IMP

Process View

Homo sapiens

22 genes annotated in human

anoikis

Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "anoikis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "anoikis" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.998
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.975	Human
FHL2	four and a half LIM domains 2	0.968
FYN	FYN oncogene related to SRC, FGR, YES	0.854	Human
PSG9	pregnancy specific beta-1-glycoprotein 9	0.634	Human
BCL2L1	BCL2-like 1	0.611
SYK	spleen tyrosine kinase	0.537
BCL2	B-cell CLL/lymphoma 2	0.527
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.510	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.501
MAPT	microtubule-associated protein tau	0.500
BAX	BCL2-associated X protein	0.484	Human
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.423
PSG6	pregnancy specific beta-1-glycoprotein 6	0.334	Human
SFN	stratifin	0.323
BAD	BCL2-associated agonist of cell death	0.310
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.296
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.292
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.211
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.206
ENG	endoglin	0.200
CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	0.191
JAG1	jagged 1	0.165
TLN1	talin 1	0.134
PDIA3	protein disulfide isomerase family A, member 3	0.128
BCAR1	breast cancer anti-estrogen resistance 1	0.119
WIPF1	WAS/WASL interacting protein family, member 1	0.115
LAPTM5	lysosomal protein transmembrane 5	0.113
PSG4	pregnancy specific beta-1-glycoprotein 4	0.104
PLEC	plectin	0.090
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.075
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.075
BAK1	BCL2-antagonist/killer 1	0.073	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.070
PKP2	plakophilin 2	0.068
PSG5	pregnancy specific beta-1-glycoprotein 5	0.068	Human
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.066
E2F4	E2F transcription factor 4, p107/p130-binding	0.059
CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	0.058	Human
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.057
RB1	retinoblastoma 1	0.054
PSG3	pregnancy specific beta-1-glycoprotein 3	0.053
IRS1	insulin receptor substrate 1	0.052
HCK	hemopoietic cell kinase	0.049	Human
CTGF	connective tissue growth factor	0.048
PTK2	PTK2 protein tyrosine kinase 2	0.044
JUB	jub, ajuba homolog (Xenopus laevis)	0.043
FN1	fibronectin 1	0.043
TP53	tumor protein p53	0.042
EGR1	early growth response 1	0.038
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.038
PXN	paxillin	0.038
BID	BH3 interacting domain death agonist	0.037
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.037
STRADA	STE20-related kinase adaptor alpha	0.037
PSG1	pregnancy specific beta-1-glycoprotein 1	0.036
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.036
PDCD6IP	programmed cell death 6 interacting protein	0.036
BLNK	B-cell linker	0.035
NOTCH3	notch 3	0.029	Human
SPRR2A	small proline-rich protein 2A	0.029
CYTH1	cytohesin 1	0.028
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.027
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.026
SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.024	Human
CLTC	clathrin, heavy chain (Hc)	0.024
E2F2	E2F transcription factor 2	0.024
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.024
E2F1	E2F transcription factor 1	0.023	Mouse
TCEA2	transcription elongation factor A (SII), 2	0.023
BTK	Bruton agammaglobulinemia tyrosine kinase	0.022	Human
MYO10	myosin X	0.022
ITGA6	integrin, alpha 6	0.022	Human
FLNA	filamin A, alpha	0.022
EPS8	epidermal growth factor receptor pathway substrate 8	0.021
VAV1	vav 1 guanine nucleotide exchange factor	0.021
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.020
JAG2	jagged 2	0.019
ICAM1	intercellular adhesion molecule 1	0.018
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.018	Human
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.018	Human
C14orf1	chromosome 14 open reading frame 1	0.018
COL17A1	collagen, type XVII, alpha 1	0.017
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.017
HDAC1	histone deacetylase 1	0.016
STRADB	STE20-related kinase adaptor beta	0.016
PRKCB	protein kinase C, beta	0.016
CLEC4M	C-type lectin domain family 4, member M	0.016
KIF5B	kinesin family member 5B	0.016
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.016
PSG7	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)	0.015
NCK1	NCK adaptor protein 1	0.015
E2F6	E2F transcription factor 6	0.015
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.015	Human
UNC119	unc-119 homolog (C. elegans)	0.015
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.015
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.015
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.014
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.014
CUX1	cut-like homeobox 1	0.014
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.014	Human
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.013
ANGPTL4	angiopoietin-like 4	0.013
WRN	Werner syndrome, RecQ helicase-like	0.013
NOTCH2NL	notch 2 N-terminal like	0.013
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.013
PITPNM1	phosphatidylinositol transfer protein, membrane-associated 1	0.013
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.013
RCOR1	REST corepressor 1	0.013
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.012
CDK2	cyclin-dependent kinase 2	0.012
PSG2	pregnancy specific beta-1-glycoprotein 2	0.012
RNF144B	ring finger protein 144B	0.012
MCPH1	microcephalin 1	0.012
STK11	serine/threonine kinase 11	0.012
VDAC1	voltage-dependent anion channel 1	0.012
VCL	vinculin	0.012
HPS6	Hermansky-Pudlak syndrome 6	0.012
MARK2	MAP/microtubule affinity-regulating kinase 2	0.011	Human
DBN1	drebrin 1	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
ANXA1	annexin A1	0.011
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.011
TP53BP2	tumor protein p53 binding protein, 2	0.011
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.011
PDCD6	programmed cell death 6	0.011
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.011
PTEN	phosphatase and tensin homolog	0.011
TNK2	tyrosine kinase, non-receptor, 2	0.010	Human
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.010
TNS4	tensin 4	0.010
MED28	mediator complex subunit 28	0.010
F2R	coagulation factor II (thrombin) receptor	0.010