
Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma 0.128
Timm23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.126
Arhgef1 Rho guanine nucleotide exchange factor (GEF) 1 0.119
Wnt1 wingless-related MMTV integration site 1 0.118
Bmp7 bone morphogenetic protein 7 0.118
Pou4f2 POU domain, class 4, transcription factor 2 0.118
Dlg2 discs, large homolog 2 (Drosophila) 0.113
Irs1 insulin receptor substrate 1 0.113
Dpysl4 dihydropyrimidinase-like 4 0.108
Gata3 GATA binding protein 3 0.108
Gpr37 G protein-coupled receptor 37 0.108
Ptch1 patched homolog 1 0.107
Dctpp1 dCTP pyrophosphatase 1 0.107
Tbx3 T-box 3 0.106
Emx2 empty spiracles homolog 2 (Drosophila) 0.104
Samm50 sorting and assembly machinery component 50 homolog (S. cerevisiae) 0.104
Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10 0.102
Clpp caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) 0.100
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.099
Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.099
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.096
Sv2b synaptic vesicle glycoprotein 2 b 0.094
Cdh2 cadherin 2 0.093
Igf1r insulin-like growth factor I receptor 0.093
Vamp2 vesicle-associated membrane protein 2 0.092
Dnm2 dynamin 2 0.091
Gas1 growth arrest specific 1 0.091
Pax6 paired box gene 6 0.090
Sox11 SRY-box containing gene 11 0.089
Msi1 Musashi homolog 1(Drosophila) 0.088
L1cam L1 cell adhesion molecule 0.087
Tbpl2 TATA box binding protein like 2 0.087
Tnnt2 troponin T2, cardiac 0.087
Lrp6 low density lipoprotein receptor-related protein 6 0.085
Peg3 paternally expressed 3 0.084
Cic capicua homolog (Drosophila) 0.083
Ripply2 ripply2 homolog (zebrafish) 0.082
Scg2 secretogranin II 0.080
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.079
Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.077
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.045
unc-7 Protein UNC-7 0.036
gtl-1 Protein GTL-1 0.036
nlg-1 Protein NLG-1 0.033
lin-11 Protein LIN-11 0.029
mec-2 Protein MEC-2 0.028
CELE_B0513.5 Protein B0513.5 0.026
eps-8 Protein EPS-8 0.025
F28E10.1 Protein F28E10.1 0.025
unc-29 Protein UNC-29 0.024
rgs-2 Protein RGS-2 0.024
F31F7.1 Protein F31F7.1 0.024
unc-38 Protein UNC-38 0.023
rig-6 Protein RIG-6 0.023
glr-5 Protein GLR-5 0.022
F55H12.3 Protein F55H12.3 0.022
glc-4 Protein GLC-4 0.022
rgs-6 Protein RGS-6 0.022
CELE_Y67A10A.9 Protein Y67A10A.9 0.022
elt-6 Protein ELT-6 0.021
pes-1 Protein PES-1 0.021
inx-13 Protein INX-13 0.021
F45E4.3 Protein F45E4.3 0.021
cri-3 Protein CRI-3 0.020
vab-3 Protein VAB-3 0.020
unc-42 Protein UNC-42 0.020
aex-3 Protein AEX-3 0.020
lev-8 Protein LEV-8 0.020
lev-1 Protein LEV-1 0.019
F14F4.1 Protein F14F4.1 0.019
mec-4 Protein MEC-4 0.019
CELE_F52E1.13 Protein F52E1.13 0.019
faah-1 Protein FAAH-1 0.019
C13F10.6 Protein C13F10.6 0.019
nhx-1 Protein NHX-1 0.019
fshr-1 Protein FSHR-1 0.019
unc-41 Protein UNC-41 0.018
pha-4 Protein PHA-4 0.018
sdz-28 Protein SDZ-28 0.018
let-23 Protein LET-23 0.018
prmt-3 Protein PRMT-3 0.018
twk-18 Protein TWK-18 0.017
ser-2 Protein SER-2 0.017
syg-1 Protein SYG-1 0.017
K10D3.4 Protein K10D3.4 0.017
math-4 Protein MATH-4 0.017
tra-1 Protein TRA-1 0.017
ref-1 Protein REF-1 0.017
tbc-16 Protein TBC-16 0.016
C43H6.6 Protein C43H6.6 0.016
hsp-12.2 Protein HSP-12.2 0.016
CELE_Y105C5A.24 Protein Y105C5A.24 0.016
uig-1 Protein UIG-1 0.016
aqp-11 Protein AQP-11 0.016
C18G1.3 Protein C18G1.3 0.016
oac-59 Protein OAC-59 0.016
T25B9.10 Protein T25B9.10 0.016
unc-63 Protein UNC-63 0.016
CELE_C31B8.7 Protein C31B8.7 0.016
inx-4 Protein INX-4 0.015
pqn-47 Protein PQN-47 0.015
CELE_Y69H2.1 Protein Y69H2.1 0.015
H10E21.5 Protein H10E21.5 0.015
R03G8.3 Protein R03G8.3 0.015
snt-5 Protein SNT-5 0.015
frm-3 Protein FRM-3 0.015
mec-18 Protein MEC-18 0.015
clec-7 Protein CLEC-7 0.015
vab-8 Protein VAB-8 0.014
unc-122 Protein UNC-122 0.014
ZC247.2 Protein ZC247.2 0.014
asp-6 Protein ASP-6 0.014
C14C11.2 Protein C14C11.2 0.014
lgc-39 Protein LGC-39 0.014
H03A11.2 Protein H03A11.2 0.014
R04E5.2 Protein R04E5.2 0.014
nhr-2 Protein NHR-2 0.014
aex-2 Protein AEX-2 0.014
zag-1 Protein ZAG-1 0.014
sto-5 Protein STO-5 0.014
sox-3 Protein SOX-3 0.014
C36E8.4 Protein C36E8.4 0.014
pos-1 Protein POS-1 0.014
best-23 Protein BEST-23 0.013
che-3 Protein CHE-3 0.013
H43E16.1 Protein H43E16.1 0.013
efn-2 Protein EFN-2 0.013
rig-3 Protein RIG-3 0.013
pept-1 Protein PEPT-1 0.013
trpa-1 Protein TRPA-1 0.013
C48B6.9 Protein C48B6.9 0.013
B0495.7 Protein B0495.7 0.013
aex-1 Protein AEX-1 0.013
eat-6 Protein EAT-6 0.013
ida-1 Protein IDA-1 0.013
T20D3.2 Protein T20D3.2 0.013
daf-10 Protein DAF-10 0.013
rpm-1 Protein RPM-1 0.013
sad-1 Protein SAD-1 0.013
F26F12.4 Protein F26F12.4 0.013
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG2862 CG2862 gene product from transcript CG2862-RA 0.019
CG14482 CG14482 gene product from transcript CG14482-RA 0.015
levy CG17280 gene product from transcript CG17280-RA 0.014
Ssb-c31a Single stranded-binding protein c31A 0.013
RpL29 Ribosomal protein L29 0.012
Ras85D Ras oncogene at 85D 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dlg4 discs, large homolog 4 (Drosophila) 0.736
Dspp dentin sialophosphoprotein 0.549
Grm8 glutamate receptor, metabotropic 8 0.549
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.536
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.529
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.503
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.490
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.390
Slc22a25 solute carrier family 22, member 25 0.353
Cntfr ciliary neurotrophic factor receptor 0.342
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.333
Dcc deleted in colorectal carcinoma 0.305
Uncx UNC homeobox 0.303
Gja6 gap junction protein, alpha 6 0.299
St18 suppression of tumorigenicity 18 0.295
Gad2 glutamate decarboxylase 2 0.293
Crhr2 corticotropin releasing hormone receptor 2 0.285
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.257
Syn1 synapsin I 0.248
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.247
Kcnh3 potassium voltage-gated channel, subfamily H (eag-related), member 3 0.238
Csn1s1 casein alpha s1 0.235
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.234
Faslg Fas ligand (TNF superfamily, member 6) 0.232
Notch3 Notch homolog 3 (Drosophila) 0.219
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.219
Gjb4 gap junction protein, beta 4 0.195
Gata4 GATA binding protein 4 0.192
Bsn bassoon 0.191
Foxa1 forkhead box A1 0.177
Psp parotid secretory protein 0.175
Gzmk granzyme K 0.174
Csf1 colony stimulating factor 1 (macrophage) 0.170
Sdc3 syndecan 3 0.167
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.164
Nkx6-1 NK6 homeobox 1 0.162
Robo1 roundabout homolog 1 (Drosophila) 0.162
Sorcs3 sortilin-related VPS10 domain containing receptor 3 0.151
Mrgprf MAS-related GPR, member F 0.148
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.145
Il9r interleukin 9 receptor 0.140
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.134
RGD1304952 similar to RIKEN cDNA C530028O21 gene 0.134
Mag myelin-associated glycoprotein 0.133
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.131
Syt7 synaptotagmin VII 0.129
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.126
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.126
Phox2a paired-like homeobox 2a 0.120
Fev FEV (ETS oncogene family) 0.118
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.118
Gabrd gamma-aminobutyric acid (GABA) A receptor, delta 0.115
Oprl1 opiate receptor-like 1 0.114
Sh2d3c SH2 domain containing 3C 0.112
Sstr3 somatostatin receptor 3 0.110
Calcr calcitonin receptor 0.107
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.107
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.107
Cox4i2 cytochrome c oxidase subunit IV isoform 2 0.104
Olr1867 olfactory receptor 1867 0.100
Nrxn3 neurexin 3 0.100
Omp olfactory marker protein 0.099
Snhg11 small nucleolar RNA host gene 11 0.099
Fgf16 fibroblast growth factor 16 0.090
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.090
Tacr3 tachykinin receptor 3 0.090
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.089
Uhmk1 U2AF homology motif (UHM) kinase 1 0.088
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.087
Dpys dihydropyrimidinase 0.085
Dpp6 dipeptidylpeptidase 6 0.084
Rims1 regulating synaptic membrane exocytosis 1 0.084
Gucy2c guanylate cyclase 2C 0.084
Neurod2 neurogenic differentiation 2 0.082
Chm choroideremia (Rab escort protein 1) 0.081
Syt4 synaptotagmin IV 0.080
Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 0.080
Prlhr prolactin releasing hormone receptor 0.080
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.079
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.079
Csn2 casein beta 0.076
Nfasc neurofascin 0.075
Cntn3 contactin 3 (plasmacytoma associated) 0.074
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.073
Cplx2 complexin 2 0.073
Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 0.072
Bcan brevican 0.071
Shank1 SH3 and multiple ankyrin repeat domains 1 0.071
Cort cortistatin 0.070
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.069
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.069
Olr1641 olfactory receptor 1641 0.065
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.063
Mettl7b methyltransferase like 7B 0.063
Necab2 N-terminal EF-hand calcium binding protein 2 0.062
Lrp3 low density lipoprotein receptor-related protein 3 0.062
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.062
Prkcg protein kinase C, gamma 0.060
Kcnn3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 0.060
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.059
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism