The network for 'middle ear morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

middle ear morphogenesis

The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.999
Msx1 homeobox, msh-like 1 0.997
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.996
Eya1 eyes absent 1 homolog (Drosophila) 0.990
Pitx2 paired-like homeodomain transcription factor 2 0.987
Hoxa1 homeobox A1 0.977
Prrx1 paired related homeobox 1 0.970
Tbx3 T-box 3 0.967
Pitx1 paired-like homeodomain transcription factor 1 0.957
Sox9 SRY-box containing gene 9 0.940
Tbx1 T-box 1 0.930
Foxc1 forkhead box C1 0.930
Gli3 GLI-Kruppel family member GLI3 0.927
Hand2 heart and neural crest derivatives expressed transcript 2 0.925
Hand1 heart and neural crest derivatives expressed transcript 1 0.922
Hoxd3 homeobox D3 0.920
Fgfr2 fibroblast growth factor receptor 2 0.919
Foxc2 forkhead box C2 0.900
Hoxa2 homeobox A2 0.892
Fgf10 fibroblast growth factor 10 0.864
Dlx5 distal-less homeobox 5 0.861
Foxg1 forkhead box G1 0.855
Ednra endothelin receptor type A 0.825
Sox2 SRY-box containing gene 2 0.822
Pax3 paired box gene 3 0.806
Vangl2 vang-like 2 (van gogh, Drosophila) 0.785
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.776
Pax9 paired box gene 9 0.774
Pax2 paired box gene 2 0.768
Isl1 ISL1 transcription factor, LIM/homeodomain 0.737
Otx2 orthodenticle homolog 2 (Drosophila) 0.721
Hoxa3 homeobox A3 0.721
Tcfap2a transcription factor AP-2, alpha 0.715
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.689
Fgf8 fibroblast growth factor 8 0.617
Gsc goosecoid homeobox 0.608
Gli2 GLI-Kruppel family member GLI2 0.607
Hoxa5 homeobox A5 0.582
Pbx1 pre B-cell leukemia transcription factor 1 0.562
Fgfr1 fibroblast growth factor receptor 1 0.559
Gbx2 gastrulation brain homeobox 2 0.551
Dlx2 distal-less homeobox 2 0.550
Bmp4 bone morphogenetic protein 4 0.546
Chrd chordin 0.541
Zeb1 zinc finger E-box binding homeobox 1 0.507
Fgfr3 fibroblast growth factor receptor 3 0.500
Tlx3 T-cell leukemia, homeobox 3 0.491
Msx2 homeobox, msh-like 2 0.476
Nkx3-2 NK3 homeobox 2 0.445
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.445
Tcf21 transcription factor 21 0.317
Meox2 mesenchyme homeobox 2 0.312
Hoxb3 homeobox B3 0.303
Twist2 twist homolog 2 (Drosophila) 0.295
Ntf3 neurotrophin 3 0.290
Chd7 chromodomain helicase DNA binding protein 7 0.285
Hoxa13 homeobox A13 0.283
Runx2 runt related transcription factor 2 0.276
Bmp7 bone morphogenetic protein 7 0.271
Sox11 SRY-box containing gene 11 0.267
Hoxb5 homeobox B5 0.249
Sall4 sal-like 4 (Drosophila) 0.249
Hoxb4 homeobox B4 0.245
Prrx2 paired related homeobox 2 0.234
Smo smoothened homolog (Drosophila) 0.229
Lef1 lymphoid enhancer binding factor 1 0.225
Jag1 jagged 1 0.223
Lrp6 low density lipoprotein receptor-related protein 6 0.217
Pdx1 pancreatic and duodenal homeobox 1 0.216
Bdnf brain derived neurotrophic factor 0.208
Pou3f4 POU domain, class 3, transcription factor 4 0.192
Hoxb1 homeobox B1 0.183
Rarb retinoic acid receptor, beta 0.171
Hoxd13 homeobox D13 0.168
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.168
Hoxa10 homeobox A10 0.165
Hoxd11 homeobox D11 0.162
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.155
Alx4 aristaless-like homeobox 4 0.148
Uncx UNC homeobox 0.139
Dlx1 distal-less homeobox 1 0.137
Nkx6-1 NK6 homeobox 1 0.133
Emx2 empty spiracles homolog 2 (Drosophila) 0.132
Hes1 hairy and enhancer of split 1 (Drosophila) 0.129
Efna4 ephrin A4 0.126
Wt1 Wilms tumor 1 homolog 0.118
Rarg retinoic acid receptor, gamma 0.115
Ret ret proto-oncogene 0.113
Hmx2 H6 homeobox 2 0.110
Pax6 paired box gene 6 0.107
Gata3 GATA binding protein 3 0.106
Dlx6 distal-less homeobox 6 0.105
Smad6 MAD homolog 6 (Drosophila) 0.105
Pou4f3 POU domain, class 4, transcription factor 3 0.101
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.097
Hoxc5 homeobox C5 0.082
Barx1 BarH-like homeobox 1 0.082
Lmx1a LIM homeobox transcription factor 1 alpha 0.082
Sharpin SHANK-associated RH domain interacting protein 0.080
Pax7 paired box gene 7 0.078
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SC4MOL sterol-C4-methyl oxidase-like 0.403
FRS2 fibroblast growth factor receptor substrate 2 0.112
SREBF2 sterol regulatory element binding transcription factor 2 0.082
NOSTRIN nitric oxide synthase trafficker 0.072
ZADH2 zinc binding alcohol dehydrogenase domain containing 2 0.063
DICER1 dicer 1, ribonuclease type III 0.048
ZFP28 zinc finger protein 28 homolog (mouse) 0.043
FGF1 fibroblast growth factor 1 (acidic) 0.041
PLCG1 phospholipase C, gamma 1 0.040
BMP7 bone morphogenetic protein 7 0.036
HMOX2 heme oxygenase (decycling) 2 0.033
MSX2 msh homeobox 2 0.031
EYA2 eyes absent homolog 2 (Drosophila) 0.027
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.026
BMP2 bone morphogenetic protein 2 0.026
LAT linker for activation of T cells 0.023
IK IK cytokine, down-regulator of HLA II 0.022
LDLR low density lipoprotein receptor 0.020
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.019
KDM3A lysine (K)-specific demethylase 3A 0.017
ZNF746 zinc finger protein 746 0.016
EYA1 eyes absent homolog 1 (Drosophila) 0.016
CCNG2 cyclin G2 0.016
SFRP4 secreted frizzled-related protein 4 0.015
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.013
IDI1 isopentenyl-diphosphate delta isomerase 1 0.013
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.013
MAX MYC associated factor X 0.013
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.013
SHOX2 short stature homeobox 2 0.012
FGFR2 fibroblast growth factor receptor 2 0.012
FBXL7 F-box and leucine-rich repeat protein 7 0.012
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.012
TBX2 T-box 2 0.011
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.011
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.011
FOXF2 forkhead box F2 0.011
FGFR3 fibroblast growth factor receptor 3 0.011
TWIST1 twist homolog 1 (Drosophila) 0.011
CMIP c-Maf-inducing protein 0.011
FGF18 fibroblast growth factor 18 0.010
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.010
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 0.010
NKRF NFKB repressing factor 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism