The network for 'rhombomere 5 development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rhombomere 5 development

The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.

Mus musculus
Name Description Probability Func Analog Organism
Pax2 paired box gene 2 1.000
Hoxa1 homeobox A1 1.000
Hoxa2 homeobox A2 1.000
Gbx2 gastrulation brain homeobox 2 0.998
Tbx1 T-box 1 0.995
Eya1 eyes absent 1 homolog (Drosophila) 0.992
Egr2 early growth response 2 0.984
Hoxa3 homeobox A3 0.980
Hoxb2 homeobox B2 0.969
Otx1 orthodenticle homolog 1 (Drosophila) 0.965
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.965
Hoxb1 homeobox B1 0.962
Otx2 orthodenticle homolog 2 (Drosophila) 0.949
Gata3 GATA binding protein 3 0.939
Isl1 ISL1 transcription factor, LIM/homeodomain 0.939
Jag1 jagged 1 0.920
Lmx1a LIM homeobox transcription factor 1 alpha 0.892
Hoxd3 homeobox D3 0.887
Tbx10 T-box 10 0.840
Shh sonic hedgehog 0.827
Phox2b paired-like homeobox 2b 0.759
Emx2 empty spiracles homolog 2 (Drosophila) 0.739
Hmx3 H6 homeobox 3 0.735
Foxg1 forkhead box G1 0.705
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.681
Hoxb3 homeobox B3 0.656
Fgf8 fibroblast growth factor 8 0.645
Gdnf glial cell line derived neurotrophic factor 0.615
Ntf3 neurotrophin 3 0.615
Lhx1 LIM homeobox protein 1 0.579
Nab2 Ngfi-A binding protein 2 0.578
Bdnf brain derived neurotrophic factor 0.533
Junb Jun-B oncogene 0.530
Ptgs2 prostaglandin-endoperoxide synthase 2 0.475
Tcfap2a transcription factor AP-2, alpha 0.455
Hand2 heart and neural crest derivatives expressed transcript 2 0.441
Dlx5 distal-less homeobox 5 0.435
Foxc2 forkhead box C2 0.415
En1 engrailed 1 0.414
Col4a3 collagen, type IV, alpha 3 0.375
Fos FBJ osteosarcoma oncogene 0.364
Rarb retinoic acid receptor, beta 0.353
Rara retinoic acid receptor, alpha 0.350
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.338
Fgf3 fibroblast growth factor 3 0.316
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.312
Nrg1 neuregulin 1 0.299
Hoxb6 homeobox B6 0.295
Ednra endothelin receptor type A 0.292
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.291
Hoxb5 homeobox B5 0.287
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.287
Chd7 chromodomain helicase DNA binding protein 7 0.278
Fgf10 fibroblast growth factor 10 0.260
Hoxc8 homeobox C8 0.243
Vegfa vascular endothelial growth factor A 0.242
Hoxa4 homeobox A4 0.229
Wnt1 wingless-related MMTV integration site 1 0.229
Lhx9 LIM homeobox protein 9 0.223
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 0.222
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.215
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.202
Fosb FBJ osteosarcoma oncogene B 0.202
Zfp36 zinc finger protein 36 0.191
Hmx2 H6 homeobox 2 0.190
Gsc goosecoid homeobox 0.189
Hoxb4 homeobox B4 0.157
Hoxc4 homeobox C4 0.154
Fosl2 fos-like antigen 2 0.154
Jun Jun oncogene 0.151
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.145
Pax8 paired box gene 8 0.144
Chrd chordin 0.139
Pax3 paired box gene 3 0.137
Foxc1 forkhead box C1 0.135
Lmx1b LIM homeobox transcription factor 1 beta 0.128
Bnc1 basonuclin 1 0.124
Hmx1 H6 homeobox 1 0.124
Msx1 homeobox, msh-like 1 0.107
Kiss1 KiSS-1 metastasis-suppressor 0.104
Mesp1 mesoderm posterior 1 0.103
Pitx2 paired-like homeodomain transcription factor 2 0.103
Neurog1 neurogenin 1 0.102
Atf3 activating transcription factor 3 0.099
Pou4f2 POU domain, class 4, transcription factor 2 0.099
Dlx2 distal-less homeobox 2 0.098
Hoxd11 homeobox D11 0.097
Sall3 sal-like 3 (Drosophila) 0.095
Pitx1 paired-like homeodomain transcription factor 1 0.090
Hoxb9 homeobox B9 0.090
Hoxa9 homeobox A9 0.089
Zic2 zinc finger protein of the cerebellum 2 0.085
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.084
Foxd2 forkhead box D2 0.078
Foxi1 forkhead box I1 0.077
Hoxa11 homeobox A11 0.076
Hes5 hairy and enhancer of split 5 (Drosophila) 0.074
Tcf21 transcription factor 21 0.073
Pbx1 pre B-cell leukemia transcription factor 1 0.072
Dusp1 dual specificity phosphatase 1 0.069
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.920
hnf1ba HNF1 homeobox Ba 0.827
bmp2b bone morphogenetic protein 2b 0.805
bmp4 bone morphogenetic protein 4 0.745
fgf8a fibroblast growth factor 8 a 0.572
wnt1 wingless-type MMTV integration site family, member 1 0.564
nadl1.1 neural adhesion molecule L1.1 0.456
pax2a paired box gene 2a 0.442
dlx4b distal-less homeobox gene 4b 0.441
dusp6 dual specificity phosphatase 6 0.401
spry4 sprouty (Drosophila) homolog 4 0.399
hoxb1a homeo box B1a 0.391
egr2b early growth response 2b 0.346
gpr126 G protein-coupled receptor 126 0.332
tbx1 T-box 1 0.322
ptprf protein tyrosine phosphatase, receptor type, F 0.296
klf4 Kruppel-like factor 4 0.295
otomp otolith matrix protein 0.282
egr1 early growth response 1 0.281
bmp2a bone morphogenetic protein 2a 0.275
notch1a notch homolog 1a 0.275
her12 hairy-related 12 0.255
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.225
msxc muscle segment homeobox C 0.220
prdm1a PR domain containing 1a, with ZNF domain 0.206
phox2a paired-like homeobox 2a 0.200
irx3b iroquois homeobox protein 3b 0.195
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.191
frem2a Fras1 related extracellular matrix protein 2a 0.164
mecom MDS1 and EVI1 complex locus 0.160
tll1 tolloid-like 1 0.146
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.140
sb:eu697 sb:eu697 0.136
cyp4t8 cytochrome P450, family 4, subfamily T, polypeptide 8 0.129
pax8 paired box gene 8 0.128
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.127
fgf3 fibroblast growth factor 3 0.127
atoh1a atonal homolog 1a 0.119
hoxa13b homeo box A13b 0.119
vcanb versican b 0.110
hoxb1b homeo box B1b 0.109
fras1 Fraser syndrome 1 0.109
tgfb2 transforming growth factor, beta 2 0.107
fgf4 fibroblast growth factor 4 0.099
sp8a sp8 transcription factor a 0.096
onecutl one cut domain, family member, like 0.095
egr2a early growth response 2a 0.091
osr2 odd-skipped related 2 (Drosophila) 0.090
dusp2 dual specificity phosphatase 2 0.086
msxa muscle segment homeobox A 0.085
rest RE1-silencing transcription factor 0.085
lhx6 LIM homeobox 6 0.077
six2a sine oculis-related homeobox 2a 0.073
nos1 nitric oxide synthase 1 (neuronal) 0.071
crabp2a cellular retinoic acid binding protein 2, a 0.070
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.070
six4a sine oculis homeobox homolog 4a 0.070
sfrp5 secreted frizzled-related protein 5 0.067
fgf18a fibroblast growth factor 18a 0.066
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.066
hoxa2b homeo box A2b 0.066
esr1 estrogen receptor 1 0.065
pi4kb phosphatidylinositol 4-kinase, catalytic, beta 0.064
gdf6a growth differentiation factor 6a 0.063
gbx1 gastrulation brain homeobox 1 0.063
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.062
foxi1 forkhead box I1 0.062
wt1b wilms tumor 1b 0.061
msxd muscle segment homeobox D 0.061
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.060
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.059
twist3 twist3 0.059
zgc:63602 zgc:63602 0.057
her5 hairy-related 5 0.057
ntla no tail a 0.057
cdx4 caudal type homeo box transcription factor 4 0.057
rpl36a ribosomal protein L36A 0.055
dlc deltaC 0.055
pax9 paired box gene 9 0.055
mib mind bomb 0.054
prox2 prospero homeobox 2 0.051
dacha dachshund a 0.050
mafg1 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein g (avian), 1 0.048
igfbp3 insulin-like growth factor binding protein 3 0.048
fgf8b fibroblast growth factor 8 b 0.048
dbx1b developing brain homeobox 1b 0.048
fgf22 fibroblast growth factor 22 0.048
pea3 ETS-domain transcription factor pea3 0.047
grhl2b grainyhead-like 2b (Drosophila) 0.047
arl4ca ADP-ribosylation factor-like 4Ca 0.046
bmp5 bone morphogenetic protein 5 0.044
meis2.2 myeloid ecotropic viral integration site 2.2 0.044
sp5l Sp5 transcription factor-like 0.043
fosl2 fos-like antigen 2 0.043
efnb2b ephrin B2b 0.042
arrdc3a arrestin domain containing 3a 0.041
klhl31 kelch-like 31 (Drosophila) 0.041
enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.041
pdzk1 PDZ domain containing 1 0.041
hoxb2a homeo box B2a 0.040
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism