The network for 'negative regulation of mapk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mapk cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.

Danio rerio
Name Description Probability Func Analog Organism
spry4 sprouty (Drosophila) homolog 4 0.557
chd chordin 0.287
bmp2b bone morphogenetic protein 2b 0.248
spry2 sprouty homolog 2 0.236
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.178
dusp6 dual specificity phosphatase 6 0.157
nrg2a neuregulin 2a 0.148
foxi3b forkhead box I3b 0.137
ntn2 netrin 2 0.128
gro2 groucho 2 0.127
nf1a neurofibromin 1a 0.123
stau2 staufen, RNA binding protein, homolog 2 (Drosophila) 0.122
etv5a ets variant 5a 0.117
mapk1 mitogen-activated protein kinase 1 0.114
mapk3 mitogen-activated protein kinase 3 0.111
adipor1b adiponectin receptor 1b 0.110
adipor2 adiponectin receptor 2 0.108
ahsa1l AHA1, activator of heat shock protein ATPase homolog 1, like 0.106
ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa 0.101
atp1b2a ATPase, Na+/K+ transporting, beta 2a polypeptide 0.098
adipoql adiponectin, C1Q and collagen domain containing, like 0.097
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.096
spns2 spinster homolog 2 (Drosophila) 0.091
zbtb4 zinc finger and BTB domain containing 4 0.089
epha4a eph receptor A4a 0.089
arl4ab ADP-ribosylation factor-like 4ab 0.089
fgf3 fibroblast growth factor 3 0.088
ip6k2 inositol hexaphosphate kinase 2 0.087
efnb2a ephrin B2a 0.086
hspa4a heat shock protein 4a 0.086
foxa3 forkhead box A3 0.085
adipoql2 adiponectin, C1Q and collagen domain containing, like 2 0.085
mapk4 mitogen-activated protein kinase 4 0.083
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.081
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.080
notum3 notum 3 0.079
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.075
per2 period homolog 2 (Drosophila) 0.073
gpib glucose phosphate isomerase b 0.073
usp4 ubiquitin specific protease 4 (proto-oncogene) 0.071
ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.070
smad1 MAD homolog 1 (Drosophila) 0.068
sec24c SEC24 family, member C (S. cerevisiae) 0.064
nf1b neurofibromin 1b 0.063
odc1 ornithine decarboxylase 1 0.063
ism1 isthmin 1 0.063
ralgapa1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.061
gro1 groucho 1 0.060
wwp2 WW domain containing E3 ubiquitin protein ligase 2 0.059
phf23a PHD finger protein 23a 0.058
zgc:91870 zgc:91870 0.058
rab5c RAB5C, member RAS oncogene family 0.058
wnt8b wingless-type MMTV integration site family, member 8b 0.058
acvr2a activin receptor IIa 0.058
sema3fb semaphorin 3fb 0.057
gsc goosecoid 0.057
mbtps1 membrane-bound transcription factor protease, site 1 0.056
klhl11 kelch-like 11 (Drosophila) 0.054
lsm1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.051
spred1 sprouty-related, EVH1 domain containing 1 0.051
hiat1b hippocampus abundant transcript 1b 0.051
smg7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.050
fcho2 FCH domain only 2 0.050
ntn1b netrin 1b 0.049
bcl2l1 bcl2-like 1 0.049
pcsk7 proprotein convertase subtilisin/kexin type 7 0.047
phf17 PHD finger protein 17 0.047
mxi1 max interacting protein 0.046
cdc42 cell division cycle 42 0.045
lect1 leukocyte cell derived chemotaxin 1 0.045
frem3 Fras1 related extracellular matrix 3 0.045
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.045
tbx2b T-box 2b 0.045
trim13 tripartite motif-containing 13 0.044
kif14 kinesin family member 14 0.043
mllt11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.043
spc24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.043
k31 k31 gene 0.043
ythdf1 YTH domain family, member 1 0.043
pak2a p21 (CDKN1A)-activated kinase 2a 0.043
slc35e1 solute carrier family 35, member E1 0.042
zgc:153061 zgc:153061 0.042
zmynd19 zinc finger, MYND domain containing 19 0.042
papolb poly(A) polymerase beta (testis specific) 0.042
zgc:56005 zgc:56005 0.042
otx1b orthodenticle homolog 1b 0.042
wu:fi25h02 wu:fi25h02 0.042
fzd8a frizzled homolog 8a 0.041
npepl1 aminopeptidase-like 1 0.040
il17rd interleukin 17 receptor D 0.040
dkk1b dickkopf 1b 0.040
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.040
plk3 polo-like kinase 3 (Drosophila) 0.040
mpped2 metallophosphoesterase domain containing 2 0.040
etv5b ets variant 5b 0.040
slc12a10.2 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2 0.039
gclc glutamate-cysteine ligase, catalytic subunit 0.039
si:dkey-177p2.6 si:dkey-177p2.6 0.039
sfrp1a secreted frizzled-related protein 1a 0.039
fzd7a frizzled homolog 7a 0.039
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
mec-2 Protein MEC-2 0.020
glr-5 Protein GLR-5 0.011
unc-9 Protein UNC-9 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.364
rl rolled 0.327
Ras85D Ras oncogene at 85D 0.261
sax saxophone 0.227
dsh dishevelled 0.191
Akt1 CG4006 gene product from transcript CG4006-RA 0.167
ash2 absent, small, or homeotic discs 2 0.125
tkv thickveins 0.112
kay kayak 0.100
drk downstream of receptor kinase 0.075
Dsor1 Downstream of raf1 0.064
Sara Smad anchor for receptor activation 0.060
vg vestigial 0.059
E(z) Enhancer of zeste 0.057
p38b CG7393 gene product from transcript CG7393-RA 0.054
prod proliferation disrupter 0.053
Ras64B Ras oncogene at 64B 0.051
PGRP-SA Peptidoglycan recognition protein SA 0.048
Sema-1a CG18405 gene product from transcript CG18405-RD 0.047
CG10743 CG10743 gene product from transcript CG10743-RB 0.043
PGRP-LC Peptidoglycan recognition protein LC 0.042
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.040
Src64B Src oncogene at 64B 0.039
Sos Son of sevenless 0.038
loqs loquacious 0.038
sbb scribbler 0.038
mbc myoblast city 0.037
caz cabeza 0.037
foxo forkhead box, sub-group O 0.036
Ack CG14992 gene product from transcript CG14992-RA 0.035
PGRP-LF Peptidoglycan recognition protein LF 0.035
hep hemipterous 0.035
Mer Merlin 0.034
sog short gastrulation 0.034
Pp2B-14D Protein phosphatase 2B at 14D 0.034
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.034
Klp64D Kinesin-like protein at 64D 0.033
faf fat facets 0.033
Shc SHC-adaptor protein 0.032
CG14667 CG14667 gene product from transcript CG14667-RA 0.031
CalpA Calpain-A 0.029
os outstretched 0.029
krz kurtz 0.028
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.028
Spn27A Serpin 27A 0.027
Pka-C1 cAMP-dependent protein kinase 1 0.027
mys myospheroid 0.027
L Lobe 0.026
Sin3A CG8815 gene product from transcript CG8815-RC 0.026
grass Gram-positive Specific Serine protease 0.026
CG32185 CG32185 gene product from transcript CG32185-RA 0.025
rdgB retinal degeneration B 0.025
CG3371 CG3371 gene product from transcript CG3371-RA 0.025
wit wishful thinking 0.025
sev sevenless 0.025
G-oalpha47A G protein oalpha 47A 0.025
rho rhomboid 0.024
Rab7 Rab-protein 7 0.024
csw corkscrew 0.024
shi shibire 0.023
Mad Mothers against dpp 0.023
EndoGI Endonuclease G inhibitor 0.023
Irk2 Inwardly rectifying potassium channel 2 0.023
inaD inactivation no afterpotential D 0.023
mnb minibrain 0.022
ntc nutcracker 0.022
stck steamer duck 0.022
Jra Jun-related antigen 0.022
CdsA CDP diglyceride synthetase 0.022
shn schnurri 0.022
Rab5 Rab-protein 5 0.022
CG9316 CG9316 gene product from transcript CG9316-RA 0.021
dos daughter of sevenless 0.021
phl pole hole 0.021
Sp7 Serine protease 7 0.021
Apc APC-like 0.021
nbs CG6754 gene product from transcript CG6754-RC 0.021
Mpk2 CG5475 gene product from transcript CG5475-RB 0.020
pnt pointed 0.020
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.019
InR Insulin-like receptor 0.019
smo smoothened 0.018
CG16718 CG16718 gene product from transcript CG16718-RA 0.018
CG9902 CG9902 gene product from transcript CG9902-RA 0.018
WASp CG1520 gene product from transcript CG1520-RA 0.018
ninaE neither inactivation nor afterpotential E 0.018
pirk poor Imd response upon knock-in 0.018
ATP7 CG1886 gene product from transcript CG1886-RB 0.018
Eip71CD Ecdysone-induced protein 28/29kD 0.018
S6kII RPS6-protein kinase-II 0.017
sd scalloped 0.017
CG5439 CG5439 gene product from transcript CG5439-RA 0.017
Vps45 Vacuolar protein sorting 45 0.017
Socs36E Suppressor of cytokine signaling at 36E 0.017
gek genghis khan 0.017
RYBP Ring and YY1 Binding Protein 0.017
rut rutabaga 0.017
wdb widerborst 0.017
Drs Drosomycin 0.016
Myo31DF Myosin 31DF 0.016
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Homo sapiens
Name Description Probability Func Analog Organism
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
MAPK1 mitogen-activated protein kinase 1 0.998
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.984
EGFR epidermal growth factor receptor 0.974
MAPK14 mitogen-activated protein kinase 14 0.966
FYN FYN oncogene related to SRC, FGR, YES 0.964
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.848
MAPK8 mitogen-activated protein kinase 8 0.801
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.796
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.795
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.788
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.761
GHR growth hormone receptor 0.735
SH3KBP1 SH3-domain kinase binding protein 1 0.697
MAP2K4 mitogen-activated protein kinase kinase 4 0.678
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.674
DUSP1 dual specificity phosphatase 1 0.672
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.653
C1QA complement component 1, q subcomponent, A chain 0.599
GSK3B glycogen synthase kinase 3 beta 0.526
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.515
IRAK2 interleukin-1 receptor-associated kinase 2 0.511
ZNF43 zinc finger protein 43 0.460
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.454
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.434
MAP2K1 mitogen-activated protein kinase kinase 1 0.401
BCAR1 breast cancer anti-estrogen resistance 1 0.395
TRAF6 TNF receptor-associated factor 6 0.393
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.386
MET met proto-oncogene (hepatocyte growth factor receptor) 0.348
BMPR1A bone morphogenetic protein receptor, type IA 0.328
LCK lymphocyte-specific protein tyrosine kinase 0.326
ZNF273 zinc finger protein 273 0.320
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.317
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.311
CCNE1 cyclin E1 0.306
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.298
CHUK conserved helix-loop-helix ubiquitous kinase 0.290
MYD88 myeloid differentiation primary response gene (88) 0.261
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.248
PDCD6IP programmed cell death 6 interacting protein 0.244
ESR1 estrogen receptor 1 0.236
SMAD2 SMAD family member 2 0.231
PXN paxillin 0.225
ZNF746 zinc finger protein 746 0.222
CREBBP CREB binding protein 0.222
ZNF675 zinc finger protein 675 0.220
ILK integrin-linked kinase 0.217
SC4MOL sterol-C4-methyl oxidase-like 0.212
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.208
IRAK1 interleukin-1 receptor-associated kinase 1 0.198
ZNF253 zinc finger protein 253 0.191
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.186
CSNK1E casein kinase 1, epsilon 0.183
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.182
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.178
PTK2B PTK2B protein tyrosine kinase 2 beta 0.177
CAV1 caveolin 1, caveolae protein, 22kDa 0.174
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.166
SPRY2 sprouty homolog 2 (Drosophila) 0.164
JUN jun proto-oncogene 0.162
GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 0.150
CD2AP CD2-associated protein 0.148
PPP6C protein phosphatase 6, catalytic subunit 0.147
DUSP7 dual specificity phosphatase 7 0.144
EGR1 early growth response 1 0.143
ARRB1 arrestin, beta 1 0.142
DUSP6 dual specificity phosphatase 6 0.141
TICAM2 toll-like receptor adaptor molecule 2 0.140
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.137
SCHIP1 schwannomin interacting protein 1 0.119
NOXA1 NADPH oxidase activator 1 0.119
DUSP23 dual specificity phosphatase 23 0.115
DUSP3 dual specificity phosphatase 3 0.114
YAP1 Yes-associated protein 1 0.110
MAP2K7 mitogen-activated protein kinase kinase 7 0.110
MED28 mediator complex subunit 28 0.110
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.109
IRS2 insulin receptor substrate 2 0.108
ATF2 activating transcription factor 2 0.107
EPOR erythropoietin receptor 0.105
LAT linker for activation of T cells 0.103
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.103
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.100
BCR breakpoint cluster region 0.098
JAK2 Janus kinase 2 0.098
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.098
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.097
ARRB2 arrestin, beta 2 0.095
TFF1 trefoil factor 1 0.094
AR androgen receptor 0.094
IGF1R insulin-like growth factor 1 receptor 0.092
CREB1 cAMP responsive element binding protein 1 0.090
BBS10 Bardet-Biedl syndrome 10 0.088
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.088
A2M alpha-2-macroglobulin 0.086
PDCD10 programmed cell death 10 0.086
TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 0.085
STRN3 striatin, calmodulin binding protein 3 0.084
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.084
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.988
Apc adenomatosis polyposis coli 0.865
Grb2 growth factor receptor bound protein 2 0.853
Mapk1 mitogen-activated protein kinase 1 0.825
Per2 period homolog 2 (Drosophila) 0.813
Mdm2 transformed mouse 3T3 cell double minute 2 0.804
Pten phosphatase and tensin homolog 0.804
Inpp5d inositol polyphosphate-5-phosphatase D 0.775
Ctnnb1 catenin (cadherin associated protein), beta 1 0.717
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.705
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.664
Lyz2 lysozyme 2 0.621
Traf6 TNF receptor-associated factor 6 0.609
Ptprc protein tyrosine phosphatase, receptor type, C 0.592
Dok1 docking protein 1 0.592
Fcgr2b Fc receptor, IgG, low affinity IIb 0.559
Axin1 axin 1 0.526
Atf2 activating transcription factor 2 0.520
Cd44 CD44 antigen 0.508
Cav1 caveolin 1, caveolae protein 0.467
Lcp1 lymphocyte cytosolic protein 1 0.463
Fyn Fyn proto-oncogene 0.461
Cbl Casitas B-lineage lymphoma 0.439
Tsc1 tuberous sclerosis 1 0.420
Prkce protein kinase C, epsilon 0.396
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.384
Dmd dystrophin, muscular dystrophy 0.381
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.345
Nos1 nitric oxide synthase 1, neuronal 0.344
Csf1r colony stimulating factor 1 receptor 0.322
Fos FBJ osteosarcoma oncogene 0.309
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.303
Mapk14 mitogen-activated protein kinase 14 0.303
Shc1 src homology 2 domain-containing transforming protein C1 0.297
Mapk8 mitogen-activated protein kinase 8 0.297
Cyld cylindromatosis (turban tumor syndrome) 0.292
Tnf tumor necrosis factor 0.291
Vasp vasodilator-stimulated phosphoprotein 0.290
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.287
Adam17 a disintegrin and metallopeptidase domain 17 0.262
Grb10 growth factor receptor bound protein 10 0.258
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.255
Rb1 retinoblastoma 1 0.252
C1qc complement component 1, q subcomponent, C chain 0.251
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.248
Cd80 CD80 antigen 0.247
Ly86 lymphocyte antigen 86 0.236
Ccl4 chemokine (C-C motif) ligand 4 0.236
Ncoa3 nuclear receptor coactivator 3 0.229
Csf1 colony stimulating factor 1 (macrophage) 0.222
Il1b interleukin 1 beta 0.215
Prkcb protein kinase C, beta 0.207
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.205
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.194
Spnb2 spectrin beta 2 0.190
Insr insulin receptor 0.190
Mdm4 transformed mouse 3T3 cell double minute 4 0.188
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.187
Klf7 Kruppel-like factor 7 (ubiquitous) 0.186
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.185
Smad4 MAD homolog 4 (Drosophila) 0.185
Col1a1 collagen, type I, alpha 1 0.181
Btk Bruton agammaglobulinemia tyrosine kinase 0.181
Fbxw7 F-box and WD-40 domain protein 7 0.179
Prkcc protein kinase C, gamma 0.176
Skil SKI-like 0.175
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.170
Cdh5 cadherin 5 0.165
Tgfb1 transforming growth factor, beta 1 0.161
Nsf N-ethylmaleimide sensitive fusion protein 0.158
Grm1 glutamate receptor, metabotropic 1 0.158
Usp8 ubiquitin specific peptidase 8 0.157
Nf2 neurofibromatosis 2 0.156
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.154
Ccnd1 cyclin D1 0.153
Csk c-src tyrosine kinase 0.153
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.153
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.152
Ptk2 PTK2 protein tyrosine kinase 2 0.151
Ezh1 enhancer of zeste homolog 1 (Drosophila) 0.144
Jun Jun oncogene 0.144
Cotl1 coactosin-like 1 (Dictyostelium) 0.142
Mmp9 matrix metallopeptidase 9 0.141
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.141
Sh3kbp1 SH3-domain kinase binding protein 1 0.136
Igf2 insulin-like growth factor 2 0.135
Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.130
Stat3 signal transducer and activator of transcription 3 0.129
Sox9 SRY-box containing gene 9 0.127
Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 0.125
Fcgr1 Fc receptor, IgG, high affinity I 0.125
Evl Ena-vasodilator stimulated phosphoprotein 0.122
Sfrp2 secreted frizzled-related protein 2 0.117
Ghr growth hormone receptor 0.114
Il1r1 interleukin 1 receptor, type I 0.114
Il6st interleukin 6 signal transducer 0.114
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.111
Il10 interleukin 10 0.111
Ptpre protein tyrosine phosphatase, receptor type, E 0.111
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.111
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.797
Fos FBJ osteosarcoma oncogene 0.304
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.164
Jun Jun oncogene 0.161
LOC100362824 caveolin 2-like 0.137
Egr1 early growth response 1 0.129
Sirpa signal-regulatory protein alpha 0.115
Cav1 caveolin 1, caveolae protein 0.088
Klf4 Kruppel-like factor 4 (gut) 0.082
Ier2 immediate early response 2 0.079
Dusp6 dual specificity phosphatase 6 0.070
Btg2 BTG family, member 2 0.058
Vegfa vascular endothelial growth factor A 0.048
Tecr trans-2,3-enoyl-CoA reductase 0.046
Cav2 caveolin 2 0.044
Rab1b RAB1B, member RAS oncogene family 0.042
Fmnl1 formin-like 1 0.037
Klf6 Kruppel-like factor 6 0.034
Snrk SNF related kinase 0.031
Prkcd protein kinase C, delta 0.028
Ralgds ral guanine nucleotide dissociation stimulator 0.027
Tsc22d3 TSC22 domain family, member 3 0.026
Klf2 Kruppel-like factor 2 (lung) 0.026
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.026
Gprc5a G protein-coupled receptor, family C, group 5, member A 0.024
Jdp2 Jun dimerization protein 2 0.024
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.024
Pink1 PTEN induced putative kinase 1 0.023
Serinc1 serine incorporator 1 0.021
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.021
Egr2 early growth response 2 0.021
Klf9 Kruppel-like factor 9 0.021
Cd37 CD37 molecule 0.021
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.020
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.019
Matk megakaryocyte-associated tyrosine kinase 0.019
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.019
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.018
Slc48a1 solute carrier family 48 (heme transporter), member 1 0.018
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.018
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.017
Homer1 homer homolog 1 (Drosophila) 0.017
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.017
Slc30a4 solute carrier family 30 (zinc transporter), member 4 0.017
Ptk2b PTK2B protein tyrosine kinase 2 beta 0.017
Sbk1 SH3-binding domain kinase 1 0.017
Zfp36 zinc finger protein 36 0.017
Usf2 upstream transcription factor 2, c-fos interacting 0.017
Scarb1 scavenger receptor class B, member 1 0.016
Cltc clathrin, heavy chain (Hc) 0.016
Ptp4a2 protein tyrosine phosphatase 4a2 0.016
Gstm1 glutathione S-transferase mu 1 0.016
Atxn1 ataxin 1 0.016
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.015
Rhoa ras homolog gene family, member A 0.015
Ctsf cathepsin F 0.015
Hist1h1a histone cluster 1, H1a 0.015
Crip2 cysteine-rich protein 2 0.015
Crygc crystallin, gamma C 0.015
Stk10 serine/threonine kinase 10 0.015
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.015
Inpp5d inositol polyphosphate-5-phosphatase D 0.014
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.014
Fgfr1 Fibroblast growth factor receptor 1 0.014
Cdc42se1 CDC42 small effector 1 0.014
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.014
Wipf1 WAS/WASL interacting protein family, member 1 0.014
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.014
Adrbk1 adrenergic, beta, receptor kinase 1 0.013
Vegfb vascular endothelial growth factor B 0.013
Ddn dendrin 0.013
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.013
Spata2L spermatogenesis associated 2-like 0.013
Gja1 gap junction protein, alpha 1 0.013
Adprh ADP-ribosylarginine hydrolase 0.013
Gpr116 G protein-coupled receptor 116 0.013
Gpx4 glutathione peroxidase 4 0.013
Pcdhga11 protocadherin gamma subfamily A, 11 0.013
Akap1 A kinase (PRKA) anchor protein 1 0.013
Ptprc protein tyrosine phosphatase, receptor type, C 0.013
Kcnn1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 0.012
Cxcl12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 0.012
Sox4 SRY (sex determining region Y)-box 4 0.012
Synpo synaptopodin 0.012
Cxcr7 chemokine (C-X-C motif) receptor 7 0.012
Fbxo2 F-box protein 2 0.012
Gsr glutathione reductase 0.012
Dbp D site of albumin promoter (albumin D-box) binding protein 0.012
Tgfb1 transforming growth factor, beta 1 0.012
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.012
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.012
Stx6 syntaxin 6 0.012
Dusp1 dual specificity phosphatase 1 0.012
Ptpro protein tyrosine phosphatase, receptor type, O 0.012
Errfi1 ERBB receptor feedback inhibitor 1 0.012
Gda guanine deaminase 0.011
Epn2 epsin 2 0.011
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.011
Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.011
Cntfr ciliary neurotrophic factor receptor 0.011
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
KSS1 Kss1p 0.967
SLT2 Slt2p 0.647
FUS3 Fus3p 0.643
STE7 Ste7p 0.464
MSG5 Msg5p 0.350
STE11 Ste11p 0.339
NBP2 Nbp2p 0.299
BOI1 Boi1p 0.258
KDX1 Kdx1p 0.157
RLM1 Rlm1p 0.128
STE5 Ste5p 0.120
PBS2 Pbs2p 0.111
PPH21 Pph21p 0.077
BCK1 Bck1p 0.073
IRA1 Ira1p 0.063
CDC55 Cdc55p 0.057
VMA13 Vma13p 0.052
SSK22 Ssk22p 0.049
TEC1 Tec1p 0.046
LHS1 Lhs1p 0.044
SSK2 Ssk2p 0.044
SLA2 Sla2p 0.042
BOI2 Boi2p 0.040
SSK1 Ssk1p 0.039
MYO5 Myo5p 0.039
BCK2 Bck2p 0.039
YPL088W hypothetical protein 0.036
STE12 Ste12p 0.031
SHO1 Sho1p 0.028
HKR1 Hkr1p 0.027
GAL7 Gal7p 0.027
RPN2 Rpn2p 0.025
STE20 Ste20p 0.025
SKM1 Skm1p 0.023
CNE1 Cne1p 0.023
YGR205W hypothetical protein 0.023
STE18 Ste18p 0.022
CAK1 Cak1p 0.021
ARE2 Are2p 0.020
PPH22 Pph22p 0.020
VPS5 Vps5p 0.019
YOR111W hypothetical protein 0.018
INP53 Inp53p 0.018
PTC2 Ptc2p 0.017
DFG5 Dfg5p 0.017
YER071C hypothetical protein 0.017
MKK2 Mkk2p 0.017
PRS2 Prs2p 0.016
BUD7 Bud7p 0.016
ULA1 Ula1p 0.016
TWF1 Twf1p 0.016
ESF1 Esf1p 0.016
SRD1 Srd1p 0.016
CRG1 Crg1p 0.015
ARP10 Arp10p 0.015
TIP41 Tip41p 0.015
RGD1 Rgd1p 0.015
LEU2 Leu2p 0.015
SFA1 Sfa1p 0.015
CAM1 Cam1p 0.014
YNR014W hypothetical protein 0.014
YLR264C-A hypothetical protein 0.014
RHO1 Rho1p 0.014
YCF1 Ycf1p 0.014
URA3 Ura3p 0.014
KNH1 Knh1p 0.014
CRZ1 Crz1p 0.014
TFA2 Tfa2p 0.014
YIL151C hypothetical protein 0.013
YHB1 Yhb1p 0.013
YOL038C-A hypothetical protein 0.013
CUP1-1 Cup1-1p 0.013
MER1 Mer1p 0.013
YLR162W hypothetical protein 0.012
SFB3 Sfb3p 0.012
SOK1 Sok1p 0.012
STE4 Ste4p 0.012
RPN14 Rpn14p 0.012
ROM2 Rom2p 0.012
OSH3 Osh3p 0.012
YLR042C hypothetical protein 0.012
TIP1 Tip1p 0.012
ARK1 Ark1p 0.012
YCH1 Ych1p 0.012
TRS65 Trs65p 0.012
PNS1 Pns1p 0.012
YMR295C hypothetical protein 0.012
HXT3 Hxt3p 0.012
KIC1 Kic1p 0.011
PRM5 Prm5p 0.011
PPQ1 Ppq1p 0.011
OPY1 Opy1p 0.011
YIR035C hypothetical protein 0.011
YLR194C hypothetical protein 0.011
MGR1 Mgr1p 0.011
AIM25 Aim25p 0.010
GAT1 Gat1p 0.010
PAA1 Paa1p 0.010
YBR013C hypothetical protein 0.010
CHA1 Cha1p 0.010