IMP

Process View

Homo sapiens

9 genes annotated in human

t cell mediated cytotoxicity

GO:0001913

The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell mediated cytotoxicity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t cell mediated cytotoxicity" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.987	Mouse
HLA-A	major histocompatibility complex, class I, A	0.979
HLA-C	major histocompatibility complex, class I, C	0.970	Human
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.932
HLA-G	major histocompatibility complex, class I, G	0.909	Human
HLA-B	major histocompatibility complex, class I, B	0.889
TAPBP	TAP binding protein (tapasin)	0.812
CCL4	chemokine (C-C motif) ligand 4	0.742	Human
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.468
HLA-F	major histocompatibility complex, class I, F	0.404	Human
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.377
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.362
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.302
CCR5	chemokine (C-C motif) receptor 5	0.299
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.256	Human
CCL5	chemokine (C-C motif) ligand 5	0.255	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.139
HLA-E	major histocompatibility complex, class I, E	0.131	Human
PILRA	paired immunoglobin-like type 2 receptor alpha	0.116
IL1B	interleukin 1, beta	0.105
CXCL9	chemokine (C-X-C motif) ligand 9	0.096
DPP4	dipeptidyl-peptidase 4	0.092
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.080	Human
PVRL4	poliovirus receptor-related 4	0.066
PVRL3	poliovirus receptor-related 3	0.062	Human
CCL8	chemokine (C-C motif) ligand 8	0.060	Human
ICAM1	intercellular adhesion molecule 1	0.053
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.052	Human
CCR1	chemokine (C-C motif) receptor 1	0.050
SRGN	serglycin	0.049
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.047
CXCL10	chemokine (C-X-C motif) ligand 10	0.043
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.043
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.033	Human
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.031
IL6	interleukin 6 (interferon, beta 2)	0.030
CCL19	chemokine (C-C motif) ligand 19	0.029	Human
IL8	interleukin 8	0.029
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.029
BIRC3	baculoviral IAP repeat containing 3	0.027
CCL13	chemokine (C-C motif) ligand 13	0.027	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.027
IL2RB	interleukin 2 receptor, beta	0.027
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.024
CCL7	chemokine (C-C motif) ligand 7	0.024	Human
IFNG	interferon, gamma	0.023
MLPH	melanophilin	0.022
CCR7	chemokine (C-C motif) receptor 7	0.022
TRAF1	TNF receptor-associated factor 1	0.022
IDE	insulin-degrading enzyme	0.022
TNF	tumor necrosis factor	0.021
CXCL11	chemokine (C-X-C motif) ligand 11	0.021
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.020	Human
SIGLEC7	sialic acid binding Ig-like lectin 7	0.020
IL18RAP	interleukin 18 receptor accessory protein	0.019
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.019
CCL2	chemokine (C-C motif) ligand 2	0.018	Human
TJP1	tight junction protein 1 (zona occludens 1)	0.018
PRF1	perforin 1 (pore forming protein)	0.017
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.017
CD86	CD86 molecule	0.016
CXCL2	chemokine (C-X-C motif) ligand 2	0.015
CXCL13	chemokine (C-X-C motif) ligand 13	0.015
SNAP23	synaptosomal-associated protein, 23kDa	0.015
HK3	hexokinase 3 (white cell)	0.014
CD22	CD22 molecule	0.014
CCL22	chemokine (C-C motif) ligand 22	0.014	Human
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.014
PTAFR	platelet-activating factor receptor	0.014
CCL20	chemokine (C-C motif) ligand 20	0.014	Human
NLRP3	NLR family, pyrin domain containing 3	0.012
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.012
TREM1	triggering receptor expressed on myeloid cells 1	0.012
UBD	ubiquitin D	0.012
LGALS3	lectin, galactoside-binding, soluble, 3	0.012
CCL3	chemokine (C-C motif) ligand 3	0.011	Human
IL2RG	interleukin 2 receptor, gamma	0.011
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.011
CREBL2	cAMP responsive element binding protein-like 2	0.011
TYMP	thymidine phosphorylase	0.010
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.010
IDO1	indoleamine 2,3-dioxygenase 1	0.010