IMP

Process View

Homo sapiens

8 genes annotated in human

inner ear development

The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "inner ear development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "inner ear development" (in gray)

Name	Description	Probability	Func Analog Organism
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.799	Rat
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.794
PAX3	paired box 3	0.584
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.487
FSTL1	follistatin-like 1	0.447
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.418
NOTCH3	notch 3	0.279
POU3F2	POU class 3 homeobox 2	0.231
FGF1	fibroblast growth factor 1 (acidic)	0.201
NOTCH1	notch 1	0.195	Mouse
ZFYVE9	zinc finger, FYVE domain containing 9	0.173
EGFR	epidermal growth factor receptor	0.167
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.162	Mouse
SMAD7	SMAD family member 7	0.157
COL1A1	collagen, type I, alpha 1	0.157
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.139
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.130	Mouse
MEOX2	mesenchyme homeobox 2	0.126
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.125
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.100
JAG1	jagged 1	0.086	Zebrafish Mouse Rat
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.084	Rat
TAL1	T-cell acute lymphocytic leukemia 1	0.078
PTCH1	patched 1	0.077
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.061	Rat
RB1	retinoblastoma 1	0.061
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	0.057	Mouse
COL2A1	collagen, type II, alpha 1	0.057	Mouse
HSF1	heat shock transcription factor 1	0.051
BMPR1A	bone morphogenetic protein receptor, type IA	0.050
FGFR2	fibroblast growth factor receptor 2	0.050	Mouse
MEOX1	mesenchyme homeobox 1	0.048
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.048	Mouse
CHD8	chromodomain helicase DNA binding protein 8	0.046	Human
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.044
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.042	Zebrafish
PTEN	phosphatase and tensin homolog	0.042	Zebrafish
MDFI	MyoD family inhibitor	0.040
CSNK1E	casein kinase 1, epsilon	0.039
NKX2-1	NK2 homeobox 1	0.039
CHD7	chromodomain helicase DNA binding protein 7	0.038
FZD1	frizzled homolog 1 (Drosophila)	0.038
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.037
HOXA10	homeobox A10	0.036
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.035
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.035
CAV1	caveolin 1, caveolae protein, 22kDa	0.034
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.034
IDI1	isopentenyl-diphosphate delta isomerase 1	0.033
VEGFA	vascular endothelial growth factor A	0.033
BCR	breakpoint cluster region	0.031	Mouse
AHR	aryl hydrocarbon receptor	0.030
TRIM63	tripartite motif containing 63	0.030
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.029
WT1	Wilms tumor 1	0.029
SIX3	SIX homeobox 3	0.027
MSX1	msh homeobox 1	0.027	Zebrafish
SOX9	SRY (sex determining region Y)-box 9	0.026	Human Zebrafish Mouse
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.025	Mouse
USHBP1	Usher syndrome 1C binding protein 1	0.025
PDZK1	PDZ domain containing 1	0.025
POU5F1	POU class 5 homeobox 1	0.024
CALCA	calcitonin-related polypeptide alpha	0.024
FRS2	fibroblast growth factor receptor substrate 2	0.024
MAPK14	mitogen-activated protein kinase 14	0.023
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.023
PAX2	paired box 2	0.023	Human Mouse
SOX11	SRY (sex determining region Y)-box 11	0.021	Human
DCC	deleted in colorectal carcinoma	0.021
STRN3	striatin, calmodulin binding protein 3	0.021
PML	promyelocytic leukemia	0.021
PPARA	peroxisome proliferator-activated receptor alpha	0.020
COL5A1	collagen, type V, alpha 1	0.020
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.020
USH1C	Usher syndrome 1C (autosomal recessive, severe)	0.019	Mouse
SEC23A	Sec23 homolog A (S. cerevisiae)	0.018
LRP6	low density lipoprotein receptor-related protein 6	0.018
BMP1	bone morphogenetic protein 1	0.018
FBXO7	F-box protein 7	0.017
TRIP6	thyroid hormone receptor interactor 6	0.016
TGFB2	transforming growth factor, beta 2	0.016	Rat
LHX1	LIM homeobox 1	0.016	Human
MSX2	msh homeobox 2	0.016
LAT	linker for activation of T cells	0.016
COL1A2	collagen, type I, alpha 2	0.016
PDIA3	protein disulfide isomerase family A, member 3	0.016
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.016
BBS10	Bardet-Biedl syndrome 10	0.015
JUP	junction plakoglobin	0.015
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.015
GFI1B	growth factor independent 1B transcription repressor	0.014
NOTCH2	notch 2	0.014
SC4MOL	sterol-C4-methyl oxidase-like	0.014
HMGA2	high mobility group AT-hook 2	0.014
PDGFA	platelet-derived growth factor alpha polypeptide	0.014
KRTAP4-12	keratin associated protein 4-12	0.014
KCTD1	potassium channel tetramerisation domain containing 1	0.014
FGFR3	fibroblast growth factor receptor 3	0.014	Mouse
SIM2	single-minded homolog 2 (Drosophila)	0.014
FOXA2	forkhead box A2	0.014
TGFB3	transforming growth factor, beta 3	0.013	Rat
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.013
CANX	calnexin	0.013
SOX1	SRY (sex determining region Y)-box 1	0.013	Human
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.013
PLXNB1	plexin B1	0.013
TGFB1	transforming growth factor, beta 1	0.012	Zebrafish Rat
ATF2	activating transcription factor 2	0.012
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.012
APC	adenomatous polyposis coli	0.012
EMX1	empty spiracles homeobox 1	0.012
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.012
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.012
RET	ret proto-oncogene	0.012
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.012
VAX2	ventral anterior homeobox 2	0.012
POU4F2	POU class 4 homeobox 2	0.012
TCF4	transcription factor 4	0.012
HOXC8	homeobox C8	0.011
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.011
PDGFC	platelet derived growth factor C	0.011
DTX2	deltex homolog 2 (Drosophila)	0.011
ADAM12	ADAM metallopeptidase domain 12	0.011
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.011
JAK2	Janus kinase 2	0.010
LPXN	leupaxin	0.010
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.010	Zebrafish
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.010
NRP1	neuropilin 1	0.010	Mouse
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.010