IMP

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Homo sapiens

21 genes annotated in human

Multi-species View

endosome to lysosome transport

GO:0008333

The directed movement of substances from endosomes to lysosomes.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endosome to lysosome transport"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endosome to lysosome transport" (in gray)

Name	Description	Probability	Func Analog Organism
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.989
ARHGAP1	Rho GTPase activating protein 1	0.900
ARMCX3	armadillo repeat containing, X-linked 3	0.871
STAMBP	STAM binding protein	0.869
VPS33B	vacuolar protein sorting 33 homolog B (yeast)	0.821
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.802
BECN1	beclin 1, autophagy related	0.702
RAB5A	RAB5A, member RAS oncogene family	0.694
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.690
SMAD2	SMAD family member 2	0.687
VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	0.631
SYNRG	synergin, gamma	0.577
CLASP1	cytoplasmic linker associated protein 1	0.555
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.531	Human
SORT1	sortilin 1	0.530
GPRASP1	G protein-coupled receptor associated sorting protein 1	0.500
CHMP2B	chromatin modifying protein 2B	0.389
MTMR9	myotubularin related protein 9	0.382	Human
ANKRD27	ankyrin repeat domain 27 (VPS9 domain)	0.363
HEXDC	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	0.336
TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.331
PIK3C3	phosphoinositide-3-kinase, class 3	0.310
HOOK3	hook homolog 3 (Drosophila)	0.294
UBE2W	ubiquitin-conjugating enzyme E2W (putative)	0.278
ATP6V1C1	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	0.255
MTMR6	myotubularin related protein 6	0.254	Human
SNX3	sorting nexin 3	0.228
VAMP8	vesicle-associated membrane protein 8 (endobrevin)	0.225
IGF2R	insulin-like growth factor 2 receptor	0.215
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.214
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.213	Worm
AKTIP	AKT interacting protein	0.198
LAMP2	lysosomal-associated membrane protein 2	0.181
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.179
ZFYVE9	zinc finger, FYVE domain containing 9	0.168
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.157
CREB3	cAMP responsive element binding protein 3	0.153
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.145
CHMP1B	chromatin modifying protein 1B	0.127
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.125
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.120
AGFG1	ArfGAP with FG repeats 1	0.119
EIF1B	eukaryotic translation initiation factor 1B	0.112
RTN1	reticulon 1	0.107
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.102
BCL2	B-cell CLL/lymphoma 2	0.099
GOLGA7	golgin A7	0.098
EXOC8	exocyst complex component 8	0.094
OSTM1	osteopetrosis associated transmembrane protein 1	0.094
EXOC5	exocyst complex component 5	0.092
RAB10	RAB10, member RAS oncogene family	0.088
VAMP7	vesicle-associated membrane protein 7	0.086
SNAP23	synaptosomal-associated protein, 23kDa	0.077
STX12	syntaxin 12	0.075
EEA1	early endosome antigen 1	0.073
UVRAG	UV radiation resistance associated gene	0.073
PLDN	pallidin homolog (mouse)	0.063
WDR47	WD repeat domain 47	0.062
MBIP	MAP3K12 binding inhibitory protein 1	0.062
MOSPD1	motile sperm domain containing 1	0.061
RNF6	ring finger protein (C3H2C3 type) 6	0.060
DTNBP1	dystrobrevin binding protein 1	0.054
HIPK3	homeodomain interacting protein kinase 3	0.054
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.053
KPNA4	karyopherin alpha 4 (importin alpha 3)	0.052
NBR1	neighbor of BRCA1 gene 1	0.050
REEP6	receptor accessory protein 6	0.049
AMBRA1	autophagy/beclin-1 regulator 1	0.048
ZFYVE26	zinc finger, FYVE domain containing 26	0.048
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.045
SLC9A6	solute carrier family 9 (sodium/hydrogen exchanger), member 6	0.044
CAB39	calcium binding protein 39	0.043
SRI	sorcin	0.042
CHIC2	cysteine-rich hydrophobic domain 2	0.042
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.040
VPS4B	vacuolar protein sorting 4 homolog B (S. cerevisiae)	0.039
SNX2	sorting nexin 2	0.039
VTA1	Vps20-associated 1 homolog (S. cerevisiae)	0.039
TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	0.038
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.037
TGFBR1	transforming growth factor, beta receptor 1	0.037
GPBP1L1	GC-rich promoter binding protein 1-like 1	0.036
ACTR10	actin-related protein 10 homolog (S. cerevisiae)	0.034
NRBF2	nuclear receptor binding factor 2	0.034
ZNF654	zinc finger protein 654	0.033
INSR	insulin receptor	0.033
EAF1	ELL associated factor 1	0.032
EXOC1	exocyst complex component 1	0.032
GAK	cyclin G associated kinase	0.032
SMAD9	SMAD family member 9	0.032
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.031
ARL8B	ADP-ribosylation factor-like 8B	0.031	Worm
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.031
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.031
UEVLD	UEV and lactate/malate dehyrogenase domains	0.030
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.030
VPS37A	vacuolar protein sorting 37 homolog A (S. cerevisiae)	0.030
RABAC1	Rab acceptor 1 (prenylated)	0.029
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.029
RANBP9	RAN binding protein 9	0.028
SKIL	SKI-like oncogene	0.027
ABLIM1	actin binding LIM protein 1	0.027
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.026
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.026
MYST2	MYST histone acetyltransferase 2	0.026
GATAD2B	GATA zinc finger domain containing 2B	0.025
KLF2	Kruppel-like factor 2 (lung)	0.025
BAK1	BCL2-antagonist/killer 1	0.024
RAB6A	RAB6A, member RAS oncogene family	0.024
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.024
CCDC28A	coiled-coil domain containing 28A	0.024
RTN3	reticulon 3	0.024
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.023
PRPSAP1	phosphoribosyl pyrophosphate synthetase-associated protein 1	0.023
RASAL2	RAS protein activator like 2	0.023
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.023
MOSPD2	motile sperm domain containing 2	0.022
C14orf129	chromosome 14 open reading frame 129	0.022
ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	0.021
DYNLT3	dynein, light chain, Tctex-type 3	0.021
RNF11	ring finger protein 11	0.021
EZH1	enhancer of zeste homolog 1 (Drosophila)	0.021
ANTXR2	anthrax toxin receptor 2	0.020
SH3KBP1	SH3-domain kinase binding protein 1	0.020
ARMCX2	armadillo repeat containing, X-linked 2	0.019	Human
FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	0.019
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.019
BEND7	BEN domain containing 7	0.019
RAB22A	RAB22A, member RAS oncogene family	0.018
PHF20L1	PHD finger protein 20-like 1	0.018
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.018
SMAP1	small ArfGAP 1	0.018
DDR1	discoidin domain receptor tyrosine kinase 1	0.018
DLG1	discs, large homolog 1 (Drosophila)	0.017
USP25	ubiquitin specific peptidase 25	0.017
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.017
LRP3	low density lipoprotein receptor-related protein 3	0.017
TCEAL1	transcription elongation factor A (SII)-like 1	0.017
SMAD4	SMAD family member 4	0.017
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.016
RAB21	RAB21, member RAS oncogene family	0.016
EVC2	Ellis van Creveld syndrome 2	0.016
MEAF6	MYST/Esa1-associated factor 6	0.016
DOCK8	dedicator of cytokinesis 8	0.016
MPRIP	myosin phosphatase Rho interacting protein	0.015
PPP1R12C	protein phosphatase 1, regulatory (inhibitor) subunit 12C	0.015
WASH1	WAS protein family homolog 1	0.015
SAMD4A	sterile alpha motif domain containing 4A	0.015
JUP	junction plakoglobin	0.015
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	0.015
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.015
RBM18	RNA binding motif protein 18	0.015
RHOT1	ras homolog gene family, member T1	0.014
CYB5R4	cytochrome b5 reductase 4	0.014
TSG101	tumor susceptibility gene 101	0.014
DOCK9	dedicator of cytokinesis 9	0.014
EXOC4	exocyst complex component 4	0.014
VPS16	vacuolar protein sorting 16 homolog (S. cerevisiae)	0.014
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.014
CTBP2	C-terminal binding protein 2	0.014
KCTD13	potassium channel tetramerisation domain containing 13	0.014
SWAP70	SWAP switching B-cell complex 70kDa subunit	0.014
RNF146	ring finger protein 146	0.014
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.014
TSC1	tuberous sclerosis 1	0.014
ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	0.014
STX7	syntaxin 7	0.013	Rat
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.013
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.013
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.013
ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	0.013
KCTD20	potassium channel tetramerisation domain containing 20	0.013
USP15	ubiquitin specific peptidase 15	0.013
ERC1	ELKS/RAB6-interacting/CAST family member 1	0.013
DNAJC7	DnaJ (Hsp40) homolog, subfamily C, member 7	0.012
SMAD3	SMAD family member 3	0.012
WSB2	WD repeat and SOCS box containing 2	0.012
RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	0.012
TMEM188	transmembrane protein 188	0.012
MTMR12	myotubularin related protein 12	0.012	Human
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.012
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.012
KCTD10	potassium channel tetramerisation domain containing 10	0.012
USP32	ubiquitin specific peptidase 32	0.012
CREBL2	cAMP responsive element binding protein-like 2	0.012
ZEB2	zinc finger E-box binding homeobox 2	0.012
KIAA0196	KIAA0196	0.012
ARMCX1	armadillo repeat containing, X-linked 1	0.012	Human
EAPP	E2F-associated phosphoprotein	0.012
SNAPIN	SNAP-associated protein	0.012
CHM	choroideremia (Rab escort protein 1)	0.012
AZIN1	antizyme inhibitor 1	0.012
CXXC5	CXXC finger protein 5	0.011
C1D	C1D nuclear receptor corepressor	0.011
SYT11	synaptotagmin XI	0.011
NLRX1	NLR family member X1	0.011
RALBP1	ralA binding protein 1	0.011
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.011
SH3BP2	SH3-domain binding protein 2	0.011
KIF5B	kinesin family member 5B	0.011
ABHD13	abhydrolase domain containing 13	0.011
PIK3R4	phosphoinositide-3-kinase, regulatory subunit 4	0.011
NIPSNAP3A	nipsnap homolog 3A (C. elegans)	0.011
ACAP2	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	0.011
BEX4	brain expressed, X-linked 4	0.011
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.011
ZNF250	zinc finger protein 250	0.011
RABGAP1	RAB GTPase activating protein 1	0.011
CCNY	cyclin Y	0.011
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.010
BNIP2	BCL2/adenovirus E1B 19kDa interacting protein 2	0.010
CCDC53	coiled-coil domain containing 53	0.010
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.010
TMEM9B	TMEM9 domain family, member B	0.010
PNPLA3	patatin-like phospholipase domain containing 3	0.010
RAP2C	RAP2C, member of RAS oncogene family	0.010
CCDC33	coiled-coil domain containing 33	0.010
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.010