IMP

Process View

Homo sapiens

4 genes annotated in human

response to mercury ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to mercury ion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to mercury ion" (in gray)

Name	Description	Probability	Func Analog Organism
NCOA1	nuclear receptor coactivator 1	0.808
FLNA	filamin A, alpha	0.496
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.454	Fly
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.407
KAT2B	K(lysine) acetyltransferase 2B	0.399
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.387
GPI	glucose-6-phosphate isomerase	0.318
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.241	Fly
ADAMTSL4	ADAMTS-like 4	0.197
KCTD17	potassium channel tetramerisation domain containing 17	0.161
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.159
CTGF	connective tissue growth factor	0.155
HSPG2	heparan sulfate proteoglycan 2	0.123
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.117	Fly
QKI	quaking homolog, KH domain RNA binding (mouse)	0.117
TMF1	TATA element modulatory factor 1	0.110
PKM2	pyruvate kinase, muscle	0.100
PDLIM7	PDZ and LIM domain 7 (enigma)	0.092
KANK2	KN motif and ankyrin repeat domains 2	0.087
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.083	Fly
CREBBP	CREB binding protein	0.081
MDFI	MyoD family inhibitor	0.077
PXN	paxillin	0.073
RANBP3	RAN binding protein 3	0.072
RARA	retinoic acid receptor, alpha	0.067
TRIP6	thyroid hormone receptor interactor 6	0.064
VCL	vinculin	0.061
NRIP1	nuclear receptor interacting protein 1	0.059
FAM107A	family with sequence similarity 107, member A	0.059
NCOA3	nuclear receptor coactivator 3	0.058
ATXN1	ataxin 1	0.056
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.055
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.053
ELN	elastin	0.052
CD44	CD44 molecule (Indian blood group)	0.049
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.049
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.048
IGFBP3	insulin-like growth factor binding protein 3	0.048
PRKCQ	protein kinase C, theta	0.043
LGALS1	lectin, galactoside-binding, soluble, 1	0.042
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.040
SLC17A1	solute carrier family 17 (sodium phosphate), member 1	0.039
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.038
GPRIN2	G protein regulated inducer of neurite outgrowth 2	0.035
C3	complement component 3	0.034
RXRA	retinoid X receptor, alpha	0.033
NCOA2	nuclear receptor coactivator 2	0.032
FBN1	fibrillin 1	0.032
GK	glycerol kinase	0.030
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.029
GFI1B	growth factor independent 1B transcription repressor	0.028
HOXA1	homeobox A1	0.028
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.028
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.028
FAM124B	family with sequence similarity 124B	0.028
PDLIM5	PDZ and LIM domain 5	0.026
PIGR	polymeric immunoglobulin receptor	0.026
USP50	ubiquitin specific peptidase 50	0.026
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.026
CATSPER1	cation channel, sperm associated 1	0.025
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.025
ASNA1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	0.025
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.024
SH2D1A	SH2 domain containing 1A	0.024
MED13L	mediator complex subunit 13-like	0.024
F9	coagulation factor IX	0.024
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.023
HNF1B	HNF1 homeobox B	0.023
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.023
CLIP1	CAP-GLY domain containing linker protein 1	0.023
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.022
LOX	lysyl oxidase	0.022
ANXA1	annexin A1	0.021
ESR1	estrogen receptor 1	0.021
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.021
KDELR1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	0.021
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.021
CD4	CD4 molecule	0.021
SDC2	syndecan 2	0.021
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.021
TKT	transketolase	0.021
TM4SF5	transmembrane 4 L six family member 5	0.020
AR	androgen receptor	0.020
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.020
AHNAK	AHNAK nucleoprotein	0.020
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.020
ZNF707	zinc finger protein 707	0.020
C6	complement component 6	0.019
C1orf65	chromosome 1 open reading frame 65	0.019
NOV	nephroblastoma overexpressed gene	0.019
LGALS4	lectin, galactoside-binding, soluble, 4	0.019
REG1A	regenerating islet-derived 1 alpha	0.019
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.019
LRRN4	leucine rich repeat neuronal 4	0.019
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.018
C19orf6	chromosome 19 open reading frame 6	0.018
DAO	D-amino-acid oxidase	0.018
S100A10	S100 calcium binding protein A10	0.018
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.018
BHMT	betaine--homocysteine S-methyltransferase	0.018
NCOA6	nuclear receptor coactivator 6	0.018
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.018
TLN1	talin 1	0.017
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.017
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	0.017
GLYAT	glycine-N-acyltransferase	0.017
RFXANK	regulatory factor X-associated ankyrin-containing protein	0.017
CCL16	chemokine (C-C motif) ligand 16	0.017
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.017
ALDOA	aldolase A, fructose-bisphosphate	0.017
SLC6A19	solute carrier family 6 (neutral amino acid transporter), member 19	0.017
GPR116	G protein-coupled receptor 116	0.017
GPX4	glutathione peroxidase 4 (phospholipid hydroperoxidase)	0.016
WNT2	wingless-type MMTV integration site family member 2	0.016
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.016
ADAM15	ADAM metallopeptidase domain 15	0.016
DMBT1	deleted in malignant brain tumors 1	0.016
AADAC	arylacetamide deacetylase (esterase)	0.016
VCAM1	vascular cell adhesion molecule 1	0.016
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.016
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.015
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	0.015
PON1	paraoxonase 1	0.015
SVIL	supervillin	0.015
CIDEC	cell death-inducing DFFA-like effector c	0.015
CTSA	cathepsin A	0.015
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.015
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.015
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.015
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.015
CD2	CD2 molecule	0.015
PLSCR4	phospholipid scramblase 4	0.015
NUCB1	nucleobindin 1	0.015
C17orf50	chromosome 17 open reading frame 50	0.015
ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	0.015
C8A	complement component 8, alpha polypeptide	0.015
OTX1	orthodenticle homeobox 1	0.015
GANAB	glucosidase, alpha; neutral AB	0.015
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.014
KLHDC3	kelch domain containing 3	0.014
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.014
SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.014
PRODH2	proline dehydrogenase (oxidase) 2	0.014
ARHGAP32	Rho GTPase activating protein 32	0.014
PFKL	phosphofructokinase, liver	0.014
ADIPOR1	adiponectin receptor 1	0.014
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.014
ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	0.014
ATOH8	atonal homolog 8 (Drosophila)	0.014
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.014
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.014
SLC25A39	solute carrier family 25, member 39	0.014
PDZK1	PDZ domain containing 1	0.014
FLNB	filamin B, beta	0.014
ZEB2	zinc finger E-box binding homeobox 2	0.014
ANXA2	annexin A2	0.013
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.013
GFAP	glial fibrillary acidic protein	0.013
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.013
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.013
GHRHR	growth hormone releasing hormone receptor	0.013
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.013
MASP2	mannan-binding lectin serine peptidase 2	0.013
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.013
ALOX15B	arachidonate 15-lipoxygenase, type B	0.013
GYS2	glycogen synthase 2 (liver)	0.013
LINGO1	leucine rich repeat and Ig domain containing 1	0.013
PLIN1	perilipin 1	0.013
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.013
FOXN1	forkhead box N1	0.013
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.013
POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	0.013
PON3	paraoxonase 3	0.012
CLPTM1	cleft lip and palate associated transmembrane protein 1	0.012
CLCNKB	chloride channel Kb	0.012
ASPG	asparaginase homolog (S. cerevisiae)	0.012
C4BPB	complement component 4 binding protein, beta	0.012
SFTPB	surfactant protein B	0.012
SIX1	SIX homeobox 1	0.012
PTPRN	protein tyrosine phosphatase, receptor type, N	0.012
FLOT2	flotillin 2	0.012
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.012
S100A1	S100 calcium binding protein A1	0.012
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.012
ADH6	alcohol dehydrogenase 6 (class V)	0.012
TTPA	tocopherol (alpha) transfer protein	0.012
CUBN	cubilin (intrinsic factor-cobalamin receptor)	0.012
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.012
LASP1	LIM and SH3 protein 1	0.012
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.012
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.012
CYP2F1	cytochrome P450, family 2, subfamily F, polypeptide 1	0.012
C4BPA	complement component 4 binding protein, alpha	0.012
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.012
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.012
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.012
PHKG1	phosphorylase kinase, gamma 1 (muscle)	0.012
NAT8B	N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)	0.012
ZNF440	zinc finger protein 440	0.012
FMO4	flavin containing monooxygenase 4	0.012
OTC	ornithine carbamoyltransferase	0.012
PTGER1	prostaglandin E receptor 1 (subtype EP1), 42kDa	0.012
GPR6	G protein-coupled receptor 6	0.012
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.011
TUBAL3	tubulin, alpha-like 3	0.011
C10orf10	chromosome 10 open reading frame 10	0.011
TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0.011
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.011
HSPB6	heat shock protein, alpha-crystallin-related, B6	0.011
OMP	olfactory marker protein	0.011
ANXA5	annexin A5	0.011
AQP6	aquaporin 6, kidney specific	0.011	Human
LTF	lactotransferrin	0.011
HYAL1	hyaluronoglucosaminidase 1	0.011
GSTA3	glutathione S-transferase alpha 3	0.011
PRR15L	proline rich 15-like	0.011
IFNA8	interferon, alpha 8	0.011
ATP6V0A4	ATPase, H+ transporting, lysosomal V0 subunit a4	0.011
MBL2	mannose-binding lectin (protein C) 2, soluble	0.011
CYP4B1	cytochrome P450, family 4, subfamily B, polypeptide 1	0.011
C8B	complement component 8, beta polypeptide	0.011
ALDOB	aldolase B, fructose-bisphosphate	0.011
HHEX	hematopoietically expressed homeobox	0.011
TREM1	triggering receptor expressed on myeloid cells 1	0.011
SLC15A1	solute carrier family 15 (oligopeptide transporter), member 1	0.011
SGK2	serum/glucocorticoid regulated kinase 2	0.011
COL8A1	collagen, type VIII, alpha 1	0.011
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.011
GCGR	glucagon receptor	0.011
PRDX6	peroxiredoxin 6	0.011
PAH	phenylalanine hydroxylase	0.011
TGFBI	transforming growth factor, beta-induced, 68kDa	0.011
HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	0.011
DEFB1	defensin, beta 1	0.011
ZNF132	zinc finger protein 132	0.011
SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	0.011
VNN1	vanin 1	0.011
HOXB9	homeobox B9	0.011
ERN2	endoplasmic reticulum to nucleus signaling 2	0.011
MEP1B	meprin A, beta	0.011
CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.011
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.011	Rat
AVPR1B	arginine vasopressin receptor 1B	0.011
PLCD1	phospholipase C, delta 1	0.011
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.011
CNGA1	cyclic nucleotide gated channel alpha 1	0.011
ADAM2	ADAM metallopeptidase domain 2	0.011
ADIPOQ	adiponectin, C1Q and collagen domain containing	0.011
ALPI	alkaline phosphatase, intestinal	0.011
SCGB2A1	secretoglobin, family 2A, member 1	0.011
AQP5	aquaporin 5	0.011	Human
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.011
MYH10	myosin, heavy chain 10, non-muscle	0.010
TUBB6	tubulin, beta 6	0.010
FAM82A2	family with sequence similarity 82, member A2	0.010
PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.010
PAX4	paired box 4	0.010
TALDO1	transaldolase 1	0.010
ARHGEF5	Rho guanine nucleotide exchange factor (GEF) 5	0.010
F5	coagulation factor V (proaccelerin, labile factor)	0.010
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.010
CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.010
RDH13	retinol dehydrogenase 13 (all-trans/9-cis)	0.010
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.010
C8orf48	chromosome 8 open reading frame 48	0.010
APOB	apolipoprotein B (including Ag(x) antigen)	0.010
SLC7A9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.010
EGF	epidermal growth factor	0.010
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.010
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.010
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.010
ZNF426	zinc finger protein 426	0.010
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.010
PNLIP	pancreatic lipase	0.010
DRD2	dopamine receptor D2	0.010
SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.010
ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.010
SLC14A2	solute carrier family 14 (urea transporter), member 2	0.010
NR3C2	nuclear receptor subfamily 3, group C, member 2	0.010
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.010
MPDU1	mannose-P-dolichol utilization defect 1	0.010