The network for 'drug catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.

Name Description Probability Func Analog Organism
Lepr leptin receptor 1.000
Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 0.998
Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 0.980
Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 0.962
Ptgs2 prostaglandin-endoperoxide synthase 2 0.949
Ren1 renin 1 structural 0.930
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.902
Apoe apolipoprotein E 0.890
Vdr vitamin D receptor 0.890
Lep leptin 0.887
Pparg peroxisome proliferator activated receptor gamma 0.882
Cav1 caveolin 1, caveolae protein 0.864
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.853
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.852
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 0.826
Nos3 nitric oxide synthase 3, endothelial cell 0.790
Esr1 estrogen receptor 1 (alpha) 0.781
Il10 interleukin 10 0.770
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.769
Sult1d1 sulfotransferase family 1D, member 1 0.765
Vegfa vascular endothelial growth factor A 0.760
Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 0.719
G6pc glucose-6-phosphatase, catalytic 0.694
Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 0.648
Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 0.616
Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 0.615
Inmt indolethylamine N-methyltransferase 0.602
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.601
Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 0.596
Cps1 carbamoyl-phosphate synthetase 1 0.595
Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 0.556
Ces1d carboxylesterase 1D 0.540
Ldlr low density lipoprotein receptor 0.534
Otc ornithine transcarbamylase 0.512
Gsta3 glutathione S-transferase, alpha 3 0.505
Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 0.441
Fmo5 flavin containing monooxygenase 5 0.435
Sult1b1 sulfotransferase family 1B, member 1 0.398
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.383
Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 0.367
Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 0.354
Agtr1a angiotensin II receptor, type 1a 0.353
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.352
Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 0.337
Esr2 estrogen receptor 2 (beta) 0.337
Ar androgen receptor 0.323
Fmo3 flavin containing monooxygenase 3 0.322
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.310
Il6 interleukin 6 0.300
Ghr growth hormone receptor 0.293
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.288
Dpep1 dipeptidase 1 (renal) 0.271
Klk1b4 kallikrein 1-related pepidase b4 0.258
Fmo1 flavin containing monooxygenase 1 0.255
Gsta2 glutathione S-transferase, alpha 2 (Yc2) 0.251
Fmo2 flavin containing monooxygenase 2 0.248
Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 0.242
Bche butyrylcholinesterase 0.241
Gstm3 glutathione S-transferase, mu 3 0.232
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.226
Aox1 aldehyde oxidase 1 0.208
Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.206
Hamp hepcidin antimicrobial peptide 0.199
Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 0.197
Adipoq adiponectin, C1Q and collagen domain containing 0.190
Ces1g carboxylesterase 1G 0.183
Sult2a2 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 0.178
Rdh7 retinol dehydrogenase 7 0.177
Prlr prolactin receptor 0.177
Tlr4 toll-like receptor 4 0.174
Mmp9 matrix metallopeptidase 9 0.172
Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 0.169
Ifng interferon gamma 0.162
Npy1r neuropeptide Y receptor Y1 0.153
Timp4 tissue inhibitor of metalloproteinase 4 0.152
Aldob aldolase B, fructose-bisphosphate 0.139
Adh1 alcohol dehydrogenase 1 (class I) 0.138
Nos2 nitric oxide synthase 2, inducible 0.135
Rdh16 retinol dehydrogenase 16 0.130
Baat bile acid-Coenzyme A: amino acid N-acyltransferase 0.130
Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 0.127
Soat2 sterol O-acyltransferase 2 0.125
Epas1 endothelial PAS domain protein 1 0.118
Tmprss15 transmembrane protease, serine 15 0.118
Il1r1 interleukin 1 receptor, type I 0.117
Plg plasminogen 0.112
Slc22a18 solute carrier family 22 (organic cation transporter), member 18 0.112
Azgp1 alpha-2-glycoprotein 1, zinc 0.112
Tdo2 tryptophan 2,3-dioxygenase 0.111
Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 0.109
Sval1 seminal vesicle antigen-like 1 0.107
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.103
Hnf4g hepatocyte nuclear factor 4, gamma 0.103
Ces2a carboxylesterase 2A 0.101
Col4a3 collagen, type IV, alpha 3 0.100
Ppl periplakin 0.100
Tat tyrosine aminotransferase 0.098
Fas Fas (TNF receptor superfamily member 6) 0.096
Ptprb protein tyrosine phosphatase, receptor type, B 0.096
Rorc RAR-related orphan receptor gamma 0.093
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.000
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.000
NCOR2 nuclear receptor corepressor 2 1.000
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 1.000
HNF4A hepatocyte nuclear factor 4, alpha 1.000
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.980
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 0.966
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.964
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.956
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.926
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.882
VAC14 Vac14 homolog (S. cerevisiae) 0.865
HR hairless homolog (mouse) 0.756
NCOR1 nuclear receptor corepressor 1 0.738
C6 complement component 6 0.689
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.670
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 0.635
HRG histidine-rich glycoprotein 0.589
C8B complement component 8, beta polypeptide 0.564
GLYAT glycine-N-acyltransferase 0.518
ACRV1 acrosomal vesicle protein 1 0.510
RXRA retinoid X receptor, alpha 0.486
DAO D-amino-acid oxidase 0.453
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.446
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 0.406
ADH6 alcohol dehydrogenase 6 (class V) 0.390
C8A complement component 8, alpha polypeptide 0.371
MASP2 mannan-binding lectin serine peptidase 2 0.356
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.317
CHD9 chromodomain helicase DNA binding protein 9 0.278
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.272
KNG1 kininogen 1 0.258
HDAC3 histone deacetylase 3 0.243
MAT1A methionine adenosyltransferase I, alpha 0.233
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 0.211
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 0.170
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.161
F9 coagulation factor IX 0.160
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.159
OTC ornithine carbamoyltransferase 0.138
CFHR4 complement factor H-related 4 0.123
PGR progesterone receptor 0.114
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.097
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.090
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.089
AGXT2 alanine--glyoxylate aminotransferase 2 0.081
A1CF APOBEC1 complementation factor 0.078
FMO4 flavin containing monooxygenase 4 0.075
F11 coagulation factor XI 0.072
AADAC arylacetamide deacetylase (esterase) 0.068
ALDOB aldolase B, fructose-bisphosphate 0.064
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.061
HABP2 hyaluronan binding protein 2 0.059
APCS amyloid P component, serum 0.056
RARA retinoic acid receptor, alpha 0.051
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 0.047
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.047
PPARA peroxisome proliferator-activated receptor alpha 0.043
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.041
C4BPA complement component 4 binding protein, alpha 0.036
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.036
PON1 paraoxonase 1 0.035
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.034
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.033
THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) 0.033
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.032
XDH xanthine dehydrogenase 0.032
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.032
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.031
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.030
CCL16 chemokine (C-C motif) ligand 16 0.029
BHMT betaine--homocysteine S-methyltransferase 0.028
TAT tyrosine aminotransferase 0.027
BCL6 B-cell CLL/lymphoma 6 0.027
ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) 0.027
MTTP microsomal triglyceride transfer protein 0.026
PZP pregnancy-zone protein 0.026
PPARG peroxisome proliferator-activated receptor gamma 0.026
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.025
GBA3 glucosidase, beta, acid 3 (cytosolic) 0.021
APOC4 apolipoprotein C-IV 0.021
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.021
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.020
F13B coagulation factor XIII, B polypeptide 0.020
AFM afamin 0.019
TM4SF4 transmembrane 4 L six family member 4 0.018
FETUB fetuin B 0.017
GYS2 glycogen synthase 2 (liver) 0.017
TTPA tocopherol (alpha) transfer protein 0.016
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.016
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.015
MEP1B meprin A, beta 0.015
ITIH2 inter-alpha (globulin) inhibitor H2 0.014
CNGA1 cyclic nucleotide gated channel alpha 1 0.014
G6PC glucose-6-phosphatase, catalytic subunit 0.014
HIPK2 homeodomain interacting protein kinase 2 0.014
GCKR glucokinase (hexokinase 4) regulator 0.014
HPD 4-hydroxyphenylpyruvate dioxygenase 0.014
PLG plasminogen 0.013
LECT2 leukocyte cell-derived chemotaxin 2 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.989
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.957
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.950
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.891
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.843
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.837
Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 0.775
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.647
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.553
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.526
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.483
Akr1c18 aldo-keto reductase family 1, member C18 0.480
Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 0.473
Mettl7b methyltransferase like 7B 0.395
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.356
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.320
LOC494499 LOC494499 protein 0.288
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.268
Crygf crystallin, gamma F 0.227
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.210
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.209
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.204
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.190
Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.187
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.186
Slco1a4 solute carrier organic anion transporter family, member 1a4 0.176
Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 0.168
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.168
Otc ornithine carbamoyltransferase 0.161
Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 0.160
LOC100365112 carboxylesterase-like 0.155
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.153
Dhfr dihydrofolate reductase 0.148
Mosc1 MOCO sulphurase C-terminal domain containing 1 0.145
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.143
Akr1c12 aldo-keto reductase family 1, member C12 0.143
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.143
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.140
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.117
Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 0.116
LOC293989 cytochrome P450-like 0.112
Dpys dihydropyrimidinase 0.109
Olr59 olfactory receptor 59 0.105
Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 0.098
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.092
Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 0.091
Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 0.083
Fmo1 flavin containing monooxygenase 1 0.077
Olr1701 olfactory receptor 1701 0.070
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.070
Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 0.067
Fabp1 fatty acid binding protein 1, liver 0.063
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.056
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.054
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.054
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.051
Aqp9 aquaporin 9 0.049
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.049
Nat8 N-acetyltransferase 8 0.049
Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.048
LOC100361864 UDP-glucuronosyltransferase 2B3-like 0.048
Ces1c carboxylesterase 1C 0.046
Rxrg retinoid X receptor gamma 0.043
Rag1 recombination activating gene 1 0.043
Acot12 acyl-CoA thioesterase 12 0.041
Gsta2 glutathione S-transferase A2 0.040
Gckr glucokinase (hexokinase 4) regulator 0.039
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.039
Asgr1 asialoglycoprotein receptor 1 0.038
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.037
Ces1f carboxylesterase 1F 0.037
Fdxr ferredoxin reductase 0.036
Ces1e carboxylesterase 1E 0.036
Zfp37 zinc finger protein 37 0.035
Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 0.035
Apob apolipoprotein B 0.034
Dao D-amino-acid oxidase 0.034
Rdh2 retinol dehydrogenase 2 0.034
Il8ra interleukin 8 receptor, alpha 0.032
Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 0.032
Ust5r integral membrane transport protein UST5r 0.031
Qpct glutaminyl-peptide cyclotransferase 0.031
Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 0.031
Crybb1 crystallin, beta B1 0.029
Pigr polymeric immunoglobulin receptor 0.029
Cps1 carbamoyl-phosphate synthetase 1 0.029
Gnmt glycine N-methyltransferase 0.028
Spef2 sperm flagellar 2 0.027
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.027
Efcab4a EF-hand calcium binding domain 4A 0.027
L3mbtl3 l(3)mbt-like 3 (Drosophila) 0.025
Ppara peroxisome proliferator activated receptor alpha 0.024
Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 0.023
RGD1306474 similar to RIKEN cDNA 9530003J23 0.023
Barhl2 BarH-like homeobox 2 0.023
Upb1 ureidopropionase, beta 0.023
Aadac arylacetamide deacetylase (esterase) 0.022
Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.022
Slco1b3 solute carrier organic anion transporter family, member 1b3 0.022
Cyss cystatin S 0.021
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism