IMP

Process View

Homo sapiens

27 genes annotated in human

Multi-species View

histone h3 k4 methylation

GO:0051568

The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "histone h3 k4 methylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "histone h3 k4 methylation" (in gray)

Name	Description	Probability	Func Analog Organism
WDR5	WD repeat domain 5	1.000
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	1.000
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.999
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.989
H2AFX	H2A histone family, member X	0.985
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.879
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.841
RBBP5	retinoblastoma binding protein 5	0.811
NCOA6	nuclear receptor coactivator 6	0.804
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.793
HCFC1	host cell factor C1 (VP16-accessory protein)	0.792
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.761
CXXC1	CXXC finger protein 1	0.738
HDAC1	histone deacetylase 1	0.715
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.674
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.664
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.589	Human
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.481
EED	embryonic ectoderm development	0.434
SETD1A	SET domain containing 1A	0.401
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.370	Human Mouse Fly
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.359
CHD8	chromodomain helicase DNA binding protein 8	0.343
RPA2	replication protein A2, 32kDa	0.283
NCOA1	nuclear receptor coactivator 1	0.281
PARP1	poly (ADP-ribose) polymerase 1	0.220
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.218
KDM2B	lysine (K)-specific demethylase 2B	0.218
CCNT1	cyclin T1	0.187
RPA1	replication protein A1, 70kDa	0.185
ORC1	origin recognition complex, subunit 1	0.165
HIST1H3B	histone cluster 1, H3b	0.160
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.154
DAXX	death-domain associated protein	0.150
H3F3C	H3 histone, family 3C	0.141
TP53BP1	tumor protein p53 binding protein 1	0.130
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.111
SMC1A	structural maintenance of chromosomes 1A	0.109
CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.107
WDR82	WD repeat domain 82	0.104
MEN1	multiple endocrine neoplasia I	0.094
HEXIM1	hexamethylene bis-acetamide inducible 1	0.092
WDR61	WD repeat domain 61	0.091
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.083
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.078
ATM	ataxia telangiectasia mutated	0.077
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.077
BRCA1	breast cancer 1, early onset	0.068
CUL4A	cullin 4A	0.065
NBN	nibrin	0.063
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.061
KIAA1267	KIAA1267	0.058
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.056
RAD50	RAD50 homolog (S. cerevisiae)	0.056
ARID4B	AT rich interactive domain 4B (RBP1-like)	0.052
MYST1	MYST histone acetyltransferase 1	0.048
HDAC2	histone deacetylase 2	0.048
TCEA1	transcription elongation factor A (SII), 1	0.048
KAT2A	K(lysine) acetyltransferase 2A	0.046
NLK	nemo-like kinase	0.044
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.043
IK	IK cytokine, down-regulator of HLA II	0.043
CREBBP	CREB binding protein	0.042
CTCF	CCCTC-binding factor (zinc finger protein)	0.040	Human
MLL4	myeloid/lymphoid or mixed-lineage leukemia 4	0.039
PCGF1	polycomb group ring finger 1	0.038
TSC22D1	TSC22 domain family, member 1	0.037
CBX1	chromobox homolog 1	0.037
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.036
RBBP4	retinoblastoma binding protein 4	0.035
HEXA	hexosaminidase A (alpha polypeptide)	0.033
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.033
EP300	E1A binding protein p300	0.031
C16orf53	chromosome 16 open reading frame 53	0.030	Fly
ATN1	atrophin 1	0.028
ORC4	origin recognition complex, subunit 4	0.028
MBIP	MAP3K12 binding inhibitory protein 1	0.026
KDM6A	lysine (K)-specific demethylase 6A	0.026
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.026
ORC3	origin recognition complex, subunit 3	0.025
SEPT6	septin 6	0.024
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.023
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.023
CCDC85B	coiled-coil domain containing 85B	0.022
DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	0.021
HOXC4	homeobox C4	0.021
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.021
NIPBL	Nipped-B homolog (Drosophila)	0.021
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.021
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.020
RBL1	retinoblastoma-like 1 (p107)	0.020
HIST2H3C	histone cluster 2, H3c	0.020
RNF8	ring finger protein 8	0.020
HDAC3	histone deacetylase 3	0.019
PPP1R8	protein phosphatase 1, regulatory (inhibitor) subunit 8	0.019
ATRIP	ATR interacting protein	0.019
LBR	lamin B receptor	0.019
PRRC2B	proline-rich coiled-coil 2B	0.019
ETV3	ets variant 3	0.018
PIAS4	protein inhibitor of activated STAT, 4	0.018
PAPD4	PAP associated domain containing 4	0.017
ATXN7	ataxin 7	0.017
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.016
TRRAP	transformation/transcription domain-associated protein	0.016
ZNF512B	zinc finger protein 512B	0.015
HIST2H2AC	histone cluster 2, H2ac	0.015
TERF2	telomeric repeat binding factor 2	0.015
POGZ	pogo transposable element with ZNF domain	0.015
DPY30	dpy-30 homolog (C. elegans)	0.015
KDM2A	lysine (K)-specific demethylase 2A	0.014
BRD1	bromodomain containing 1	0.014
RPA3	replication protein A3, 14kDa	0.014
GATAD2B	GATA zinc finger domain containing 2B	0.014
ERH	enhancer of rudimentary homolog (Drosophila)	0.014
EHMT1	euchromatic histone-lysine N-methyltransferase 1	0.014
CELF1	CUGBP, Elav-like family member 1	0.013
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.013
CCDC101	coiled-coil domain containing 101	0.013
RBBP7	retinoblastoma binding protein 7	0.013
KLF12	Kruppel-like factor 12	0.013
SETD1B	SET domain containing 1B	0.012
HCFC2	host cell factor C2	0.012
RB1	retinoblastoma 1	0.012
TADA2A	transcriptional adaptor 2A	0.012
ZFYVE9	zinc finger, FYVE domain containing 9	0.012
PPIL3	peptidylprolyl isomerase (cyclophilin)-like 3	0.012
LIN54	lin-54 homolog (C. elegans)	0.012
PASK	PAS domain containing serine/threonine kinase	0.011
PYGO2	pygopus homolog 2 (Drosophila)	0.011	Mouse
MBD1	methyl-CpG binding domain protein 1	0.011
NELL2	NEL-like 2 (chicken)	0.011
RNF2	ring finger protein 2	0.011
JAG2	jagged 2	0.011
EAPP	E2F-associated phosphoprotein	0.011
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.011
FANCD2	Fanconi anemia, complementation group D2	0.011
ADNP	activity-dependent neuroprotector homeobox	0.011
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.011
ZBTB8A	zinc finger and BTB domain containing 8A	0.010
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.010
MAML1	mastermind-like 1 (Drosophila)	0.010
ASH1L	ash1 (absent, small, or homeotic)-like (Drosophila)	0.010	Mouse Fly
USHBP1	Usher syndrome 1C binding protein 1	0.010
C10orf12	chromosome 10 open reading frame 12	0.010
MRPL44	mitochondrial ribosomal protein L44	0.010
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.010