IMP

Process View

Homo sapiens

2 genes annotated in human

secondary heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "secondary heart field specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "secondary heart field specification" (in gray)

Name	Description	Probability	Func Analog Organism
NOTCH1	notch 1	0.995
BMPR1A	bone morphogenetic protein receptor, type IA	0.992
ATXN1L	ataxin 1-like	0.990
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.945
HDAC4	histone deacetylase 4	0.906
NCOR2	nuclear receptor corepressor 2	0.741
MAML1	mastermind-like 1 (Drosophila)	0.718
FSTL1	follistatin-like 1	0.538
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.514
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.209
SNW1	SNW domain containing 1	0.208
LHX3	LIM homeobox 3	0.149	Human
LMX1A	LIM homeobox transcription factor 1, alpha	0.115	Human
JAG1	jagged 1	0.113
ZNF830	zinc finger protein 830	0.112
HDAC9	histone deacetylase 9	0.096
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.093
ATXN1	ataxin 1	0.089
CIR1	corepressor interacting with RBPJ, 1	0.079
ZFYVE9	zinc finger, FYVE domain containing 9	0.067
EP300	E1A binding protein p300	0.058
SPTBN1	spectrin, beta, non-erythrocytic 1	0.056
FAM123C	family with sequence similarity 123C	0.049
NOG	noggin	0.047
MYOD1	myogenic differentiation 1	0.046
PAX6	paired box 6	0.043
AXIN1	axin 1	0.041
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.040
TCF4	transcription factor 4	0.039
BCL6	B-cell CLL/lymphoma 6	0.037
PPARG	peroxisome proliferator-activated receptor gamma	0.036
OTX2	orthodenticle homeobox 2	0.034
MEF2A	myocyte enhancer factor 2A	0.034
MYLK2	myosin light chain kinase 2	0.033
NCOR1	nuclear receptor corepressor 1	0.032
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.032
FHL1	four and a half LIM domains 1	0.031
LBX1	ladybird homeobox 1	0.030
PDX1	pancreatic and duodenal homeobox 1	0.029
KIAA0174	KIAA0174	0.028
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.027
CTNNBL1	catenin, beta like 1	0.027
BMPR1B	bone morphogenetic protein receptor, type IB	0.026
NOTCH3	notch 3	0.026
RAX	retina and anterior neural fold homeobox	0.025
PAX7	paired box 7	0.024
SART1	squamous cell carcinoma antigen recognized by T cells	0.024
FGF3	fibroblast growth factor 3	0.024
NOTCH2	notch 2	0.024
PGR	progesterone receptor	0.023
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.023
BHLHE23	basic helix-loop-helix family, member e23	0.023
FOXG1	forkhead box G1	0.022
XAB2	XPA binding protein 2	0.021
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.021
SNIP1	Smad nuclear interacting protein 1	0.020
FOXN4	forkhead box N4	0.020
HES2	hairy and enhancer of split 2 (Drosophila)	0.020
PAX2	paired box 2	0.019
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.019
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.019
TP73	tumor protein p73	0.019
BMP4	bone morphogenetic protein 4	0.018
DLX4	distal-less homeobox 4	0.018
FEZF2	FEZ family zinc finger 2	0.018
FOXD3	forkhead box D3	0.018
LHX1	LIM homeobox 1	0.017	Human
XIAP	X-linked inhibitor of apoptosis	0.017
NEUROG1	neurogenin 1	0.017
ISL1	ISL LIM homeobox 1	0.017
EPAS1	endothelial PAS domain protein 1	0.016
EMX1	empty spiracles homeobox 1	0.016
NKX6-1	NK6 homeobox 1	0.016
TLX3	T-cell leukemia homeobox 3	0.015
SMAD3	SMAD family member 3	0.015
FOXB1	forkhead box B1	0.015
OTP	orthopedia homeobox	0.015
GATA4	GATA binding protein 4	0.015
C12orf52	chromosome 12 open reading frame 52	0.014
MSX1	msh homeobox 1	0.014
PYY	peptide YY	0.014
PPARA	peroxisome proliferator-activated receptor alpha	0.014
FOXA2	forkhead box A2	0.014
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.014
ECEL1	endothelin converting enzyme-like 1	0.014
TLX2	T-cell leukemia homeobox 2	0.014
BMP2	bone morphogenetic protein 2	0.014	Human
SFRP5	secreted frizzled-related protein 5	0.014
SIX5	SIX homeobox 5	0.014
HOXD9	homeobox D9	0.014
EXOC3L2	exocyst complex component 3-like 2	0.013
FOXL1	forkhead box L1	0.013
C22orf39	chromosome 22 open reading frame 39	0.013
ZFP28	zinc finger protein 28 homolog (mouse)	0.013
VAX2	ventral anterior homeobox 2	0.013
CAMK2N2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.013
GSX2	GS homeobox 2	0.013
TBC1D5	TBC1 domain family, member 5	0.013
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.013
UTF1	undifferentiated embryonic cell transcription factor 1	0.012
POU4F3	POU class 4 homeobox 3	0.012
GBX2	gastrulation brain homeobox 2	0.012
SIX6	SIX homeobox 6	0.012
LHX5	LIM homeobox 5	0.012	Human
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.012
NEUROG3	neurogenin 3	0.012
MIXL1	Mix1 homeobox-like 1 (Xenopus laevis)	0.012
GSK3A	glycogen synthase kinase 3 alpha	0.011
LMX1B	LIM homeobox transcription factor 1, beta	0.011	Human
WNT1	wingless-type MMTV integration site family, member 1	0.011
DHH	desert hedgehog	0.011
NKD1	naked cuticle homolog 1 (Drosophila)	0.011
LHX4	LIM homeobox 4	0.011	Human
ISL2	ISL LIM homeobox 2	0.011	Human
FAM46A	family with sequence similarity 46, member A	0.011
JAG2	jagged 2	0.011
ZNF775	zinc finger protein 775	0.011
PAX1	paired box 1	0.011
GSC	goosecoid homeobox	0.011
ALX4	ALX homeobox 4	0.011
DLL1	delta-like 1 (Drosophila)	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
TMEM132E	transmembrane protein 132E	0.011
SOX1	SRY (sex determining region Y)-box 1	0.011
HOXC12	homeobox C12	0.011
KDM5A	lysine (K)-specific demethylase 5A	0.011
NKX3-2	NK3 homeobox 2	0.010
MESP1	mesoderm posterior 1 homolog (mouse)	0.010	Mouse
IRS4	insulin receptor substrate 4	0.010
ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	0.010
SLC30A2	solute carrier family 30 (zinc transporter), member 2	0.010
BMP6	bone morphogenetic protein 6	0.010
NOVA2	neuro-oncological ventral antigen 2	0.010
PRDM12	PR domain containing 12	0.010
TGFB1	transforming growth factor, beta 1	0.010