The network for 'adenylate cyclase inhibiting g protein coupled receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adenylate cyclase inhibiting g protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).

Mus musculus
Name Description Probability Func Analog Organism
Drd2 dopamine receptor D2 0.963
Cckbr cholecystokinin B receptor 0.926
Kiss1r KISS1 receptor 0.913
Esr1 estrogen receptor 1 (alpha) 0.905
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.724
Ar androgen receptor 0.669
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.604
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.590
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.559
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.558
Crhr1 corticotropin releasing hormone receptor 1 0.539
Lep leptin 0.479
Fshr follicle stimulating hormone receptor 0.465
Mc3r melanocortin 3 receptor 0.464
Kiss1 KiSS-1 metastasis-suppressor 0.412
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.409
Ppyr1 pancreatic polypeptide receptor 1 0.372
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.359
Fgf23 fibroblast growth factor 23 0.332
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.331
Cnr1 cannabinoid receptor 1 (brain) 0.318
Cx3cr1 chemokine (C-X3-C) receptor 1 0.304
Kl klotho 0.304
Gnrh1 gonadotropin releasing hormone 1 0.291
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.286
Ghr growth hormone receptor 0.283
Plcb1 phospholipase C, beta 1 0.280
Rgs9 regulator of G-protein signaling 9 0.269
Sstr1 somatostatin receptor 1 0.257
Cga glycoprotein hormones, alpha subunit 0.247
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.247
Grm1 glutamate receptor, metabotropic 1 0.236
Lhb luteinizing hormone beta 0.235
Bglap bone gamma carboxyglutamate protein 0.234
Pgr progesterone receptor 0.229
Hcrt hypocretin 0.225
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.219
Agrp agouti related protein 0.206
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.204
Tacr1 tachykinin receptor 1 0.203
Has1 hyaluronan synthase1 0.203
Sncb synuclein, beta 0.202
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.199
Foxf2 forkhead box F2 0.194
Npy2r neuropeptide Y receptor Y2 0.190
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.190
Thrb thyroid hormone receptor beta 0.179
Gnrhr gonadotropin releasing hormone receptor 0.176
Htr4 5 hydroxytryptamine (serotonin) receptor 4 0.169
Lhx3 LIM homeobox protein 3 0.168
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 0.164
Slc12a5 solute carrier family 12, member 5 0.158
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.158
Sdc3 syndecan 3 0.157
Npy1r neuropeptide Y receptor Y1 0.154
Npy5r neuropeptide Y receptor Y5 0.147
Prlr prolactin receptor 0.147
Syn2 synapsin II 0.142
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.140
Oxt oxytocin 0.138
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.137
Oprm1 opioid receptor, mu 1 0.136
Oprk1 opioid receptor, kappa 1 0.132
Drd3 dopamine receptor D3 0.128
Lepr leptin receptor 0.116
Grid2 glutamate receptor, ionotropic, delta 2 0.114
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.113
Cntn1 contactin 1 0.112
Gp5 glycoprotein 5 (platelet) 0.110
Chrm3 cholinergic receptor, muscarinic 3, cardiac 0.109
Wwox WW domain-containing oxidoreductase 0.109
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.108
Gpr83 G protein-coupled receptor 83 0.108
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.108
Ncf1 neutrophil cytosolic factor 1 0.106
Tac2 tachykinin 2 0.103
Rgs8 regulator of G-protein signaling 8 0.101
Itgb2l integrin beta 2-like 0.101
Olfr16 olfactory receptor 16 0.101
Duox2 dual oxidase 2 0.100
Npas1 neuronal PAS domain protein 1 0.097
Krtap12-1 keratin associated protein 12-1 0.097
Cntn4 contactin 4 0.096
Gabbr2 gamma-aminobutyric acid (GABA) B receptor, 2 0.093
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.092
Esr2 estrogen receptor 2 (beta) 0.090
Retnlb resistin like beta 0.089
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.089
Adrb1 adrenergic receptor, beta 1 0.089
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.086
Apln apelin 0.086
Gpr27 G protein-coupled receptor 27 0.084
St6galnac3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.083
Hic1 hypermethylated in cancer 1 0.082
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.080
C5ar1 complement component 5a receptor 1 0.078
Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 0.076
Lhx9 LIM homeobox protein 9 0.076
Rit2 Ras-like without CAAX 2 0.076
Avp arginine vasopressin 0.075
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
MPDZ multiple PDZ domain protein 0.999
FLNA filamin A, alpha 0.990
MYH9 myosin, heavy chain 9, non-muscle 0.957
ADORA2A adenosine A2a receptor 0.952
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.930
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.834
NSF N-ethylmaleimide-sensitive factor 0.722
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.651
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.633
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.539
PSEN1 presenilin 1 0.526
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.392
FLNB filamin B, beta 0.391
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.383
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.356
DRD2 dopamine receptor D2 0.340
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.295
GRIP1 glutamate receptor interacting protein 1 0.294
SSTR3 somatostatin receptor 3 0.274
PRKCG protein kinase C, gamma 0.267
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.237
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.236
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.235
GPR6 G protein-coupled receptor 6 0.227
SH3GL3 SH3-domain GRB2-like 3 0.226
GRM1 glutamate receptor, metabotropic 1 0.214
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.208
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.201
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.194
OPCML opioid binding protein/cell adhesion molecule-like 0.191
SSTR2 somatostatin receptor 2 0.188
CAPZB capping protein (actin filament) muscle Z-line, beta 0.177
PTCH1 patched 1 0.169
GHRHR growth hormone releasing hormone receptor 0.135
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.132
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.131
FBLIM1 filamin binding LIM protein 1 0.131
ACTN4 actinin, alpha 4 0.129
CCKBR cholecystokinin B receptor 0.128
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.125
GRIA4 glutamate receptor, ionotrophic, AMPA 4 0.123
AFF2 AF4/FMR2 family, member 2 0.112
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 0.111
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.108
TBC1D10A TBC1 domain family, member 10A 0.105
ITGB7 integrin, beta 7 0.104
GLP1R glucagon-like peptide 1 receptor 0.103
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.100
PNOC prepronociceptin 0.093
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.092
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.089
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 0.087
XIRP1 xin actin-binding repeat containing 1 0.087
GRM5 glutamate receptor, metabotropic 5 0.082
CRHR2 corticotropin releasing hormone receptor 2 0.079
ITGB4 integrin, beta 4 0.078
PLEC plectin 0.078
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 0.075
GFAP glial fibrillary acidic protein 0.074
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.073
ZBED1 zinc finger, BED-type containing 1 0.073
KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9 0.070
NEUROD2 neurogenic differentiation 2 0.065
OPRD1 opioid receptor, delta 1 0.065
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.063
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.063
HRH3 histamine receptor H3 0.063
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 0.062
CD81 CD81 molecule 0.062
GALR3 galanin receptor 3 0.060
OPRM1 opioid receptor, mu 1 0.059
DRD1 dopamine receptor D1 0.058
OPRL1 opiate receptor-like 1 0.057
ILK integrin-linked kinase 0.057
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.054
ADRA1D adrenergic, alpha-1D-, receptor 0.054
OPRK1 opioid receptor, kappa 1 0.054
KCNF1 potassium voltage-gated channel, subfamily F, member 1 0.051
SLC6A7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.050
TUBB2A tubulin, beta 2A 0.050
ACTN1 actinin, alpha 1 0.050
PSEN2 presenilin 2 (Alzheimer disease 4) 0.049
ARRDC3 arrestin domain containing 3 0.049
FSTL4 follistatin-like 4 0.049
APLP2 amyloid beta (A4) precursor-like protein 2 0.048
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.048
NTSR2 neurotensin receptor 2 0.047
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.046
CALY calcyon neuron-specific vesicular protein 0.044
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.044
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 0.043
CA10 carbonic anhydrase X 0.043
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.043
FEZF2 FEZ family zinc finger 2 0.043
SSTR4 somatostatin receptor 4 0.043
CCK cholecystokinin 0.042
CD63 CD63 molecule 0.042
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 0.042
NCAN neurocan 0.042
PLD3 phospholipase D family, member 3 0.042
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.739
Adora2a adenosine A2a receptor 0.555
Bcan brevican 0.470
Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.465
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.438
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.412
Grm6 glutamate receptor, metabotropic 6 0.357
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.351
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.343
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.315
Fgfr2 fibroblast growth factor receptor 2 0.299
Cd4 Cd4 molecule 0.294
Folh1 folate hydrolase 1 0.291
Pnlip pancreatic lipase 0.287
Aqp4 aquaporin 4 0.280
Pou3f2 POU class 3 homeobox 2 0.271
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.253
Fgf2 fibroblast growth factor 2 0.239
Adora1 adenosine A1 receptor 0.239
Mag myelin-associated glycoprotein 0.236
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.230
Chrm4 cholinergic receptor, muscarinic 4 0.224
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.211
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.189
Strn striatin, calmodulin binding protein 0.162
Myo1d myosin ID 0.152
Atxn1 ataxin 1 0.150
Hpca hippocalcin 0.147
Hr hairless 0.143
Gria1 glutamate receptor, ionotropic, AMPA 1 0.142
Glra1 glycine receptor, alpha 1 0.140
Svs1 seminal vesicle secretory protein 1 0.134
Grik1 glutamate receptor, ionotropic, kainate 1 0.120
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.114
Mchr1 melanin-concentrating hormone receptor 1 0.110
Unc13c unc-13 homolog C (C. elegans) 0.109
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.106
Oprk1 opioid receptor, kappa 1 0.103
Nxph1 neurexophilin 1 0.101
Prp15 proline-rich protein 15 0.100
Cntn5 contactin 5 0.099
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.097
Nmbr neuromedin B receptor 0.096
Fgf14 fibroblast growth factor 14 0.095
Mobp myelin-associated oligodendrocyte basic protein 0.094
Oprd1 opioid receptor, delta 1 0.092
Cacng4 calcium channel, voltage-dependent, gamma subunit 4 0.092
Syt12 synaptotagmin XII 0.091
Pld2 phospholipase D2 0.088
Cpb1 carboxypeptidase B1 (tissue) 0.088
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.087
Hrh3 histamine receptor H3 0.082
Pcdhb12 protocadherin beta 12 0.082
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.082
Smad3 SMAD family member 3 0.078
Prph2 peripherin 2 0.078
Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.077
Grip1 glutamate receptor interacting protein 1 0.077
Dlg4 discs, large homolog 4 (Drosophila) 0.076
Ncan neurocan 0.075
Cckar cholecystokinin A receptor 0.075
Plcd4 phospholipase C, delta 4 0.074
Cntn1 contactin 1 0.073
RGD1564664 similar to LOC387763 protein 0.073
Gad2 glutamate decarboxylase 2 0.073
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.071
Synpo synaptopodin 0.071
Syn3 synapsin III 0.069
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.068
Npy5r neuropeptide Y receptor Y5 0.066
Drd2 dopamine receptor D2 0.065
Mpeg1 macrophage expressed 1 0.065
Cmklr1 chemokine-like receptor 1 0.064
Adam7 ADAM metallopeptidase domain 7 0.064
Sstr1 somatostatin receptor 1 0.062
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.062
Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.061
Gad1 glutamate decarboxylase 1 0.061
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.060
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.060
Gna15 guanine nucleotide binding protein, alpha 15 0.057
Trim9 tripartite motif-containing 9 0.056
Olr1078 olfactory receptor 1078 0.056
Ntsr2 neurotensin receptor 2 0.055
Cxcr5 chemokine (C-X-C motif) receptor 5 0.055
Vom2r53 vomeronasal 2 receptor, 53 0.053
Vom2r27 vomeronasal 2 receptor, 27 0.052
Ccr5 chemokine (C-C motif) receptor 5 0.051
Itgam integrin, alpha M 0.050
Chrm5 cholinergic receptor, muscarinic 5 0.049
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.049
Vat1 vesicle amine transport protein 1 homolog (T californica) 0.047
Grm1 glutamate receptor, metabotropic 1 0.047
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.046
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.045
Gpr83 G protein-coupled receptor 83 0.045
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.045
Pax6 paired box 6 0.044
Nr2c2 nuclear receptor subfamily 2, group C, member 2 0.043
Calcr calcitonin receptor 0.043
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism