The network for 'g1 s transition of mitotic cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

g1 s transition of mitotic cell cycle

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.

Danio rerio
Name Description Probability Func Analog Organism
itgb1b.2 integrin, beta 1b.2 0.669
ccnd1 cyclin D1 0.597
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.558
tp53 tumor protein p53 0.502
itgb1a integrin, beta 1a 0.499
gli2a GLI-Kruppel family member GLI2a 0.496
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.435
zff9 zinc finger protein 9 0.293
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.259
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.259
hoxd4a homeo box D4a 0.245
rbb4 retinoblastoma binding protein 4 0.207
igf1rb insulin-like growth factor 1b receptor 0.191
cfl2l cofilin 2, like 0.190
ndr1 nodal-related 1 0.189
anxa1b annexin A1b 0.186
smad9 MAD homolog 9 (Drosophila) 0.172
myca myelocytomatosis oncogene a 0.166
nutf2l nuclear transport factor 2, like 0.164
arl4ab ADP-ribosylation factor-like 4ab 0.160
orc6 origin recognition complex, subunit 6 0.158
wu:fb76c12 wu:fb76c12 0.158
fabp11a fatty acid binding protein 11a 0.154
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.154
zgc:110113 zgc:110113 0.145
klf2a Kruppel-like factor 2a 0.142
stmn1b stathmin 1b 0.141
fancd2 Fanconi anemia, complementation group D2 0.141
olig4 oligodendrocyte transcription factor 4 0.139
gro2 groucho 2 0.136
zgc:165373 zgc:165373 0.133
dtl denticleless homolog (Drosophila) 0.128
LOC100150924 DNA polymerase subunit gamma-1-like 0.126
tal1 T-cell acute lymphocytic leukemia 1 0.120
ccna2 cyclin A2 0.119
smyhc1 slow myosin heavy chain 1 0.118
ndnl2 necdin-like 2 0.115
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.114
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.111
boc brother of CDO 0.109
ass1 argininosuccinate synthetase 1 0.107
itgb1b integrin, beta 1b 0.105
gata3 GATA-binding protein 3 0.105
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.102
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.100
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.098
tipin timeless interacting protein 0.096
akirin1 akirin 1 0.096
ca15b carbonic anhydrase XV b 0.095
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.094
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.092
gro1 groucho 1 0.090
ptgs2a prostaglandin-endoperoxide synthase 2a 0.090
LOC566708 FL cytokine receptor-like 0.089
nrg1 neuregulin 1 0.087
rpa3 replication protein A3 0.087
hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 0.087
LOC100151531 zinc finger protein Gfi-1b-like 0.086
gsna gelsolin a 0.085
tgfb1a transforming growth factor, beta 1a 0.084
pld1a phospholipase D1a 0.082
mcmbp minichromosome maintenance complex binding protein 0.082
stc1l stanniocalcin 1, like 0.081
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.080
g3bp1 GTPase activating protein (SH3 domain) binding protein 1 0.080
twist1a twist1a 0.080
gmnn geminin, DNA replication inhibitor 0.080
notch1b notch homolog 1b 0.079
ppargc1al peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like 0.079
dag1 dystroglycan 1 0.078
zgc:92061 zgc:92061 0.078
tbpl2 TATA box binding protein like 2 0.078
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.077
gata1a GATA binding protein 1a 0.076
si:dkeyp-113d7.7 si:dkeyp-113d7.7 0.076
icn2 ictacalcin 2 0.074
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.074
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.074
rnf2 ring finger protein 2 0.073
tshb thyroid stimulating hormone, beta subunit 0.073
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.073
btg2 B-cell translocation gene 2 0.073
cdt1 chromatin licensing and DNA replication factor 1 0.072
vps26a vacuolar protein sorting 26 homolog A (yeast) 0.072
gtf2b general transcription factor IIB 0.072
zgc:65979 zgc:65979 0.072
mstna myostatin a 0.071
igfbp6a insulin-like growth factor binding protein 6a 0.071
dzip1 DAZ interacting protein 1 0.070
ccnt2a cyclin T2a 0.070
igfbp3 insulin-like growth factor binding protein 3 0.069
dlc deltaC 0.069
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.069
zgc:110434 zgc:110434 0.069
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.068
sox3 SRY-box containing gene 3 0.068
si:ch211-215h6.2 si:ch211-215h6.2 0.068
fabp7a fatty acid binding protein 7, brain, a 0.067
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.067
fam84a family with sequence similarity 84, member A 0.067
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cul-2 Protein CUL-2 0.040
lig-1 Protein LIG-1 0.035
ced-9 Protein CED-9 0.030
egl-18 Protein EGL-18 0.030
let-60 Protein LET-60 0.027
swsn-7 Protein SWSN-7 0.026
sli-1 Protein SLI-1 0.025
csn-5 Protein CSN-5 0.024
prp-8 Protein PRP-8 0.024
K03H4.2 Protein K03H4.2 0.024
pha-4 Protein PHA-4 0.024
K02A11.3 Protein K02A11.3 0.023
kin-29 Protein KIN-29 0.023
trr-1 Protein TRR-1 0.023
apc-2 Protein APC-2 0.023
CELE_C24H12.5 Protein C24H12.5 0.023
air-1 Protein AIR-1 0.023
R05D3.2 Protein R05D3.2 0.022
Y71H2B.2 Protein Y71H2B.2 0.021
F37C4.5 Protein F37C4.5 0.021
rpl-16 Protein RPL-16 0.021
mix-1 Protein MIX-1 0.021
plc-3 Protein PLC-3 0.020
ZK524.4 Protein ZK524.4 0.020
cyn-15 Protein CYN-15 0.020
sel-12 Protein SEL-12 0.020
R02F11.4 Protein R02F11.4 0.020
zyg-11 Protein ZYG-11 0.020
Y44E3A.6 Protein Y44E3A.6 0.020
atg-18 Protein ATG-18 0.020
ifg-1 Protein IFG-1 0.020
Y17G7B.17 Protein Y17G7B.17 0.019
lin-12 Protein LIN-12 0.019
flt-1 Protein FLT-1 0.019
daf-21 Protein DAF-21 0.019
sig-7 Protein SIG-7 0.019
xpo-1 Protein XPO-1 0.019
F31C3.3 Protein F31C3.3 0.019
fox-1 Protein FOX-1 0.019
cdc-25.1 Protein CDC-25.1 0.019
mcm-7 Protein MCM-7 0.018
mcm-2 Protein MCM-2 0.018
C34F6.9 Protein C34F6.9 0.018
CELE_F25B4.5 Protein F25B4.5 0.018
elc-1 Protein ELC-1 0.018
ran-1 Protein RAN-1 0.018
T22C1.1 Protein T22C1.1 0.018
zim-1 Protein ZIM-1 0.018
npp-8 Protein NPP-8 0.018
bet-1 Protein BET-1 0.018
F59E12.1 Protein F59E12.1 0.018
K10C3.4 Protein K10C3.4 0.018
F39G3.3 Protein F39G3.3 0.018
top-2 Protein TOP-2 0.018
sel-8 Protein SEL-8 0.018
snfc-5 Protein SNFC-5 0.017
hmg-4 Protein HMG-4 0.017
glp-1 Protein GLP-1 0.017
rfc-4 Protein RFC-4 0.017
icp-1 Protein ICP-1 0.017
eef-1G Protein EEF-1G 0.017
vab-1 Protein VAB-1 0.017
W08E3.2 Protein W08E3.2 0.017
gon-2 Protein GON-2 0.017
ulp-2 Protein ULP-2 0.017
pisy-1 Protein PISY-1 0.017
F58G11.3 Protein F58G11.3 0.017
dsh-2 Protein DSH-2 0.017
cfim-2 Protein CFIM-2 0.017
pbrm-1 Protein PBRM-1 0.017
cdt-1 Protein CDT-1 0.017
CELE_C50B6.3 Protein C50B6.3 0.017
cpb-1 Protein CPB-1 0.016
hcf-1 Protein HCF-1 0.016
tam-1 Protein TAM-1 0.016
mel-28 Protein MEL-28 0.016
gla-3 Protein GLA-3 0.016
hsp-43 Protein HSP-43 0.016
attf-2 Protein ATTF-2 0.016
F25H5.8 Protein F25H5.8 0.016
rpn-2 Protein RPN-2 0.016
hcp-6 Protein HCP-6 0.016
vps-26 Protein VPS-26 0.016
CELE_W05H9.2 Protein W05H9.2 0.016
K07E3.2 Protein K07E3.2 0.016
nhr-69 Protein NHR-69 0.016
swsn-4 Protein SWSN-4 0.016
T18D3.1 Protein T18D3.1 0.016
F33H2.3 Protein F33H2.3 0.016
panl-2 Protein PANL-2 0.016
trim-9 Protein TRIM-9 0.016
R05D11.9 Protein R05D11.9 0.016
C35C5.3 Protein C35C5.3 0.016
npp-1 Protein NPP-1 0.016
mom-2 Protein MOM-2 0.016
plk-1 Protein PLK-1 0.016
scc-3 Protein SCC-3 0.016
ttm-1 Protein TTM-1 0.016
swsn-3 Protein SWSN-3 0.016
asd-1 Protein ASD-1 0.016
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rbf Retinoblastoma-family protein 0.929
Ras85D Ras oncogene at 85D 0.746
dap dacapo 0.674
Akt1 CG4006 gene product from transcript CG4006-RA 0.597
shn schnurri 0.433
Mad Mothers against dpp 0.369
gig gigas 0.349
Pten CG5671 gene product from transcript CG5671-RB 0.307
Stat92E Signal-transducer and activator of transcription protein at 92E 0.295
Pk61C Protein kinase 61C 0.263
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.247
phl pole hole 0.231
cdc2c CG10498 gene product from transcript CG10498-RC 0.218
Dp DP transcription factor 0.210
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.187
EcR Ecdysone receptor 0.187
tkv thickveins 0.178
osa CG7467 gene product from transcript CG7467-RD 0.167
yki yorkie 0.160
heph hephaestus 0.157
Myd88 CG2078 gene product from transcript CG2078-RA 0.155
CycA Cyclin A 0.124
ci cubitus interruptus 0.119
Cdk4 Cyclin-dependent kinase 4 0.115
rap retina aberrant in pattern 0.106
CSN8 COP9 complex homolog subunit 8 0.093
Pabp2 CG2163 gene product from transcript CG2163-RA 0.089
RASSF8 CG5053 gene product from transcript CG5053-RA 0.085
Rab11 Rab-protein 11 0.084
hep hemipterous 0.083
CycB Cyclin B 0.080
dm diminutive 0.080
Mer Merlin 0.079
bel belle 0.075
kay kayak 0.075
jub Ajuba LIM protein 0.073
spen split ends 0.069
Tao-1 CG14217 gene product from transcript CG14217-RF 0.065
MED6 Mediator complex subunit 6 0.062
l(1)dd4 lethal (1) discs degenerate 4 0.061
p53 CG33336 gene product from transcript CG33336-RB 0.060
RecQ4 CG7487 gene product from transcript CG7487-RA 0.059
caz cabeza 0.056
Smr Smrter 0.056
cnk connector enhancer of ksr 0.052
Tsc1 CG6147 gene product from transcript CG6147-RA 0.052
mip120 Myb-interacting protein 120 0.051
myoglianin CG1838 gene product from transcript CG1838-RD 0.050
HmgD High mobility group protein D 0.050
Med Medea 0.049
Psf2 CG18013 gene product from transcript CG18013-RA 0.049
Map60 Microtubule-associated protein 60 0.049
CG9339 CG9339 gene product from transcript CG9339-RG 0.049
gek genghis khan 0.048
CycD Cyclin D 0.048
brm brahma 0.047
MED17 Mediator complex subunit 17 0.047
Rm62 CG10279 gene product from transcript CG10279-RD 0.045
Mes2 CG11100 gene product from transcript CG11100-RB 0.044
CycG Cyclin G 0.043
imd immune deficiency 0.043
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.043
Atf6 CG3136 gene product from transcript CG3136-RA 0.042
SAK Sak kinase 0.042
sd scalloped 0.042
wdb widerborst 0.041
CycE Cyclin E 0.041
pie pineapple eye 0.041
emb embargoed 0.040
skd skuld 0.040
kto kohtalo 0.040
gbb glass bottom boat 0.039
Sfmbt Scm-related gene containing four mbt domains 0.039
Rac1 CG2248 gene product from transcript CG2248-RA 0.039
Fs(2)Ket Female sterile (2) Ketel 0.039
pan pangolin 0.039
fdl fused lobes 0.039
CG4400 CG4400 gene product from transcript CG4400-RA 0.038
asf1 anti-silencing factor 1 0.038
CG9772 CG9772 gene product from transcript CG9772-RB 0.038
hpo hippo 0.036
growl CG14648 gene product from transcript CG14648-RA 0.035
Pc Polycomb 0.035
Cbl CG7037 gene product from transcript CG7037-RB 0.034
Mcm3 Minichromosome maintenance 3 0.034
brat brain tumor 0.034
CtBP C-terminal Binding Protein 0.034
Tor Target of rapamycin 0.034
simj simjang 0.033
cdc2 CG5363 gene product from transcript CG5363-RA 0.033
eIF4AIII CG7483 gene product from transcript CG7483-RA 0.033
MED26 Mediator complex subunit 26 0.033
pic piccolo 0.033
RnrL Ribonucleoside diphosphate reductase large subunit 0.032
emc extra macrochaetae 0.032
e(y)3 enhancer of yellow 3 0.032
Snoo Sno oncogene 0.031
cdm cadmus 0.031
ago archipelago 0.031
mad2 CG17498 gene product from transcript CG17498-RA 0.031
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Homo sapiens
Name Description Probability Func Analog Organism
CDK2 cyclin-dependent kinase 2 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 1.000
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.999
RB1 retinoblastoma 1 0.999
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.981
RBL2 retinoblastoma-like 2 (p130) 0.975
E2F1 E2F transcription factor 1 0.967
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.963
NOTCH1 notch 1 0.960
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.936
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.919
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.909
FGFR2 fibroblast growth factor receptor 2 0.891
YY1 YY1 transcription factor 0.886
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.886
CDK6 cyclin-dependent kinase 6 0.867
JAG1 jagged 1 0.852
SKP1 S-phase kinase-associated protein 1 0.846
RBL1 retinoblastoma-like 1 (p107) 0.822
CCND1 cyclin D1 0.804
SKP2 S-phase kinase-associated protein 2 (p45) 0.768
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.699
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.684
EGFR epidermal growth factor receptor 0.654
CCNA2 cyclin A2 0.651
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.642
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.590
SMAD7 SMAD family member 7 0.573
CUL1 cullin 1 0.552
EIF4E eukaryotic translation initiation factor 4E 0.534
INADL InaD-like (Drosophila) 0.515
NCOA1 nuclear receptor coactivator 1 0.512
CDK4 cyclin-dependent kinase 4 0.508
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.482
CREBBP CREB binding protein 0.479
CCND3 cyclin D3 0.470
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.454
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.453
TFDP1 transcription factor Dp-1 0.448
FBXW11 F-box and WD repeat domain containing 11 0.436
CDK1 cyclin-dependent kinase 1 0.415
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.398
E2F7 E2F transcription factor 7 0.390
E2F8 E2F transcription factor 8 0.389
CKS1B CDC28 protein kinase regulatory subunit 1B 0.386
BCL2 B-cell CLL/lymphoma 2 0.374
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.368
NXF1 nuclear RNA export factor 1 0.363
EP300 E1A binding protein p300 0.359
BTRC beta-transducin repeat containing 0.359
GSK3B glycogen synthase kinase 3 beta 0.350
E2F4 E2F transcription factor 4, p107/p130-binding 0.349
FASLG Fas ligand (TNF superfamily, member 6) 0.348
FAS Fas (TNF receptor superfamily, member 6) 0.344
IER3 immediate early response 3 0.342
XIAP X-linked inhibitor of apoptosis 0.340
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.333
FGFR1 fibroblast growth factor receptor 1 0.333
TP53 tumor protein p53 0.332
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.331
ABI2 abl-interactor 2 0.331
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.331
CCNE1 cyclin E1 0.322
FKBP1A FK506 binding protein 1A, 12kDa 0.309
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.305
MCM2 minichromosome maintenance complex component 2 0.305
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.303
SETD7 SET domain containing (lysine methyltransferase) 7 0.288
BCOR BCL6 corepressor 0.282
APAF1 apoptotic peptidase activating factor 1 0.270
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.259
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.247
HEXIM1 hexamethylene bis-acetamide inducible 1 0.245
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.243
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 0.243
LIN9 lin-9 homolog (C. elegans) 0.241
STK38L serine/threonine kinase 38 like 0.234
DDB1 damage-specific DNA binding protein 1, 127kDa 0.234
PRNP prion protein 0.232
CDT1 chromatin licensing and DNA replication factor 1 0.226
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.225
POU3F2 POU class 3 homeobox 2 0.222
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.217
AHR aryl hydrocarbon receptor 0.211
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.210
CDK9 cyclin-dependent kinase 9 0.203
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.199
RYBP RING1 and YY1 binding protein 0.197
CNOT8 CCR4-NOT transcription complex, subunit 8 0.192
RUNX1 runt-related transcription factor 1 0.190
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.186
ARID1B AT rich interactive domain 1B (SWI1-like) 0.184
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.183
HBP1 HMG-box transcription factor 1 0.182
PRKCZ protein kinase C, zeta 0.177
MCM7 minichromosome maintenance complex component 7 0.176
FOXM1 forkhead box M1 0.175
KEAP1 kelch-like ECH-associated protein 1 0.175
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.169
BMP2 bone morphogenetic protein 2 0.166
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Rb1 retinoblastoma 1 0.998
E2f1 E2F transcription factor 1 0.992
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.983
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.976
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.922
Mdm2 transformed mouse 3T3 cell double minute 2 0.882
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.862
Nf1 neurofibromatosis 1 0.855
Id1 inhibitor of DNA binding 1 0.843
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.834
Bax BCL2-associated X protein 0.823
Notch1 Notch gene homolog 1 (Drosophila) 0.771
Mdm4 transformed mouse 3T3 cell double minute 4 0.742
Arid1b AT rich interactive domain 1B (SWI-like) 0.740
Pcna proliferating cell nuclear antigen 0.649
Cdk4 cyclin-dependent kinase 4 0.637
Jarid2 jumonji, AT rich interactive domain 2 0.626
Pten phosphatase and tensin homolog 0.610
Bcl2 B-cell leukemia/lymphoma 2 0.596
Tgfb2 transforming growth factor, beta 2 0.596
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.586
Ccne1 cyclin E1 0.555
Skil SKI-like 0.553
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.536
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.533
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.516
Tcf3 transcription factor 3 0.513
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.482
Kit kit oncogene 0.475
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.461
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.439
Gli3 GLI-Kruppel family member GLI3 0.420
Apc adenomatosis polyposis coli 0.403
Meox2 mesenchyme homeobox 2 0.398
Cdk2 cyclin-dependent kinase 2 0.374
Psen1 presenilin 1 0.369
Trp63 transformation related protein 63 0.369
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.358
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.354
Ccna2 cyclin A2 0.345
Braf Braf transforming gene 0.344
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.340
Igh immunoglobulin heavy chain complex 0.336
Fgfr1 fibroblast growth factor receptor 1 0.332
Cd80 CD80 antigen 0.324
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.321
Socs1 suppressor of cytokine signaling 1 0.312
Plk1 polo-like kinase 1 (Drosophila) 0.298
Cdk1 cyclin-dependent kinase 1 0.297
Ctnnb1 catenin (cadherin associated protein), beta 1 0.295
Ptch1 patched homolog 1 0.290
Ccnd2 cyclin D2 0.287
Rara retinoic acid receptor, alpha 0.284
Ube2c ubiquitin-conjugating enzyme E2C 0.282
Brca1 breast cancer 1 0.260
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.259
Aurka aurora kinase A 0.249
Smad5 MAD homolog 5 (Drosophila) 0.249
Ret ret proto-oncogene 0.243
Hes1 hairy and enhancer of split 1 (Drosophila) 0.241
Msh2 mutS homolog 2 (E. coli) 0.236
Cdk6 cyclin-dependent kinase 6 0.235
Bmpr1a bone morphogenetic protein receptor, type 1A 0.232
Birc5 baculoviral IAP repeat-containing 5 0.229
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.218
Id3 inhibitor of DNA binding 3 0.212
Bmp4 bone morphogenetic protein 4 0.210
Brca2 breast cancer 2 0.204
Tcf4 transcription factor 4 0.202
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.198
Nbn nibrin 0.198
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.197
Sox9 SRY-box containing gene 9 0.192
Klf3 Kruppel-like factor 3 (basic) 0.190
Arid1a AT rich interactive domain 1A (SWI-like) 0.187
Ccnd1 cyclin D1 0.179
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.178
Anxa5 annexin A5 0.178
Ccnf cyclin F 0.171
Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a 0.169
Gtse1 G two S phase expressed protein 1 0.161
Daxx Fas death domain-associated protein 0.160
S100a11 S100 calcium binding protein A11 (calgizzarin) 0.145
Mybl2 myeloblastosis oncogene-like 2 0.145
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.144
Vhl von Hippel-Lindau tumor suppressor 0.144
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.143
Sox4 SRY-box containing gene 4 0.140
Ccnb2 cyclin B2 0.137
Cbl Casitas B-lineage lymphoma 0.135
Itga3 integrin alpha 3 0.134
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.133
Smad1 MAD homolog 1 (Drosophila) 0.133
Rpgrip1l Rpgrip1-like 0.131
Cdt1 chromatin licensing and DNA replication factor 1 0.130
Thbs1 thrombospondin 1 0.127
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.126
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.124
Lgals3 lectin, galactose binding, soluble 3 0.124
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Top2a topoisomerase (DNA) II alpha 0.546
Ccnd1 cyclin D1 0.085
Rrm2 ribonucleotide reductase M2 0.084
Cdk4 cyclin-dependent kinase 4 0.070
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.059
Cntn3 contactin 3 (plasmacytoma associated) 0.059
Tubb5 tubulin, beta 5 0.038
Cct4 chaperonin containing Tcp1, subunit 4 (delta) 0.037
Cdk2 cyclin dependent kinase 2 0.034
Usf2 upstream transcription factor 2, c-fos interacting 0.031
Mki67 antigen identified by monoclonal antibody Ki-67 0.030
Casp7 caspase 7 0.029
Kif2c kinesin family member 2C 0.028
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.028
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.027
Tmpo thymopoietin 0.027
Melk maternal embryonic leucine zipper kinase 0.026
Smad2 SMAD family member 2 0.026
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.025
Dnah2 dynein, axonemal, heavy chain 2 0.024
Oprm1 opioid receptor, mu 1 0.024
Casp2 caspase 2 0.024
Lmnb1 lamin B1 0.023
Prkce protein kinase C, epsilon 0.023
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.022
Cdkn3 cyclin-dependent kinase inhibitor 3 0.021
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.021
Sept11 septin 11 0.021
Pttg1 pituitary tumor-transforming 1 0.021
Tcf4 transcription factor 4 0.020
Apba3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.020
Tcfe2a transcription factor E2a 0.020
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.019
Ccnd3 cyclin D3 0.019
Xpo1 exportin 1, CRM1 homolog (yeast) 0.018
Cdk1 cyclin-dependent kinase 1 0.018
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.018
Kifc1 kinesin family member C1 0.018
Mapk3 mitogen activated protein kinase 3 0.018
Fgfr1 Fibroblast growth factor receptor 1 0.018
Csda cold shock domain protein A 0.018
Supt16h suppressor of Ty 16 homolog (S. cerevisiae) 0.017
Cbfb core-binding factor, beta subunit 0.017
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.017
Rln1 relaxin 1 0.017
Nup88 nucleoporin 88 0.017
Caprin1 cell cycle associated protein 1 0.017
Eif1ay eukaryotic translation initiation factor 1A, Y-linked 0.017
Zfand6 zinc finger, AN1-type domain 6 0.016
Mcm6 minichromosome maintenance complex component 6 0.016
Traf4af1 TRAF4 associated factor 1 0.016
Olr837 olfactory receptor 837 0.015
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.015
Ube2c ubiquitin-conjugating enzyme E2C 0.015
Ccnb1 cyclin B1 0.015
Hck hemopoietic cell kinase 0.014
Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.014
Nusap1 nucleolar and spindle associated protein 1 0.014
Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.014
Ryk receptor-like tyrosine kinase 0.014
Aspm asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.014
Hnrpd heterogeneous nuclear ribonucleoprotein D 0.013
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.013
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.013
Kif22 kinesin family member 22 0.013
Mbtps1 membrane-bound transcription factor peptidase, site 1 0.013
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.012
Hist1h1a histone cluster 1, H1a 0.012
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.012
Racgap1 Rac GTPase-activating protein 1 0.012
Parp1 poly (ADP-ribose) polymerase 1 0.011
Ctnna1 catenin (cadherin associated protein), alpha 1 0.011
Cdca3 cell division cycle associated 3 0.011
Fgf14 fibroblast growth factor 14 0.011
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.011
Iqgap1 IQ motif containing GTPase activating protein 1 0.011
Rgs19 regulator of G-protein signaling 19 0.011
Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.011
Svs4 seminal vesicle secretory protein 4 0.011
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.011
Prc1 protein regulator of cytokinesis 1 0.011
Igf2r insulin-like growth factor 2 receptor 0.011
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.010
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.010
Myh9 myosin, heavy chain 9, non-muscle 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC28 Cdc28p 0.930
SIC1 Sic1p 0.727
CKS1 Cks1p 0.706
CDC4 Cdc4p 0.681
HHO1 Hho1p 0.647
RSC4 Rsc4p 0.611
MSA1 Msa1p 0.607
SWI6 Swi6p 0.594
CLN1 Cln1p 0.569
SWI5 Swi5p 0.567
CLB5 Clb5p 0.562
CDC14 Cdc14p 0.520
SIT4 Sit4p 0.509
PPH22 Pph22p 0.458
RTF1 Rtf1p 0.453
WHI5 Whi5p 0.445
SWI4 Swi4p 0.435
CLN2 Cln2p 0.434
CDC34 Cdc34p 0.426
MSA2 Msa2p 0.390
FKH2 Fkh2p 0.341
MIG1 Mig1p 0.333
TIF4632 Tif4632p 0.286
ADR1 Adr1p 0.286
HIR2 Hir2p 0.277
CLN3 Cln3p 0.274
TAF6 Taf6p 0.270
RTG3 Rtg3p 0.264
CLB3 Clb3p 0.262
PPH21 Pph21p 0.250
NUP157 Nup157p 0.246
HST3 Hst3p 0.241
CDC6 Cdc6p 0.219
CLB2 Clb2p 0.218
NRM1 Nrm1p 0.210
TPD3 Tpd3p 0.202
CLB6 Clb6p 0.192
GIN4 Gin4p 0.190
SKP1 Skp1p 0.186
YPL014W hypothetical protein 0.181
SIP2 Sip2p 0.181
SWI3 Swi3p 0.171
MIG2 Mig2p 0.169
MBP1 Mbp1p 0.169
CLB1 Clb1p 0.169
RTS3 Rts3p 0.168
PPH3 Pph3p 0.162
PSF1 Psf1p 0.162
ARP8 Arp8p 0.161
SPT16 Spt16p 0.160
TOR1 Tor1p 0.148
SLD2 Sld2p 0.147
IES1 Ies1p 0.143
TOR2 Tor2p 0.142
DSE3 Dse3p 0.140
IES3 Ies3p 0.139
HTB2 Htb2p 0.133
CKA1 Cka1p 0.130
LTE1 Lte1p 0.128
NET1 Net1p 0.127
FKH1 Fkh1p 0.121
HIR1 Hir1p 0.118
MSN4 Msn4p 0.117
NDD1 Ndd1p 0.114
SAK1 Sak1p 0.114
SPC98 Spc98p 0.114
AFT1 Aft1p 0.113
MUS81 Mus81p 0.110
CDC53 Cdc53p 0.107
GIC1 Gic1p 0.106
MCM1 Mcm1p 0.104
MOT1 Mot1p 0.102
STP4 Stp4p 0.099
HAL5 Hal5p 0.099
SPT5 Spt5p 0.098
PTK2 Ptk2p 0.098
CRZ1 Crz1p 0.097
NRG1 Nrg1p 0.097
KSP1 Ksp1p 0.096
HXT3 Hxt3p 0.095
CSR2 Csr2p 0.092
SPT15 Spt15p 0.091
KCC4 Kcc4p 0.091
KIN1 Kin1p 0.091
SET2 Set2p 0.090
RSC2 Rsc2p 0.089
VID24 Vid24p 0.089
SKS1 Sks1p 0.088
SAP190 Sap190p 0.088
RSC8 Rsc8p 0.087
PSK1 Psk1p 0.086
MCM3 Mcm3p 0.086
SFG1 Sfg1p 0.084
LYS5 Lys5p 0.084
SEF1 Sef1p 0.083
PSP2 Psp2p 0.081
AIM20 Aim20p 0.077
SWI1 Swi1p 0.077
YLR455W hypothetical protein 0.076
YRR1 Yrr1p 0.076