IMP

Process View

Homo sapiens

2 genes annotated in human

Multi-species View

blood vessel remodeling

GO:0001974

The reorganization or renovation of existing blood vessels.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "blood vessel remodeling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "blood vessel remodeling" (in gray)

Name	Description	Probability	Func Analog Organism
NOTCH1	notch 1	0.989
PDZD11	PDZ domain containing 11	0.332
ARNT	aryl hydrocarbon receptor nuclear translocator	0.317
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.249
NOTCH3	notch 3	0.187
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.184
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	0.161
GAS6	growth arrest-specific 6	0.159
RNR2	l-rRNA	0.138
RNF144B	ring finger protein 144B	0.121
CCL5	chemokine (C-C motif) ligand 5	0.119
EPAS1	endothelial PAS domain protein 1	0.116	Mouse
BAK1	BCL2-antagonist/killer 1	0.112
ACVR1	activin A receptor, type I	0.108
PRKG1	protein kinase, cGMP-dependent, type I	0.078
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.075
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.071
SMAD3	SMAD family member 3	0.069
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.058
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.057
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.051
NOTCH2	notch 2	0.051
ATXN1L	ataxin 1-like	0.050
WDFY3	WD repeat and FYVE domain containing 3	0.045
HDAC9	histone deacetylase 9	0.044
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.043
MAPK8	mitogen-activated protein kinase 8	0.042
HDAC4	histone deacetylase 4	0.039
C3	complement component 3	0.034
SERTAD1	SERTA domain containing 1	0.034
BECN1	beclin 1, autophagy related	0.034
VHL	von Hippel-Lindau tumor suppressor	0.033
NCOA7	nuclear receptor coactivator 7	0.032
CXCR4	chemokine (C-X-C motif) receptor 4	0.032
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.031
MAML1	mastermind-like 1 (Drosophila)	0.031
THBS1	thrombospondin 1	0.030
CHRD	chordin	0.030
LTBP2	latent transforming growth factor beta binding protein 2	0.029
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.029
EGLN1	egl nine homolog 1 (C. elegans)	0.026
NCOR2	nuclear receptor corepressor 2	0.025
MYOD1	myogenic differentiation 1	0.025
ATG16L1	ATG16 autophagy related 16-like 1 (S. cerevisiae)	0.025
VEGFC	vascular endothelial growth factor C	0.024
BAD	BCL2-associated agonist of cell death	0.024
IGFBP3	insulin-like growth factor binding protein 3	0.023
CUX1	cut-like homeobox 1	0.023
ELN	elastin	0.023
ZEB2	zinc finger E-box binding homeobox 2	0.023
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.022
BMP2	bone morphogenetic protein 2	0.022
PLD3	phospholipase D family, member 3	0.022
BHLHE40	basic helix-loop-helix family, member e40	0.022
ECHDC1	enoyl CoA hydratase domain containing 1	0.021
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.021
CXCR6	chemokine (C-X-C motif) receptor 6	0.020
STC1	stanniocalcin 1	0.019
BCL2L1	BCL2-like 1	0.019
ZFYVE9	zinc finger, FYVE domain containing 9	0.019
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.019
PCOLCE	procollagen C-endopeptidase enhancer	0.019
EP300	E1A binding protein p300	0.018
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.018
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.018
CST1	cystatin SN	0.018	Human
CTSD	cathepsin D	0.018
PLCD1	phospholipase C, delta 1	0.018
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.018
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.017
SLAMF7	SLAM family member 7	0.017
BID	BH3 interacting domain death agonist	0.017
RB1CC1	RB1-inducible coiled-coil 1	0.017
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.017
SPTBN1	spectrin, beta, non-erythrocytic 1	0.017
EFNB2	ephrin-B2	0.017
TIMP1	TIMP metallopeptidase inhibitor 1	0.017
LIFR	leukemia inhibitory factor receptor alpha	0.016
KIAA0174	KIAA0174	0.016
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.016
BIK	BCL2-interacting killer (apoptosis-inducing)	0.016
MEF2C	myocyte enhancer factor 2C	0.016	Mouse
MEF2A	myocyte enhancer factor 2A	0.015
TSPO	translocator protein (18kDa)	0.015
QKI	quaking homolog, KH domain RNA binding (mouse)	0.015
GABARAP	GABA(A) receptor-associated protein	0.015
CLEC3B	C-type lectin domain family 3, member B	0.015
CFD	complement factor D (adipsin)	0.015
PPARA	peroxisome proliferator-activated receptor alpha	0.015
EGLN3	egl nine homolog 3 (C. elegans)	0.015
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.015
MYLK2	myosin light chain kinase 2	0.015
FN1	fibronectin 1	0.015
SQSTM1	sequestosome 1	0.015
PTPRB	protein tyrosine phosphatase, receptor type, B	0.014
BBC3	BCL2 binding component 3	0.014
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.014
GIMAP4	GTPase, IMAP family member 4	0.014
MRC2	mannose receptor, C type 2	0.014
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.014
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.014
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.014
AP1S1	adaptor-related protein complex 1, sigma 1 subunit	0.014
CST2	cystatin SA	0.014	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.014
CTSA	cathepsin A	0.014
CLU	clusterin	0.014
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.014
KRT8	keratin 8	0.014
CIR1	corepressor interacting with RBPJ, 1	0.014
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.013
DEDD	death effector domain containing	0.013
ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.013
CTGF	connective tissue growth factor	0.013
INHBA	inhibin, beta A	0.013
SH3GLB1	SH3-domain GRB2-like endophilin B1	0.013
BBX	bobby sox homolog (Drosophila)	0.013
HSPG2	heparan sulfate proteoglycan 2	0.013
PSAP	prosaposin	0.013
ZC3H12A	zinc finger CCCH-type containing 12A	0.013
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.013
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.013
C8B	complement component 8, beta polypeptide	0.013
XIAP	X-linked inhibitor of apoptosis	0.013
PRAF2	PRA1 domain family, member 2	0.013
PCDH1	protocadherin 1	0.013
IGFBP4	insulin-like growth factor binding protein 4	0.013
CCL22	chemokine (C-C motif) ligand 22	0.013
TBC1D5	TBC1 domain family, member 5	0.013
COL1A1	collagen, type I, alpha 1	0.013
TIMP3	TIMP metallopeptidase inhibitor 3	0.013
FGF18	fibroblast growth factor 18	0.012
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.012
PMEPA1	prostate transmembrane protein, androgen induced 1	0.012
UVRAG	UV radiation resistance associated gene	0.012
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.012
S100A10	S100 calcium binding protein A10	0.012
DLL1	delta-like 1 (Drosophila)	0.012
GGT5	gamma-glutamyltransferase 5	0.012
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
MFAP2	microfibrillar-associated protein 2	0.012
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.012
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.012
DUSP6	dual specificity phosphatase 6	0.012
A2M	alpha-2-macroglobulin	0.012
E2F2	E2F transcription factor 2	0.012
CCR2	chemokine (C-C motif) receptor 2	0.012	Rat
SELPLG	selectin P ligand	0.012
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.012
CST4	cystatin S	0.012	Human
OLFML2B	olfactomedin-like 2B	0.012
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.012
CSTB	cystatin B (stefin B)	0.012
RRAS	related RAS viral (r-ras) oncogene homolog	0.012
S100A4	S100 calcium binding protein A4	0.011
TMEM176A	transmembrane protein 176A	0.011
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.011
PRKCB	protein kinase C, beta	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
CELF2	CUGBP, Elav-like family member 2	0.011
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.011
LOX	lysyl oxidase	0.011
CD81	CD81 molecule	0.011
TCAP	titin-cap (telethonin)	0.011
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.011	Rat
ZFYVE1	zinc finger, FYVE domain containing 1	0.011
GIMAP6	GTPase, IMAP family member 6	0.011
RNASE6	ribonuclease, RNase A family, k6	0.011
FGFR1	fibroblast growth factor receptor 1	0.011
GREM1	gremlin 1	0.011
TRAK2	trafficking protein, kinesin binding 2	0.011
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.011
RBMS3	RNA binding motif, single stranded interacting protein 3	0.011
TCN2	transcobalamin II	0.011
SDC4	syndecan 4	0.011
CCL4	chemokine (C-C motif) ligand 4	0.011
CTSB	cathepsin B	0.011
MYOG	myogenin (myogenic factor 4)	0.011
CCIN	calicin	0.011
KDM5A	lysine (K)-specific demethylase 5A	0.011
TFEC	transcription factor EC	0.011
BMP4	bone morphogenetic protein 4	0.011
GAB2	GRB2-associated binding protein 2	0.011
PURA	purine-rich element binding protein A	0.011
CXCL12	chemokine (C-X-C motif) ligand 12	0.011
CYB5R4	cytochrome b5 reductase 4	0.011
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011
CALCRL	calcitonin receptor-like	0.011
ACVR1B	activin A receptor, type IB	0.011
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.011
SIPA1L2	signal-induced proliferation-associated 1 like 2	0.011
NOV	nephroblastoma overexpressed gene	0.011
DUSP4	dual specificity phosphatase 4	0.011
GPR18	G protein-coupled receptor 18	0.010
CD84	CD84 molecule	0.010
HP	haptoglobin	0.010
CD1C	CD1c molecule	0.010
RHOU	ras homolog gene family, member U	0.010
ODF1	outer dense fiber of sperm tails 1	0.010
CCL2	chemokine (C-C motif) ligand 2	0.010
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.010
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.010
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.010
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.010
PHACTR2	phosphatase and actin regulator 2	0.010
JAG1	jagged 1	0.010	Mouse
SCARB2	scavenger receptor class B, member 2	0.010
DDIT3	DNA-damage-inducible transcript 3	0.010
EXOC4	exocyst complex component 4	0.010
TCF4	transcription factor 4	0.010
NDRG1	N-myc downstream regulated 1	0.010
ENG	endoglin	0.010
TRPS1	trichorhinophalangeal syndrome I	0.010
VCAM1	vascular cell adhesion molecule 1	0.010
MBNL2	muscleblind-like 2 (Drosophila)	0.010
CFH	complement factor H	0.010
CFI	complement factor I	0.010
FAM46A	family with sequence similarity 46, member A	0.010
CD151	CD151 molecule (Raph blood group)	0.010
IGFBP5	insulin-like growth factor binding protein 5	0.010
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.010
PVR	poliovirus receptor	0.010
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	0.010
SPRY2	sprouty homolog 2 (Drosophila)	0.010
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.010
SPACA4	sperm acrosome associated 4	0.010
KLF5	Kruppel-like factor 5 (intestinal)	0.010
ACTC1	actin, alpha, cardiac muscle 1	0.010
ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	0.010
C10orf54	chromosome 10 open reading frame 54	0.010
COL8A1	collagen, type VIII, alpha 1	0.010
PITX2	paired-like homeodomain 2	0.010
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.010
CLEC4A	C-type lectin domain family 4, member A	0.010