IMP

Process View

Homo sapiens

21 genes annotated in human

Multi-species View

negative regulation of chromatin modification

GO:1903309

Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of chromatin modification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of chromatin modification" (in gray)

Name	Description	Probability	Func Analog Organism
CBX5	chromobox homolog 5	0.869
RB1	retinoblastoma 1	0.427
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.406	Human
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.380
EED	embryonic ectoderm development	0.359
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.341
RUNX1	runt-related transcription factor 1	0.332
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.325
HIPK2	homeodomain interacting protein kinase 2	0.265
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.229
NRIP1	nuclear receptor interacting protein 1	0.203
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.201
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.177
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.160
ADNP	activity-dependent neuroprotector homeobox	0.160
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	0.150
KDM2B	lysine (K)-specific demethylase 2B	0.147
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.113
MTF2	metal response element binding transcription factor 2	0.104	Human Mouse
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.096
SETD8	SET domain containing (lysine methyltransferase) 8	0.090
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.088
NIPBL	Nipped-B homolog (Drosophila)	0.074
RSF1	remodeling and spacing factor 1	0.073
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.067
SUV39H2	suppressor of variegation 3-9 homolog 2 (Drosophila)	0.060
SNCAIP	synuclein, alpha interacting protein	0.059
CBX1	chromobox homolog 1	0.056	Fly
TGIF1	TGFB-induced factor homeobox 1	0.055
GSK3B	glycogen synthase kinase 3 beta	0.048
TAL1	T-cell acute lymphocytic leukemia 1	0.047	Human
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.043
GATA2	GATA binding protein 2	0.043
HDAC1	histone deacetylase 1	0.043
LRIF1	ligand dependent nuclear receptor interacting factor 1	0.043
RSRC2	arginine/serine-rich coiled-coil 2	0.039
TBP	TATA box binding protein	0.036
RLF	rearranged L-myc fusion	0.036
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.036	Mouse
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.032
PAIP2	poly(A) binding protein interacting protein 2	0.032
MAPT	microtubule-associated protein tau	0.031
ZRANB1	zinc finger, RAN-binding domain containing 1	0.029
CDCA4	cell division cycle associated 4	0.029
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.029
PCNA	proliferating cell nuclear antigen	0.028
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.028
TRIM33	tripartite motif containing 33	0.028
TRIM28	tripartite motif containing 28	0.028
ANKRD28	ankyrin repeat domain 28	0.028
GATAD2B	GATA zinc finger domain containing 2B	0.026
PCGF1	polycomb group ring finger 1	0.026
SH3KBP1	SH3-domain kinase binding protein 1	0.025
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.025
NELL2	NEL-like 2 (chicken)	0.024
SUPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	0.023
HDAC9	histone deacetylase 9	0.022
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.020
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.020
CTBP1	C-terminal binding protein 1	0.020
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.019
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.019
HNF4A	hepatocyte nuclear factor 4, alpha	0.018
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.018	Mouse
SMAD3	SMAD family member 3	0.017
LBR	lamin B receptor	0.017
MARCH7	membrane-associated ring finger (C3HC4) 7	0.017
TPPP	tubulin polymerization promoting protein	0.017
RBM39	RNA binding motif protein 39	0.017
ZBTB4	zinc finger and BTB domain containing 4	0.017
HIC1	hypermethylated in cancer 1	0.017
ZNF292	zinc finger protein 292	0.016
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.016
DAXX	death-domain associated protein	0.016
MBD1	methyl-CpG binding domain protein 1	0.016
BIRC2	baculoviral IAP repeat containing 2	0.016
HIST2H3C	histone cluster 2, H3c	0.016
AARSD1	alanyl-tRNA synthetase domain containing 1	0.015
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.015
HDAC2	histone deacetylase 2	0.015
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.015
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.015
RNF168	ring finger protein 168	0.015
SH3BP2	SH3-domain binding protein 2	0.014
PHIP	pleckstrin homology domain interacting protein	0.014
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.014
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.014	Human
GPBP1	GC-rich promoter binding protein 1	0.014
PHF19	PHD finger protein 19	0.014	Human
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.014
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.013
SMAD4	SMAD family member 4	0.013
LRRN2	leucine rich repeat neuronal 2	0.013
JAG2	jagged 2	0.013
TK1	thymidine kinase 1, soluble	0.013
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.013
ANKRD17	ankyrin repeat domain 17	0.013
KLHDC4	kelch domain containing 4	0.013
MTA1	metastasis associated 1	0.012
USHBP1	Usher syndrome 1C binding protein 1	0.012
ADNP2	ADNP homeobox 2	0.012
UBXN7	UBX domain protein 7	0.012
SKIL	SKI-like oncogene	0.012
TPR	translocated promoter region (to activated MET oncogene)	0.012
RING1	ring finger protein 1	0.012
MYOD1	myogenic differentiation 1	0.012
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.012
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.011
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.011
HIST1H3B	histone cluster 1, H3b	0.011
SNAI1	snail homolog 1 (Drosophila)	0.011
PHOX2A	paired-like homeobox 2a	0.011
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.011
WRN	Werner syndrome, RecQ helicase-like	0.011
ATXN7	ataxin 7	0.011
MKRN1	makorin ring finger protein 1	0.011
RARA	retinoic acid receptor, alpha	0.011
RCOR1	REST corepressor 1	0.011
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.011
HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.011
RUNDC3A	RUN domain containing 3A	0.011
PARP1	poly (ADP-ribose) polymerase 1	0.010
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.010
IKZF4	IKAROS family zinc finger 4 (Eos)	0.010
MAGEA2	melanoma antigen family A, 2	0.010
POU2F2	POU class 2 homeobox 2	0.010
TROVE2	TROVE domain family, member 2	0.010
SAP25	sin3A-binding protein 25	0.010
H3F3B	H3 histone, family 3B (H3.3B)	0.010