IMP

Process View

Mus musculus

12 genes annotated in mouse

nuclear transcribed mrna catabolic process deadenylation dependent decay

A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "nuclear transcribed mrna catabolic process deadenylation dependent decay"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "nuclear transcribed mrna catabolic process deadenylation dependent decay" (in gray)

Name	Description	Probability	Func Analog Organism
Eif2c2	eukaryotic translation initiation factor 2C, 2	1.000
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.984	Yeast
Tnrc6b	trinucleotide repeat containing 6b	0.744
Mll3	myeloid/lymphoid or mixed-lineage leukemia 3	0.667
Junb	Jun-B oncogene	0.634
Fos	FBJ osteosarcoma oncogene	0.598
Bptf	bromodomain PHD finger transcription factor	0.524
Dusp1	dual specificity phosphatase 1	0.520
Neurl1a	neuralized homolog 1A (Drosophila)	0.343
Egr1	early growth response 1	0.279
Zfp36	zinc finger protein 36	0.219
Gsk3b	glycogen synthase kinase 3 beta	0.214
Trim32	tripartite motif-containing 32	0.204
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.181
Brd4	bromodomain containing 4	0.173
Btg2	B-cell translocation gene 2, anti-proliferative	0.172	Human
Btg1	B-cell translocation gene 1, anti-proliferative	0.170
Cnot6	CCR4-NOT transcription complex, subunit 6	0.145	Human Mouse Fly
Sp1	trans-acting transcription factor 1	0.123
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.109
Actn2	actinin alpha 2	0.108
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.104
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.096
Wnk1	WNK lysine deficient protein kinase 1	0.086
Caprin1	cell cycle associated protein 1	0.083
Ier2	immediate early response 2	0.083
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.082
Igf1r	insulin-like growth factor I receptor	0.081
Nudcd2	NudC domain containing 2	0.079
Irs2	insulin receptor substrate 2	0.077
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.072
Klf6	Kruppel-like factor 6	0.071
Rcor1	REST corepressor 1	0.068
Jun	Jun oncogene	0.067
Ldb3	LIM domain binding 3	0.065
Trrap	transformation/transcription domain-associated protein	0.060
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.059
Ankhd1	ankyrin repeat and KH domain containing 1	0.056
Pum1	pumilio 1 (Drosophila)	0.054	Yeast
Tnrc6c	trinucleotide repeat containing 6C	0.052	Human
Pabpc1	poly(A) binding protein, cytoplasmic 1	0.047
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.047
Brd2	bromodomain containing 2	0.045
Rc3h1	RING CCCH (C3H) domains 1	0.044
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.043
Vegfa	vascular endothelial growth factor A	0.042
Akt2	thymoma viral proto-oncogene 2	0.042	Yeast
Nupl1	nucleoporin like 1	0.038
Celf1	CUGBP, Elav-like family member 1	0.038
Cd28	CD28 antigen	0.038
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.037
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.037
Nfatc3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0.037
Arid1a	AT rich interactive domain 1A (SWI-like)	0.036
Gm2223	predicted pseudogene 2223	0.035
Rasal1	RAS protein activator like 1 (GAP1 like)	0.034
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.034
Kpnb1	karyopherin (importin) beta 1	0.034
Cnot7	CCR4-NOT transcription complex, subunit 7	0.034
Rfx7	regulatory factor X, 7	0.033
Ncoa1	nuclear receptor coactivator 1	0.033
Smad1	MAD homolog 1 (Drosophila)	0.033
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.033
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.032
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.031
Klf7	Kruppel-like factor 7 (ubiquitous)	0.030
Vhl	von Hippel-Lindau tumor suppressor	0.028
Irf2bp2	interferon regulatory factor 2 binding protein 2	0.028
Atf3	activating transcription factor 3	0.027
Purb	purine rich element binding protein B	0.027
Ep300	E1A binding protein p300	0.027
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.027
Akt1	thymoma viral proto-oncogene 1	0.027	Yeast
Tnrc6a	trinucleotide repeat containing 6a	0.026
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.026
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.025
Rhog	ras homolog gene family, member G	0.025
Chd4	chromodomain helicase DNA binding protein 4	0.025
Xpot	exportin, tRNA (nuclear export receptor for tRNAs)	0.024
D19Wsu162e	DNA segment, Chr 19, Wayne State University 162, expressed	0.024
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.022
Smad4	MAD homolog 4 (Drosophila)	0.022
Mael	maelstrom homolog (Drosophila)	0.022
Pafah1b2	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2	0.022
Pknox1	Pbx/knotted 1 homeobox	0.022
Nanos2	nanos homolog 2 (Drosophila)	0.021
Man1a2	mannosidase, alpha, class 1A, member 2	0.021
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.021
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.020
Taok1	TAO kinase 1	0.020
Bcl2	B-cell leukemia/lymphoma 2	0.020
Klf3	Kruppel-like factor 3 (basic)	0.020
Zmym5	zinc finger, MYM-type 5	0.020
Wdr36	WD repeat domain 36	0.019
Wdr77	WD repeat domain 77	0.019
Kctd20	potassium channel tetramerisation domain containing 20	0.019
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.019
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.019
Gspt1	G1 to S phase transition 1	0.019	Yeast
Chd1l	chromodomain helicase DNA binding protein 1-like	0.018
Foxo3	forkhead box O3	0.018
Midn	midnolin	0.018
Actb	actin, beta	0.018
Adam10	a disintegrin and metallopeptidase domain 10	0.017
Nr2c2	nuclear receptor subfamily 2, group C, member 2	0.017
Scaf8	SR-related CTD-associated factor 8	0.017
Dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	0.017
Lep	leptin	0.017
Foxo1	forkhead box O1	0.017
Med13l	mediator complex subunit 13-like	0.017
Ddx46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.016
Znrf2	zinc and ring finger 2	0.016
Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	0.016
Crebbp	CREB binding protein	0.016
Prkce	protein kinase C, epsilon	0.015
Gpatch8	G patch domain containing 8	0.015
Pdcd4	programmed cell death 4	0.015
Igh	immunoglobulin heavy chain complex	0.015
Casp2	caspase 2	0.015
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.015
Pparg	peroxisome proliferator activated receptor gamma	0.015
Sp4	trans-acting transcription factor 4	0.015
Synrg	synergin, gamma	0.014
Mapkap1	mitogen-activated protein kinase associated protein 1	0.014
Actn4	actinin alpha 4	0.014
Elp3	elongation protein 3 homolog (S. cerevisiae)	0.014
Tob2	transducer of ERBB2, 2	0.013
2210419D22Rik	RIKEN cDNA 2210419D22 gene	0.013
Utp6	UTP6, small subunit (SSU) processome component, homolog (yeast)	0.013
Pim1	proviral integration site 1	0.013
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.013
Kdm6a	4lysine (K)-specific demethylase 6A	0.013
Klf4	Kruppel-like factor 4 (gut)	0.013
Cbll1	Casitas B-lineage lymphoma-like 1	0.013
Cand1	cullin associated and neddylation disassociated 1	0.013
Crb2	crumbs homolog 2 (Drosophila)	0.013
Tbl1x	transducin (beta)-like 1 X-linked	0.013
Mau2	MAU2 chromatid cohesion factor homolog (C. elegans)	0.012
Rsf1	remodeling and spacing factor 1	0.012
Cd151	CD151 antigen	0.012
Ccni	cyclin I	0.012
Elf2	E74-like factor 2	0.012
Pias2	protein inhibitor of activated STAT 2	0.012
Clock	circadian locomotor output cycles kaput	0.012
Pbx2	pre B-cell leukemia transcription factor 2	0.012
Ide	insulin degrading enzyme	0.012
Phf21a	PHD finger protein 21A	0.012
Fas	Fas (TNF receptor superfamily member 6)	0.012
Fosb	FBJ osteosarcoma oncogene B	0.012
Eri1	exoribonuclease 1	0.012
Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.011
Bzw1	basic leucine zipper and W2 domains 1	0.011
Cul4b	cullin 4B	0.011
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.011
Kif1b	kinesin family member 1B	0.011
Hnrnpul1	heterogeneous nuclear ribonucleoprotein U-like 1	0.011
Vasp	vasodilator-stimulated phosphoprotein	0.011
Usp10	ubiquitin specific peptidase 10	0.011
Tomm40	translocase of outer mitochondrial membrane 40 homolog (yeast)	0.011
Abce1	ATP-binding cassette, sub-family E (OABP), member 1	0.011
Bach2	BTB and CNC homology 2	0.011
Tgif1	TGFB-induced factor homeobox 1	0.011
Mlf2	myeloid leukemia factor 2	0.011
Prpf40a	PRP40 pre-mRNA processing factor 40 homolog A (yeast)	0.011
Peli1	pellino 1	0.011
Cnot1	CCR4-NOT transcription complex, subunit 1	0.011
Elf1	E74-like factor 1	0.010
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.010
Zfp362	zinc finger protein 362	0.010
Nipa2	non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)	0.010
Pim3	proviral integration site 3	0.010
Impad1	inositol monophosphatase domain containing 1	0.010