IMP

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Homo sapiens

20 genes annotated in human

hippo signaling

The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hippo signaling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "hippo signaling" (in gray)

Name	Description	Probability	Func Analog Organism
YAP1	Yes-associated protein 1	1.000	Human Mouse Fly
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	1.000
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	1.000
AMOTL1	angiomotin like 1	1.000	Human Mouse
STK3	serine/threonine kinase 3	1.000
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.999
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.999
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.998	Fly
AMOT	angiomotin	0.991
STK4	serine/threonine kinase 4	0.986
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.973
SAV1	salvador homolog 1 (Drosophila)	0.959	Mouse
AMOTL2	angiomotin like 2	0.952	Human
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.945
HIPK2	homeodomain interacting protein kinase 2	0.783	Fly
STK38L	serine/threonine kinase 38 like	0.761
MPDZ	multiple PDZ domain protein	0.757
SNAI1	snail homolog 1 (Drosophila)	0.741
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.727
INADL	InaD-like (Drosophila)	0.695
ANKRD28	ankyrin repeat domain 28	0.600
EZR	ezrin	0.484	Human
VCL	vinculin	0.437
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.423
TOX4	TOX high mobility group box family member 4	0.408
JUB	jub, ajuba homolog (Xenopus laevis)	0.339
FBXW11	F-box and WD repeat domain containing 11	0.324
FERMT2	fermitin family member 2	0.310
CD44	CD44 molecule (Indian blood group)	0.306
WWTR1	WW domain containing transcription regulator 1	0.265
ACTN1	actinin, alpha 1	0.260
TJP2	tight junction protein 2 (zona occludens 2)	0.248
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.243
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.235
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.225
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.214
SCHIP1	schwannomin interacting protein 1	0.207
TBC1D10A	TBC1 domain family, member 10A	0.165
LRCH1	leucine-rich repeats and calponin homology (CH) domain containing 1	0.156
TP53BP2	tumor protein p53 binding protein, 2	0.132
RUNX1	runt-related transcription factor 1	0.120
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.112
CSNK1E	casein kinase 1, epsilon	0.104
WWC1	WW and C2 domain containing 1	0.099
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.094
PPP6C	protein phosphatase 6, catalytic subunit	0.089
HOXA9	homeobox A9	0.078
MED28	mediator complex subunit 28	0.077
TEAD3	TEA domain family member 3	0.065
MAP2K3	mitogen-activated protein kinase kinase 3	0.062
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.060
MTMR4	myotubularin related protein 4	0.058
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.056
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.048
NF2	neurofibromin 2 (merlin)	0.046
PPP6R3	protein phosphatase 6, regulatory subunit 3	0.045
CRLF3	cytokine receptor-like factor 3	0.040
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.036
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.035
MSN	moesin	0.030	Human
MCC	mutated in colorectal cancers	0.027
TEAD4	TEA domain family member 4	0.027
SFN	stratifin	0.026
FLNB	filamin B, beta	0.026
LIMK2	LIM domain kinase 2	0.026
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.025
CNN2	calponin 2	0.025
KIAA1683	KIAA1683	0.024
MPP5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.023
RHOC	ras homolog gene family, member C	0.023
BTBD7	BTB (POZ) domain containing 7	0.022
LRCH2	leucine-rich repeats and calponin homology (CH) domain containing 2	0.022
LZTS2	leucine zipper, putative tumor suppressor 2	0.022
TJP1	tight junction protein 1 (zona occludens 1)	0.022
DCAF7	DDB1 and CUL4 associated factor 7	0.021	Fly
FHL3	four and a half LIM domains 3	0.021
DOCK6	dedicator of cytokinesis 6	0.021
LASP1	LIM and SH3 protein 1	0.020
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.020
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.020
WBP1	WW domain binding protein 1	0.020
WT1	Wilms tumor 1	0.019
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.018
IPO11	importin 11	0.018
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.018
DST	dystonin	0.018
SRCIN1	SRC kinase signaling inhibitor 1	0.017
MYH9	myosin, heavy chain 9, non-muscle	0.017
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.016
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.016
C5orf55	chromosome 5 open reading frame 55	0.015
ADRB2	adrenergic, beta-2-, receptor, surface	0.015
SNIP1	Smad nuclear interacting protein 1	0.014
HOXA1	homeobox A1	0.013
GORASP1	golgi reassembly stacking protein 1, 65kDa	0.013
TGFB2	transforming growth factor, beta 2	0.013
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.012
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.012
PDCD7	programmed cell death 7	0.012
CLIC4	chloride intracellular channel 4	0.012
ATN1	atrophin 1	0.012
GNG12	guanine nucleotide binding protein (G protein), gamma 12	0.011
PHLDB2	pleckstrin homology-like domain, family B, member 2	0.011
CNTROB	centrobin, centrosomal BRCA2 interacting protein	0.011
NMNAT1	nicotinamide nucleotide adenylyltransferase 1	0.011
VPRBP	Vpr (HIV-1) binding protein	0.011
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.011
NEK7	NIMA (never in mitosis gene a)-related kinase 7	0.011
RHOA	ras homolog gene family, member A	0.010
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.010
TP73	tumor protein p73	0.010