IMP
Process View
somatic motor neuron differentiation
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "somatic motor neuron differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Otx2 | orthodenticle homolog 2 (Drosophila) | 1.000 | ||
| Shh | sonic hedgehog | 0.999 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.995 | ||
| Pax3 | paired box gene 3 | 0.992 | ||
| Pax2 | paired box gene 2 | 0.988 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.985 | Mouse | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.985 | ||
| Foxc1 | forkhead box C1 | 0.961 | ||
| Msx1 | homeobox, msh-like 1 | 0.920 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.890 | ||
| Fgf8 | fibroblast growth factor 8 | 0.890 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.884 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.880 | ||
| Pax6 | paired box gene 6 | 0.868 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.842 | ||
| Tcfap2a | transcription factor AP-2, alpha | 0.841 | ||
| Chrd | chordin | 0.824 | ||
| Gbx2 | gastrulation brain homeobox 2 | 0.798 | ||
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.798 | ||
| Sox9 | SRY-box containing gene 9 | 0.691 | ||
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.678 | ||
| Foxg1 | forkhead box G1 | 0.655 | ||
| Foxc2 | forkhead box C2 | 0.645 | ||
| Tbx1 | T-box 1 | 0.582 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.582 | ||
| Smo | smoothened homolog (Drosophila) | 0.551 | Zebrafish | |
| Bmp7 | bone morphogenetic protein 7 | 0.488 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.463 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.388 | ||
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.381 | ||
| Dlx5 | distal-less homeobox 5 | 0.343 | ||
| Ret | ret proto-oncogene | 0.332 | ||
| Ednra | endothelin receptor type A | 0.319 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.298 | ||
| Psen1 | presenilin 1 | 0.291 | ||
| En1 | engrailed 1 | 0.290 | ||
| Lhx1 | LIM homeobox protein 1 | 0.287 | Mouse | |
| Sox11 | SRY-box containing gene 11 | 0.275 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.244 | ||
| Rarg | retinoic acid receptor, gamma | 0.229 | ||
| Jag1 | jagged 1 | 0.222 | ||
| Nog | noggin | 0.198 | ||
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.194 | Mouse | |
| Prrx1 | paired related homeobox 1 | 0.185 | Mouse | |
| Sox2 | SRY-box containing gene 2 | 0.176 | ||
| Msx2 | homeobox, msh-like 2 | 0.165 | ||
| Hes5 | hairy and enhancer of split 5 (Drosophila) | 0.160 | ||
| Erbb3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.150 | ||
| Gfra1 | glial cell line derived neurotrophic factor family receptor alpha 1 | 0.120 | ||
| Phox2b | paired-like homeobox 2b | 0.106 | Mouse | |
| Gsc | goosecoid homeobox | 0.098 | ||
| Hoxa1 | homeobox A1 | 0.085 | ||
| Neurod1 | neurogenic differentiation 1 | 0.084 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.076 | Zebrafish | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.073 | ||
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.072 | ||
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.069 | ||
| Mks1 | Meckel syndrome, type 1 | 0.069 | ||
| Fgf10 | fibroblast growth factor 10 | 0.063 | ||
| Rarb | retinoic acid receptor, beta | 0.061 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.061 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.058 | Zebrafish | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.054 | ||
| Prrx2 | paired related homeobox 2 | 0.053 | Mouse | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.051 | ||
| Nr2e1 | nuclear receptor subfamily 2, group E, member 1 | 0.048 | ||
| Dlx6 | distal-less homeobox 6 | 0.046 | ||
| Neurog2 | neurogenin 2 | 0.046 | ||
| Sox10 | SRY-box containing gene 10 | 0.044 | ||
| Rb1 | retinoblastoma 1 | 0.044 | ||
| Pou4f2 | POU domain, class 4, transcription factor 2 | 0.044 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.040 | ||
| Nrg1 | neuregulin 1 | 0.040 | ||
| Insm1 | insulinoma-associated 1 | 0.040 | ||
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.038 | ||
| Phox2a | paired-like homeobox 2a | 0.037 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.037 | ||
| Ptch1 | patched homolog 1 | 0.036 | ||
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.036 | ||
| Tbx15 | T-box 15 | 0.035 | ||
| En2 | engrailed 2 | 0.034 | ||
| Ptf1a | pancreas specific transcription factor, 1a | 0.034 | ||
| Lhx9 | LIM homeobox protein 9 | 0.034 | Mouse | |
| Meox2 | mesenchyme homeobox 2 | 0.033 | ||
| Wnt3a | wingless-related MMTV integration site 3A | 0.033 | ||
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.032 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.031 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.029 | Zebrafish | |
| Mab21l2 | mab-21-like 2 (C. elegans) | 0.029 | ||
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.029 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.028 | ||
| Wnt1 | wingless-related MMTV integration site 1 | 0.026 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.025 | ||
| Col2a1 | collagen, type II, alpha 1 | 0.024 | ||
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.024 | Mouse | |
| Rara | retinoic acid receptor, alpha | 0.024 | ||
| Pax7 | paired box gene 7 | 0.024 | ||
| Alx4 | aristaless-like homeobox 4 | 0.023 | ||
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.023 | ||
| Nodal | nodal | 0.022 | ||
| Six3 | sine oculis-related homeobox 3 homolog (Drosophila) | 0.021 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.020 | ||
| Atoh7 | atonal homolog 7 (Drosophila) | 0.020 | ||
| Bdnf | brain derived neurotrophic factor | 0.020 | ||
| Zic3 | zinc finger protein of the cerebellum 3 | 0.020 | ||
| Uncx | UNC homeobox | 0.019 | ||
| Ntf3 | neurotrophin 3 | 0.019 | ||
| Nrtn | neurturin | 0.019 | ||
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.018 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.018 | ||
| T | brachyury | 0.016 | ||
| Zic2 | zinc finger protein of the cerebellum 2 | 0.016 | ||
| Wt1 | Wilms tumor 1 homolog | 0.015 | ||
| Gata4 | GATA binding protein 4 | 0.015 | ||
| Hoxd13 | homeobox D13 | 0.014 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.014 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.014 | ||
| Hoxa2 | homeobox A2 | 0.014 | ||
| Tcf15 | transcription factor 15 | 0.014 | ||
| Lhx5 | LIM homeobox protein 5 | 0.014 | Mouse | |
| Jag2 | jagged 2 | 0.012 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.012 | ||
| Zic1 | zinc finger protein of the cerebellum 1 | 0.012 | ||
| Arx | aristaless related homeobox | 0.012 | ||
| Hes3 | hairy and enhancer of split 3 (Drosophila) | 0.012 | ||
| Fgf3 | fibroblast growth factor 3 | 0.012 | ||
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.011 | ||
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.011 | ||
| Pax9 | paired box gene 9 | 0.011 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.010 | ||
| Disp1 | dispatched homolog 1 (Drosophila) | 0.010 |