IMP

Process View

Homo sapiens

15 genes annotated in human

glomerulus development

The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "glomerulus development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "glomerulus development" (in gray)

Name	Description	Probability	Func Analog Organism
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.998
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.996	Mouse
JAG1	jagged 1	0.994
NOTCH1	notch 1	0.993	Mouse
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.971	Mouse Rat
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.962
VEGFA	vascular endothelial growth factor A	0.943	Human
PLCG1	phospholipase C, gamma 1	0.862
TEK	TEK tyrosine kinase, endothelial	0.806
ACTB	actin, beta	0.781	Human
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.701
EGR1	early growth response 1	0.675	Human Rat
NRP1	neuropilin 1	0.647
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.606
BCL2L1	BCL2-like 1	0.549
PDGFA	platelet-derived growth factor alpha polypeptide	0.487	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.460
ADRB1	adrenergic, beta-1-, receptor	0.439
CFL1	cofilin 1 (non-muscle)	0.378
NOTCH3	notch 3	0.372	Mouse
BMPR1B	bone morphogenetic protein receptor, type IB	0.336
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.325	Human Mouse
COL4A4	collagen, type IV, alpha 4	0.322
TIMP3	TIMP metallopeptidase inhibitor 3	0.321
COL4A1	collagen, type IV, alpha 1	0.279	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.268
EGR2	early growth response 2	0.267	Human
CCNE1	cyclin E1	0.241
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.233
EGR3	early growth response 3	0.226	Human
ACTG1	actin, gamma 1	0.185	Human
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.145
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.144
PGF	placental growth factor	0.141	Human
COL4A2	collagen, type IV, alpha 2	0.135	Human
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.131
COL4A6	collagen, type IV, alpha 6	0.126	Human
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.124	Zebrafish
NOG	noggin	0.120	Mouse
PDGFC	platelet derived growth factor C	0.107
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.102
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.096
MAML1	mastermind-like 1 (Drosophila)	0.093
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.086
COL2A1	collagen, type II, alpha 1	0.083
BMP2	bone morphogenetic protein 2	0.082	Human
BMP7	bone morphogenetic protein 7	0.067
DLL1	delta-like 1 (Drosophila)	0.067
COL4A5	collagen, type IV, alpha 5	0.066	Human
IER2	immediate early response 2	0.063
COL6A1	collagen, type VI, alpha 1	0.063
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.061
FSTL1	follistatin-like 1	0.061
HDAC4	histone deacetylase 4	0.060
GRB2	growth factor receptor-bound protein 2	0.059
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.058
CFL2	cofilin 2 (muscle)	0.057
DUSP6	dual specificity phosphatase 6	0.055
EPAS1	endothelial PAS domain protein 1	0.054
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.051
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.050
NID1	nidogen 1	0.046	Mouse
DPYSL4	dihydropyrimidinase-like 4	0.042
EGFR	epidermal growth factor receptor	0.042
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.040
LAPTM5	lysosomal protein transmembrane 5	0.039
LAT	linker for activation of T cells	0.039
ZNF512B	zinc finger protein 512B	0.038
CD93	CD93 molecule	0.037
NID2	nidogen 2 (osteonidogen)	0.037
CDH5	cadherin 5, type 2 (vascular endothelium)	0.033
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.033
IGFBP5	insulin-like growth factor binding protein 5	0.033
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.032
COL1A1	collagen, type I, alpha 1	0.031
NCOA7	nuclear receptor coactivator 7	0.030
TCF4	transcription factor 4	0.029
TGFB2	transforming growth factor, beta 2	0.029
GHR	growth hormone receptor	0.028
IGFBP7	insulin-like growth factor binding protein 7	0.028
MYH11	myosin, heavy chain 11, smooth muscle	0.028
DPPA4	developmental pluripotency associated 4	0.027
SH3KBP1	SH3-domain kinase binding protein 1	0.027
ATXN1L	ataxin 1-like	0.026
TPM2	tropomyosin 2 (beta)	0.026
FBXW7	F-box and WD repeat domain containing 7	0.025
DSCAML1	Down syndrome cell adhesion molecule like 1	0.025
SNAI1	snail homolog 1 (Drosophila)	0.024
ATXN1	ataxin 1	0.023
FZD4	frizzled homolog 4 (Drosophila)	0.022
BBS1	Bardet-Biedl syndrome 1	0.022
PRRX1	paired related homeobox 1	0.021
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.021
PXDN	peroxidasin homolog (Drosophila)	0.019
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.019
PTPRB	protein tyrosine phosphatase, receptor type, B	0.019	Human
CALD1	caldesmon 1	0.019
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.019
TGFB1	transforming growth factor, beta 1	0.018
COL6A2	collagen, type VI, alpha 2	0.018
VCAN	versican	0.018
TRIM63	tripartite motif containing 63	0.018
ZNF331	zinc finger protein 331	0.017
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.017
IQGAP1	IQ motif containing GTPase activating protein 1	0.017
JUN	jun proto-oncogene	0.017
STC1	stanniocalcin 1	0.017
COL5A1	collagen, type V, alpha 1	0.017
MYL9	myosin, light chain 9, regulatory	0.017
BBS10	Bardet-Biedl syndrome 10	0.016
HDAC9	histone deacetylase 9	0.015
NOTCH2	notch 2	0.015	Mouse
BMP4	bone morphogenetic protein 4	0.015
ACTC1	actin, alpha, cardiac muscle 1	0.015	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.015
SPTBN1	spectrin, beta, non-erythrocytic 1	0.015
COL1A2	collagen, type I, alpha 2	0.014
TMSB4X	thymosin beta 4, X-linked	0.014
TGFB3	transforming growth factor, beta 3	0.013
FOXF1	forkhead box F1	0.013
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.013
SH3GL3	SH3-domain GRB2-like 3	0.013
THBS1	thrombospondin 1	0.013
DUSP2	dual specificity phosphatase 2	0.013
BCL2	B-cell CLL/lymphoma 2	0.013	Mouse
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.013
ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.013
ACTA2	actin, alpha 2, smooth muscle, aorta	0.013
ARNT	aryl hydrocarbon receptor nuclear translocator	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
LAMB1	laminin, beta 1	0.012
CTNND1	catenin (cadherin-associated protein), delta 1	0.012
JAG2	jagged 2	0.012
NOTCH2NL	notch 2 N-terminal like	0.012
GEM	GTP binding protein overexpressed in skeletal muscle	0.011
TCF21	transcription factor 21	0.011	Mouse
RBPMS	RNA binding protein with multiple splicing	0.011
COL13A1	collagen, type XIII, alpha 1	0.011
LDLR	low density lipoprotein receptor	0.011
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.011
MYOZ1	myozenin 1	0.011
ACP5	acid phosphatase 5, tartrate resistant	0.011
SPRY4	sprouty homolog 4 (Drosophila)	0.011
ICAM2	intercellular adhesion molecule 2	0.011
GAB1	GRB2-associated binding protein 1	0.010
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.010
EDNRA	endothelin receptor type A	0.010
SKIL	SKI-like oncogene	0.010
CYR61	cysteine-rich, angiogenic inducer, 61	0.010