IMP

Process View

Mus musculus

4 genes annotated in mouse

activation of membrane attack complex

GO:0001905

The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of membrane attack complex"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activation of membrane attack complex" (in gray)

Name	Description	Probability	Func Analog Organism
Apoe	apolipoprotein E	0.988
Cd59a	CD59a antigen	0.978
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.721
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.703
Cd59b	CD59b antigen	0.685
Lyz2	lysozyme 2	0.589
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.350
Rab27a	RAB27A, member RAS oncogene family	0.283
Apcs	serum amyloid P-component	0.282
Cd28	CD28 antigen	0.280
Pzp	pregnancy zone protein	0.275	Mouse
Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	0.231
C1ra	complement component 1, r subcomponent A	0.221
Fgg	fibrinogen gamma chain	0.204
1300017J02Rik	RIKEN cDNA 1300017J02 gene	0.199
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.199
Ces3a	carboxylesterase 3A	0.197
Plg	plasminogen	0.187
Proc	protein C	0.186
C8a	complement component 8, alpha polypeptide	0.182	Mouse
Spna1	spectrin alpha 1	0.174
Gc	group specific component	0.165
Mug2	murinoglobulin 2	0.149
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.148
Saa4	serum amyloid A 4	0.148
Fas	Fas (TNF receptor superfamily member 6)	0.147
Ahsg	alpha-2-HS-glycoprotein	0.134
F12	coagulation factor XII (Hageman factor)	0.134
Stx11	syntaxin 11	0.118
Itih1	inter-alpha trypsin inhibitor, heavy chain 1	0.117
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.115
F7	coagulation factor VII	0.112
F9	coagulation factor IX	0.112
Ifng	interferon gamma	0.105
Hpx	hemopexin	0.097
Orm1	orosomucoid 1	0.095
Kng1	kininogen 1	0.093
Hc	hemolytic complement	0.090	Mouse
Cfh	complement component factor h	0.090
Lyst	lysosomal trafficking regulator	0.087
Il10	interleukin 10	0.080
C1qb	complement component 1, q subcomponent, beta polypeptide	0.080
F11	coagulation factor XI	0.075
Lipc	lipase, hepatic	0.075
Cp	ceruloplasmin	0.074
Cd55	CD55 antigen	0.072
Serpina11	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	0.072
Mug1	murinoglobulin 1	0.070	Mouse
Hp	haptoglobin	0.070
Mup3	major urinary protein 3	0.067
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.067
Flt3	FMS-like tyrosine kinase 3	0.065
Lbp	lipopolysaccharide binding protein	0.064
Ambp	alpha 1 microglobulin/bikunin	0.063
Fga	fibrinogen alpha chain	0.063
F10	coagulation factor X	0.062
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.062
C8b	complement component 8, beta polypeptide	0.059	Mouse
Foxp3	forkhead box P3	0.059
Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.058
Cfb	complement factor B	0.057
Klkb1	kallikrein B, plasma 1	0.056
Tlr2	toll-like receptor 2	0.055
Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	0.055
Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.054
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.051
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.051
Inpp5d	inositol polyphosphate-5-phosphatase D	0.049
Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	0.049
C9	complement component 9	0.047	Mouse
Gckr	glucokinase regulatory protein	0.047
Hrg	histidine-rich glycoprotein	0.047
C2	complement component 2 (within H-2S)	0.044
Folr2	folate receptor 2 (fetal)	0.043
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.042
Stat3	signal transducer and activator of transcription 3	0.042
Creb3l3	cAMP responsive element binding protein 3-like 3	0.041
Saa3	serum amyloid A 3	0.041
F2	coagulation factor II	0.041
Mbl1	mannose-binding lectin (protein A) 1	0.040
Otc	ornithine transcarbamylase	0.039
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.038
Stat1	signal transducer and activator of transcription 1	0.036
Rag2	recombination activating gene 2	0.036
Hao1	hydroxyacid oxidase 1, liver	0.035
F13b	coagulation factor XIII, beta subunit	0.034
Saa2	serum amyloid A 2	0.034
Ces1c	carboxylesterase 1C	0.034
Akr1c6	aldo-keto reductase family 1, member C6	0.033
Cyp2f2	cytochrome P450, family 2, subfamily f, polypeptide 2	0.033
Fgb	fibrinogen beta chain	0.032
Ank1	ankyrin 1, erythroid	0.030
C1s	complement component 1, s subcomponent	0.030
Apoa1	apolipoprotein A-I	0.029
Rdh7	retinol dehydrogenase 7	0.029
Irf1	interferon regulatory factor 1	0.028
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.028
B2m	beta-2 microglobulin	0.028
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.027
Tdo2	tryptophan 2,3-dioxygenase	0.027
Cpn2	carboxypeptidase N, polypeptide 2	0.027
A2m	alpha-2-macroglobulin	0.026
Apof	apolipoprotein F	0.026
Tcra	T-cell receptor alpha chain	0.026
Serpina1a	serine (or cysteine) peptidase inhibitor, clade A, member 1A	0.026
Rag1	recombination activating gene 1	0.025
Enam	enamelin	0.025
Mbl2	mannose-binding lectin (protein C) 2	0.025
Apom	apolipoprotein M	0.024
Tmem176b	transmembrane protein 176B	0.024
Tat	tyrosine aminotransferase	0.023
Orm2	orosomucoid 2	0.023
Azgp1	alpha-2-glycoprotein 1, zinc	0.023
Cd4	CD4 antigen	0.023
C4bp	complement component 4 binding protein	0.022
Trf	transferrin	0.022
Clec4f	C-type lectin domain family 4, member f	0.022
Dpys	dihydropyrimidinase	0.021
Crp	C-reactive protein, pentraxin-related	0.021
Il1r1	interleukin 1 receptor, type I	0.021
Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	0.021
Il18bp	interleukin 18 binding protein	0.020
Nlrp3	NLR family, pyrin domain containing 3	0.019
Serpina3m	serine (or cysteine) peptidase inhibitor, clade A, member 3M	0.019
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.019
Apon	apolipoprotein N	0.019
Fabp1	fatty acid binding protein 1, liver	0.019
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.019
Fetub	fetuin beta	0.019
Myd88	myeloid differentiation primary response gene 88	0.018
Cpn1	carboxypeptidase N, polypeptide 1	0.018
Fggy	FGGY carbohydrate kinase domain containing	0.018
Prg4	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	0.018
Vtn	vitronectin	0.018
Proz	protein Z, vitamin K-dependent plasma glycoprotein	0.018
Stat6	signal transducer and activator of transcription 6	0.017
Il6	interleukin 6	0.017
Xdh	xanthine dehydrogenase	0.017
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.017
Tmprss6	transmembrane serine protease 6	0.016
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.016
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.016
Slc17a2	solute carrier family 17 (sodium phosphate), member 2	0.016
Ifitm3	interferon induced transmembrane protein 3	0.016
Hfe	hemochromatosis	0.016
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.016
Ftcd	formiminotransferase cyclodeaminase	0.016
Timd2	T-cell immunoglobulin and mucin domain containing 2	0.015
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.015
Tmem176a	transmembrane protein 176A	0.015
Afm	afamin	0.015
Cps1	carbamoyl-phosphate synthetase 1	0.015
Bhmt	betaine-homocysteine methyltransferase	0.015
Ang	angiogenin, ribonuclease, RNase A family, 5	0.015
Fech	ferrochelatase	0.014
Gfi1	growth factor independent 1	0.014
Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.014
Tlr4	toll-like receptor 4	0.014
Hgd	homogentisate 1, 2-dioxygenase	0.014
Clu	clusterin	0.014
Lyz1	lysozyme 1	0.014
Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5	0.014
Iigp1	interferon inducible GTPase 1	0.014
Gnmt	glycine N-methyltransferase	0.013
Alb	albumin	0.013
Hal	histidine ammonia lyase	0.013
Slc3a1	solute carrier family 3, member 1	0.013
Aox3	aldehyde oxidase 3	0.013
Prodh2	proline dehydrogenase (oxidase) 2	0.013
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.013
Mif4gd	MIF4G domain containing	0.013
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.012
Wap	whey acidic protein	0.012
Hsd11b1	hydroxysteroid 11-beta dehydrogenase 1	0.011
Krtap12-1	keratin associated protein 12-1	0.011
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
Cyp2c37	cytochrome P450, family 2. subfamily c, polypeptide 37	0.011
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.011
C1qc	complement component 1, q subcomponent, C chain	0.011
F5	coagulation factor V	0.011
Asgr1	asialoglycoprotein receptor 1	0.011
Pon1	paraoxonase 1	0.011
Lect2	leukocyte cell-derived chemotaxin 2	0.010
Rc3h1	RING CCCH (C3H) domains 1	0.010
Spp1	secreted phosphoprotein 1	0.010
C1rb	complement component 1, r subcomponent B	0.010