IMP

Process View

Mus musculus

2 genes annotated in mouse

dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator" (in gray)

Name	Description	Probability	Func Analog Organism
Pten	phosphatase and tensin homolog	0.999
Apc	adenomatosis polyposis coli	0.831
Mdm2	transformed mouse 3T3 cell double minute 2	0.760
Brca1	breast cancer 1	0.726
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.714
Rb1	retinoblastoma 1	0.487
Ctnnb1	catenin (cadherin associated protein), beta 1	0.402
Atm	ataxia telangiectasia mutated homolog (human)	0.392
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.191
Trp53	transformation related protein 53	0.184	Human Zebrafish
Col1a1	collagen, type I, alpha 1	0.160
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.160
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.145
Arid1b	AT rich interactive domain 1B (SWI-like)	0.124
Mdm4	transformed mouse 3T3 cell double minute 4	0.121
Nbn	nibrin	0.087
Dmap1	DNA methyltransferase 1-associated protein 1	0.075
Ep400	E1A binding protein p400	0.061
Ikzf1	IKAROS family zinc finger 1	0.059
Kit	kit oncogene	0.059
Trrap	transformation/transcription domain-associated protein	0.057
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.056
Sfn	stratifin	0.056
Kif19a	kinesin family member 19A	0.055
Smad3	MAD homolog 3 (Drosophila)	0.055
Nf2	neurofibromatosis 2	0.048
Ccnd1	cyclin D1	0.046
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.043
Max	Max protein	0.042
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.037
Stk11	serine/threonine kinase 11	0.032
Ep300	E1A binding protein p300	0.032
Fas	Fas (TNF receptor superfamily member 6)	0.031
Dyx1c1	dyslexia susceptibility 1 candidate 1 homolog (human)	0.031
Braf	Braf transforming gene	0.031
Dnahc11	dynein, axonemal, heavy chain 11	0.030
Msh2	mutS homolog 2 (E. coli)	0.027
Lats1	large tumor suppressor	0.027
Huwe1	HECT, UBA and WWE domain containing 1	0.026
Runx1	runt related transcription factor 1	0.025
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.024
Stat3	signal transducer and activator of transcription 3	0.024
Fbrs	fibrosin	0.024
Fancd2	Fanconi anemia, complementation group D2	0.020
Csf1	colony stimulating factor 1 (macrophage)	0.020
Noto	notochord homolog (Xenopus laevis)	0.020
Ifi203	interferon activated gene 203	0.020
Tsc1	tuberous sclerosis 1	0.020
Crebbp	CREB binding protein	0.020
Mybl2	myeloblastosis oncogene-like 2	0.019
Rara	retinoic acid receptor, alpha	0.019
Mks1	Meckel syndrome, type 1	0.019
Rsph1	radial spoke head 1 homolog (Chlamydomonas)	0.018
Hipk1	homeodomain interacting protein kinase 1	0.018
Ncoa3	nuclear receptor coactivator 3	0.018
Bcl2	B-cell leukemia/lymphoma 2	0.017
Ikbkg	inhibitor of kappaB kinase gamma	0.017
Sox2	SRY-box containing gene 2	0.017
Exosc10	exosome component 10	0.017
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.017
Vangl1	vang-like 1 (van gogh, Drosophila)	0.017
Lyz2	lysozyme 2	0.017
Foxp3	forkhead box P3	0.016
Mapk14	mitogen-activated protein kinase 14	0.016
Kitl	kit ligand	0.016
Meox2	mesenchyme homeobox 2	0.016
Vhl	von Hippel-Lindau tumor suppressor	0.016
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.016
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.015
Pyhin1	pyrin and HIN domain family, member 1	0.015
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.015
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.015
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.015
Tcf3	transcription factor 3	0.014
Ptk7	PTK7 protein tyrosine kinase 7	0.014
Kif3a	kinesin family member 3A	0.014
Naa40	N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)	0.014
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.014
Tgfb1	transforming growth factor, beta 1	0.013
Pms2	postmeiotic segregation increased 2 (S. cerevisiae)	0.013
Tsc2	tuberous sclerosis 2	0.013
Notch1	Notch gene homolog 1 (Drosophila)	0.013
Kif4	kinesin family member 4	0.013
Gtse1	G two S phase expressed protein 1	0.013
Irs2	insulin receptor substrate 2	0.013
Foxo1	forkhead box O1	0.013
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.013
Bcl2l1	BCL2-like 1	0.012
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.012
Hcfc1	host cell factor C1	0.012
Gatad2b	GATA zinc finger domain containing 2B	0.012
Axin2	axin2	0.012
Odf2	outer dense fiber of sperm tails 2	0.012
Gps2	G protein pathway suppressor 2	0.012
Atxn1	ataxin 1	0.012
Myb	myeloblastosis oncogene	0.012
Ap1m2	adaptor protein complex AP-1, mu 2 subunit	0.012
Il6st	interleukin 6 signal transducer	0.012
Atr	ataxia telangiectasia and Rad3 related	0.011
Rxra	retinoid X receptor alpha	0.011
Pola2	polymerase (DNA directed), alpha 2	0.011
Pou2f1	POU domain, class 2, transcription factor 1	0.011
Plagl2	pleiomorphic adenoma gene-like 2	0.011
Pum1	pumilio 1 (Drosophila)	0.011
Daxx	Fas death domain-associated protein	0.011
E2f1	E2F transcription factor 1	0.011
Gpr56	G protein-coupled receptor 56	0.011
Arrb2	arrestin, beta 2	0.011
Arrb1	arrestin, beta 1	0.011
Smad4	MAD homolog 4 (Drosophila)	0.010
Jak3	Janus kinase 3	0.010
Lyst	lysosomal trafficking regulator	0.010
Mark4	MAP/microtubule affinity-regulating kinase 4	0.010
Tmem67	transmembrane protein 67	0.010
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.010
Myo10	myosin X	0.010
Itgb4	integrin beta 4	0.010
Mllt1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.010