IMP

Process View

Mus musculus

1 genes annotated in mouse

negative regulation of action potential

Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of action potential"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of action potential" (in gray)

Name	Description	Probability	Func Analog Organism
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.958
Lpar5	lysophosphatidic acid receptor 5	0.900
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.813	Mouse
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.741
Chrnb4	cholinergic receptor, nicotinic, beta polypeptide 4	0.677	Mouse
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.636
Chrna9	cholinergic receptor, nicotinic, alpha polypeptide 9	0.589	Mouse
Myog	myogenin	0.515
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.395
Oprm1	opioid receptor, mu 1	0.388
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.352
Th	tyrosine hydroxylase	0.274
Cntn3	contactin 3	0.267
Cplx1	complexin 1	0.228
Nos1	nitric oxide synthase 1, neuronal	0.220
Chrna5	cholinergic receptor, nicotinic, alpha polypeptide 5	0.212	Mouse
Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	0.210
Krtap12-1	keratin associated protein 12-1	0.209
Scgn	secretagogin, EF-hand calcium binding protein	0.203
Chrna10	cholinergic receptor, nicotinic, alpha polypeptide 10	0.196	Mouse
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.172
Isl2	insulin related protein 2 (islet 2)	0.170
Psapl1	prosaposin-like 1	0.157
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.155	Mouse
Gjd2	gap junction protein, delta 2	0.147
Stk32b	serine/threonine kinase 32B	0.139
Olfr140	olfactory receptor 140	0.139
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.138
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)	0.134
Srrm3	serine/arginine repetitive matrix 3	0.133
Rapsn	receptor-associated protein of the synapse	0.129
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.120
Drd2	dopamine receptor D2	0.113
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.113
Musk	muscle, skeletal, receptor tyrosine kinase	0.112
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.111
Syt13	synaptotagmin XIII	0.110
Syt1	synaptotagmin I	0.106
Krt6a	keratin 6A	0.104
Krtap5-1	keratin associated protein 5-1	0.102
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.098
Reg2	regenerating islet-derived 2	0.096
Smyd1	SET and MYND domain containing 1	0.095
Ecel1	endothelin converting enzyme-like 1	0.092
Lcn8	lipocalin 8	0.091
Tex19.1	testis expressed gene 19.1	0.088
Rit2	Ras-like without CAAX 2	0.087
Otog	otogelin	0.086
Gprin1	G protein-regulated inducer of neurite outgrowth 1	0.078
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.077	Mouse
Mab21l2	mab-21-like 2 (C. elegans)	0.075
Dcx	doublecortin	0.075
Smad9	MAD homolog 9 (Drosophila)	0.074
Otx2	orthodenticle homolog 2 (Drosophila)	0.074
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.073
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.072
Pramel7	preferentially expressed antigen in melanoma like 7	0.071
Rgs8	regulator of G-protein signaling 8	0.070
Rgs7	regulator of G protein signaling 7	0.070
Gjc2	gap junction protein, gamma 2	0.068
Tssk1	testis-specific serine kinase 1	0.068
Cntn2	contactin 2	0.067
Drd4	dopamine receptor D4	0.067
Igfbpl1	insulin-like growth factor binding protein-like 1	0.064
Sfrp5	secreted frizzled-related sequence protein 5	0.062
Myod1	myogenic differentiation 1	0.062
Lhx3	LIM homeobox protein 3	0.061
Gzmm	granzyme M (lymphocyte met-ase 1)	0.060
Alk	anaplastic lymphoma kinase	0.059
Thrb	thyroid hormone receptor beta	0.059
Chrnb3	cholinergic receptor, nicotinic, beta polypeptide 3	0.059	Mouse
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.058
Has1	hyaluronan synthase1	0.058
Onecut1	one cut domain, family member 1	0.056
Gpr12	G-protein coupled receptor 12	0.055
Sult4a1	sulfotransferase family 4A, member 1	0.055
Clcn1	chloride channel 1	0.054
Gckr	glucokinase regulatory protein	0.054
Slc5a7	solute carrier family 5 (choline transporter), member 7	0.053
Diras1	DIRAS family, GTP-binding RAS-like 1	0.052
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.051
Dpf3	D4, zinc and double PHD fingers, family 3	0.049
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.048
Cct6b	chaperonin containing Tcp1, subunit 6b (zeta)	0.048
Nell2	NEL-like 2 (chicken)	0.047
Crygs	crystallin, gamma S	0.046
Gabrg2	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	0.046
Dbh	dopamine beta hydroxylase	0.046
Gal	galanin	0.045
Retnlb	resistin like beta	0.045
Gh	growth hormone	0.044
Ncam2	neural cell adhesion molecule 2	0.044
Aanat	arylalkylamine N-acetyltransferase	0.044
Atcay	ataxia, cerebellar, Cayman type homolog (human)	0.044
Omp	olfactory marker protein	0.043
Kcnk4	potassium channel, subfamily K, member 4	0.043
Mybph	myosin binding protein H	0.043
Avil	advillin	0.043
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.042
Pdc	phosducin	0.042
Cga	glycoprotein hormones, alpha subunit	0.042
Fitm1	fat storage-inducing transmembrane protein 1	0.041
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.040
Lrfn1	leucine rich repeat and fibronectin type III domain containing 1	0.039
Oprl1	opioid receptor-like 1	0.039
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.038
Slc45a2	solute carrier family 45, member 2	0.037
Dmbx1	diencephalon/mesencephalon homeobox 1	0.037
Gnb3	guanine nucleotide binding protein (G protein), beta 3	0.037
Dbndd1	dysbindin (dystrobrevin binding protein 1) domain containing 1	0.036
Pde6c	phosphodiesterase 6C, cGMP specific, cone, alpha prime	0.036
Gad2	glutamic acid decarboxylase 2	0.034
Slitrk1	SLIT and NTRK-like family, member 1	0.034
Uts2r	urotensin 2 receptor	0.034
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.034
Svop	SV2 related protein	0.033
Nxnl2	nucleoredoxin-like 2	0.033
Camk1g	calcium/calmodulin-dependent protein kinase I gamma	0.033
Sstr1	somatostatin receptor 1	0.032
Dcc	deleted in colorectal carcinoma	0.032
Ghrhr	growth hormone releasing hormone receptor	0.031
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.030
Ache	acetylcholinesterase	0.030
Ntsr2	neurotensin receptor 2	0.030
Rorb	RAR-related orphan receptor beta	0.030
Lalba	lactalbumin, alpha	0.030
Gsbs	G substrate	0.029
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.029
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.029
Nxph1	neurexophilin 1	0.029
Gcm2	glial cells missing homolog 2 (Drosophila)	0.029
Gpr45	G protein-coupled receptor 45	0.029
Ptprn	protein tyrosine phosphatase, receptor type, N	0.029
Gulo	gulonolactone (L-) oxidase	0.028
Necab2	N-terminal EF-hand calcium binding protein 2	0.028
Slc6a17	solute carrier family 6 (neurotransmitter transporter), member 17	0.028
Pspn	persephin	0.028
Nxnl1	nucleoredoxin-like 1	0.028
Rrh	retinal pigment epithelium derived rhodopsin homolog	0.028
Meox1	mesenchyme homeobox 1	0.028
Snca	synuclein, alpha	0.027
Cldn26	claudin 26	0.027
Gdap1l1	ganglioside-induced differentiation-associated protein 1-like 1	0.027
Gpr37l1	G protein-coupled receptor 37-like 1	0.027
Olfr672	olfactory receptor 672	0.027
Syt6	synaptotagmin VI	0.026
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.026
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.025
Ghrl	ghrelin	0.025
Apc2	adenomatosis polyposis coli 2	0.025
Pomc	pro-opiomelanocortin-alpha	0.025
Esrrb	estrogen related receptor, beta	0.025
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.025
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.025
Ins1	insulin I	0.024
Fbll1	fibrillarin-like 1	0.024
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.024
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.024
C1ql1	complement component 1, q subcomponent-like 1	0.024
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.024
Kif5a	kinesin family member 5A	0.024
Trp63	transformation related protein 63	0.024
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.024
Dspp	dentin sialophosphoprotein	0.023
Cadm3	cell adhesion molecule 3	0.023
Slc18a3	solute carrier family 18 (vesicular monoamine), member 3	0.023
S100a5	S100 calcium binding protein A5	0.023
Psg16	pregnancy specific glycoprotein 16	0.022
Syt8	synaptotagmin VIII	0.022
Krt4	keratin 4	0.022
Kcnip1	Kv channel-interacting protein 1	0.022
Myoz1	myozenin 1	0.022
Ido2	indoleamine 2,3-dioxygenase 2	0.022
Barhl1	BarH-like 1 (Drosophila)	0.022
Wasf3	WAS protein family, member 3	0.022
Dusp13	dual specificity phosphatase 13	0.022
Scube1	signal peptide, CUB domain, EGF-like 1	0.022
Upp2	uridine phosphorylase 2	0.022
Spry4	sprouty homolog 4 (Drosophila)	0.021
Fmn1	formin 1	0.021
Ebf3	early B-cell factor 3	0.021
Wdr95	WD40 repeat domain 95	0.021
Celsr3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)	0.021
Myot	myotilin	0.020
Eras	ES cell-expressed Ras	0.020
Crhr2	corticotropin releasing hormone receptor 2	0.020
Epha5	Eph receptor A5	0.020
Glra1	glycine receptor, alpha 1 subunit	0.020
Allc	allantoicase	0.020
Oxtr	oxytocin receptor	0.020
Rab3c	RAB3C, member RAS oncogene family	0.020
Gsx2	GS homeobox 2	0.020
Sprr1a	small proline-rich protein 1A	0.020
A2m	alpha-2-macroglobulin	0.020
Galr1	galanin receptor 1	0.020
Msc	musculin	0.020
Gjc3	gap junction protein, gamma 3	0.020
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.020
Npy1r	neuropeptide Y receptor Y1	0.020
Cryga	crystallin, gamma A	0.019
Trpm5	transient receptor potential cation channel, subfamily M, member 5	0.019
Klhl1	kelch-like 1 (Drosophila)	0.019
2310021H06Rik	RIKEN cDNA 2310021H06 gene	0.019
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.019
Klf12	Kruppel-like factor 12	0.019
Cox8c	cytochrome c oxidase, subunit VIIIc	0.019
Fgf14	fibroblast growth factor 14	0.019
Slit1	slit homolog 1 (Drosophila)	0.019
Tff1	trefoil factor 1	0.019
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.018
Rbp3	retinol binding protein 3, interstitial	0.018
Darc	Duffy blood group, chemokine receptor	0.018
Mc3r	melanocortin 3 receptor	0.018
Mchr1	melanin-concentrating hormone receptor 1	0.018
Psap	prosaposin	0.018
Mip	major intrinsic protein of eye lens fiber	0.018
Guca1b	guanylate cyclase activator 1B	0.018
Ropn1	ropporin, rhophilin associated protein 1	0.018
Opn4	opsin 4 (melanopsin)	0.018
Gnat1	guanine nucleotide binding protein, alpha transducing 1	0.017
Calb2	calbindin 2	0.017
Phox2b	paired-like homeobox 2b	0.017
Adarb2	adenosine deaminase, RNA-specific, B2	0.017
Prox1	prospero-related homeobox 1	0.017
Myo15	myosin XV	0.017
Sall4	sal-like 4 (Drosophila)	0.017
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.016
Apoa5	apolipoprotein A-V	0.016
Dio2	deiodinase, iodothyronine, type II	0.016
Wnt7b	wingless-related MMTV integration site 7B	0.016
Olfr159	olfactory receptor 159	0.016
Olfr16	olfactory receptor 16	0.016
Gng3	guanine nucleotide binding protein (G protein), gamma 3	0.016
Srd5a2	steroid 5 alpha-reductase 2	0.016
Aff2	AF4/FMR2 family, member 2	0.016
Asb6	ankyrin repeat and SOCS box-containing 6	0.015
Chic1	cysteine-rich hydrophobic domain 1	0.015
Dll3	delta-like 3 (Drosophila)	0.015
Neurod1	neurogenic differentiation 1	0.015
Smok3a	sperm motility kinase 3A	0.015
Pde6h	phosphodiesterase 6H, cGMP-specific, cone, gamma	0.015
Clstn3	calsyntenin 3	0.015
Tmem8c	transmembrane protein 8C	0.015
Ccr10	chemokine (C-C motif) receptor 10	0.015
Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.015
Krt33a	keratin 33A	0.015
Sst	somatostatin	0.015
Adam1b	a disintegrin and metallopeptidase domain 1b	0.015
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.015
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.015
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.015
Chrnd	cholinergic receptor, nicotinic, delta polypeptide	0.014	Mouse
Pemt	phosphatidylethanolamine N-methyltransferase	0.014
Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.014
Krtap3-1	keratin associated protein 3-1	0.014
Brsk2	BR serine/threonine kinase 2	0.014
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.014
Cabp5	calcium binding protein 5	0.014
Prph	peripherin	0.014
Cend1	cell cycle exit and neuronal differentiation 1	0.014
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.014
Il9r	interleukin 9 receptor	0.014
Stx1b	syntaxin 1B	0.014
C1ql3	C1q-like 3	0.014
Grpr	gastrin releasing peptide receptor	0.014
Cacna1f	calcium channel, voltage-dependent, alpha 1F subunit	0.014
Gfap	glial fibrillary acidic protein	0.014
Nap1l2	nucleosome assembly protein 1-like 2	0.014
Alppl2	alkaline phosphatase, placental-like 2	0.013
Pcdh10	protocadherin 10	0.013
Creb3l3	cAMP responsive element binding protein 3-like 3	0.013
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.013
Hspb3	heat shock protein 3	0.013
Aldh8a1	aldehyde dehydrogenase 8 family, member A1	0.013
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.013
Atoh1	atonal homolog 1 (Drosophila)	0.013
Spp2	secreted phosphoprotein 2	0.013
Lhfpl5	lipoma HMGIC fusion partner-like 5	0.013
Rho	rhodopsin	0.013
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.013
Kcnk10	potassium channel, subfamily K, member 10	0.013
Gpr143	G protein-coupled receptor 143	0.013
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.013
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.013
Chst10	carbohydrate sulfotransferase 10	0.013
Bdkrb1	bradykinin receptor, beta 1	0.013
Tmem130	transmembrane protein 130	0.013
Cdh20	cadherin 20	0.012
Prpmp5	proline-rich protein MP5	0.012
Avp	arginine vasopressin	0.012
1810041L15Rik	RIKEN cDNA 1810041L15 gene	0.012
Krtap6-2	keratin associated protein 6-2	0.012
Htr3b	5-hydroxytryptamine (serotonin) receptor 3B	0.012
Tmem169	transmembrane protein 169	0.012
Rgs4	regulator of G-protein signaling 4	0.012
Pcsk1n	proprotein convertase subtilisin/kexin type 1 inhibitor	0.012
Hgf	hepatocyte growth factor	0.012
Prl2a1	prolactin family 2, subfamily a, member 1	0.012
Snn	stannin	0.012
Prl4a1	prolactin family 4, subfamily a, member 1	0.012
Cngb3	cyclic nucleotide gated channel beta 3	0.012
Kcnj14	potassium inwardly-rectifying channel, subfamily J, member 14	0.012
Olig1	oligodendrocyte transcription factor 1	0.012
Arpp21	cyclic AMP-regulated phosphoprotein, 21	0.012
Rgr	retinal G protein coupled receptor	0.012
Gngt1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.012
Mas1	MAS1 oncogene	0.012
Syngr1	synaptogyrin 1	0.012
Nrsn1	neurensin 1	0.011
Syn1	synapsin I	0.011
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.011
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.011
Oc90	otoconin 90	0.011
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.011
Myf6	myogenic factor 6	0.011
Dscam	Down syndrome cell adhesion molecule	0.011
Lix1	limb expression 1 homolog (chicken)	0.011
Serpinb6c	serine (or cysteine) peptidase inhibitor, clade B, member 6c	0.011
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.011
Grid1	glutamate receptor, ionotropic, delta 1	0.011
Prodh2	proline dehydrogenase (oxidase) 2	0.011
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.011
Slc6a12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.011
Cplx3	complexin 3	0.011
Ctsll3	cathepsin L-like 3	0.011
Aif1l	allograft inflammatory factor 1-like	0.011
Adcyap1	adenylate cyclase activating polypeptide 1	0.011
Mug1	murinoglobulin 1	0.011
Pcdhb5	protocadherin beta 5	0.011
Lingo1	leucine rich repeat and Ig domain containing 1	0.011
Ctrc	chymotrypsin C (caldecrin)	0.011
2900011O08Rik	RIKEN cDNA 2900011O08 gene	0.011
Art1	ADP-ribosyltransferase 1	0.011
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.011
Thbs2	thrombospondin 2	0.010
Pou4f1	POU domain, class 4, transcription factor 1	0.010
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.010
Tmc2	transmembrane channel-like gene family 2	0.010
Scn9a	sodium channel, voltage-gated, type IX, alpha	0.010
Vmn1r40	vomeronasal 1 receptor 40	0.010
Mylk2	myosin, light polypeptide kinase 2, skeletal muscle	0.010
Sfrp4	secreted frizzled-related protein 4	0.010
Tspan10	tetraspanin 10	0.010
Insm2	insulinoma-associated 2	0.010
Abcg8	ATP-binding cassette, sub-family G (WHITE), member 8	0.010
Dusp26	dual specificity phosphatase 26 (putative)	0.010
Gjd4	gap junction protein, delta 4	0.010