IMP

Process View

Mus musculus

2 genes annotated in mouse

regulation of heart induction by regulation of canonical wnt signaling pathway

Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of heart induction by regulation of canonical wnt signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of heart induction by regulation of canonical wnt signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Sall4	sal-like 4 (Drosophila)	0.996
Fgf8	fibroblast growth factor 8	0.962
Pitx2	paired-like homeodomain transcription factor 2	0.952
Shh	sonic hedgehog	0.948
Foxc2	forkhead box C2	0.905
Nanog	Nanog homeobox	0.902
Bmp4	bone morphogenetic protein 4	0.817
Pax3	paired box gene 3	0.804
Hand2	heart and neural crest derivatives expressed transcript 2	0.799
Tcfap2a	transcription factor AP-2, alpha	0.777
Foxc1	forkhead box C1	0.764
Tbx1	T-box 1	0.760
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.699
Hand1	heart and neural crest derivatives expressed transcript 1	0.581
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.530
Otx2	orthodenticle homolog 2 (Drosophila)	0.527
Gli3	GLI-Kruppel family member GLI3	0.514
Tcfcp2l1	transcription factor CP2-like 1	0.474
Fgfr2	fibroblast growth factor receptor 2	0.394
Tgfb2	transforming growth factor, beta 2	0.352
Eya1	eyes absent 1 homolog (Drosophila)	0.339
Sox9	SRY-box containing gene 9	0.311
Hoxa3	homeobox A3	0.307
Hoxa1	homeobox A1	0.299
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.286
Ednra	endothelin receptor type A	0.278
Smo	smoothened homolog (Drosophila)	0.271
Gsc	goosecoid homeobox	0.265
Sall1	sal-like 1 (Drosophila)	0.262
Isl1	ISL1 transcription factor, LIM/homeodomain	0.261
Msx1	homeobox, msh-like 1	0.254
Prrx1	paired related homeobox 1	0.246
Rarg	retinoic acid receptor, gamma	0.212
Gata4	GATA binding protein 4	0.207
Sall3	sal-like 3 (Drosophila)	0.195
Msx2	homeobox, msh-like 2	0.189
Rarb	retinoic acid receptor, beta	0.170
Sox2	SRY-box containing gene 2	0.169
Nodal	nodal	0.167
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.159
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.121
Wnt3a	wingless-related MMTV integration site 3A	0.117
Rara	retinoic acid receptor, alpha	0.112
Hoxa2	homeobox A2	0.110
Vegfa	vascular endothelial growth factor A	0.109
Chd7	chromodomain helicase DNA binding protein 7	0.104
Gli2	GLI-Kruppel family member GLI2	0.097
Dlx5	distal-less homeobox 5	0.094
Meox2	mesenchyme homeobox 2	0.085
Gbx2	gastrulation brain homeobox 2	0.085
Mta3	metastasis associated 3	0.078
Pitx1	paired-like homeodomain transcription factor 1	0.073
Prrx2	paired related homeobox 2	0.073
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.066
Bmp7	bone morphogenetic protein 7	0.060
Lmx1b	LIM homeobox transcription factor 1 beta	0.059
Chrd	chordin	0.056
Rxra	retinoid X receptor alpha	0.056
Alx4	aristaless-like homeobox 4	0.054
Jag1	jagged 1	0.053
Gata6	GATA binding protein 6	0.050
Fgfr1	fibroblast growth factor receptor 1	0.045
Pax8	paired box gene 8	0.045
Hoxd3	homeobox D3	0.045
Hoxb3	homeobox B3	0.044
Pax6	paired box gene 6	0.044
Ntf3	neurotrophin 3	0.042
Pax2	paired box gene 2	0.039
T	brachyury	0.038
En1	engrailed 1	0.036
Vangl2	vang-like 2 (van gogh, Drosophila)	0.036
Nkx3-2	NK3 homeobox 2	0.035
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.033
Esrrb	estrogen related receptor, beta	0.033
Fgf15	fibroblast growth factor 15	0.032
Hesx1	homeobox gene expressed in ES cells	0.031
Foxg1	forkhead box G1	0.030
Hoxd11	homeobox D11	0.030
Nog	noggin	0.029
Foxe3	forkhead box E3	0.029
Wnt6	wingless-related MMTV integration site 6	0.029
Crabp1	cellular retinoic acid binding protein I	0.028
Pax1	paired box gene 1	0.028
Ribc2	RIB43A domain with coiled-coils 2	0.028
Ece1	endothelin converting enzyme 1	0.028
Fgf3	fibroblast growth factor 3	0.027
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.027
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.027
Acvr1	activin A receptor, type 1	0.026
Fgf10	fibroblast growth factor 10	0.026
Ctnnb1	catenin (cadherin associated protein), beta 1	0.026
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.026
Cldn6	claudin 6	0.026
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.025
Pax9	paired box gene 9	0.024
Rhox6	reproductive homeobox 6	0.023
Sox11	SRY-box containing gene 11	0.022
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.022
Tcf15	transcription factor 15	0.022
Alx3	aristaless-like homeobox 3	0.022
Lrp6	low density lipoprotein receptor-related protein 6	0.021
Tcfap2c	transcription factor AP-2, gamma	0.021
Twist2	twist homolog 2 (Drosophila)	0.020
Foxh1	forkhead box H1	0.020
Pla2g10	phospholipase A2, group X	0.019
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.019
Fgf17	fibroblast growth factor 17	0.018
Col2a1	collagen, type II, alpha 1	0.018
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.018
Sox4	SRY-box containing gene 4	0.018
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.017
Odf3	outer dense fiber of sperm tails 3	0.017
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.017
Dll3	delta-like 3 (Drosophila)	0.017
Rnf2	ring finger protein 2	0.017
Hoxc6	homeobox C6	0.017
Cdx2	caudal type homeobox 2	0.017
Psen1	presenilin 1	0.016
Dpep3	dipeptidase 3	0.016
Rdh10	retinol dehydrogenase 10 (all-trans)	0.016
Utf1	undifferentiated embryonic cell transcription factor 1	0.016
Pou5f1	POU domain, class 5, transcription factor 1	0.016	Human
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.016
Hoxd13	homeobox D13	0.016
Hoxc5	homeobox C5	0.016
Zfp42	zinc finger protein 42	0.015
Lhx1	LIM homeobox protein 1	0.015
Hoxa13	homeobox A13	0.015
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.015
Barx1	BarH-like homeobox 1	0.015
Zic3	zinc finger protein of the cerebellum 3	0.015
Sox3	SRY-box containing gene 3	0.015
Phlda2	pleckstrin homology-like domain, family A, member 2	0.015
Padi3	peptidyl arginine deiminase, type III	0.015
Tgfbr2	transforming growth factor, beta receptor II	0.015
Stag3	stromal antigen 3	0.014
Tbx15	T-box 15	0.014
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.014
Lhx3	LIM homeobox protein 3	0.014
Wnt1	wingless-related MMTV integration site 1	0.014
Chd4	chromodomain helicase DNA binding protein 4	0.014
Ubl4b	ubiquitin-like 4B	0.013
Wdr5	WD repeat domain 5	0.013
Etv2	ets variant gene 2	0.013
Lrp2	low density lipoprotein receptor-related protein 2	0.013
Efna4	ephrin A4	0.012
Hoxd4	homeobox D4	0.012
Gli1	GLI-Kruppel family member GLI1	0.012
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.012
Cfc1	cripto, FRL-1, cryptic family 1	0.012
Hoxa5	homeobox A5	0.012
Pyy	peptide YY	0.012
Hoxd9	homeobox D9	0.012
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.011
Hoxc4	homeobox C4	0.011
Bmp2	bone morphogenetic protein 2	0.011
Tbx3	T-box 3	0.011
Lef1	lymphoid enhancer binding factor 1	0.011
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.011
Hmx1	H6 homeobox 1	0.011
Ep400	E1A binding protein p400	0.011
Gjb5	gap junction protein, beta 5	0.011
Tsnaxip1	translin-associated factor X (Tsnax) interacting protein 1	0.010
Hist1h1t	histone cluster 1, H1t	0.010
Plac1	placental specific protein 1	0.010
Emid2	EMI domain containing 2	0.010
Matn3	matrilin 3	0.010
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.010