The network for 't cell tolerance induction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell tolerance induction

A process involving any mechanism for tolerance induction in T cells.

Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 1.000
RT1-S3 RT1 class Ib, locus S3 0.703
Oas1a 2'-5' oligoadenylate synthetase 1A 0.691
RT1-CE12 RT1 class I, locus CE12 0.629
LOC100364500 RT1 class I, locus CE11-like 0.608
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.535
B2m beta-2 microglobulin 0.354
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.268
Dock8 dedicator of cytokinesis 8 0.240
RT1-M3-1 RT1 class Ib, locus M3, gene 1 0.209
Cybb cytochrome b-245, beta polypeptide 0.185
Ifi35 interferon-induced protein 35 0.152
RT1-N3 RT1 class Ib, locus N3 0.137
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.130
Cd4 Cd4 molecule 0.125
Yy1 YY1 transcription factor 0.120
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.115
Apol3 apolipoprotein L, 3 0.111
Hnf4a hepatocyte nuclear factor 4, alpha 0.110
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.101
Cxcl9 chemokine (C-X-C motif) ligand 9 0.101
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.097
Cd38 CD38 molecule 0.092
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.091
Capn5 calpain 5 0.086
Fgfr2 fibroblast growth factor receptor 2 0.085
RT1-CE5 RT1 class I, locus CE5 0.081
Calcrl calcitonin receptor-like 0.080
Casp1 caspase 1 0.079
LOC246267 resection-induced TPI (rs11) 0.078
Mmp12 matrix metallopeptidase 12 0.077
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.077
Ifi27 interferon, alpha-inducible protein 27 0.076
Il1r1 interleukin 1 receptor, type I 0.072
RT1-Cl RT1 class Ib, locus Cl 0.070
Mx1 myxovirus (influenza virus) resistance 1 0.067
Cxcl10 chemokine (C-X-C motif) ligand 10 0.061
RT1-A3 RT1 class I, locus A3 0.061
Tas1r3 taste receptor, type 1, member 3 0.060
Met met proto-oncogene 0.056
Ctsh cathepsin H 0.054
RGD1305793 similar to hypothetical protein FLJ20154 0.051
Man2b1 mannosidase, alpha, class 2B, member 1 0.049
Rtp4 receptor (chemosensory) transporter protein 4 0.048
Irf7 interferon regulatory factor 7 0.046
Mpeg1 macrophage expressed 1 0.046
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.046
Ahr aryl hydrocarbon receptor 0.046
Irf1 interferon regulatory factor 1 0.045
Pld1 phospholipase D1 0.042
LOC100364352 cytochrome P450, family 2, subfamily b, polypeptide 9-like 0.040
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.039
Gbp2 guanylate binding protein 2 0.039
Foxc2 forkhead box C2 0.039
Tgfbr2 transforming growth factor, beta receptor II 0.038
Ephx1 epoxide hydrolase 1, microsomal 0.037
Lck lymphocyte-specific protein tyrosine kinase 0.037
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.037
Il7 interleukin 7 0.037
Cyba cytochrome b-245, alpha polypeptide 0.037
Lgals5 lectin, galactose binding, soluble 5 0.037
Adora3 adenosine A3 receptor 0.036
Aif1 allograft inflammatory factor 1 0.035
Lgals9 lectin, galactoside-binding, soluble, 9 0.035
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.034
Ccl5 chemokine (C-C motif) ligand 5 0.034
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.033
Anpep alanyl (membrane) aminopeptidase 0.033
Ocln occludin 0.033
Ptch1 patched homolog 1 (Drosophila) 0.032
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.032
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.031
Tbxa2r thromboxane A2 receptor 0.031
Cst8 cystatin 8 (cystatin-related epididymal specific) 0.031
Dnase1l3 deoxyribonuclease 1-like 3 0.031
Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 0.031
Olr1082 olfactory receptor 1082 0.030
C2 complement component 2 0.030
Ednra endothelin receptor type A 0.030
Myo1a myosin IA 0.030
Bmp6 bone morphogenetic protein 6 0.029
Akr1c14 aldo-keto reductase family 1, member C14 0.029
Tapbp TAP binding protein 0.029
Galm galactose mutarotase (aldose 1-epimerase) 0.029
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.028
Cd247 Cd247 molecule 0.028
Olr837 olfactory receptor 837 0.028
Gpr116 G protein-coupled receptor 116 0.028
P2ry12 purinergic receptor P2Y, G-protein coupled, 12 0.027
Olr1346 olfactory receptor 1346 0.027
Gbp5 guanylate binding protein 5 0.027
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.027
RT1-M6-2 RT1 class I, locus M6, gene 2 0.027
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.026
Stat6 signal transducer and activator of transcription 6 0.026
Lifr leukemia inhibitory factor receptor alpha 0.026
Elf1 E74-like factor 1 0.025
Gstm2 glutathione S-transferase mu 2 0.025
RT1-CE2 RT1 class I, locus CE2 0.025
Mr1 major histocompatibility complex, class I-related 0.024
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-G major histocompatibility complex, class I, G 0.997
HLA-A major histocompatibility complex, class I, A 0.997
HLA-B major histocompatibility complex, class I, B 0.996
HLA-C major histocompatibility complex, class I, C 0.992
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.967
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.917
HLA-F major histocompatibility complex, class I, F 0.879
B2M beta-2-microglobulin 0.849
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.834
PILRA paired immunoglobin-like type 2 receptor alpha 0.730
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.690
HLA-E major histocompatibility complex, class I, E 0.567
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.463
SIGLEC7 sialic acid binding Ig-like lectin 7 0.415
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.292
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.239
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.221
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.209
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.151
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.116
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.099
TGFB1 transforming growth factor, beta 1 0.098
HK3 hexokinase 3 (white cell) 0.083
PTAFR platelet-activating factor receptor 0.078
SLC15A3 solute carrier family 15, member 3 0.065
TAPBP TAP binding protein (tapasin) 0.052
TGFB3 transforming growth factor, beta 3 0.051
AOAH acyloxyacyl hydrolase (neutrophil) 0.048
TYMP thymidine phosphorylase 0.046
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.044
CD80 CD80 molecule 0.043
CD247 CD247 molecule 0.041
CCR1 chemokine (C-C motif) receptor 1 0.039
SIRPB1 signal-regulatory protein beta 1 0.039
ENG endoglin 0.035
CD300C CD300c molecule 0.033
CA12 carbonic anhydrase XII 0.032
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.031
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.031
CFLAR CASP8 and FADD-like apoptosis regulator 0.031
TREM1 triggering receptor expressed on myeloid cells 1 0.029
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.029
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.026
CD33 CD33 molecule 0.026
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.026
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.025
NLRP3 NLR family, pyrin domain containing 3 0.025
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.025
SNX9 sorting nexin 9 0.025
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.025
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.025
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.024
FSTL1 follistatin-like 1 0.024
TAPBPL TAP binding protein-like 0.024
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.023
NOD2 nucleotide-binding oligomerization domain containing 2 0.022
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.022
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.021
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.020
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.020
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.020
TF transferrin 0.019
FCAR Fc fragment of IgA, receptor for 0.019
TPP1 tripeptidyl peptidase I 0.019
SNX18 sorting nexin 18 0.019
CD86 CD86 molecule 0.018
SIGLEC9 sialic acid binding Ig-like lectin 9 0.018
NCK2 NCK adaptor protein 2 0.018
ASGR2 asialoglycoprotein receptor 2 0.017
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 0.017
TLR8 toll-like receptor 8 0.016
HCP5 HLA complex P5 0.016
TMEM176A transmembrane protein 176A 0.016
PSAP prosaposin 0.016
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 0.016
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.015
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.015
TGFBR1 transforming growth factor, beta receptor 1 0.015
FPR2 formyl peptide receptor 2 0.015
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 0.015
VSIG4 V-set and immunoglobulin domain containing 4 0.015
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.014
PECAM1 platelet/endothelial cell adhesion molecule 0.014
MARCO macrophage receptor with collagenous structure 0.014
APOBR apolipoprotein B receptor 0.014
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.014
DPEP2 dipeptidase 2 0.013
RNASE3 ribonuclease, RNase A family, 3 0.013
CST3 cystatin C 0.013
FOLR3 folate receptor 3 (gamma) 0.013
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.013
USP38 ubiquitin specific peptidase 38 0.013
SIRPA signal-regulatory protein alpha 0.013
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.013
BEST1 bestrophin 1 0.013
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.013
SIGLEC5 sialic acid binding Ig-like lectin 5 0.012
P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 0.012
EPOR erythropoietin receptor 0.012
HFE hemochromatosis 0.012
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Mus musculus
Name Description Probability Func Analog Organism
Tgfbr1 transforming growth factor, beta receptor I 0.743
H2-D1 histocompatibility 2, D region locus 1 0.492
Tgfbr2 transforming growth factor, beta receptor II 0.448
Apc adenomatosis polyposis coli 0.380
Shc1 src homology 2 domain-containing transforming protein C1 0.300
B2m beta-2 microglobulin 0.300
Smad4 MAD homolog 4 (Drosophila) 0.218
H2-Q7 histocompatibility 2, Q region locus 7 0.172
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.142
Smad6 MAD homolog 6 (Drosophila) 0.142
Rac1 RAS-related C3 botulinum substrate 1 0.132
Acvr1 activin A receptor, type 1 0.123
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.079
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.072
Smad3 MAD homolog 3 (Drosophila) 0.069
Stat3 signal transducer and activator of transcription 3 0.068
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.065
Cdh5 cadherin 5 0.058
Lat linker for activation of T cells 0.055
Cyld cylindromatosis (turban tumor syndrome) 0.055
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.054
Ece1 endothelin converting enzyme 1 0.053
Bmpr1a bone morphogenetic protein receptor, type 1A 0.050
Bptf bromodomain PHD finger transcription factor 0.048
Rnf11 ring finger protein 11 0.041
Grb10 growth factor receptor bound protein 10 0.037
Tgfbr3 transforming growth factor, beta receptor III 0.037
Smad7 MAD homolog 7 (Drosophila) 0.034
Itk IL2-inducible T-cell kinase 0.033
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.024
Eng endoglin 0.024
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.023
Prkg1 protein kinase, cGMP-dependent, type I 0.020
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.019
Il6st interleukin 6 signal transducer 0.019
Foxp2 forkhead box P2 0.018
Cd28 CD28 antigen 0.018
Tgfb2 transforming growth factor, beta 2 0.017
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.017
Cd6 CD6 antigen 0.016
Grb2 growth factor receptor bound protein 2 0.016
Cd3e CD3 antigen, epsilon polypeptide 0.016
Fyn Fyn proto-oncogene 0.015
Il2rg interleukin 2 receptor, gamma chain 0.015
Cd8a CD8 antigen, alpha chain 0.015
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.015
Irf1 interferon regulatory factor 1 0.014
Foxp1 forkhead box P1 0.014
Smad1 MAD homolog 1 (Drosophila) 0.014
Batf basic leucine zipper transcription factor, ATF-like 0.014
Tmem64 transmembrane protein 64 0.013
Ar androgen receptor 0.013
Cd8b1 CD8 antigen, beta chain 1 0.013
Bmp2 bone morphogenetic protein 2 0.013
Tcra T-cell receptor alpha chain 0.013
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.012
Sox9 SRY-box containing gene 9 0.012
H2-Q8 histocompatibility 2, Q region locus 8 0.012
Cd19 CD19 antigen 0.012
Lck lymphocyte protein tyrosine kinase 0.012
Xiap X-linked inhibitor of apoptosis 0.012
Kiss1 KiSS-1 metastasis-suppressor 0.012
Hipk3 homeodomain interacting protein kinase 3 0.011
Il2rb interleukin 2 receptor, beta chain 0.011
Cflar CASP8 and FADD-like apoptosis regulator 0.011
Zap70 zeta-chain (TCR) associated protein kinase 0.011
Flt1 FMS-like tyrosine kinase 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism