The network for 'heart valve development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart valve development

The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.

Danio rerio
Name Description Probability Func Analog Organism
tbx5a T-box 5a 0.981
fli1a friend leukemia integration 1a 0.603
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.589
bmp4 bone morphogenetic protein 4 0.551
tbx1 T-box 1 0.507
hand2 heart and neural crest derivatives expressed transcript 2 0.471
hhex hematopoietically expressed homeobox 0.358
tal1 T-cell acute lymphocytic leukemia 1 0.335
nkx2.5 NK2 transcription factor related 5 0.318
hnf1ba HNF1 homeobox Ba 0.265
gata6 GATA-binding protein 6 0.254
fn1 fibronectin 1 0.226
ptch1 patched 1 0.207
tbx16 T-box gene 16 0.188
dld deltaD 0.174
dlc deltaC 0.173
tbx20 T-box 20 0.168
cdh2 cadherin 2, neuronal 0.148
wnt5b wingless-type MMTV integration site family, member 5b 0.139
mef2cb myocyte enhancer factor 2cb 0.136
alcama activated leukocyte cell adhesion molecule a 0.132
myod1 myogenic differentiation 1 0.132
runx1 runt-related transcription factor 1 0.125
vcana versican a 0.116
wnt11r wingless-type MMTV integration site family, member 11, related 0.112
tbx24 T-box 24 0.111
fgf8a fibroblast growth factor 8 a 0.109
myf5 myogenic factor 5 0.104
lft2 lefty2 0.103
her1 hairy-related 1 0.100
tbx18 T-box 18 0.095
tbx2a T-box gene 2a 0.089
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.087
shha sonic hedgehog a 0.087
crip2 cysteine-rich protein 2 0.086
gsna gelsolin a 0.079
neo1 neogenin 1 0.078
tpm4 tropomyosin 4 0.074
wnt11 wingless-type MMTV integration site family, member 11 0.071
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.069
osr2 odd-skipped related 2 (Drosophila) 0.067
bmp2b bone morphogenetic protein 2b 0.064
cxcr4a chemokine (C-X-C motif) receptor 4a 0.055
unc45b unc-45 homolog B (C. elegans) 0.053
drl draculin 0.052
gata2a GATA-binding protein 2a 0.051
tbx5b T-box 5b 0.049
notch1b notch homolog 1b 0.048
lft1 lefty1 0.046
tcf21 transcription factor 21 0.045
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.045
znfl2a zinc finger-like gene 2a 0.042
foxi1 forkhead box I1 0.041
tgfb3 transforming growth factor, beta 3 0.041
her7 hairy and enhancer of split related-7 0.040
mib mind bomb 0.040
acvr1l activin A receptor, type I like 0.040
myl7 myosin, light polypeptide 7, regulatory 0.040
tnni1b troponin I, skeletal, slow b 0.039
jag1b jagged 1b 0.039
pkd2 polycystic kidney disease 2 0.037
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.036
gli2a GLI-Kruppel family member GLI2a 0.035
foxa3 forkhead box A3 0.035
smyd1b SET and MYND domain containing 1b 0.035
bmp3 bone morphogenetic protein 3 0.033
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.032
zfpm1 zinc finger protein, multitype 1 0.031
pcdh8 protocadherin 8 0.031
krt4 keratin 4 0.031
LOC566708 FL cytokine receptor-like 0.030
pdlim7 PDZ and LIM domain 7 0.030
lmo2 LIM domain only 2 (rhombotin-like 1) 0.030
foxn4 forkhead box N4 0.030
tfap2a transcription factor AP-2 alpha 0.030
mef2ca myocyte enhancer factor 2ca 0.029
kdrl kinase insert domain receptor like 0.029
eve1 even-skipped-like1 0.028
oep one-eyed pinhead 0.028
znf703 zinc finger protein 703 0.027
tp63 tumor protein p63 0.027
tnnc1a troponin C type 1a (slow) 0.026
hes6 hairy and enhancer of split 6 (Drosophila) 0.026
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.026
foxh1 forkhead box H1 0.024
gja3 gap junction protein, alpha 3 0.024
nppa natriuretic peptide precursor A 0.024
six4b sine oculis homeobox homolog 4b 0.024
prdm1a PR domain containing 1a, with ZNF domain 0.024
hspb1 heat shock protein, alpha-crystallin-related, 1 0.023
spaw southpaw 0.023
has2 hyaluronan synthase 2 0.023
ndr2 nodal-related 2 0.022
sox32 SRY-box containing gene 32 0.022
wls wntless homolog (Drosophila) 0.022
nkx3.2 NK3 homeobox 2 0.022
tmem2 transmembrane protein 2 0.022
edn1 endothelin 1 0.022
tfeb transcription factor EB 0.021
ltbp3 latent transforming growth factor beta binding protein 3 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 0.987
NOTCH1 notch 1 0.985
NOTCH3 notch 3 0.959
BMPR1A bone morphogenetic protein receptor, type IA 0.815
BMP2 bone morphogenetic protein 2 0.763
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.593
FKBP1A FK506 binding protein 1A, 12kDa 0.547
SKIL SKI-like oncogene 0.209
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.183
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.086
FSTL1 follistatin-like 1 0.083
NOTCH2 notch 2 0.075
DLL1 delta-like 1 (Drosophila) 0.069
HDAC4 histone deacetylase 4 0.068
SMAD2 SMAD family member 2 0.066
TGFB1 transforming growth factor, beta 1 0.065
TAL1 T-cell acute lymphocytic leukemia 1 0.059
GATA4 GATA binding protein 4 0.058
SMAD3 SMAD family member 3 0.054
SMAD1 SMAD family member 1 0.048
TGFB3 transforming growth factor, beta 3 0.047
TBX5 T-box 5 0.043
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.042
RUNX1 runt-related transcription factor 1 0.041
GDF5 growth differentiation factor 5 0.037
JAG2 jagged 2 0.031
GATA2 GATA binding protein 2 0.029
SMAD7 SMAD family member 7 0.028
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.027
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.024
ENG endoglin 0.024
HEYL hairy/enhancer-of-split related with YRPW motif-like 0.022
PRKG1 protein kinase, cGMP-dependent, type I 0.020
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.018
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.018
TCF12 transcription factor 12 0.017
HAND2 heart and neural crest derivatives expressed 2 0.016
CXXC5 CXXC finger protein 5 0.016
NCOR1 nuclear receptor corepressor 1 0.016
GFI1B growth factor independent 1B transcription repressor 0.015
MAML1 mastermind-like 1 (Drosophila) 0.015
CTNNBIP1 catenin, beta interacting protein 1 0.014
TGFBR1 transforming growth factor, beta receptor 1 0.014
HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.014
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.013
SMAD4 SMAD family member 4 0.013
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.012
SKI v-ski sarcoma viral oncogene homolog (avian) 0.012
XIAP X-linked inhibitor of apoptosis 0.011
TSC22D1 TSC22 domain family, member 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Gata4 GATA binding protein 4 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Efnb2 ephrin B2 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.996
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.995
Shh sonic hedgehog 0.995
Gli3 GLI-Kruppel family member GLI3 0.986
Hoxa1 homeobox A1 0.975
Tgfb2 transforming growth factor, beta 2 0.966
Fgfr2 fibroblast growth factor receptor 2 0.939
Tbx3 T-box 3 0.934
Prrx1 paired related homeobox 1 0.909
Pitx1 paired-like homeodomain transcription factor 1 0.893
Notch1 Notch gene homolog 1 (Drosophila) 0.873
Sox9 SRY-box containing gene 9 0.872
Foxc1 forkhead box C1 0.860
Hand2 heart and neural crest derivatives expressed transcript 2 0.858
Nodal nodal 0.855
Pax3 paired box gene 3 0.853
Fgf8 fibroblast growth factor 8 0.849
Meox2 mesenchyme homeobox 2 0.832
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.810
Nos3 nitric oxide synthase 3, endothelial cell 0.792
Apc adenomatosis polyposis coli 0.756
Smad6 MAD homolog 6 (Drosophila) 0.723
Foxc2 forkhead box C2 0.721
Gata6 GATA binding protein 6 0.691
Bmpr1a bone morphogenetic protein receptor, type 1A 0.689
Smad1 MAD homolog 1 (Drosophila) 0.668
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.640
Ntf3 neurotrophin 3 0.601
Ptf1a pancreas specific transcription factor, 1a 0.583
Bmp4 bone morphogenetic protein 4 0.576
Rxra retinoid X receptor alpha 0.553
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.549
Fgfr3 fibroblast growth factor receptor 3 0.546
Snai1 snail homolog 1 (Drosophila) 0.539
Ctnnb1 catenin (cadherin associated protein), beta 1 0.538
Zfpm2 zinc finger protein, multitype 2 0.504
Zic3 zinc finger protein of the cerebellum 3 0.494
Foxh1 forkhead box H1 0.467
Notch3 Notch gene homolog 3 (Drosophila) 0.447
Pax2 paired box gene 2 0.427
Fgfr1 fibroblast growth factor receptor 1 0.422
Sox11 SRY-box containing gene 11 0.405
Jag1 jagged 1 0.377
Klf3 Kruppel-like factor 3 (basic) 0.354
Pten phosphatase and tensin homolog 0.348
Tal1 T-cell acute lymphocytic leukemia 1 0.344
Smad4 MAD homolog 4 (Drosophila) 0.342
Gli2 GLI-Kruppel family member GLI2 0.337
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.332
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.321
Hoxa13 homeobox A13 0.318
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.318
Sox4 SRY-box containing gene 4 0.302
Efna2 ephrin A2 0.293
Neurod1 neurogenic differentiation 1 0.282
Gdf3 growth differentiation factor 3 0.282
Pax6 paired box gene 6 0.275
En1 engrailed 1 0.275
Foxg1 forkhead box G1 0.263
Adcy4 adenylate cyclase 4 0.256
Dll4 delta-like 4 (Drosophila) 0.255
Col1a1 collagen, type I, alpha 1 0.240
Twist2 twist homolog 2 (Drosophila) 0.230
Hand1 heart and neural crest derivatives expressed transcript 1 0.218
Ephb2 Eph receptor B2 0.218
Hhex hematopoietically expressed homeobox 0.211
Sox2 SRY-box containing gene 2 0.210
Fgf10 fibroblast growth factor 10 0.207
Nog noggin 0.205
Tbx20 T-box 20 0.205
Nf1 neurofibromatosis 1 0.203
Gata5 GATA binding protein 5 0.199
Gja1 gap junction protein, alpha 1 0.199
She src homology 2 domain-containing transforming protein E 0.199
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.198
Isl1 ISL1 transcription factor, LIM/homeodomain 0.191
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.189
Hic1 hypermethylated in cancer 1 0.187
Otx2 orthodenticle homolog 2 (Drosophila) 0.186
Tbx5 T-box 5 0.185
Runx2 runt related transcription factor 2 0.184
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.180
Tcfap2a transcription factor AP-2, alpha 0.179
Hoxa10 homeobox A10 0.168
Egfr epidermal growth factor receptor 0.162
Gpr50 G-protein-coupled receptor 50 0.159
Sox17 SRY-box containing gene 17 0.158
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.157
Btbd17 BTB (POZ) domain containing 17 0.157
Wt1 Wilms tumor 1 homolog 0.155
Hoxd13 homeobox D13 0.155
Chd7 chromodomain helicase DNA binding protein 7 0.153
Sox7 SRY-box containing gene 7 0.147
Hes1 hairy and enhancer of split 1 (Drosophila) 0.141
Hoxa11 homeobox A11 0.137
Acvr2b activin receptor IIB 0.133
Bnc1 basonuclin 1 0.129
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Rattus norvegicus
Name Description Probability Func Analog Organism
Sox13 SRY (sex determining region Y)-box 13 0.024
Igf2 insulin-like growth factor 2 0.021
Tcfe2a transcription factor E2a 0.021
Olr1469 olfactory receptor Olr1469 0.021
Lamc1 laminin, gamma 1 0.018
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.016
Btg2 BTG family, member 2 0.016
Irs1 insulin receptor substrate 1 0.015
Hes1 hairy and enhancer of split 1 (Drosophila) 0.014
LOC100360403 ATP-binding cassette, sub-family C, member 9-like 0.013
Myh11 myosin, heavy chain 11, smooth muscle 0.013
Prrx1 paired related homeobox 1 0.012
Golga1 golgi autoantigen, golgin subfamily a, 1 0.012
RGD1311307 similar to 1300014I06Rik protein 0.011
Selp selectin P 0.011
Ccnd1 cyclin D1 0.011
Thbd thrombomodulin 0.011
Dock6 dedicator of cytokinesis 6 0.011
Snrk SNF related kinase 0.010
Sox17 SRY (sex determining region Y)-box 17 0.010
Egr1 early growth response 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism