The network for 'positive regulation of wnt signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of wnt signaling pathway

Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.

Danio rerio
Name Description Probability Func Analog Organism
bmp4 bone morphogenetic protein 4 0.137
wnt4a wingless-type MMTV integration site family, member 4a 0.100
bmp2a bone morphogenetic protein 2a 0.085
sparc secreted acidic cysteine rich glycoprotein 0.080
spry2 sprouty homolog 2 0.071
mib mind bomb 0.051
wnt3a wingless-type MMTV integration site family, member 3A 0.051
sulf1 sulfatase 1 0.047
igfbp3 insulin-like growth factor binding protein 3 0.045
wnt5b wingless-type MMTV integration site family, member 5b 0.042
per3 period homolog 3 (Drosophila) 0.038
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.038
lhx2b LIM homeobox 2b 0.036
tbx1 T-box 1 0.035
twist3 twist3 0.033
msxb muscle segment homeobox B 0.033
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.028
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.027
fgf3 fibroblast growth factor 3 0.025
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.023
col2a1a collagen type II, alpha-1a 0.021
sulf2l sulfatase 2, like 0.021
sulf2 sulfatase 2 0.020
dusp6 dual specificity phosphatase 6 0.020
vim vimentin 0.019
wnt3 wingless-type MMTV integration site family, member 3 0.019
pcdh19 protocadherin 19 0.019
robo1 roundabout homolog 1 0.019
gli3 GLI-Kruppel family member GLI3 0.018
wls wntless homolog (Drosophila) 0.017
col5a1 procollagen, type V, alpha 1 0.017
map2k4a mitogen-activated protein kinase kinase 4a 0.016
zbtb4 zinc finger and BTB domain containing 4 0.016
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.016
bty bloodthirsty 0.015
vcanb versican b 0.014
fgfr1a fibroblast growth factor receptor 1a 0.014
flh floating head 0.014
col14a1 collagen, type XIV, alpha 1 0.013
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.013
col1a2 collagen, type I, alpha 2 0.013
oprm1 opioid receptor, mu 1 0.013
her5 hairy-related 5 0.013
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.013
dctn1a dynactin 1a 0.013
frem3 Fras1 related extracellular matrix 3 0.012
crb2a crumbs homolog 2a 0.012
tuba1l tubulin, alpha 1, like 0.012
zfyve26 zinc finger, FYVE domain containing 26 0.012
wnt9a wingless-type MMTV integration site family, member 9A 0.012
atp6v1g1 ATPase, H+ transporting, V1 subunit G isoform 1 0.012
dlb deltaB 0.012
lhx6 LIM homeobox 6 0.012
guca1c guanylate cyclase activator 1C 0.012
postn periostin, osteoblast specific factor 0.012
efnb2a ephrin B2a 0.012
runx2a runt-related transcription factor 2a 0.012
dcn decorin 0.012
foxo3b forkhead box O3b 0.012
wnt9b wingless-type MMTV integration site family, member 9B 0.011
mpp5b membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b) 0.011
crb3a crumbs homolog 3a 0.011
wnt7bb wingless-type MMTV integration site family, member 7Bb 0.011
wnt8b wingless-type MMTV integration site family, member 8b 0.011
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.011
wnt16 wingless-type MMTV integration site family, member 16 0.010
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.010
wif1 wnt inhibitory factor 1 0.010
csnk1da casein kinase 1, delta a 0.010
sfrp1a secreted frizzled-related protein 1a 0.010
flt4 fms-related tyrosine kinase 4 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
skd skuld 0.880
wls wntless 0.872
fz frizzled 0.664
O-fut1 O-fucosyltransferase 1 0.618
Wnt2 Wnt oncogene analog 2 0.618
Tsc1 CG6147 gene product from transcript CG6147-RA 0.583
dsh dishevelled 0.467
bai baiser 0.423
p24-1 p24-related-1 0.410
phl pole hole 0.360
EcR Ecdysone receptor 0.360
eca eclair 0.343
wg wingless 0.340
p24-2 p24-related-2 0.282
rdx roadkill 0.262
yki yorkie 0.256
hpo hippo 0.234
jing CG9397 gene product from transcript CG9397-RI 0.228
ovo CG6824 gene product from transcript CG6824-RE 0.225
sd scalloped 0.218
Bre1 CG10542 gene product from transcript CG10542-RA 0.216
nct nicastrin 0.212
Wnk CG7177 gene product from transcript CG7177-RA 0.195
CHOp24 CG3564 gene product from transcript CG3564-RA 0.184
ash2 absent, small, or homeotic discs 2 0.178
garz gartenzwerg 0.166
Hs6st Heparan sulfate 6-O-sulfotransferase 0.154
rok Rho-kinase 0.148
G-oalpha47A G protein oalpha 47A 0.138
CkIIalpha Casein kinase II alpha subunit 0.134
bip2 CG2009 gene product from transcript CG2009-RA 0.133
Zyx102EF CG32018 gene product from transcript CG32018-RA 0.127
Dok Downstream of kinase 0.120
stg string 0.115
bnl branchless 0.113
foi fear-of-intimacy 0.109
CG9941 CG9941 gene product from transcript CG9941-RA 0.107
Smr Smrter 0.102
mib1 mind bomb 1 0.096
Fs Follistatin 0.096
sfl sulfateless 0.090
Tollo CG6890 gene product from transcript CG6890-RA 0.089
pnt pointed 0.088
gig gigas 0.085
Klp64D Kinesin-like protein at 64D 0.083
klar klarsicht 0.081
CG4567 CG4567 gene product from transcript CG4567-RA 0.078
fz2 frizzled 2 0.077
insc inscuteable 0.077
Ser Serrate 0.076
CG9053 CG9053 gene product from transcript CG9053-RA 0.074
Hsc70-3 Heat shock protein cognate 3 0.073
Dcr-1 Dicer-1 0.071
arm armadillo 0.070
car carnation 0.069
disp dispatched 0.067
Rab23 CG2108 gene product from transcript CG2108-RA 0.067
rk rickets 0.066
wdb widerborst 0.064
CtBP C-terminal Binding Protein 0.064
TER94 CG2331 gene product from transcript CG2331-RA 0.064
capt capulet 0.063
Max CG9648 gene product from transcript CG9648-RA 0.057
opa odd paired 0.056
LamC Lamin C 0.056
vg vestigial 0.055
sgl sugarless 0.055
Syx5 Syntaxin 5 0.054
Axn Axin 0.053
pie pineapple eye 0.053
EloA Elongin A 0.052
CG11347 CG11347 gene product from transcript CG11347-RE 0.051
dap dacapo 0.050
pnr pannier 0.050
Pcaf CG4107 gene product from transcript CG4107-RA 0.049
sbb scribbler 0.049
simj simjang 0.047
dve defective proventriculus 0.045
tai taiman 0.044
flr flare 0.044
Su(H) Suppressor of Hairless 0.044
mam mastermind 0.043
heph hephaestus 0.042
CycD Cyclin D 0.042
Marf Mitochondrial assembly regulatory factor 0.042
JhI-1 Juvenile hormone-inducible protein 1 0.042
arr arrow 0.041
trc tricornered 0.040
ecd ecdysoneless 0.039
CG9630 CG9630 gene product from transcript CG9630-RA 0.039
CG42574 CG42574 gene product from transcript CG42574-RE 0.038
Ptp61F Protein tyrosine phosphatase 61F 0.038
pygo pygopus 0.036
dome domeless 0.036
EndoGI Endonuclease G inhibitor 0.035
Sac1 CG9128 gene product from transcript CG9128-RB 0.035
jim CG11352 gene product from transcript CG11352-RB 0.035
Pax Paxillin 0.035
prod proliferation disrupter 0.034
sr stripe 0.034
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
CSNK1E casein kinase 1, epsilon 0.998
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.997
SMAD3 SMAD family member 3 0.991
APC adenomatous polyposis coli 0.982
SMAD2 SMAD family member 2 0.980
FGFR1 fibroblast growth factor receptor 1 0.962
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.949
LRP6 low density lipoprotein receptor-related protein 6 0.945
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.842
BIRC2 baculoviral IAP repeat containing 2 0.834
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.776
BMPR1A bone morphogenetic protein receptor, type IA 0.769
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.737
GSK3B glycogen synthase kinase 3 beta 0.718
COL1A1 collagen, type I, alpha 1 0.696
AXIN1 axin 1 0.685
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.670
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.637
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.627
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.616
SMAD4 SMAD family member 4 0.596
SMAD1 SMAD family member 1 0.556
FGF1 fibroblast growth factor 1 (acidic) 0.553
TNIP2 TNFAIP3 interacting protein 2 0.524
SMAD5 SMAD family member 5 0.515
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.512
YY1 YY1 transcription factor 0.510
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.506
GIPC1 GIPC PDZ domain containing family, member 1 0.494
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.480
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.475
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.471
DDR2 discoidin domain receptor tyrosine kinase 2 0.447
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.444
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.420
COL5A1 collagen, type V, alpha 1 0.420
COL1A2 collagen, type I, alpha 2 0.402
FZD1 frizzled homolog 1 (Drosophila) 0.366
ERBB2IP erbb2 interacting protein 0.348
KIF5B kinesin family member 5B 0.345
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.337
BIRC3 baculoviral IAP repeat containing 3 0.315
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.281
FBXW11 F-box and WD repeat domain containing 11 0.267
GLIS2 GLIS family zinc finger 2 0.259
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.255
RIN1 Ras and Rab interactor 1 0.252
FGF10 fibroblast growth factor 10 0.243
XIAP X-linked inhibitor of apoptosis 0.237
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.231
FSTL1 follistatin-like 1 0.228
BTRC beta-transducin repeat containing 0.226
CAV1 caveolin 1, caveolae protein, 22kDa 0.215
RANBP2 RAN binding protein 2 0.211
KLHL3 kelch-like 3 (Drosophila) 0.200
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.199
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.195
SMAD7 SMAD family member 7 0.193
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.190
CDK6 cyclin-dependent kinase 6 0.190
ARID1A AT rich interactive domain 1A (SWI-like) 0.190
POSTN periostin, osteoblast specific factor 0.186
WNT3A wingless-type MMTV integration site family, member 3A 0.185
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.184
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.178
ATF7IP activating transcription factor 7 interacting protein 0.177
COL4A1 collagen, type IV, alpha 1 0.171
WNT5A wingless-type MMTV integration site family, member 5A 0.166
TRIM33 tripartite motif containing 33 0.163
PARVA parvin, alpha 0.161
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.156
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.154
SFRP1 secreted frizzled-related protein 1 0.154
DAXX death-domain associated protein 0.154
COL3A1 collagen, type III, alpha 1 0.152
COL6A1 collagen, type VI, alpha 1 0.149
MXRA5 matrix-remodelling associated 5 0.146
CSNK1A1 casein kinase 1, alpha 1 0.145
SKIL SKI-like oncogene 0.145
NCOA1 nuclear receptor coactivator 1 0.141
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.139
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.136
SIRT1 sirtuin 1 0.130
SMAD6 SMAD family member 6 0.129
RNF111 ring finger protein 111 0.126
SMAD9 SMAD family member 9 0.122
MCC mutated in colorectal cancers 0.122
RNF11 ring finger protein 11 0.121
LIMD1 LIM domains containing 1 0.119
USP9X ubiquitin specific peptidase 9, X-linked 0.119
APP amyloid beta (A4) precursor protein 0.118
OCLN occludin 0.118
TOX4 TOX high mobility group box family member 4 0.115
GATAD2A GATA zinc finger domain containing 2A 0.114
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.110
ARID1B AT rich interactive domain 1B (SWI1-like) 0.110
HUWE1 HECT, UBA and WWE domain containing 1 0.108
PUM1 pumilio homolog 1 (Drosophila) 0.101
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.098
STRN3 striatin, calmodulin binding protein 3 0.098
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.998
Gli3 GLI-Kruppel family member GLI3 0.994
Bmp4 bone morphogenetic protein 4 0.990
Sox9 SRY-box containing gene 9 0.984
Trp53 transformation related protein 53 0.978
Fgfr1 fibroblast growth factor receptor 1 0.963
Msx1 homeobox, msh-like 1 0.963
Vangl2 vang-like 2 (van gogh, Drosophila) 0.957
Shh sonic hedgehog 0.912
Bmp7 bone morphogenetic protein 7 0.905
Ctnnb1 catenin (cadherin associated protein), beta 1 0.891
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.887
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.880
Lrp6 low density lipoprotein receptor-related protein 6 0.860
Wnt3a wingless-related MMTV integration site 3A 0.852
Smo smoothened homolog (Drosophila) 0.849
Fgfr3 fibroblast growth factor receptor 3 0.842
Fgf8 fibroblast growth factor 8 0.841
Fgf10 fibroblast growth factor 10 0.832
Hand1 heart and neural crest derivatives expressed transcript 1 0.815
Pax8 paired box gene 8 0.813
Prrx1 paired related homeobox 1 0.796
Ahr aryl-hydrocarbon receptor 0.781
Efs embryonal Fyn-associated substrate 0.760
Wnt5a wingless-related MMTV integration site 5A 0.758
Pax3 paired box gene 3 0.752
Tgfb2 transforming growth factor, beta 2 0.720
Chrd chordin 0.717
Gli2 GLI-Kruppel family member GLI2 0.715
Alx4 aristaless-like homeobox 4 0.713
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.699
Hand2 heart and neural crest derivatives expressed transcript 2 0.686
Nodal nodal 0.685
Foxc1 forkhead box C1 0.673
Lepr leptin receptor 0.670
Dlx5 distal-less homeobox 5 0.642
Ptk2 PTK2 protein tyrosine kinase 2 0.635
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.615
Ntf3 neurotrophin 3 0.611
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.539
Pten phosphatase and tensin homolog 0.538
Ret ret proto-oncogene 0.533
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.502
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.488
Zeb1 zinc finger E-box binding homeobox 1 0.473
Sfrp2 secreted frizzled-related protein 2 0.472
Acvr1 activin A receptor, type 1 0.471
Axin1 axin 1 0.462
Bmpr1a bone morphogenetic protein receptor, type 1A 0.427
Csf1 colony stimulating factor 1 (macrophage) 0.413
Bmp2 bone morphogenetic protein 2 0.405
Sall4 sal-like 4 (Drosophila) 0.386
Runx2 runt related transcription factor 2 0.372
Amhr2 anti-Mullerian hormone type 2 receptor 0.369
Gsk3b glycogen synthase kinase 3 beta 0.366
Tgfa transforming growth factor alpha 0.352
Prrx2 paired related homeobox 2 0.352
Lmx1b LIM homeobox transcription factor 1 beta 0.351
Vangl1 vang-like 1 (van gogh, Drosophila) 0.349
Msx2 homeobox, msh-like 2 0.349
Pou3f3 POU domain, class 3, transcription factor 3 0.341
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.334
Ptk7 PTK7 protein tyrosine kinase 7 0.332
Gbx2 gastrulation brain homeobox 2 0.323
Apc adenomatosis polyposis coli 0.317
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.311
En1 engrailed 1 0.303
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.303
Yap1 yes-associated protein 1 0.298
Nog noggin 0.297
Sfrp1 secreted frizzled-related protein 1 0.294
Lef1 lymphoid enhancer binding factor 1 0.293
Wnt6 wingless-related MMTV integration site 6 0.287
Smad6 MAD homolog 6 (Drosophila) 0.281
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.274
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.274
Pax2 paired box gene 2 0.273
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.270
Efnb2 ephrin B2 0.269
Foxn1 forkhead box N1 0.262
Zic3 zinc finger protein of the cerebellum 3 0.258
Ednrb endothelin receptor type B 0.257
Bdnf brain derived neurotrophic factor 0.253
Gli1 GLI-Kruppel family member GLI1 0.248
Lhx1 LIM homeobox protein 1 0.236
Hoxd13 homeobox D13 0.233
Npr3 natriuretic peptide receptor 3 0.231
Eya1 eyes absent 1 homolog (Drosophila) 0.226
Lrp2 low density lipoprotein receptor-related protein 2 0.225
Lama5 laminin, alpha 5 0.222
Cbl Casitas B-lineage lymphoma 0.216
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.215
Hes1 hairy and enhancer of split 1 (Drosophila) 0.211
Wnt4 wingless-related MMTV integration site 4 0.210
Ar androgen receptor 0.207
Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 0.202
Foxc2 forkhead box C2 0.199
Alx3 aristaless-like homeobox 3 0.197
Esr1 estrogen receptor 1 (alpha) 0.189
Hhex hematopoietically expressed homeobox 0.189
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism