IMP

Process View

Homo sapiens

25 genes annotated in human

negative regulation of wound healing

Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of wound healing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of wound healing" (in gray)

Name	Description	Probability	Func Analog Organism
VEGFA	vascular endothelial growth factor A	0.999	Human
FGFR2	fibroblast growth factor receptor 2	0.999
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.993	Human
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.992
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.988	Human
NRP1	neuropilin 1	0.986
PLAU	plasminogen activator, urokinase	0.919	Human Mouse
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.878
FGFR1	fibroblast growth factor receptor 1	0.835
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.827
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.770
FGA	fibrinogen alpha chain	0.765
C1QA	complement component 1, q subcomponent, A chain	0.726	Human
PLG	plasminogen	0.718
KNG1	kininogen 1	0.663
PTPRB	protein tyrosine phosphatase, receptor type, B	0.626
A2M	alpha-2-macroglobulin	0.622	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.619
ACTB	actin, beta	0.553
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.543
FGB	fibrinogen beta chain	0.517
PDGFC	platelet derived growth factor C	0.458
APOE	apolipoprotein E	0.435
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.419
SYK	spleen tyrosine kinase	0.404
FGF1	fibroblast growth factor 1 (acidic)	0.394	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.379
C1QB	complement component 1, q subcomponent, B chain	0.368	Human
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.361	Human
S100A10	S100 calcium binding protein A10	0.350
NCF1	neutrophil cytosolic factor 1	0.341
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.330
PLAT	plasminogen activator, tissue	0.322	Human
HP	haptoglobin	0.322
INADL	InaD-like (Drosophila)	0.322
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.283
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.237
FGF10	fibroblast growth factor 10	0.205	Human
APOC1	apolipoprotein C-I	0.196
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.174
LRP1	low density lipoprotein receptor-related protein 1	0.160
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.144
C1S	complement component 1, s subcomponent	0.139
FGF7	fibroblast growth factor 7	0.139	Human
APOC3	apolipoprotein C-III	0.134
CDH5	cadherin 5, type 2 (vascular endothelium)	0.132
PLCG1	phospholipase C, gamma 1	0.125
APOA2	apolipoprotein A-II	0.124
SMAD2	SMAD family member 2	0.121
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.118
FLT4	fms-related tyrosine kinase 4	0.118	Human
VWF	von Willebrand factor	0.116
LCAT	lecithin-cholesterol acyltransferase	0.113
F11	coagulation factor XI	0.113
EMP1	epithelial membrane protein 1	0.096
C1QC	complement component 1, q subcomponent, C chain	0.093	Human
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.091
ALB	albumin	0.088
GYPC	glycophorin C (Gerbich blood group)	0.080
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.070
PLAUR	plasminogen activator, urokinase receptor	0.070
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.069
DCN	decorin	0.069
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.068
ANXA1	annexin A1	0.067
CDCP1	CUB domain containing protein 1	0.067
LIN7A	lin-7 homolog A (C. elegans)	0.066
C6	complement component 6	0.064
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.063
COL6A1	collagen, type VI, alpha 1	0.061
HRG	histidine-rich glycoprotein	0.056	Mouse
ENG	endoglin	0.054
TGFB1	transforming growth factor, beta 1	0.052
VEGFC	vascular endothelial growth factor C	0.050	Human
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.050
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.046
F11R	F11 receptor	0.046
PGF	placental growth factor	0.045	Human
STAB1	stabilin 1	0.045
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.045
VTN	vitronectin	0.044
COL1A1	collagen, type I, alpha 1	0.043
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.043
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.043
C8A	complement component 8, alpha polypeptide	0.043
SLC38A3	solute carrier family 38, member 3	0.043
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.042	Human
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.042
MASP2	mannan-binding lectin serine peptidase 2	0.041
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.041
APOB	apolipoprotein B (including Ag(x) antigen)	0.041
ORM1	orosomucoid 1	0.040
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.040	Human
WNT2	wingless-type MMTV integration site family member 2	0.039
COL2A1	collagen, type II, alpha 1	0.039
SDC2	syndecan 2	0.039
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.037
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.037
FN1	fibronectin 1	0.036
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.036
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.036
C8B	complement component 8, beta polypeptide	0.036
LDLR	low density lipoprotein receptor	0.036
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.035
LPA	lipoprotein, Lp(a)	0.034	Human
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.034
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.034
AFM	afamin	0.034
ITIH2	inter-alpha (globulin) inhibitor H2	0.033
ADH6	alcohol dehydrogenase 6 (class V)	0.031
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.030
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.030
ACTG1	actin, gamma 1	0.030
HAP1	huntingtin-associated protein 1	0.029
TTR	transthyretin	0.028
AXL	AXL receptor tyrosine kinase	0.028
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.028
PDGFA	platelet-derived growth factor alpha polypeptide	0.028
COL4A1	collagen, type IV, alpha 1	0.028
ITIH1	inter-alpha (globulin) inhibitor H1	0.028
TGFB3	transforming growth factor, beta 3	0.027
GAB2	GRB2-associated binding protein 2	0.026
PTH1R	parathyroid hormone 1 receptor	0.025
ITGB5	integrin, beta 5	0.024
THBS2	thrombospondin 2	0.024	Human
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.024
C2	complement component 2	0.024
OSMR	oncostatin M receptor	0.023
F3	coagulation factor III (thromboplastin, tissue factor)	0.023
F10	coagulation factor X	0.023	Human
PRODH2	proline dehydrogenase (oxidase) 2	0.023
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.023
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.023
FGG	fibrinogen gamma chain	0.023
ANGPT2	angiopoietin 2	0.022
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.022
GAB1	GRB2-associated binding protein 1	0.021
LGALS1	lectin, galactoside-binding, soluble, 1	0.021
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.021	Human Mouse
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.021
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.021
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.020
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.020
HPN	hepsin	0.020
TIMP3	TIMP metallopeptidase inhibitor 3	0.020
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.020
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.019
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.019
STC1	stanniocalcin 1	0.019
MAPT	microtubule-associated protein tau	0.018
ITIH3	inter-alpha (globulin) inhibitor H3	0.018
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.018
F2	coagulation factor II (thrombin)	0.018
LIPC	lipase, hepatic	0.018
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.017
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.017	Human
CD248	CD248 molecule, endosialin	0.017
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.017
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.017
DPYS	dihydropyrimidinase	0.017
CPN1	carboxypeptidase N, polypeptide 1	0.017
PON3	paraoxonase 3	0.016
COL3A1	collagen, type III, alpha 1	0.016
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.016
COL5A1	collagen, type V, alpha 1	0.016
MSN	moesin	0.016
ASGR2	asialoglycoprotein receptor 2	0.016
NCF4	neutrophil cytosolic factor 4, 40kDa	0.016
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.016
HABP2	hyaluronan binding protein 2	0.016	Human
FGFR3	fibroblast growth factor receptor 3	0.016
COL4A2	collagen, type IV, alpha 2	0.016
AHSG	alpha-2-HS-glycoprotein	0.015
SPP2	secreted phosphoprotein 2, 24kDa	0.015
IGFBP1	insulin-like growth factor binding protein 1	0.015
EPAS1	endothelial PAS domain protein 1	0.015
BLNK	B-cell linker	0.015
PLTP	phospholipid transfer protein	0.015
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.015	Human
F9	coagulation factor IX	0.015	Human
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.015
ANGPTL2	angiopoietin-like 2	0.015
STAB2	stabilin 2	0.015
SOS1	son of sevenless homolog 1 (Drosophila)	0.015
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.015
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.015
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.014
CYBA	cytochrome b-245, alpha polypeptide	0.014
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.014
FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	0.014	Human
S100A11	S100 calcium binding protein A11	0.014
ECM1	extracellular matrix protein 1	0.014
EMP3	epithelial membrane protein 3	0.014
EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.014
PLXDC1	plexin domain containing 1	0.013
APCS	amyloid P component, serum	0.013
MRVI1	murine retrovirus integration site 1 homolog	0.013
MRC1	mannose receptor, C type 1	0.013
FMOD	fibromodulin	0.013
SPARCL1	SPARC-like 1 (hevin)	0.013
MMP19	matrix metallopeptidase 19	0.013
CPN2	carboxypeptidase N, polypeptide 2	0.013
HAS2	hyaluronan synthase 2	0.013
CFHR2	complement factor H-related 2	0.013
APOC4	apolipoprotein C-IV	0.013
IGF1	insulin-like growth factor 1 (somatomedin C)	0.013
TAT	tyrosine aminotransferase	0.013
HNF4A	hepatocyte nuclear factor 4, alpha	0.013
RPH3A	rabphilin 3A homolog (mouse)	0.013
MYO1D	myosin ID	0.013
DDIT4	DNA-damage-inducible transcript 4	0.012
PRKCB	protein kinase C, beta	0.012
FETUB	fetuin B	0.012
BMP4	bone morphogenetic protein 4	0.012
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.012
C4B	complement component 4B (Chido blood group)	0.012
TGFB2	transforming growth factor, beta 2	0.012
IQGAP1	IQ motif containing GTPase activating protein 1	0.012
EZR	ezrin	0.012
F13B	coagulation factor XIII, B polypeptide	0.012
BHMT	betaine--homocysteine S-methyltransferase	0.012
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.012
VCAM1	vascular cell adhesion molecule 1	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.011
GJB1	gap junction protein, beta 1, 32kDa	0.011
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.011
FGL1	fibrinogen-like 1	0.011
COL1A2	collagen, type I, alpha 2	0.011
CPB2	carboxypeptidase B2 (plasma)	0.011	Rat
RDH16	retinol dehydrogenase 16 (all-trans)	0.011
APOC2	apolipoprotein C-II	0.011
TGFBI	transforming growth factor, beta-induced, 68kDa	0.011
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.011
COMP	cartilage oligomeric matrix protein	0.011	Human
A1BG	alpha-1-B glycoprotein	0.011
FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	0.011
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.011
CNTNAP2	contactin associated protein-like 2	0.011
EGFR	epidermal growth factor receptor	0.011
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.011
CCL16	chemokine (C-C motif) ligand 16	0.011
F13A1	coagulation factor XIII, A1 polypeptide	0.011
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.011
GCKR	glucokinase (hexokinase 4) regulator	0.011
TMSB10	thymosin beta 10	0.011
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.011
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.011	Human
AVPR2	arginine vasopressin receptor 2	0.011
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.011
CHRD	chordin	0.011
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.011	Human
SEMA5B	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.011
DAO	D-amino-acid oxidase	0.011
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.010
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.010
CXCL12	chemokine (C-X-C motif) ligand 12	0.010
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.010
APOA1	apolipoprotein A-I	0.010	Human
ENPEP	glutamyl aminopeptidase (aminopeptidase A)	0.010
TM4SF4	transmembrane 4 L six family member 4	0.010
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.010
SDS	serine dehydratase	0.010
HGFAC	HGF activator	0.010	Human
AEBP1	AE binding protein 1	0.010
MARCO	macrophage receptor with collagenous structure	0.010
INHBA	inhibin, beta A	0.010
GDF9	growth differentiation factor 9	0.010
SARDH	sarcosine dehydrogenase	0.010
TRIM9	tripartite motif containing 9	0.010
ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	0.010	Human
KRT5	keratin 5	0.010
NID1	nidogen 1	0.010