IMP

Process View

Homo sapiens

2 genes annotated in human

establishment of lymphocyte polarity

The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of lymphocyte polarity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment of lymphocyte polarity" (in gray)

Name	Description	Probability	Func Analog Organism
CCL4	chemokine (C-C motif) ligand 4	0.995	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.984
CCL5	chemokine (C-C motif) ligand 5	0.981	Human
IL8	interleukin 8	0.961
CCL8	chemokine (C-C motif) ligand 8	0.958	Human
CCL2	chemokine (C-C motif) ligand 2	0.935	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.909
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.899	Human
CCR5	chemokine (C-C motif) receptor 5	0.882
DPP4	dipeptidyl-peptidase 4	0.854
IDE	insulin-degrading enzyme	0.754
CXCL11	chemokine (C-X-C motif) ligand 11	0.685
CCL22	chemokine (C-C motif) ligand 22	0.651	Human
CCL19	chemokine (C-C motif) ligand 19	0.609
CCL13	chemokine (C-C motif) ligand 13	0.539	Human
CCR7	chemokine (C-C motif) receptor 7	0.520
CXCL13	chemokine (C-X-C motif) ligand 13	0.464
VCAM1	vascular cell adhesion molecule 1	0.406
CXCL3	chemokine (C-X-C motif) ligand 3	0.392
TNF	tumor necrosis factor	0.352
CCL7	chemokine (C-C motif) ligand 7	0.321	Human
IL1B	interleukin 1, beta	0.281
CCL3	chemokine (C-C motif) ligand 3	0.272	Human
DARC	Duffy blood group, chemokine receptor	0.271
IL6	interleukin 6 (interferon, beta 2)	0.249
MYL9	myosin, light chain 9, regulatory	0.205
CCR4	chemokine (C-C motif) receptor 4	0.195
SELE	selectin E	0.180
CD83	CD83 molecule	0.176
TPM4	tropomyosin 4	0.168
ZYX	zyxin	0.164
UBD	ubiquitin D	0.154
IFNG	interferon, gamma	0.152
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.130
FPR3	formyl peptide receptor 3	0.121
IL7R	interleukin 7 receptor	0.119
CXCL2	chemokine (C-X-C motif) ligand 2	0.110
CCR1	chemokine (C-C motif) receptor 1	0.108
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.108
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.106
ICAM1	intercellular adhesion molecule 1	0.105
RGS1	regulator of G-protein signaling 1	0.100
FLNA	filamin A, alpha	0.084
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.081
IL2RG	interleukin 2 receptor, gamma	0.078
LAMP3	lysosomal-associated membrane protein 3	0.078
SLAMF8	SLAM family member 8	0.077
CCL11	chemokine (C-C motif) ligand 11	0.073	Human
ARRB1	arrestin, beta 1	0.071
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.067
CH25H	cholesterol 25-hydroxylase	0.062
IL1RN	interleukin 1 receptor antagonist	0.062
CLEC10A	C-type lectin domain family 10, member A	0.060
IDO1	indoleamine 2,3-dioxygenase 1	0.059
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.054
C1QA	complement component 1, q subcomponent, A chain	0.053
CXCL5	chemokine (C-X-C motif) ligand 5	0.052
EBI3	Epstein-Barr virus induced 3	0.051
ADAMDEC1	ADAM-like, decysin 1	0.046
C1QB	complement component 1, q subcomponent, B chain	0.043
APOC1	apolipoprotein C-I	0.043
XCL2	chemokine (C motif) ligand 2	0.042	Human
CCL20	chemokine (C-C motif) ligand 20	0.040	Human
IL32	interleukin 32	0.039
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.037
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.037
MSC	musculin	0.037
CD40	CD40 molecule, TNF receptor superfamily member 5	0.036
CCL21	chemokine (C-C motif) ligand 21	0.035
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.035
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.032
CD80	CD80 molecule	0.031
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.031
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.030
CCL17	chemokine (C-C motif) ligand 17	0.029	Human
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.029
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.029
XCL1	chemokine (C motif) ligand 1	0.029	Human
CCR3	chemokine (C-C motif) receptor 3	0.028
GNLY	granulysin	0.028
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.027
CCL23	chemokine (C-C motif) ligand 23	0.026	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.026
IL21R	interleukin 21 receptor	0.025
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.024
SLAMF7	SLAM family member 7	0.024
CD69	CD69 molecule	0.024
IL18RAP	interleukin 18 receptor accessory protein	0.024
IL2RB	interleukin 2 receptor, beta	0.023
CXCR3	chemokine (C-X-C motif) receptor 3	0.023
INHBA	inhibin, beta A	0.023
STAT4	signal transducer and activator of transcription 4	0.022
NKG7	natural killer cell group 7 sequence	0.022
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.022
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.021
RGS16	regulator of G-protein signaling 16	0.021
IL10	interleukin 10	0.020
C2	complement component 2	0.020
DPT	dermatopontin	0.020
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.020
C1QC	complement component 1, q subcomponent, C chain	0.020
IL2RA	interleukin 2 receptor, alpha	0.020
CCRL2	chemokine (C-C motif) receptor-like 2	0.019
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.019
WDR1	WD repeat domain 1	0.019
SRGN	serglycin	0.019
BATF	basic leucine zipper transcription factor, ATF-like	0.019
TM7SF4	transmembrane 7 superfamily member 4	0.018
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.018
CD163	CD163 molecule	0.018
CD1B	CD1b molecule	0.018
TPSB2	tryptase beta 2 (gene/pseudogene)	0.018
DNASE1L3	deoxyribonuclease I-like 3	0.017
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.016
CCL1	chemokine (C-C motif) ligand 1	0.015	Human
ARHGAP15	Rho GTPase activating protein 15	0.015
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.015
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.015
ACP5	acid phosphatase 5, tartrate resistant	0.015
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.014
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.014
OASL	2'-5'-oligoadenylate synthetase-like	0.014
IQGAP1	IQ motif containing GTPase activating protein 1	0.014
CXCR5	chemokine (C-X-C motif) receptor 5	0.014
CHIT1	chitinase 1 (chitotriosidase)	0.014
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.014
MARCO	macrophage receptor with collagenous structure	0.013
CMKLR1	chemokine-like receptor 1	0.013
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.013
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.013
CST7	cystatin F (leukocystatin)	0.013
ART4	ADP-ribosyltransferase 4 (Dombrock blood group)	0.013
IL18R1	interleukin 18 receptor 1	0.013
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.013
IL4	interleukin 4	0.013
HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	0.012
ACTN4	actinin, alpha 4	0.012
EZR	ezrin	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
TRAF1	TNF receptor-associated factor 1	0.012
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.012
IGL@	immunoglobulin lambda locus	0.012
TPSAB1	tryptase alpha/beta 1	0.012
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.012
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.012
IRF4	interferon regulatory factor 4	0.012
LAG3	lymphocyte-activation gene 3	0.012
ASCC2	activating signal cointegrator 1 complex subunit 2	0.012
CCBP2	chemokine binding protein 2	0.012
SH3RF1	SH3 domain containing ring finger 1	0.012
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.012
IL1A	interleukin 1, alpha	0.012
IL13	interleukin 13	0.012
PLA2G2D	phospholipase A2, group IID	0.011
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.011
CD40LG	CD40 ligand	0.011
LGALS2	lectin, galactoside-binding, soluble, 2	0.011
IL1R2	interleukin 1 receptor, type II	0.011
FLNB	filamin B, beta	0.011
GAB2	GRB2-associated binding protein 2	0.011
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.011
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.011
ICOS	inducible T-cell co-stimulator	0.011
TREM2	triggering receptor expressed on myeloid cells 2	0.011
MMP19	matrix metallopeptidase 19	0.011
IL4I1	interleukin 4 induced 1	0.010
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.010
C3AR1	complement component 3a receptor 1	0.010
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.010