IMP

Process View

Homo sapiens

7 genes annotated in human

oligodendrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "oligodendrocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "oligodendrocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	0.949	Zebrafish Mouse Rat
EGFR	epidermal growth factor receptor	0.907
JAG1	jagged 1	0.847
BCL2L1	BCL2-like 1	0.742
NOTCH1	notch 1	0.725	Mouse Rat
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.659
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.503
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.498
CTNND1	catenin (cadherin-associated protein), delta 1	0.442
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.385
POU3F2	POU class 3 homeobox 2	0.359
NOTCH3	notch 3	0.345	Zebrafish
PAX3	paired box 3	0.213
EIF2B4	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	0.171
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.164	Mouse
TCF4	transcription factor 4	0.161
CSNK2B	casein kinase 2, beta polypeptide	0.147
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.139
PTK2	PTK2 protein tyrosine kinase 2	0.100
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.095
MED24	mediator complex subunit 24	0.069
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.058
FGF1	fibroblast growth factor 1 (acidic)	0.056
APP	amyloid beta (A4) precursor protein	0.055
EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	0.055
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	0.052
PSEN1	presenilin 1	0.051
PTCH1	patched 1	0.050
MEOX2	mesenchyme homeobox 2	0.046
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.046
GAB1	GRB2-associated binding protein 1	0.045
ESR1	estrogen receptor 1	0.044
EIF6	eukaryotic translation initiation factor 6	0.041
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.038
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.038	Rat
EIF2B5	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	0.037
HDAC3	histone deacetylase 3	0.035
TNRC6A	trinucleotide repeat containing 6A	0.034
JUP	junction plakoglobin	0.033
PXN	paxillin	0.033
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.031
MED16	mediator complex subunit 16	0.030
MUC1	mucin 1, cell surface associated	0.030
SMAD7	SMAD family member 7	0.030
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.030
EIF2B1	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	0.029
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.029
KRT8	keratin 8	0.029
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.029
CD63	CD63 molecule	0.028
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.028
EGR3	early growth response 3	0.027
EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	0.026
DUSP1	dual specificity phosphatase 1	0.025
ANAPC5	anaphase promoting complex subunit 5	0.023
CDK19	cyclin-dependent kinase 19	0.023
EP300	E1A binding protein p300	0.022
IER2	immediate early response 2	0.022
FGFR2	fibroblast growth factor receptor 2	0.021
ALK	anaplastic lymphoma receptor tyrosine kinase	0.021
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.020
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.020
FBLN1	fibulin 1	0.019
NTF4	neurotrophin 4	0.019
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.019
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.018
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.018	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.018
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.017
ADRB2	adrenergic, beta-2-, receptor, surface	0.017
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.017
LAT	linker for activation of T cells	0.016
SOX2	SRY (sex determining region Y)-box 2	0.016
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.015
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.015
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.015
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.015
PAX8	paired box 8	0.014
EGR2	early growth response 2	0.014
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.014
MED29	mediator complex subunit 29	0.014
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.014
HIC1	hypermethylated in cancer 1	0.013
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.013
TNRC6C	trinucleotide repeat containing 6C	0.013
GLIS2	GLIS family zinc finger 2	0.013
NCOR2	nuclear receptor corepressor 2	0.013
HNF4A	hepatocyte nuclear factor 4, alpha	0.013
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.012
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.012
AR	androgen receptor	0.012
UBASH3B	ubiquitin associated and SH3 domain containing B	0.012
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.011
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.011
SOX10	SRY (sex determining region Y)-box 10	0.011	Mouse
ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	0.011
WDR46	WD repeat domain 46	0.011
ESRRG	estrogen-related receptor gamma	0.011
ZFYVE9	zinc finger, FYVE domain containing 9	0.010
OLIG2	oligodendrocyte lineage transcription factor 2	0.010	Zebrafish Mouse
WWOX	WW domain containing oxidoreductase	0.010
TNRC6B	trinucleotide repeat containing 6B	0.010