The network for 'retinoic acid receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

retinoic acid receptor signaling pathway

The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands.

Danio rerio
Name Description Probability Func Analog Organism
rxraa retinoid X receptor, alpha a 0.891
pparg peroxisome proliferator activated receptor gamma 0.802
raraa retinoic acid receptor, alpha a 0.770
dlc deltaC 0.650
crabp2a cellular retinoic acid binding protein 2, a 0.646
etv5b ets variant 5b 0.603
fabp2 fatty acid binding protein 2, intestinal 0.572
gata5 GATA-binding protein 5 0.433
gli2a GLI-Kruppel family member GLI2a 0.348
rxrga retinoid x receptor, gamma a 0.315
cdx4 caudal type homeo box transcription factor 4 0.218
pou1f1 POU domain, class 1, transcription factor 1 0.192
hoxb1b homeo box B1b 0.187
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.187
nr1d2b nuclear receptor subfamily 1, group D, member 2b 0.183
fabp11a fatty acid binding protein 11a 0.172
kctd15a potassium channel tetramerisation domain containing 15a 0.169
tm4sf4 transmembrane 4 L six family member 4 0.163
dct dopachrome tautomerase 0.155
nrp2b neuropilin 2b 0.154
rxrba retinoid x receptor, beta a 0.150
mtp microsomal triglyceride transfer protein 0.136
fgfr2 fibroblast growth factor receptor 2 0.127
axin2 axin 2 (conductin, axil) 0.115
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.109
lfng lunatic fringe homolog 0.107
tgif1 TGFB-induced factor homeobox 1 0.092
LOC795916 mucolipin-1-like 0.088
sox11a SRY-box containing gene 11a 0.084
rarab retinoic acid receptor, alpha b 0.083
pvrl1a poliovirus receptor-related 1a 0.080
ptbp2 polypyrimidine tract binding protein 2 0.079
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.078
fzd7a frizzled homolog 7a 0.076
esr2b estrogen receptor 2b 0.074
tcf12 transcription factor 12 0.073
tead3a TEA domain family member 3 a 0.071
fabp1b.1 fatty acid binding protein 1b, tandem duplicate 1 0.069
rdh10a retinol dehydrogenase 10a 0.069
fabp3 fatty acid binding protein 3, muscle and heart 0.069
rxrab retinoid x receptor, alpha b 0.068
meis2.1 myeloid ecotropic viral integration site 2.1 0.067
rxrgb retinoid X receptor, gamma b 0.067
sox9a SRY-box containing gene 9a 0.067
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.064
tp53 tumor protein p53 0.063
prdm5 PR domain containing 5 0.063
gng13a guanine nucleotide binding protein (G protein), gamma 13a 0.061
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.061
fzd7b frizzled homolog 7b 0.059
znf703 zinc finger protein 703 0.059
sox17 SRY-box containing gene 17 0.059
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.059
hdac4 histone deacetylase 4 0.059
ncor2 nuclear receptor co-repressor 2 0.058
gamt guanidinoacetate N-methyltransferase 0.058
ntn1a netrin 1a 0.058
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.056
ldb1a LIM-domain binding factor 1a 0.055
rassf1 Ras association (RalGDS/AF-6) domain family 1 0.052
sox19a SRY-box containing gene 19a 0.052
nr1i2 nuclear receptor subfamily 1, group I, member 2 0.052
ryr3 ryanodine receptor 3 0.052
caprin1a cell cycle associated protein 1a 0.051
fgf8a fibroblast growth factor 8 a 0.051
sema3aa semaphorin 3aa 0.050
fsta follistatin a 0.049
pcdh18b protocadherin 18b 0.049
mab21l2 mab-21-like 2 0.049
cnot6 CCR4-NOT transcription complex, subunit 6 0.046
nr1d2a nuclear receptor subfamily 1, group D, member 2a 0.045
cacnb2b calcium channel, voltage-dependent, beta 2b 0.044
tfr1b transferrin receptor 1b 0.044
robo4 roundabout homolog 4 0.043
efnb3b ephrin B3b 0.042
pbx1a pre-B-cell leukemia transcription factor 1a 0.042
jam3b junctional adhesion molecule 3b 0.040
s100a1 S100 calcium binding protein A1 0.040
prtga protogenin homolog a (Gallus gallus) 0.039
rorab RAR-related orphan receptor A, paralog b 0.039
aldh2a aldehyde dehydrogenase 2 family (mitochondrial)a 0.038
nrip1b nuclear receptor interacting protein 1b 0.038
pax3a paired box gene 3a 0.037
per2 period homolog 2 (Drosophila) 0.036
id1 inhibitor of DNA binding 1 0.035
irx3b iroquois homeobox protein 3b 0.035
fstl1a follistatin-like 1a 0.035
sb:cb541 sb:cb541 0.035
pdzd7a PDZ domain containing 7a 0.035
zgc:123180 zgc:123180 0.035
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.035
jag1a jagged 1a 0.034
cat catalase 0.034
sf1 splicing factor 1 0.034
cga glycoprotein hormones, alpha polypeptide 0.034
fzd8a frizzled homolog 8a 0.033
smarcd3b SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b 0.032
nme4 non-metastatic cells 4, protein expressed in 0.032
nr5a2 nuclear receptor subfamily 5, group A, member 2 0.032
efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RARA retinoic acid receptor, alpha 0.988
ESR1 estrogen receptor 1 0.834
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.785
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.672
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.572
NCOA1 nuclear receptor coactivator 1 0.455
RXRA retinoid X receptor, alpha 0.438
MED1 mediator complex subunit 1 0.282
NCOR2 nuclear receptor corepressor 2 0.209
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.127
HNF4A hepatocyte nuclear factor 4, alpha 0.073
CREBBP CREB binding protein 0.071
MED25 mediator complex subunit 25 0.069
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.060
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 0.048
PDIA3 protein disulfide isomerase family A, member 3 0.047
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.034
PPARG peroxisome proliferator-activated receptor gamma 0.034
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.031
SPOP speckle-type POZ protein 0.028
IK IK cytokine, down-regulator of HLA II 0.028
ESRRG estrogen-related receptor gamma 0.026
NRIP1 nuclear receptor interacting protein 1 0.020
NCOA3 nuclear receptor coactivator 3 0.019
LGALS8 lectin, galactoside-binding, soluble, 8 0.019
NCOA6 nuclear receptor coactivator 6 0.016
PPP5C protein phosphatase 5, catalytic subunit 0.016
RXRB retinoid X receptor, beta 0.015
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.015
CNOT8 CCR4-NOT transcription complex, subunit 8 0.014
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.013
TRRAP transformation/transcription domain-associated protein 0.012
KLHL24 kelch-like 24 (Drosophila) 0.012
MYLK2 myosin light chain kinase 2 0.012
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Mus musculus
Name Description Probability Func Analog Organism
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.852
Tbx3 T-box 3 0.828
Pitx2 paired-like homeodomain transcription factor 2 0.735
Rxra retinoid X receptor alpha 0.690
Rarg retinoic acid receptor, gamma 0.545
Otx2 orthodenticle homolog 2 (Drosophila) 0.518
Pitx1 paired-like homeodomain transcription factor 1 0.496
Pbx1 pre B-cell leukemia transcription factor 1 0.362
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.355
Rara retinoic acid receptor, alpha 0.333
Foxg1 forkhead box G1 0.304
Pax2 paired box gene 2 0.300
Cdx2 caudal type homeobox 2 0.223
Pax3 paired box gene 3 0.201
Ghr growth hormone receptor 0.185
Neurod1 neurogenic differentiation 1 0.179
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.166
Shh sonic hedgehog 0.166
Pou4f2 POU domain, class 4, transcription factor 2 0.155
Hoxa9 homeobox A9 0.150
Foxc2 forkhead box C2 0.126
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.124
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.110
Gsc goosecoid homeobox 0.102
Tbx5 T-box 5 0.097
Lhx3 LIM homeobox protein 3 0.085
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.080
Neurod4 neurogenic differentiation 4 0.079
Sox11 SRY-box containing gene 11 0.078
Btbd17 BTB (POZ) domain containing 17 0.074
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.069
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.067
Gdf11 growth differentiation factor 11 0.065
Tcfap2a transcription factor AP-2, alpha 0.063
Skil SKI-like 0.062
Emx1 empty spiracles homolog 1 (Drosophila) 0.061
Lepr leptin receptor 0.059
Hoxd3 homeobox D3 0.054
Hoxa13 homeobox A13 0.053
Rnf2 ring finger protein 2 0.052
Myf5 myogenic factor 5 0.051
Prox1 prospero-related homeobox 1 0.051
Pbx3 pre B-cell leukemia transcription factor 3 0.050
Gja5 gap junction protein, alpha 5 0.047
Mesp1 mesoderm posterior 1 0.047
Notch2 Notch gene homolog 2 (Drosophila) 0.047
Efna2 ephrin A2 0.047
Hand2 heart and neural crest derivatives expressed transcript 2 0.045
Pax8 paired box gene 8 0.045
Scn5a sodium channel, voltage-gated, type V, alpha 0.044
Hoxa2 homeobox A2 0.044
Igf1 insulin-like growth factor 1 0.044
Lif leukemia inhibitory factor 0.042
Fgf8 fibroblast growth factor 8 0.040
Dll4 delta-like 4 (Drosophila) 0.039
Kdm2b lysine (K)-specific demethylase 2B 0.038
Sox2 SRY-box containing gene 2 0.037
Tlx3 T-cell leukemia, homeobox 3 0.036
Hoxa5 homeobox A5 0.035
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.035
Isl1 ISL1 transcription factor, LIM/homeodomain 0.035
Ebf2 early B-cell factor 2 0.034
Rarb retinoic acid receptor, beta 0.034
Pax6 paired box gene 6 0.034
Hoxb4 homeobox B4 0.033
Il10 interleukin 10 0.031
Snai1 snail homolog 1 (Drosophila) 0.031
Chd7 chromodomain helicase DNA binding protein 7 0.031
T brachyury 0.031
Ptf1a pancreas specific transcription factor, 1a 0.030
Neurog2 neurogenin 2 0.029
Gata4 GATA binding protein 4 0.029
Bdnf brain derived neurotrophic factor 0.029
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.028
Mecom MDS1 and EVI1 complex locus 0.028
Dlx1 distal-less homeobox 1 0.027
Lhx1 LIM homeobox protein 1 0.027
Smad6 MAD homolog 6 (Drosophila) 0.027
Dbp D site albumin promoter binding protein 0.026
Thra thyroid hormone receptor alpha 0.025
Lef1 lymphoid enhancer binding factor 1 0.025
Insm1 insulinoma-associated 1 0.025
Gli3 GLI-Kruppel family member GLI3 0.024
Pou3f3 POU domain, class 3, transcription factor 3 0.024
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.024
Gata5 GATA binding protein 5 0.024
Hand1 heart and neural crest derivatives expressed transcript 1 0.023
Tcf3 transcription factor 3 0.023
Sox4 SRY-box containing gene 4 0.023
Zic3 zinc finger protein of the cerebellum 3 0.022
Prdm16 PR domain containing 16 0.022
Vdr vitamin D receptor 0.022
Ncor1 nuclear receptor co-repressor 1 0.022
Nhlh1 nescient helix loop helix 1 0.022
Hoxa3 homeobox A3 0.022
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.021
Foxc1 forkhead box C1 0.021
Crb2 crumbs homolog 2 (Drosophila) 0.020
Shox2 short stature homeobox 2 0.020
Col13a1 collagen, type XIII, alpha 1 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dbp D site of albumin promoter (albumin D-box) binding protein 0.623
Pdia4 protein disulfide isomerase family A, member 4 0.416
Tgfbr2 transforming growth factor, beta receptor II 0.382
Nfib nuclear factor I/B 0.244
Rara retinoic acid receptor, alpha 0.162
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.110
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.099
Gstm2 glutathione S-transferase mu 2 0.080
Stat6 signal transducer and activator of transcription 6 0.080
Nfia nuclear factor I/A 0.079
Pdia3 protein disulfide isomerase family A, member 3 0.075
Rxra retinoid X receptor alpha 0.075
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.072
Enpep glutamyl aminopeptidase 0.058
Tcf3 transcription factor 3 0.050
Rxrg retinoid X receptor gamma 0.050
Agtr1a angiotensin II receptor, type 1a 0.050
Znf532 zinc finger protein 532 0.048
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.044
Il10ra interleukin 10 receptor, alpha 0.043
Hsp90b1 heat shock protein 90, beta, member 1 0.042
Epn1 Epsin 1 0.041
Tcf4 transcription factor 4 0.040
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.038
Efnb1 ephrin B1 0.038
Hspa5 heat shock protein 5 0.038
Nfat5 nuclear factor of activated T-cells 5 0.038
Zfp362 zinc finger protein 362 0.037
Vipr1 vasoactive intestinal peptide receptor 1 0.037
Il1r1 interleukin 1 receptor, type I 0.036
Sorbs3 sorbin and SH3 domain containing 3 0.035
Ppt2 palmitoyl-protein thioesterase 2 0.032
Ddr1 discoidin domain receptor tyrosine kinase 1 0.032
Nup153 nucleoporin 153 0.031
Sdc3 syndecan 3 0.031
Mpz myelin protein zero 0.029
Tgfbr3 transforming growth factor, beta receptor III 0.029
Synpo synaptopodin 0.029
Brd3 bromodomain containing 3 0.027
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.025
Foxo1 forkhead box O1 0.024
Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 0.024
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.024
Cyb5r1 cytochrome b5 reductase 1 0.023
Slc25a10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 0.023
Map3k11 mitogen-activated protein kinase kinase kinase 11 0.023
Sardh sarcosine dehydrogenase 0.022
LOC100362331 rCG59612-like 0.022
Hyou1 hypoxia up-regulated 1 0.020
Erg v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.020
Gulo gulonolactone (L-) oxidase 0.019
Nfic nuclear factor I/C 0.018
Zfp469 zinc finger protein 469 0.018
Thbd thrombomodulin 0.018
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.018
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.018
Timp3 TIMP metallopeptidase inhibitor 3 0.018
Falz fetal Alzheimer antigen 0.017
Hsf4 heat shock transcription factor 4 0.017
LOC287004 Mg1 protein 0.017
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.016
Neu2 sialidase 2 (cytosolic sialidase) 0.015
Map3k3 mitogen activated protein kinase kinase kinase 3 0.015
Zbtb4 zinc finger and BTB domain containing 4 0.015
Lgals9 lectin, galactoside-binding, soluble, 9 0.015
Igfbp5 insulin-like growth factor binding protein 5 0.015
Syngr2 synaptogyrin 2 0.015
Cdc2l6 cell division cycle 2-like 6 (CDK8-like) 0.014
Chrne cholinergic receptor, nicotinic, epsilon 0.014
Pde4d phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) 0.014
Srebf1 sterol regulatory element binding transcription factor 1 0.014
Il15 interleukin 15 0.014
Cald1 caldesmon 1 0.013
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.013
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.013
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.013
Taf6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.013
Col8a1 collagen, type VIII, alpha 1 0.013
Dhfr dihydrofolate reductase 0.012
Bcl2 B-cell CLL/lymphoma 2 0.012
Masp1 mannan-binding lectin serine peptidase 1 0.012
Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.012
Spata24 spermatogenesis associated 24 0.011
Acacb acetyl-Coenzyme A carboxylase beta 0.011
Tfeb transcription factor EB 0.011
Rnase1 ribonuclease, RNase A family, 1 (pancreatic) 0.011
C1qtnf2 C1q and tumor necrosis factor related protein 2 0.011
Mef2d myocyte enhancer factor 2D 0.011
Rfc1 replication factor C (activator 1) 1 0.011
Ptms parathymosin 0.011
Pde4a phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) 0.011
Cysltr2 cysteinyl leukotriene receptor 2 0.011
Tat tyrosine aminotransferase 0.010
Sod3 superoxide dismutase 3, extracellular 0.010
Acot2 acyl-CoA thioesterase 2 0.010
Tef thyrotrophic embryonic factor 0.010
Pdia6 protein disulfide isomerase family A, member 6 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism