The network for 'positive regulation of programmed cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of programmed cell death

Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

Rattus norvegicus
Name Description Probability Func Analog Organism
Egr1 early growth response 1 0.959
Fos FBJ osteosarcoma oncogene 0.927
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.540
Itgam integrin, alpha M 0.510
Klf4 Kruppel-like factor 4 (gut) 0.491
Casp3 caspase 3 0.482
Btg2 BTG family, member 2 0.450
Gna15 guanine nucleotide binding protein, alpha 15 0.422
Anxa4 annexin A4 0.420
Slit3 slit homolog 3 (Drosophila) 0.419
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.396
Dusp1 dual specificity phosphatase 1 0.384
Arpc1b actin related protein 2/3 complex, subunit 1B 0.366
Hck hemopoietic cell kinase 0.362
Egr2 early growth response 2 0.359
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.335
Tlr4 toll-like receptor 4 0.333
Cd44 Cd44 molecule 0.329
Nras neuroblastoma ras oncogene 0.320
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.309
Junb jun B proto-oncogene 0.303
Agtr1a angiotensin II receptor, type 1a 0.295
S100a8 S100 calcium binding protein A8 0.274
Pgk1 phosphoglycerate kinase 1 0.274
Gucy2d guanylate cyclase 2d 0.270
Akp3 alkaline phosphatase 3, intestine, not Mn requiring 0.266
Anxa5 annexin A5 0.264
S100a9 S100 calcium binding protein A9 0.254
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.253
Dnase1l3 deoxyribonuclease 1-like 3 0.249
Sgk1 serum/glucocorticoid regulated kinase 1 0.235
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.234
Klf6 Kruppel-like factor 6 0.225
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.218
Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a 0.217
Jak2 Janus kinase 2 0.208
Dhdpsl dihydrodipicolinate synthase-like, mitochondrial 0.206
Ppard peroxisome proliferator-activated receptor delta 0.205
Lgals3 lectin, galactoside-binding, soluble, 3 0.204
S100a10 S100 calcium binding protein A10 0.202
Vegfa vascular endothelial growth factor A 0.199
Ar androgen receptor 0.199
Zfp36 zinc finger protein 36 0.197
Map3k1 mitogen activated protein kinase kinase kinase 1 0.194
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.192
Prkcg protein kinase C, gamma 0.190
Mmp12 matrix metallopeptidase 12 0.187
LOC299282 Serine protease inhibitor 0.186
Ptprc protein tyrosine phosphatase, receptor type, C 0.186
Matk megakaryocyte-associated tyrosine kinase 0.183
Ccl5 chemokine (C-C motif) ligand 5 0.180
Cpa3 carboxypeptidase A3, mast cell 0.179
Arhgap4 Rho GTPase activating protein 4 0.176
Cdk2 cyclin dependent kinase 2 0.175
Hand2 heart and neural crest derivatives expressed 2 0.173
Ier2 immediate early response 2 0.172
Gria2 glutamate receptor, ionotropic, AMPA 2 0.172
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.171
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.171
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.171
Neurod2 neurogenic differentiation 2 0.170
Jak1 Janus kinase 1 0.170
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.165
Gpx2 glutathione peroxidase 2 0.163
Vim vimentin 0.160
LOC498222 similar to specifically androgen-regulated protein 0.159
Vip vasoactive intestinal peptide 0.156
Plxnb2 plexin B2 0.155
Cd38 CD38 molecule 0.154
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.154
Iapp islet amyloid polypeptide 0.154
Ptch1 patched homolog 1 (Drosophila) 0.153
Phlda1 pleckstrin homology-like domain, family A, member 1 0.152
Lgals2 lectin, galactoside-binding, soluble, 2 0.152
Ccl4 chemokine (C-C motif) ligand 4 0.150
Fgf5 fibroblast growth factor 5 0.149
Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.149
Homer3 homer homolog 3 (Drosophila) 0.149
Galntl1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 0.149
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.148
Anxa1 annexin A1 0.148
Tacr1 tachykinin receptor 1 0.148
LOC305103 cell surface glycoprotein gp42 0.146
Tpi1 triosephosphate isomerase 1 0.146
Mpeg1 macrophage expressed 1 0.146
Mras muscle RAS oncogene homolog 0.145
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.145
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.144
Jun Jun oncogene 0.144
Cd14 CD14 molecule 0.143
Myd88 myeloid differentiation primary response gene 88 0.143
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.142
Prkch protein kinase C, eta 0.141
Casp1 caspase 1 0.140
Ccl3 chemokine (C-C motif) ligand 3 0.140
Tmod3 tropomodulin 3 0.140
Rap1b RAP1B, member of RAS oncogene family 0.138
Edn1 endothelin 1 0.138
Foxa3 forkhead box A3 0.138
Amph amphiphysin 0.137
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.112
inx-3 Protein INX-3 0.047
hsp-1 Protein HSP-1 0.043
pry-1 Protein PRY-1 0.039
bar-1 Protein BAR-1 0.039
egl-46 Protein EGL-46 0.038
ceh-20 Protein CEH-20 0.032
zyg-11 Protein ZYG-11 0.028
ced-3 Protein CED-3 0.026
par-5 Protein PAR-5 0.024
cfim-2 Protein CFIM-2 0.023
fkh-2 Protein FKH-2 0.023
eya-1 Protein EYA-1 0.023
tufm-1 Protein TUFM-1 0.022
vab-1 Protein VAB-1 0.021
sos-1 Protein SOS-1 0.021
acs-4 Protein ACS-4 0.020
lin-17 Protein LIN-17 0.020
brp-1 Protein BRP-1 0.020
fbxa-150 Protein FBXA-150 0.020
ceh-44 Protein CEH-44 0.020
zyg-1 Protein ZYG-1 0.019
vha-17 Protein VHA-17 0.019
dyb-1 Protein DYB-1 0.018
hpo-34 Protein HPO-34 0.018
elc-1 Protein ELC-1 0.018
egl-44 Protein EGL-44 0.018
sem-5 Protein SEM-5 0.018
C35C5.3 Protein C35C5.3 0.018
atp-5 Protein ATP-5 0.018
arrd-13 Protein ARRD-13 0.017
idh-1 Protein IDH-1 0.017
F55C12.5 Protein F55C12.5 0.017
gex-3 Protein GEX-3 0.017
hum-6 Protein HUM-6 0.017
rpl-15 Protein RPL-15 0.017
rla-0 Protein RLA-0 0.016
imb-2 Protein IMB-2 0.016
vha-19 Protein VHA-19 0.016
hcp-3 Protein HCP-3 0.016
soc-2 Protein SOC-2 0.016
unc-40 Protein UNC-40 0.016
sma-6 Protein SMA-6 0.016
T28C6.7 Protein T28C6.7 0.016
pmk-1 Protein PMK-1 0.016
flt-1 Protein FLT-1 0.016
nhr-2 Protein NHR-2 0.016
lmn-1 Protein LMN-1 0.015
F36D4.5 Protein F36D4.5 0.015
ant-1.1 Protein ANT-1.1 0.015
smp-1 Protein SMP-1 0.015
rpl-7 Protein RPL-7 0.015
eor-2 Protein EOR-2 0.015
atg-18 Protein ATG-18 0.015
vav-1 Protein VAV-1 0.015
act-4 Protein ACT-4 0.015
tlk-1 Protein TLK-1 0.015
rpl-5 Protein RPL-5 0.015
ten-1 Protein TEN-1 0.015
nhr-25 Protein NHR-25 0.014
atp-2 Protein ATP-2 0.014
egl-1 Protein EGL-1 0.014
rhi-1 Protein RHI-1 0.014
let-19 Protein LET-19 0.014
imp-2 Protein IMP-2 0.014
rpt-3 Protein RPT-3 0.014
unc-78 Protein UNC-78 0.014
rps-2 Protein RPS-2 0.014
eps-8 Protein EPS-8 0.014
mrg-1 Protein MRG-1 0.013
hum-5 Protein HUM-5 0.013
cam-1 Protein CAM-1 0.013
tct-1 Protein TCT-1 0.013
F47A4.5 Protein F47A4.5 0.013
cec-1 Protein CEC-1 0.013
ubq-1 Protein UBQ-1 0.013
cyk-3 Protein CYK-3 0.013
nhr-67 Protein NHR-67 0.013
let-60 Protein LET-60 0.013
ced-4 Protein CED-4 0.013
cks-1 Protein CKS-1 0.013
vha-13 Protein VHA-13 0.013
hnd-1 Protein HND-1 0.013
mel-28 Protein MEL-28 0.013
kle-2 Protein KLE-2 0.013
inf-1 Protein INF-1 0.013
ahcy-1 Protein AHCY-1 0.013
smf-2 Protein SMF-2 0.013
rskn-2 Protein RSKN-2 0.012
cdf-1 Protein CDF-1 0.012
tag-340 Protein TAG-340 0.012
F36A2.13 Protein F36A2.13 0.012
unc-104 Protein UNC-104 0.012
cul-2 Protein CUL-2 0.012
C52A10.1 Protein C52A10.1 0.012
dsh-2 Protein DSH-2 0.012
ing-3 Protein ING-3 0.012
rde-2 Protein RDE-2 0.012
lin-25 Protein LIN-25 0.012
CELE_C01G12.3 Protein C01G12.3 0.012
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.867
bmp2b bone morphogenetic protein 2b 0.684
bcl2l1 bcl2-like 1 0.478
spry2 sprouty homolog 2 0.456
lef1 lymphocyte enhancer binding factor 1 0.451
itgb1b.2 integrin, beta 1b.2 0.442
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.398
pycard PYD and CARD domain containing 0.361
notch1a notch homolog 1a 0.358
epas1b endothelial PAS domain protein 1b 0.358
wnt5b wingless-type MMTV integration site family, member 5b 0.297
baxa bcl2-associated X protein, a 0.290
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.287
cmyb transcription factor cmyb 0.278
gli1 GLI-Kruppel family member 1 0.277
alcama activated leukocyte cell adhesion molecule a 0.276
dlx5a distal-less homeobox gene 5a 0.267
inhbaa inhibin, beta Aa 0.260
pou5f1 POU domain, class 5, transcription factor 1 0.250
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.249
egr1 early growth response 1 0.241
mmp2 matrix metalloproteinase 2 0.240
id1 inhibitor of DNA binding 1 0.217
chrm2a cholinergic receptor, muscarinic 2a 0.208
rhoab ras homolog gene family, member Ab 0.200
acvr2a activin receptor IIa 0.192
csnk1da casein kinase 1, delta a 0.186
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.169
fstl1b follistatin-like 1b 0.164
scinlb scinderin like b 0.158
esr1 estrogen receptor 1 0.155
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.148
neurog1 neurogenin 1 0.144
bida BH3 interacting domain death agonist 0.142
meis1 myeloid ecotropic viral integration 1 0.141
fgf8a fibroblast growth factor 8 a 0.139
slc1a2b solute carrier family 1 (glial high affinity glutamate transporter), member 2b 0.139
hoxa4a homeo box A4a 0.138
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.135
atp1b3b ATPase, Na+/K+ transporting, beta 3b polypeptide 0.132
fn1 fibronectin 1 0.130
sox9a SRY-box containing gene 9a 0.128
robo3 roundabout homolog 3 0.127
cfl2l cofilin 2, like 0.125
sox11a SRY-box containing gene 11a 0.122
satb2 SATB homeobox 2 0.120
mmp13a matrix metalloproteinase 13a 0.119
foxo3b forkhead box O3b 0.118
bbc3 BCL2 binding component 3 0.118
acvr2b activin receptor IIb 0.117
hoxd4a homeo box D4a 0.116
cx43 connexin 43 0.114
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.110
adrb2a adrenergic receptor, beta 2a 0.107
mcl1a myeloid cell leukemia sequence 1a 0.107
itgb1b integrin, beta 1b 0.106
per2 period homolog 2 (Drosophila) 0.105
lum lumican 0.105
col15a1b collagen, type XV, alpha 1b 0.104
sgk1 serum/glucocorticoid regulated kinase 1 0.103
vegfab vascular endothelial growth factor Ab 0.099
adipor1a adiponectin receptor 1a 0.099
fras1 Fraser syndrome 1 0.098
fgfr1a fibroblast growth factor receptor 1a 0.097
igf1rb insulin-like growth factor 1b receptor 0.097
rnd3a Rho family GTPase 3a 0.097
bad BCL2-antagonist of cell death 0.097
nf1a neurofibromin 1a 0.094
pdx1 pancreatic and duodenal homeobox 1 0.093
csad cysteine sulfinic acid decarboxylase 0.091
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.091
gcm2 glial cells missing homolog 2 (Drosophila) 0.089
ptrfb polymerase I and transcript release factor b 0.089
mga MAX gene associated 0.089
atp6v1g1 ATPase, H+ transporting, V1 subunit G isoform 1 0.087
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.087
junb jun B proto-oncogene 0.086
gpia glucose phosphate isomerase a 0.085
rarga retinoic acid receptor gamma a 0.085
th tyrosine hydroxylase 0.085
znf503 zinc finger protein 503 0.084
wnt1 wingless-type MMTV integration site family, member 1 0.083
prg4b proteoglycan 4b 0.083
tfeb transcription factor EB 0.082
ext1b exostoses (multiple) 1b 0.082
col10a1 collagen, type X, alpha 1 0.082
rargb retinoic acid receptor, gamma b 0.081
msh6 mutS homolog 6 (E. coli) 0.081
col7a1l collagen type VII alpha 1-like 0.080
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.077
csrnp1b cysteine-serine-rich nuclear protein 1b 0.077
spry4 sprouty (Drosophila) homolog 4 0.077
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.076
bmp2a bone morphogenetic protein 2a 0.075
lhx1a LIM homeobox 1a 0.075
gpr126 G protein-coupled receptor 126 0.075
prdx2 peroxiredoxin 2 0.075
ved ventrally expressed dharma/bozozok antagonist 0.075
frem3 Fras1 related extracellular matrix 3 0.075
gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.074
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.931
nej nejire 0.902
Rac1 CG2248 gene product from transcript CG2248-RA 0.769
ed echinoid 0.763
debcl death executioner Bcl-2 homologue 0.760
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.716
ex expanded 0.710
Dcp-1 Death caspase-1 0.673
pan pangolin 0.613
Akt1 CG4006 gene product from transcript CG4006-RA 0.605
slmb supernumerary limbs 0.592
N Notch 0.578
nkd naked cuticle 0.554
Moe Moesin 0.539
rpr reaper 0.496
Stim Stromal interaction molecule 0.470
tsr twinstar 0.452
shn schnurri 0.431
dm diminutive 0.417
S6k RPS6-p70-protein kinase 0.400
wts warts 0.387
ci cubitus interruptus 0.368
hep hemipterous 0.364
tin tinman 0.352
mys myospheroid 0.333
key kenny 0.332
caz cabeza 0.317
CG5741 CG5741 gene product from transcript CG5741-RC 0.315
Atg1 Autophagy-specific gene 1 0.311
Ser Serrate 0.299
Trf2 TATA box binding protein-related factor 2 0.292
Eip74EF Ecdysone-induced protein 74EF 0.285
Rbf Retinoblastoma-family protein 0.279
th thread 0.277
bchs blue cheese 0.272
SAK Sak kinase 0.271
InR Insulin-like receptor 0.267
hh hedgehog 0.264
ush u-shaped 0.254
park parkin 0.247
pr-set7 CG3307 gene product from transcript CG3307-RC 0.247
robo roundabout 0.245
ptc patched 0.245
CG11347 CG11347 gene product from transcript CG11347-RE 0.236
Imp IGF-II mRNA-binding protein 0.236
jar jaguar 0.235
kay kayak 0.229
Atpalpha Na pump alpha subunit 0.226
Int6 Int6 homologue 0.224
Mi-2 CG8103 gene product from transcript CG8103-RA 0.220
yuri yuri gagarin 0.218
G-salpha60A G protein salpha 60A 0.218
jumu jumeau 0.217
ds dachsous 0.216
Egfr Epidermal growth factor receptor 0.213
asf1 anti-silencing factor 1 0.210
gcm glial cells missing 0.202
fkh fork head 0.199
unc-13 CG2999 gene product from transcript CG2999-RA 0.198
Wnt2 Wnt oncogene analog 2 0.198
rno rhinoceros 0.192
Notum CG13076 gene product from transcript CG13076-RB 0.190
Fs Follistatin 0.184
jeb jelly belly 0.183
jing CG9397 gene product from transcript CG9397-RI 0.182
gig gigas 0.180
vimar visceral mesodermal armadillo-repeats 0.180
sli slit 0.177
Nrx-IV Neurexin IV 0.177
Myb Myb oncogene-like 0.172
SoxN SoxNeuro 0.172
sina seven in absentia 0.170
Ack CG14992 gene product from transcript CG14992-RA 0.167
gsb gooseberry 0.165
RASSF8 CG5053 gene product from transcript CG5053-RA 0.164
car carnation 0.163
pros prospero 0.161
CG9772 CG9772 gene product from transcript CG9772-RB 0.161
Src42A Src oncogene at 42A 0.157
Abl Abl tyrosine kinase 0.154
brat brain tumor 0.153
EcR Ecdysone receptor 0.147
en engrailed 0.147
trx trithorax 0.146
Hrb98DE Heterogeneous nuclear ribonucleoprotein at 98DE 0.146
gt giant 0.144
Gyc76C Guanylyl cyclase at 76C 0.144
Atg13 Autophagy-specific gene 13 0.144
Cyt-c-d Cytochrome c distal 0.142
kto kohtalo 0.140
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.140
brm brahma 0.140
fru fruitless 0.138
Kr Kruppel 0.135
mid midline 0.133
usp ultraspiracle 0.133
emc extra macrochaetae 0.133
Sdc Syndecan 0.129
pyd polychaetoid 0.128
aop anterior open 0.127
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Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
EGFR epidermal growth factor receptor 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
BCL2 B-cell CLL/lymphoma 2 1.000
SMAD3 SMAD family member 3 1.000
CREBBP CREB binding protein 1.000
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.999
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.999
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.998
FAS Fas (TNF receptor superfamily, member 6) 0.998
ESR1 estrogen receptor 1 0.997
AR androgen receptor 0.997
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.997
FHL2 four and a half LIM domains 2 0.995
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.994
MAPK14 mitogen-activated protein kinase 14 0.993
CAV1 caveolin 1, caveolae protein, 22kDa 0.993
JUN jun proto-oncogene 0.993
BIRC3 baculoviral IAP repeat containing 3 0.992
MAPK8 mitogen-activated protein kinase 8 0.992
TRAF2 TNF receptor-associated factor 2 0.992
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.992
RB1 retinoblastoma 1 0.992
EP300 E1A binding protein p300 0.992
BCL2L1 BCL2-like 1 0.989
FN1 fibronectin 1 0.987
XIAP X-linked inhibitor of apoptosis 0.985
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.977
SMAD7 SMAD family member 7 0.975
APP amyloid beta (A4) precursor protein 0.973
BIRC2 baculoviral IAP repeat containing 2 0.973
RIPK2 receptor-interacting serine-threonine kinase 2 0.971
GSK3B glycogen synthase kinase 3 beta 0.965
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.963
ANXA1 annexin A1 0.960
SP1 Sp1 transcription factor 0.958
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.958
E2F1 E2F transcription factor 1 0.956
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.951
SQSTM1 sequestosome 1 0.950
MAPK1 mitogen-activated protein kinase 1 0.949
UBC ubiquitin C 0.948
SMAD1 SMAD family member 1 0.943
SIRT1 sirtuin 1 0.942
FADD Fas (TNFRSF6)-associated via death domain 0.939
GADD45A growth arrest and DNA-damage-inducible, alpha 0.928
TRAF1 TNF receptor-associated factor 1 0.926
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.919
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.916
THBS1 thrombospondin 1 0.914
DUSP1 dual specificity phosphatase 1 0.910
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.907
PARP1 poly (ADP-ribose) polymerase 1 0.901
NCOR2 nuclear receptor corepressor 2 0.900
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.895
TRAF3 TNF receptor-associated factor 3 0.895
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.892
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.889
CFLAR CASP8 and FADD-like apoptosis regulator 0.870
DLG4 discs, large homolog 4 (Drosophila) 0.869
MAP2K4 mitogen-activated protein kinase kinase 4 0.868
CCNE1 cyclin E1 0.865
TGFB1 transforming growth factor, beta 1 0.863
MAPT microtubule-associated protein tau 0.860
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.857
SMAD2 SMAD family member 2 0.857
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.851
BID BH3 interacting domain death agonist 0.840
CDK2 cyclin-dependent kinase 2 0.835
TRADD TNFRSF1A-associated via death domain 0.831
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.831
ATF3 activating transcription factor 3 0.831
FOS FBJ murine osteosarcoma viral oncogene homolog 0.827
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.814
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.813
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.810
STK3 serine/threonine kinase 3 0.809
CCR5 chemokine (C-C motif) receptor 5 0.786
VIM vimentin 0.777
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.776
MYD88 myeloid differentiation primary response gene (88) 0.772
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.769
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.767
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.764
CHUK conserved helix-loop-helix ubiquitous kinase 0.763
PTEN phosphatase and tensin homolog 0.744
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.743
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.742
NCOA3 nuclear receptor coactivator 3 0.736
HTT huntingtin 0.732
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.727
CXCL9 chemokine (C-X-C motif) ligand 9 0.725
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.722
TUBA1A tubulin, alpha 1a 0.722
BRCA1 breast cancer 1, early onset 0.721
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.720
SLAMF1 signaling lymphocytic activation molecule family member 1 0.719
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.718
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.715
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Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 1.000
Nos2 nitric oxide synthase 2, inducible 0.998
Tnf tumor necrosis factor 0.995
Igh immunoglobulin heavy chain complex 0.995
Ptgs2 prostaglandin-endoperoxide synthase 2 0.994
Gli3 GLI-Kruppel family member GLI3 0.989
Trp53 transformation related protein 53 0.989
Foxc1 forkhead box C1 0.972
Mdm2 transformed mouse 3T3 cell double minute 2 0.972
Cd44 CD44 antigen 0.971
Ctnnb1 catenin (cadherin associated protein), beta 1 0.969
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.963
Fgfr2 fibroblast growth factor receptor 2 0.959
Ren1 renin 1 structural 0.958
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.956
En1 engrailed 1 0.955
Ncoa3 nuclear receptor coactivator 3 0.953
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.949
Bcl2 B-cell leukemia/lymphoma 2 0.938
Lepr leptin receptor 0.921
Cd40 CD40 antigen 0.921
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.909
Fgfr1 fibroblast growth factor receptor 1 0.906
Tgfb2 transforming growth factor, beta 2 0.900
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.899
Sfrp2 secreted frizzled-related protein 2 0.898
Axin1 axin 1 0.892
Csf1 colony stimulating factor 1 (macrophage) 0.880
Rara retinoic acid receptor, alpha 0.876
Lyz2 lysozyme 2 0.875
Tgfb1 transforming growth factor, beta 1 0.874
Otx2 orthodenticle homolog 2 (Drosophila) 0.867
Shh sonic hedgehog 0.864
Smad3 MAD homolog 3 (Drosophila) 0.859
Lep leptin 0.856
Ccl2 chemokine (C-C motif) ligand 2 0.849
Nos3 nitric oxide synthase 3, endothelial cell 0.844
Mcl1 myeloid cell leukemia sequence 1 0.843
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.836
Thbs1 thrombospondin 1 0.835
Vdr vitamin D receptor 0.834
E2f1 E2F transcription factor 1 0.833
Alx4 aristaless-like homeobox 4 0.828
Hoxd13 homeobox D13 0.826
Fas Fas (TNF receptor superfamily member 6) 0.821
Casp1 caspase 1 0.821
Gdnf glial cell line derived neurotrophic factor 0.816
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.811
Neurod1 neurogenic differentiation 1 0.810
Gli2 GLI-Kruppel family member GLI2 0.809
Apc adenomatosis polyposis coli 0.802
Hoxd11 homeobox D11 0.795
Dusp1 dual specificity phosphatase 1 0.795
Rxra retinoid X receptor alpha 0.792
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.789
Mmp9 matrix metallopeptidase 9 0.771
Klf6 Kruppel-like factor 6 0.749
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.746
Fos FBJ osteosarcoma oncogene 0.735
Stk4 serine/threonine kinase 4 0.729
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.728
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.727
Bmp4 bone morphogenetic protein 4 0.727
Il1r1 interleukin 1 receptor, type I 0.723
Casp8 caspase 8 0.721
Id1 inhibitor of DNA binding 1 0.714
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.713
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.710
Drd2 dopamine receptor D2 0.688
Egfr epidermal growth factor receptor 0.688
Mapk8 mitogen-activated protein kinase 8 0.684
Gsk3b glycogen synthase kinase 3 beta 0.684
Lif leukemia inhibitory factor 0.678
Jag1 jagged 1 0.677
Apoe apolipoprotein E 0.676
Lef1 lymphoid enhancer binding factor 1 0.671
Tgfbr2 transforming growth factor, beta receptor II 0.667
Ptch1 patched homolog 1 0.666
Rarg retinoic acid receptor, gamma 0.665
Ccnd1 cyclin D1 0.651
Wt1 Wilms tumor 1 homolog 0.650
Mapk14 mitogen-activated protein kinase 14 0.649
Ch25h cholesterol 25-hydroxylase 0.647
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.647
Tcf4 transcription factor 4 0.646
Klf4 Kruppel-like factor 4 (gut) 0.644
Zeb1 zinc finger E-box binding homeobox 1 0.639
Egr1 early growth response 1 0.639
Wls wntless homolog (Drosophila) 0.632
Tcf3 transcription factor 3 0.631
Sox11 SRY-box containing gene 11 0.630
Ccr1 chemokine (C-C motif) receptor 1 0.627
Cxcl2 chemokine (C-X-C motif) ligand 2 0.622
Cdk4 cyclin-dependent kinase 4 0.622
Efnb2 ephrin B2 0.618
S1pr2 sphingosine-1-phosphate receptor 2 0.617
Dbp D site albumin promoter binding protein 0.617
Ret ret proto-oncogene 0.614
Inhba inhibin beta-A 0.610
Dok1 docking protein 1 0.607
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HYP2 Hyp2p 0.298
CDC53 Cdc53p 0.088
STI1 Sti1p 0.084
PBS2 Pbs2p 0.078
GUT2 Gut2p 0.077
DNM1 Dnm1p 0.069
SSA4 Ssa4p 0.065
EAF1 Eaf1p 0.065
HSL1 Hsl1p 0.062
CPR1 Cpr1p 0.062
SKP1 Skp1p 0.062
YLR257W hypothetical protein 0.061
PMT3 Pmt3p 0.059
PSP2 Psp2p 0.058
HAL5 Hal5p 0.051
NDE1 Nde1p 0.047
CDC37 Cdc37p 0.046
NPL3 Npl3p 0.046
UFO1 Ufo1p 0.046
HOS4 Hos4p 0.044
NBP2 Nbp2p 0.043
IKI1 Iki1p 0.043
TEF2 Tef2p 0.042
MEX67 Mex67p 0.042
ATG2 Atg2p 0.042
OCH1 Och1p 0.041
RPL10 Rpl10p 0.041
RTS1 Rts1p 0.041
RAD16 Rad16p 0.040
CDC34 Cdc34p 0.039
CCP1 Ccp1p 0.039
YRA1 Yra1p 0.038
AHP1 Ahp1p 0.038
ULA1 Ula1p 0.038
CAK1 Cak1p 0.038
SGE1 Sge1p 0.038
PTP2 Ptp2p 0.037
ATG18 Atg18p 0.037
COX15 Cox15p 0.037
IZH3 Izh3p 0.037
ALD6 Ald6p 0.037
ZDS1 Zds1p 0.037
UPS3 Ups3p 0.036
PET9 Pet9p 0.036
DCS2 Dcs2p 0.036
RPS6B Rps6bp 0.036
GAD1 Gad1p 0.036
ATG10 Atg10p 0.035
PCH2 Pch2p 0.035
YJR085C hypothetical protein 0.034
BDH1 Bdh1p 0.034
OLA1 Ola1p 0.033
SDH1 Sdh1p 0.033
TAX4 Tax4p 0.033
MAS1 Mas1p 0.033
YIR035C hypothetical protein 0.033
TEF1 Tef1p 0.033
EPL1 Epl1p 0.032
YPL088W hypothetical protein 0.032
COT1 Cot1p 0.032
MCD4 Mcd4p 0.032
EAF3 Eaf3p 0.032
STE7 Ste7p 0.032
HUG1 Hug1p 0.032
SCO2 Sco2p 0.031
ENT3 Ent3p 0.031
ALD3 Ald3p 0.031
SUT1 Sut1p 0.031
BRE5 Bre5p 0.030
DIA2 Dia2p 0.030
CAR1 Car1p 0.030
RNY1 Rny1p 0.030
SNT1 Snt1p 0.030
MCH5 Mch5p 0.030
QCR6 Qcr6p 0.030
SMA1 Sma1p 0.030
YKU70 Yku70p 0.030
THO2 Tho2p 0.030
UBP9 Ubp9p 0.030
PRS2 Prs2p 0.030
MDM32 Mdm32p 0.030
CMK1 Cmk1p 0.029
SMP1 Smp1p 0.029
REV7 Rev7p 0.029
GIC2 Gic2p 0.029
BFR1 Bfr1p 0.029
ECM30 Ecm30p 0.029
YLR162W hypothetical protein 0.029
BIT61 Bit61p 0.029
RPS1B Rps1bp 0.029
TPM1 Tpm1p 0.028
BEM3 Bem3p 0.028
SRD1 Srd1p 0.028
HOG1 Hog1p 0.028
SUI1 Sui1p 0.028
YJU3 Yju3p 0.028
RAD28 Rad28p 0.028
ROD1 Rod1p 0.028
HSP60 Hsp60p 0.028
LPP1 Lpp1p 0.028